Toxic anterior segment syndrome: Role of enzymatic detergents used in the cleaning of intraocular surgical instruments

2016 ◽  
Vol 42 (9) ◽  
pp. 1249-1250 ◽  
Author(s):  
Nick Mamalis
Keyword(s):  
Anterior Segment ◽  
Surgical Instruments ◽  
Toxic Anterior Segment Syndrome

Toxic anterior segment syndrome (TASS). Literature review

2021 ◽  
pp. 86-90
Author(s):  
N.V. Pasikova ◽  
◽  
I.V. Kuznetsov ◽  
Keyword(s):  
Differential Diagnosis ◽  
Clinical Symptoms ◽  
Anterior Segment ◽  
Corneal Edema ◽  
Surgical Instruments ◽  
Rare Occurrence ◽  
Drug Injection ◽  
Toxic Anterior Segment Syndrome ◽  
American Society ◽  
Methods Of Treatment

This review presents the literature data on the etiology, clinical symptoms, differential diagnosis and methods of treatment of toxic anterior segment syndrome (TASS) – one of the complications of eye surgery. Despite the rare occurrence, in severe cases, the syndrome leads to a significant and persistent decrease in vision. The recommendations proposed by the American Society of Cataract and Refractive Surgeons for the prevention of the syndrome allow to avoid its occurrence. Key words: corneal edema, toxic anterior segment syndrome, surgical instruments, intracameral drug injection.

scholarly journals Toxic Anterior Segment Syndrome after Foldable Artiflex Iris-Fixated Phakic Intraocular Lens Implantation

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Lucien A. M. van Philips
Keyword(s):  
Intraocular Lens ◽  
Anterior Segment ◽  
Topical Steroid ◽  
Steroid Treatment ◽  
Surgical Instruments ◽  
Intraocular Lens Implantation ◽  
Phakic Intraocular Lens ◽  
Lens Implantation ◽  
Toxic Anterior Segment Syndrome

Toxic anterior segment syndrome (TASS) developed in four cases after uneventful implantation of a foldable iris-fixated phakic intraocular lens (pIOL). Two cases occurred sequentially in one patient. The TASS subsided without complications in all cases after intensive topical steroid treatment. A multitude of possible causes is considered for the occurrence of these TASS cases. From the sterilization and cleaning of surgical instruments to the possibility of endotoxines in ophthalmic viscosurgical devices (OVD). These rare cases should alert the surgeon to the possibility of TASS after pIOL implantation.

scholarly journals Impact of Indocyanine Green Concentration, Exposure Time, and Degree of Dissolution in Creating Toxic Anterior Segment Syndrome: Evaluation in a Rabbit Model

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Tamer Tandogan ◽  
Ramin Khoramnia ◽  
Gerd Uwe Auffarth ◽  
Michael Janusz Koss ◽  
Chul Young Choi
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Indocyanine Green ◽  
Exposure Time ◽  
Anterior Segment ◽  
Rabbit Model ◽  
Ultrasound Pachymetry ◽  
Toxic Anterior Segment Syndrome ◽  
Scanning Electron

Purpose. To investigate the role of indocyanine green (ICG) dye as a causative material of toxic anterior segment syndrome (TASS) in an experimental rabbit model.Method. Eight eyes of four rabbits were allocated to this study. Capsular staining was performed using ICG dye, after which the anterior chamber was irrigated with a balanced salt solution. The effects of different concentrations (control, 0.25, 0.5, and 1.0%), exposure times (10 and 60 seconds), and the degree of dissolution (differently vortexed) were investigated. The analysis involved anterior segment photography, ultrasound pachymetry, prostaglandin assay (PGE2Parameter Assay, R&D systems, Inc.), and scanning electron microscopy of each iris.Result. There was no reaction in the control eye. A higher aqueous level of PGE2and more severe inflammatory reaction were observed in cases of eyes with higher concentration, longer exposure time, and poorly dissolved dye. Additionally, scanning electron microscopy revealed larger and coarser ICG particles.Conclusion. TASS occurrence may be associated with the concentration, exposure time, and degree of dissolution of ICG dye during cataract surgery.

