Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: The impact of medication

The recent development of the Z-contrast imaging technique for the VG HB501 UX dedicated STEM, has added a high-resolution imaging facility to a microscope used mainly for microanalysis. This imaging technique not only provides a high-resolution reference image, but as it can be performed simultaneously with electron energy loss spectroscopy (EELS), can be used to position the electron probe at the atomic scale. The spatial resolution of both the image and the energy loss spectrum can be identical, and in principle limited only by the 2.2 Å probe size of the microscope. There now exists, therefore, the possibility to perform chemical analysis of materials on the scale of single atomic columns or planes.In order to achieve atomic resolution energy loss spectroscopy, the range over which a fast electron can cause a particular excitation event, must be less than the interatomic spacing. This range is described classically by the impact parameter, b, which ranges from ~10 Å for the low loss region of the spectrum to <1Å for the core losses.

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The impact of ziprasidone in combination with sertraline on visually-evoked event-related potentials in depressed patients with psychotic features

Pharmacopsychiatry ◽

10.1055/s-2007-991717 ◽

2007 ◽

Vol 40 (05) ◽

Author(s):

O Moeller ◽

S Evers ◽

J Deckert ◽

B Baune ◽

U Dannlowski ◽

...

Keyword(s):

Event Related Potentials ◽

Depressed Patients ◽

Related Potentials ◽

Psychotic Features ◽

The Impact

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F117EVALUATING THE IMPACT OF NON-RANDOM MATING: PSYCHIATRIC OUTCOMES AMONG THE OFFSPRING OF PAIRS DIAGNOSED WITH SCHIZOPHRENIA AND BIPOLAR DISORDER

European Neuropsychopharmacology ◽

10.1016/j.euroneuro.2018.08.197 ◽

2019 ◽

Vol 29 ◽

pp. S1173-S1174

Author(s):

James Crowley ◽

Ashley Nordsletten ◽

Gustaf Brander ◽

Patrick Sullivan ◽

Naomi Wray ◽

...

Keyword(s):

Bipolar Disorder ◽

Random Mating ◽

Psychiatric Outcomes ◽

The Impact

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High-Resolution Climate Change Impact Analysis on Expected Future Water Availability in the Upper Jordan Catchment and the Middle East

Journal of Hydrometeorology ◽

10.1175/jhm-d-13-0153.1 ◽

2014 ◽

Vol 15 (4) ◽

pp. 1517-1531 ◽

Cited By ~ 15

Author(s):

Gerhard Smiatek ◽

Harald Kunstmann ◽

Andreas Heckl

Keyword(s):

Climate Change ◽

High Resolution ◽

Water Availability ◽

Impact Analysis ◽

River Flow ◽

Climate Model ◽

Mesoscale Model ◽

Global Climate Model ◽

Full Range ◽

The Impact

Abstract The impact of climate change on the future water availability of the upper Jordan River (UJR) and its tributaries Dan, Snir, and Hermon located in the eastern Mediterranean is evaluated by a highly resolved distributed approach with the fifth-generation Pennsylvania State University–NCAR Mesoscale Model (MM5) run at 18.6- and 6.2-km resolution offline coupled with the Water Flow and Balance Simulation Model (WaSiM). The MM5 was driven with NCEP reanalysis for 1971–2000 and with Hadley Centre Coupled Model, version 3 (HadCM3), GCM forcings for 1971–2099. Because only one regional–global climate model combination was applied, the results may not give the full range of possible future projections. To describe the Dan spring behavior, the hydrological model was extended by a bypass approach to allow the fast discharge components of the Snir to enter the Dan catchment. Simulation results for the period 1976–2000 reveal that the coupled system was able to reproduce the observed discharge rates in the partially karstic complex terrain to a reasonable extent with the high-resolution 6.2-km meteorological input only. The performed future climate simulations show steadily rising temperatures with 2.2 K above the 1976–2000 mean for the period 2031–60 and 3.5 K for the period 2070–99. Precipitation trends are insignificant until the middle of the century, although a decrease of approximately 12% is simulated. For the end of the century, a reduction in rainfall ranging between 10% and 35% can be expected. Discharge in the UJR is simulated to decrease by 12% until 2060 and by 26% until 2099, both related to the 1976–2000 mean. The discharge decrease is associated with a lower number of high river flow years.

