scholarly journals Decades of emerging infectious disease, food safety, and antimicrobial resistance response in Vietnam: The role of One Health

One Health ◽  
2021 ◽  
pp. 100361
Author(s):  
Hung Nguyen-Viet ◽  
Steven Lam ◽  
Huong Nguyen-Mai ◽  
Dao Thu Trang ◽  
Vu Thi Phuong ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Food Safety ◽  
Antimicrobial Resistance ◽  
One Health ◽  
Emerging Infectious Disease ◽  
Resistance Response

scholarly journals Antimicrobials and Food-Related Stresses as Selective Factors for Antibiotic Resistance along the Farm to Fork Continuum

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 671
Author(s):  
Federica Giacometti ◽  
Hesamaddin Shirzad-Aski ◽  
Susana Ferreira
Keyword(s):  
Antibiotic Resistance ◽  
Food Safety ◽  
Antimicrobial Resistance ◽  
Food Processing ◽  
Resistance Mechanisms ◽  
Human Environment ◽  
Real Risk ◽  
Cross Adaptation ◽  
Novel Approaches

Antimicrobial resistance (AMR) is a global problem and there has been growing concern associated with its widespread along the animal–human–environment interface. The farm-to-fork continuum was highlighted as a possible reservoir of AMR, and a hotspot for the emergence and spread of AMR. However, the extent of the role of non-antibiotic antimicrobials and other food-related stresses as selective factors is still in need of clarification. This review addresses the use of non-antibiotic stressors, such as antimicrobials, food-processing treatments, or even novel approaches to ensure food safety, as potential drivers for resistance to clinically relevant antibiotics. The co-selection and cross-adaptation events are covered, which may induce a decreased susceptibility of foodborne bacteria to antibiotics. Although the available studies address the complexity involved in these phenomena, further studies are needed to help better understand the real risk of using food-chain-related stressors, and possibly to allow the establishment of early warnings of potential resistance mechanisms.

scholarly journals High Prevalence and Diversity of Cephalosporin-Resistant Enterobacteriaceae Including Extraintestinal Pathogenic E. coli CC648 Lineage in Rural and Urban Dogs in Northwest Spain

Antibiotics ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 468 ◽  
Author(s):  
Fátima Abreu-Salinas ◽  
Dafne Díaz-Jiménez ◽  
Isidro García-Meniño ◽  
Pilar Lumbreras ◽  
Ana María López-Beceiro ◽  
...  
Keyword(s):  
High Risk ◽  
Antimicrobial Resistance ◽  
One Health ◽  
Potential Role ◽  
Multidrug Resistant ◽  
E Coli ◽  
Rural And Urban ◽  
High Prevalence ◽  
Healthy Dogs

The aim of this work was to assess the prevalence of extended spectrum-β-lactamase (ESBL)- and carbapenemase-producing Enterobacteriaceae in fecal samples recovered from rural and urban healthy dogs in Northwest Spain (Galicia) to identify potential high-risk clones and to molecularly characterize positive isolates regarding the genes coding for ESBL/pAmpC resistance and virulence. Thirty-five (19.6%) out of 179 dogs were positive for cephalosporin-resistant Enterobacteriaceae, including Escherichiacoli and Klebsiella pneumoniae (39 and three isolates, respectively). All the isolates were multidrug resistant, with high rates of resistance to different drugs, including ciprofloxacin (71.4%). A wide diversity of ESBL/pAmpC enzymes, as well as E. coli phylogroups (A, B1, C, D, E, F and clade I) were found. The eight isolates (20.5%) found to conform to the ExPEC status, belonged to clones O1:H45-clade I-ST770 (CH11-552), O18:H11-A-ST93-CC168 (CH11-neg), O23:H16-B1-ST453-CC86 (CH6-31), and O83:H42-F-ST1485-CC648 (CH231-58), with the latter also complying the uropathogenic (UPEC) status. The three K. pneumoniae recovered produced CTX-M-15 and belonged to the ST307, a clone previously reported in human clinical isolates. Our study highlights the potential role of both rural and urban dogs as a reservoir of high-risk Enterobacteriaceae clones, such as the CC648 of E. coli and antimicrobial resistance traits. Within a One-Health approach, their surveillance should be a priority in the fight against antimicrobial resistance.

scholarly journals Implementing a One Health approach to emerging infectious disease: reflections on the socio-political, ethical and legal dimensions

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Chris Degeling ◽  
Jane Johnson ◽  
Ian Kerridge ◽  
Andrew Wilson ◽  
Michael Ward ◽  
...  
Keyword(s):  
Infectious Disease ◽  
One Health ◽  
Emerging Infectious Disease

Clinical value of echocardiography in patients with COVID-19: a systematic review

2021 ◽  
pp. 8-13
Author(s):  
M. N. Alekhin ◽  
S. I. Ivanov ◽  
A. I. Stepanova
Keyword(s):  
Infectious Disease ◽  
Systematic Review ◽  
Clinical Studies ◽  
Cardiovascular Complications ◽  
Emerging Infectious Disease ◽  
Clinical Value ◽  
Medical Databases ◽  
Contagious Disease ◽  
The Given

This systematic review is dedicated to the role of echocardiography in diagnostics of possible cardiovascular complications in patients with COVID-19, the emerging infectious disease that has recently challenged global healthcare. The results of the largest current available clinical studies on the given topic from the leading medical databases were analyzed. Up-to-date data about the beneficial advantages and possible limitations of the use of echocardiography in the highly contagious disease pandemic is provided.

