The relationship between 8-oxo-7,8-dihydro-2′-deoxyguanosine level and extent of cytosine methylation in leukocytes DNA of healthy subjects and in patients with colon adenomas and carcinomas

2008 ◽  
Vol 640 (1-2) ◽  
pp. 170-173 ◽  
Author(s):  
Jolanta Guz ◽  
Marek Foksinski ◽  
Agnieszka Siomek ◽  
Daniel Gackowski ◽  
Rafal Rozalski ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Cytosine Methylation ◽  
Colon Adenomas ◽  
The Relationship

scholarly journals Study onYang-XuUsing Body Constitution Questionnaire and Blood Variables in Healthy Volunteers

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Hong-Jhang Chen ◽  
Yii-Jeng Lin ◽  
Pei-Chen Wu ◽  
Wei-Hsiang Hsu ◽  
Wan-Chung Hu ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Logistic Regression Model ◽  
Cross Validation ◽  
Blood Biomarkers ◽  
Metabolic Characteristics ◽  
Body Constitution ◽  
Leave One Out ◽  
The Relationship ◽  
Fold Cross Validation ◽  
Blood Variables

Traditional Chinese medicine (TCM) formulates treatment according to body constitution (BC) differentiation. Different constitutions have specific metabolic characteristics and different susceptibility to certain diseases. This study aimed to assess theYang-Xuconstitution using a body constitution questionnaire (BCQ) and clinical blood variables. A BCQ was employed to assess the clinical manifestation ofYang-Xu. The logistic regression model was conducted to explore the relationship between BC scores and biomarkers. Leave-one-out cross-validation (LOOCV) and K-fold cross-validation were performed to evaluate the accuracy of a predictive model in practice. Decision trees (DTs) were conducted to determine the possible relationships between blood biomarkers and BC scores. According to the BCQ analysis, 49% participants without any BC were classified as healthy subjects. Among them, 130 samples were selected for further analysis and divided into two groups. One group comprised healthy subjects without any BC (68%), while subjects of the other group, named as the sub-healthy group, had three BCs (32%). Six biomarkers, CRE, TSH, HB, MONO, RBC, and LH, were found to have the greatest impact on BCQ outcomes inYang-Xusubjects. This study indicated significant biochemical differences inYang-Xusubjects, which may provide a connection between blood variables and theYang-XuBC.

The Relationship Between Metoprolol Plasma Concentration and Beta1-Blockade in Healthy Subjects: A Study on Conventional Metoprolol and Metoprolol CR/ZOK Formulations

1990 ◽  
Vol 30 (S2) ◽  
pp. S46-S54 ◽  
Author(s):  
Bertil Abrahamsson ◽  
Peter Lücker ◽  
Bertil Olofsson ◽  
Carl-Gunnar Regårdh ◽  
Anders Sandberg ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Healthy Subjects ◽  
The Relationship

scholarly journals UPLC-MS/MS Determination of Linezolid and Heme in Plasma of Infected Patients and Correlation Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yingying Wang ◽  
Xuemei Ye ◽  
Qin Lan ◽  
Xiaofang Ke ◽  
Lufeng Hu ◽  
...  
Keyword(s):  
Correlation Analysis ◽  
Healthy Subjects ◽  
Haematological Toxicity ◽  
Diagnostic Value ◽  
High Concentration ◽  
High Positive Correlation ◽  
Positive Correlation ◽  
Early Diagnose ◽  
The Relationship

Linezolid can cause serious haematological toxicity, such as thrombocytopenia and aneamia. Heme, composed of iron and porphyrin, is an important component of hemoglobin. In order to investigate the relationship between the concentration of linezolid and heme in the plasma of infected patients, a UPLC-MS/MS method that can determine the concentrations of linezolid and heme simultaneously was developed and validated. A total of 96 healthy subjects and 81 infected patients, who received blood routine blood tests, were included and determined by the UPLC-MS/MS method. The results showed that the concentration of linezolid was 5.08 ± 3.46   μ g / mL in infected patients who were treated with linezolid. The heme in healthy subjects was 7.05 ± 8.68   μ g / mL , and it was significantly decreased to 0.88 ± 0.79   μ g / mL in infected patients ( P < 0.01 ). Spearman correlation analysis showed that linezolid had a high negative correlation with platelet (PLT) ( R = − 0.309 ). Heme had a high positive correlation with hemoglobin (Hb) ( R = 0.249 ) in healthy subjects and infected patients. The ROC analysis showed that heme had diagnostic value to distinguish low Hb (110 g/L). In conclusion, there was a positive correlation between heme and Hb, and this correlation was also observed in infected patients. A high concentration of linezolid was inclined to decrease PLT. Monitoring of heme and linezolid helps in the early diagnose of low Hb and PLT.