scholarly journals Toxic anterior segment syndrome following phakic posterior chamber IOL: a rarity

2018 ◽  
Vol 11 (1) ◽  
pp. bcr-2018-225806 ◽  
Author(s):  
Archita Singh ◽  
Noopur Gupta ◽  
Vinod Kumar ◽  
Radhika Tandon
Keyword(s):  
Intensive Therapy ◽  
Anterior Segment ◽  
Secondary Glaucoma ◽  
Sterile Inflammation ◽  
Posterior Chamber ◽  
Refractive Errors ◽  
Corneal Decompensation ◽  
Toxic Anterior Segment Syndrome ◽  
Idiosyncratic Response ◽  
Posterior Chamber Iol

Implantable collamer lenses (ICL) have gained popularity for correction of myopia where kerato-refractive procedures are not indicated as in cases of high myopic refractive errors. Toxic anterior segment syndrome (TASS) is a very uncommonly reported postoperative complication following ICL implantation. A young patient developed severe corneal oedema and anterior segment inflammation on the first day after ICL implantation. Analysing retrospectively, possible idiosyncratic response to intracameral pilocarpine was considered as a cause for TASS. Prompt and intensive therapy with oral and topical potent steroids was visually rewarding. TASS, though a sterile inflammation can have catastrophic sequelae such as corneal decompensation and secondary glaucoma. Hence, timely identification and management is important.

scholarly journals Toxic anterior segment syndrome after uncomplicated cataract surgery possibly associated with intracamaral use of cefuroxime

2015 ◽  
pp. 493 ◽  
Author(s):  
Burçin Çakir ◽  
Erkan Celik ◽  
Nilgün Aksoy ◽  
Ozlem Bursalı ◽  
Turgay Uçak ◽  
...  
Keyword(s):  
Cataract Surgery ◽  
Anterior Segment ◽  
Toxic Anterior Segment Syndrome

Abstract 12770: The Significant Role of Endothelium and Arterial Wall Properties in Patients With Pseudoexfoliative Glaucoma

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Georgia Siasou ◽  
Gerasimos Siasos ◽  
Marilita M Moschos ◽  
Nikolaos Gouliopoulos ◽  
Evangelos Oikonomou ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Endothelial Function ◽  
Significant Role ◽  
Vascular Function ◽  
Arterial Wall ◽  
Augmentation Index ◽  
Open Angle Glaucoma ◽  
Anterior Segment ◽  
Pseudoexfoliative Glaucoma

Introduction: Primary open-angle glaucoma (POAG) is one of the most prevalent causes of irreversible blindness and is associated with endothelial dysfunction and arterial stiffness. Pseudoexfoliative glaucoma (PEG) is another type of glaucoma observed in pseudoexfoliation syndrome. It is characterized by the deposition of pseudoexfoliative material not only to the anterior segment of the eye, but also to the vessels, heart and other organs. Hypothesis: Endothelial function and arterial stiffness are impaired in patients with POAG and PEG supporting the significant role of vascular function impairment in the progression of the disease. Methods: Forty four POAG patients, 22 PEG and 38 healthy subjects (Cl) were included in this study. All subjects were free of cardiovascular or inflammatory diseases. Endothelial function was evaluated by flow-mediated dilatation (FMD). Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) as a measure of arterial wave reflections Results: Between the three study groups CL, POAG, PEG there was no difference in age (67±10years vs. 70±9years vs. 66±12yeras, p=0.12) or prevalence of male sex (70% vs. 57% vs. 50%, p=0.21). Importantly, there was a linear impairment of FMD (7.35±2.77% vs. 6.58±3.18% vs. 4.88±3.29%, p=0.006), PWV (7.98±1.56m/sec vs. 9.20±1.84m/sec vs. 9.22±2.16m/sec, p=0.004) and AIx (21.29±8.77% vs. 25.14±5.71% vs. 28.20±8.75%, p=0.002) from CL to POAG and PEG. Interestingly post hoc test after Scheffe correction revealed also that PEG subjects had not only significantly impaired FMD, compared to control subjects, but also compared to POAG subjects (4.88±3.29% vs. 6.58±3.18%, p=0.02). Conclusions: Endothelial function and arterial stiffness are significantly impaired in patients with pseudoexfoliative glaucoma. These findings shed some light in the pathophysiology of pseudoexfoliative glaucoma and support the theory that pseudoexfoliative fibrils may also accumulate and damage the arterial wall.