scholarly journals Role of different wastewater treatment plants in antibiotic resistance spreading

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
S Bonetta ◽  
C Pignata ◽  
S a Bonetta ◽  
E Gasparro ◽  
E Lorenzi ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Wastewater Treatment ◽  
Antimicrobial Resistance ◽  
One Health ◽  
Wastewater Treatment Plants ◽  
Water Cycle ◽  
Action Plan ◽  
Urban Water ◽  
Urban Water Cycle

Abstract The global action plan on antimicrobial resistance reports the necessity to develop standards and guidance for the presence of antimicrobial agents in the environment, especially in wastewater, highlighting its possible role in the antibiotic resistance spreading. In addition, the New European One Health Action Plan against Antimicrobial Resistance underlines the need to support research into knowledge gaps on the release of resistant microorganisms into the environment and their dissemination. The aim of this study was to evaluate the presence of Antibiotic Resistance Bacteria (ARB) and Antibiotic Resistance Genes (ARG) in wastewater treatment plants (WWTPs). At this scope, untreated sewage and treated effluents of three different WWTPs (A, B and C) were sampled for one year. Sample dilutions were plated on R2Agar added/not-added with 4 different antibiotics (ampicillin 32mg/L; tetracycline 16 mg/L; chloramphenicol 32 mg/L; sulfamethoxazole 50,4 mg/L) to evaluate the percentage of antibiotic resistant bacteria and their WWTPs removal rate (%). DNA extraction on the filter used to concentrate the wastewater samples was performed to reveal the ARG presence; subsequently specific PCRs for ARG (blaTEM, tetA, sul II, sul III) were carried out. ARB were detected in all samples analysed. The highest antibiotic resistance percentage was revealed in the sewage (mean 21,7%±4,8) and effluent (mean 21,1%±3,0) of the three wastewater treatment plants for sulfamethoxazole. Moreover, sul II was the most present gene in the samples (81% of all samples, 89 % of sewages and 72% of effluents). The lower WWTPs removal was recovered in the plant B for the tetracycline (95, 7%). The results obtained underlines the need to monitor WWTP as critical hot spot for the antibiotic resistance spreading also considering the One Health approach. Furthermore, the results obtained could suggest interventions to reduce the spread of the antibiotic resistance in the integrated urban water cycle. Key messages The information obtained could provide usefulness information about the role of wastewater treatment plant in the antibiotic resistance spreading. The results could contribute to suggest the interventions targeted to reduce the antibiotic resistance phenomenon in the integrated urban water cycle.

Bacteriocins: antibiotics in the age of the microbiome

2017 ◽  
Vol 1 (1) ◽  
pp. 55-63 ◽  
Author(s):  
Kevin Egan ◽  
R. Paul Ross ◽  
Colin Hill
Keyword(s):  
Infectious Disease ◽  
Animal Models ◽  
Antimicrobial Resistance ◽  
Animal Health ◽  
Collateral Damage ◽  
Safety And Efficacy ◽  
Antibiotic Development ◽  
The Impact ◽  
Activity Animal

Antibiotics have revolutionised the treatment of infectious disease and improved the lives of billions of people worldwide over many decades. With the rise in antimicrobial resistance (AMR) and corresponding lack of antibiotic development, we find ourselves in dire need of alternative treatments. Bacteriocins are a class of bacterially produced, ribosomally synthesised, antimicrobial peptides that may be narrow or broad in their spectra of activity. Animal models have demonstrated the safety and efficacy of bacteriocins in treating a broad range of infections; however, one of the principal drawbacks has been their relatively narrow spectra when compared with small-molecule antibiotics. In an era where we are beginning to appreciate the role of the microbiota in human and animal health, the fact that bacteriocins cause much less collateral damage to the host microbiome makes them a highly desirable therapeutic. This review makes a case for the implementation of bacteriocins as therapeutic antimicrobials, either alone or in combination with existing antibiotics to alleviate the AMR crisis and to lessen the impact of antibiotics on the host microbiome.

scholarly journals The Phagocyte Oxidase Controls Tolerance toMycobacterium tuberculosisinfection

2017 ◽  
Author(s):  
Andrew J Olive ◽  
Clare M Smith ◽  
Michael C Kiritsy ◽  
Christopher M Sassetti
Keyword(s):  
Infectious Disease ◽  
Antimicrobial Resistance ◽  
Disease Progression ◽  
Persistent Infection ◽  
Tissue Damage ◽  
Immune Mediator ◽  
Neutrophil Influx ◽  
Phagocyte Oxidase ◽  
Deficient Mice

SummaryProtection from infectious disease relies on two distinct mechanisms. “Antimicrobial resistance” directly inhibits pathogen growth, whereas “infection tolerance” controls tissue damage. A single immune-mediator can differentially contribute to these mechanisms in distinct contexts, confounding our understanding of protection to different pathogens. For example, the NADPH-dependent phagocyte oxidase complex (Phox) produces anti-microbial superoxides and protects from tuberculosis in humans. However, Phox-deficient mice do not display the expected defect in resistance toM. tuberculosisleaving the role of this complex unclear. We re-examined the mechanisms by which Phox contributes to protection from TB and found that mice lacking the Cybb subunit of Phox suffered from a specific defect in tolerance, which was due to unregulated Caspase1 activation, IL-1β production, and neutrophil influx into the lung. These studies demonstrate that Phox-derived superoxide protect against TB by promoting tolerance to persistent infection, and highlight a central role for Caspase1 in regulating TB disease progression.

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