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Impact of depression on quality of life in systemic lupus erythematosus patients

The Egyptian Journal of Neurology Psychiatry and Neurosurgery ◽

10.1186/s41983-021-00343-y ◽

2021 ◽

Vol 57 (1) ◽

Author(s):

Eman M. Khedr ◽

Rania M. Gamal ◽

Sounia M. Rashad ◽

Mary Yacoub ◽

Gellan K. Ahmed

Keyword(s):

Quality Of Life ◽

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Short Form ◽

Systemic Lupus ◽

Positive Correlation ◽

Depressed Patients ◽

Sf 36 ◽

The Impact

Abstract Background Depression is common in systemic lupus erythematosus (SLE) and is an unmeasured risk factor, yet its symptoms can be neglected in standard disease evaluations. The purpose of this study was to assess the frequency and the impact of depression on quality of life in SLE patients. We recruited 32 patients with SLE and 15 healthy control volunteers in the study. The following investigations were undertaken in each patient: clinical and rheumatologic assessment, SLE Disease Activity Index-2k (SLEDAI-2k), Beck Depression Inventory (BDI), Short-Form Health Survey (SF-36) questionnaire, and routine laboratory tests. Results There was a high percentage of depression (46.9%) in the SLE patients. Regarding quality of life (SF-36), there were significant affection of the physical and mental composite summary domains (PCS and MCS) scores in lupus patients compared with controls (P < 0.000 for both) with the same significant in depressed compared with non-depressed patients. SF-36 subscales (physical function, limit emotional, emotional wellbeing, and social function) were significantly affected in depressed lupus patients compared with non-depressed patients. There was a significant negative correlation between the score of MCS domain of SF-36 with BDI (P < 0.000) while positive correlation between SLEDAI score with depression score. In contrast, there were no significant correlations between MCS or PCS with age, duration of illness, or SLEDAI-2K. Conclusions Depression is common in SLE patients and had a negative impact on quality of life particularly on MCS domain and positive correlation with disease severity score. Trial registration This study was registered on clinical trial with registration number: NCT03165682 https://clinicaltrials.gov/ct2/show/NCT03165682 on 24 May 2017.

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Treatment of bipolar depression with supraphysiologic doses of levothyroxine: a randomized, placebo-controlled study of comorbid anxiety symptoms

International Journal of Bipolar Disorders ◽

10.1186/s40345-019-0155-y ◽

2019 ◽

Vol 7 (1) ◽

Author(s):

Maximilian Pilhatsch ◽

Thomas J Stamm ◽

Petra Stahl ◽

Ute Lewitzka ◽

Anne Berghöfer ◽

...

Keyword(s):

Bipolar Disorder ◽

Rating Scale ◽

Bipolar Depression ◽

Phenotypic Expression ◽

Anxiety Symptoms ◽

Controlled Study ◽

Double Blind ◽

Comorbid Anxiety ◽

Depressed Patients ◽

Depressive Episodes

Abstract Background Symptoms of anxiety co-occur in a variety of disorders including in depressive episodes of bipolar disorder and in patients with thyrotoxicosis. Treatment of refractory bipolar disorder with supraphysiologic doses of levothyroxine (L-T4) has been shown to improve the phenotypic expression of the disorder and is associated with an increase of circulating thyroid hormones. However, it might be associated with somatic and mental adverse effects. Here we report the investigation of the influence of treatment with supraphysiologic doses of L-T4 on symptoms of anxiety in patients with refractory bipolar depression. Methods Post-hoc analysis from a 6-week, multi-center, randomized, double-blind, placebo-controlled study of the effects of supraphysiologic L-T4 treatment on anxiety symptoms in bipolar depression. Anxiety symptoms were measured weekly with the Hamilton anxiety/somatization factor (HASF) score of the Hamilton Depression Rating Scale (HAMD) and the State- and Trait Anxiety Inventory (STAI). Results Treatment of both groups was associated with a significant reduction in anxiety symptoms (p < 0.001) with no statistical difference between groups (LT-4: from 5.9 (SD = 2.0) at baseline to 3.7 (SD = 2.4) at study end; placebo: from 6.1 (SD = 2.4) at baseline to 4.4 (SD = 2.8) at study end; p = 0.717). Severity of anxiety at baseline did not show a statistically significant correlation to the antidepressive effect of treatment with supraphysiologic doses of L-T4 (p = 0.811). Gender did not show an influence on the reduction of anxiety symptoms (females: from 5.6 (SD = 1.7) at baseline to 3.5 (SD = 2.4) at study end; males: from 6.1 (SD = 2.3) at baseline to 4.0 (SD = 2.4) at study end; p = 0.877). Conclusions This study failed to detect a difference in change of anxiety between bipolar depressed patients treated with supraphysiologic doses of L-T4 or placebo. Comorbid anxiety symptoms should not be considered a limitation for the administration of supraphysiologic doses of L-T4 refractory bipolar depressed patients. Trial registration ClinicalTrials, ClinicalTrials.gov identifier: NCT01528839. Registered 2 June 2012—Retrospectively registered, https://clinicaltrials.gov/ct2/show/study/NCT01528839