Barium-induced toxic anterior segment syndrome

2021 ◽  
pp. 112067212110692
Author(s):  
Kenji Matsushita ◽  
Rumi Kawashima ◽  
Noriyasu Hashida ◽  
Yuki Hamano ◽  
Kazuo Harada ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Inductively Coupled Plasma ◽  
Anterior Segment ◽  
Rapid Onset ◽  
Ocular Surgery ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Baerveldt Glaucoma Implant ◽  
Toxic Anterior Segment Syndrome

Toxic anterior segment syndrome (TASS) is a rapid-onset inflammation of the eye following uneventful ocular surgery. We report a case of TASS following Baerveldt glaucoma implant (BGI) surgery. Inductively coupled plasma-mass spectrometry (ICP-MS) identified barium in the eye and in the eluate from the bleb of the BGI. We attribute TASS in our patient to the dissolution of barium from the BGI and its entry into the eye, where it causes severe inflammation.

scholarly journals Enzymotherapy of toxic anterior segment syndrome after phacoemulsification

2017 ◽  
Vol 10 (2) ◽  
pp. 87-93
Author(s):  
Alexander S Suvorov ◽  
Timur G Sazhin
Keyword(s):  
Visual Acuity ◽  
Anterior Chamber ◽  
Treatment Initiation ◽  
Anterior Segment ◽  
Treatment Result ◽  
Eye Drops ◽  
Group Iii ◽  
Group I ◽  
Toxic Anterior Segment Syndrome ◽  
Observation Period

Purpose. To investigate the efficacy of recombinant prourokinase (RPU) treatment in patients with toxic anterior segment syndrome after phacoemulsification. Material and methods. We observed 123 patients (123 eyes) with toxic anterior segment syndrome after phacoemulsification; patients of the group I (n = 30) received only antiinflammatory treatment; in treatment of patients of the group II (n = 31), instillations of the RPU solution were used, in the group III (n = 31), RPU solution was injected subconjunctivally, in the group IV (n = 31) - RPU solution electrophoresis was used. Treatment result analysis was carried out within 30 days. Results. Initial mean visual acuity in groups was 0.09 ± 0.04; 0.1 ± 0.04; 0.09 ± 0.04; 0.08 ± 0.04, and was virtually the same (p > 0.05). In 24 hours after treatment initiation, mean visual acuity in the group III was higher, than in the others. In three days and up to the end of observation period, the lowest mean visual acuity was noted in the group I (p < 0.05). Anterior chamber assessment showed that beginning from the first 24 hours after treatment initiation, in groups III and IV, fibrin lysis in the anterior chamber was more pronounced, than in groups I and II (p < 0.05); by the end of the observation period, worst indices of anterior chamber state were found in the group I (p < 0.05), in other groups, they were almost identical (p < 0.05). When using RPU, no allergic reaction was noted. Conclusions. RPU use in combined toxic anterior segment syndrome therapy after phacoemulsification allows increasing visual acuity, reducing convalescence time, and reducing the number of laser dissections. It was established that all methods of RPU administration are effective. RPU may be administered as eye drops on an outpatient basis, receiving efficacy similar to other administration methods.

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