scholarly journals Urine CA-2 as a biomarker for diagnosis urinary stone and prediction of its complications

2020 ◽  
Author(s):  
Yuan-jing Leng ◽  
Hai-bin Zhou ◽  
Jiang-ling Fu ◽  
Wen-juan Wang
Keyword(s):  
Healthy Subjects ◽  
Characteristic Curve ◽  
Urinary Stone ◽  
Urinary Stones ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Control ◽  
The Mean ◽  
The Difference ◽  
The Relationship

Abstract PURPOSECarbonic anhydrase-2 (CA-2) plays a role in mineralization and calcification in organism. Strong evidence suggests that CA-2 is associated with urolithiasis. However, the relationship between CA-2 and urinary stone remains unclear. The study aimed to assess the association of urine CA-2 (uCA-2) level and the potential risk of urinary stone.METHODSFrom March 2017 to November 2019, a prospective cohort study was conducted on patients with urinary stones and healthy subjects to determine the pretreatment uCA-2 level detection by Enzyme linked immunosorbent assay (ELISA). The difference of uCA-2 level between patients with urinary stones and healthy subjects was compared. Then comparison between stone patients with complications and without complications was carried out as well as correlation analysis to detect factors associated with biomarker expression.RESULTS118 patients with urinary stones were into urinary stones group and 42 healthy subjects were into healthy control group. The mean pretreatment uCA-2 level was significantly higher in patients with urinary stones group than healthy controls group (P=0.028). Furthermore, The uCA-2 level was positive correlation with urinary stones complications (R=0.379, P=0.000), especially pain complications (R=0.524, P=0.000) and hematuria complications (R=0.374, P=0.000). Receiver operating characteristic curve (ROC) analysis that a uCA-2 level threshold of 10.94 ng/mL had 83.67% sensitivity and 68.12% specificity for predicting urinary stones complications. CONCLUSIONSExcessive uCA-2 excretion is a major risk factor for urinary stone. Our findings suggested that uCA-2 may be used as an unappreciated biomarker for the diagnosis urinary stone in patients and to predict its complications.

scholarly journals Angiotensin-Converting Enzyme (ACE) D Allele as a Risk Factor for Increase Serum Interleukin-6 and Interleukin-8 in Psoriasis Patients

2018 ◽  
Vol 6 (5) ◽  
pp. 772-776 ◽  
Author(s):  
Ahmed I. Abd Elneam ◽  
Mohammed Saleh Al-Dhubaibi ◽  
Ali Ismaiel Ali Abd Alrheam
Keyword(s):  
Risk Factor ◽  
Healthy Subjects ◽  
Serum Levels ◽  
Converting Enzyme ◽  
Inflammatory Skin Disease ◽  
Ace Polymorphism ◽  
Ace Gene ◽  
Ace Gene Polymorphism ◽  
The Relationship

BACKGROUND: Psoriasis is a chronic, recurrent inflammatory skin disease. It is characterised by autoimmune, environmental factors and complex genetic disorder.AIM: To explore the role of IL-6, IL-8, and ACE I/D polymorphism in the pathogenesis of Psoriasis and investigation of the relationship between ACE polymorphism and occurrence of psoriasis.PATIENTS AND METHODS: In this study, we took 73 psoriasis patients and 47 healthy patients as a control. These two groups subjected to analysis for ACE gene I/D polymorphism by PCR and biochemical methods.RESULTS: The serum levels of ACE, IL-8 and IL-6 were statistically significantly higher in psoriasis patients compared to healthy subjects (P < 0.001). ID and DD polymorphism were more common in psoriasis patients than healthy subjects. Also, D allele was significantly over-represented in patients compared to controls (52.7% Vs 35.1%).CONCLUSION: ACE gene polymorphism might grant susceptibility to develop psoriasis.

scholarly journals The Relationship Between Hyperglycemia and the Rheumatoid Factor in the Serum of Diabetic Patients

2009 ◽  
Vol 6 (1) ◽  
pp. 99-105
Author(s):  
Baghdad Science Journal
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Healthy Subjects ◽  
Diabetic Patients ◽  
Diabetic Mellitus ◽  
Positive Rheumatoid Factor ◽  
Common Diseases ◽  
Males And Females ◽  
The Relationship ◽  
Apparently Healthy