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Emotional availability in women with bipolar disorder and major depression: A longitudinal pregnancy cohort study

Australian & New Zealand Journal of Psychiatry ◽

10.1177/0004867421998796 ◽

2021 ◽

pp. 000486742199879

Author(s):

Pavitra Aran ◽

Andrew J Lewis ◽

Stuart J Watson ◽

Thinh Nguyen ◽

Megan Galbally

Keyword(s):

Bipolar Disorder ◽

Major Depressive Disorder ◽

Depressive Symptoms ◽

Major Depression ◽

Depressive Disorder ◽

Emotional Availability ◽

Major Depressive ◽

Interaction Quality ◽

Pregnancy Cohort ◽

The Impact

Objective: Poorer mother–infant interaction quality has been identified among women with major depression; however, there is a dearth of research examining the impact of bipolar disorder. This study sought to compare mother–infant emotional availability at 6 months postpartum among women with perinatal major depressive disorder, bipolar disorder and no disorder (control). Methods: Data were obtained for 127 mother–infant dyads from an Australian pregnancy cohort. The Structured Clinical Interview for the DSM-5 was used to diagnose major depressive disorder ( n = 60) and bipolar disorder ( n = 12) in early pregnancy (less than 20 weeks) and review diagnosis at 6 months postpartum. Prenatal and postnatal depressive symptoms were measured using the Edinburgh Postnatal Depression Scale, along with self-report psychotropic medication use. Mother and infant’s interaction quality was measured using the Emotional Availability Scales when infants reached 6 months of age. Multivariate analyses of covariance examining the effects of major depressive disorder and bipolar disorder on maternal emotional availability (sensitivity, structuring, non-intrusiveness, non-hostility) and child emotional availability (responsiveness, involvement) were conducted. Results: After controlling for maternal age and postpartum depressive symptoms, perinatal disorder (major depressive disorder, bipolar disorder) accounted for 17% of the variance in maternal and child emotional availability combined. Compared to women with major depressive disorder and their infants, women with bipolar disorder and their infants displayed lower ratings across all maternal and child emotional availability qualities, with the greatest mean difference seen in non-intrusiveness scores. Conclusions: Findings suggest that perinatal bipolar disorder may be associated with additional risk, beyond major depressive disorder alone, to a mother and her offspring’s emotional availability at 6 months postpartum, particularly in maternal intrusiveness.

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Quantifying the impact of cropland wind erosion on air quality: A high-resolution modeling case study of an Arizona dust storm

Atmospheric Environment ◽

10.1016/j.atmosenv.2021.118658 ◽

2021 ◽

pp. 118658

Author(s):

Janak Raj Joshi

Keyword(s):

Air Quality ◽

High Resolution ◽

Dust Storm ◽

Wind Erosion ◽

The Impact

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Splash formation by spherical drops

Journal of Fluid Mechanics ◽

10.1017/s0022112000002500 ◽

2001 ◽

Vol 427 ◽

pp. 73-105 ◽

Cited By ~ 91

Author(s):

LIOW JONG LENG

Keyword(s):

High Resolution ◽

Quantitative Data ◽

Water Surface ◽

High Speed ◽

Scaling Laws ◽

Capillary Wave ◽

Water Drop ◽

Qualitative And Quantitative ◽

High Resolution Images ◽

The Impact

The impact of a spherical water drop onto a water surface has been studied experimentally with the aid of a 35 mm drum camera giving high-resolution images that provided qualitative and quantitative data on the phenomena. Scaling laws for the time to reach maximum cavity sizes have been derived and provide a good fit to the experimental results. Transitions between the regimes for coalescence-only, the formation of a high-speed jet and bubble entrapment have been delineated. The high-speed jet was found to occur without bubble entrapment. This was caused by the rapid retraction of the trough formed by a capillary wave converging to the centre of the cavity base. The converging capillary wave has a profile similar to a Crapper wave. A plot showing the different regimes of cavity and impact drop behaviour in the Weber–Froude number-plane has been constructed for Fr and We less than 1000.

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