This study was conducted to determine the relationship between two most common diseases in Iraqis patients , which are Diabetic mellitus (DM) and Rheumatoid Arthritis (RA); seeking rheumatoid factor in hyperglycemic sera. The results revealed that ; 62.5% of hyperglycemic (HG) patients had positive rheumatoid factor (RF) . No difference in number between both gender of HG patients (20 males and 20 females ) , RF reaction was nearly similar in males and females of HG patients ( 12 &13 respectively ) . Only 40% out of patient controls had positive RF . None of the apparently healthy subjects had positive RF .

scholarly journals Possible Effect of Headphone Usage on Working Memory Among Students in Faculty of Medicine, Ahmadu Bello University, Zaria‒Nigeria

2019 ◽  
pp. 1-4
Author(s):  
Yushau Yusuf ◽  
Muhammad U.A ◽  
Isah F.A
Keyword(s):  
Working Memory ◽  
Signal Processing ◽  
Cognitive Abilities ◽  
Healthy Subjects ◽  
Significant Difference ◽  
Stored Information ◽  
Age Range ◽  
The Relationship ◽  
The Brain ◽  
Back Task

Working memory is a system that is responsible for transient holding and processing of new and already stored information. It also involves processing for reasoning, comprehension, learning and memory updating. Headphones are a pair of small loudspeakers that are designed to be held in place close to a user’s ear. They are electroacoustic transducers which convert electrical signals to a corresponding sound in the user’s ear. Several studies have recently shown a link between cognitive abilities and response to hearing aid and signal processing in the brain. Therefore, the relationship between headphone usage among healthy subjects become pertinent. This study is aimed at evaluating the effect of headphone on working memory using N-back task. One hundred (100) participants (55 headphone users and 45 non-headphone user’s) within the age range of 18-31 years were assessed. Participants were instructed to keep in memory, a series of letters and say “target” whenever there was a repetition of letter with exactly one intervening letter and to remain silent when any other letter appeared. The results of this study showed that there was no statistically significant difference in working memory between headphone and non-headphone users with p>0.05. In conclusion, this study revealed headphone use has no effect on working memory of the participants subjected to N–back test.

Circadian Changes in Subfoveal Choroidal Thickness and the Relationship with Circulatory Factors in Healthy Subjects

2012 ◽  
Vol 53 (4) ◽  
pp. 2300 ◽  
Author(s):  
Shinichi Usui ◽  
Yasushi Ikuno ◽  
Masahiro Akiba ◽  
Ichiro Maruko ◽  
Tetsuju Sekiryu ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Choroidal Thickness ◽  
Subfoveal Choroidal Thickness ◽  
Circadian Changes ◽  
The Relationship

scholarly journals Relationship between neutrophil/lymphocyte ratio and epicardial fat tissue thickness in patients with newly diagnosed hypertension

2018 ◽  
Vol 46 (3) ◽  
pp. 940-950 ◽  
Author(s):  
Mehmet Ali Derya ◽  
Vahit Demir ◽  
Huseyin Ede
Keyword(s):  
Blood Pressure ◽  
Healthy Subjects ◽  
Control Group ◽  
Newly Diagnosed ◽  
Fat Tissue ◽  
Tissue Thickness ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Epicardial Fat Tissue ◽  
The Relationship

Objective Epicardial fat tissue thickness (EFT) and the neutrophil/lymphocyte ratio (NLR) are associated with atherosclerosis. Few studies have focused on the relationship between these parameters in patients with newly diagnosed hypertension. In this study, we examined the relationship between EFT and the NLR in patients with newly diagnosed hypertension detected by 24-hour ambulatory blood pressure monitoring (ABPM). Methods Eighty consecutive patients without chronic illness who were diagnosed with hypertension according to ABPM results and 80 otherwise healthy subjects were enrolled in the study. EFT of each participant was measured echocardiographically. The C-reactive protein (CRP) concentration and NLR were measured from venous blood samples. Results The 24-hour average systolic blood pressure was significantly higher in the hypertension group than in the control group (143±17 vs. 117±7 mmHg, respectively). There were no significant differences in age, sex, or body mass index between the two groups. EFT, the NLR, and the CRP concentration were significantly higher in the hypertension group than control group. Additionally, a significantly positive correlation between EFT and the NLR was found in both the control group and hypertension group. Conclusion A higher EFT and NLR were detected in patients with newly diagnosed hypertension than in healthy subjects.

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