scholarly journals Learning to read new words in individuals with Down syndrome: Testing the role of phonological knowledge

2014 ◽  
Vol 35 (5) ◽  
pp. 1098-1109 ◽  
Author(s):  
Silvana E. Mengoni ◽  
Hannah M. Nash ◽  
Charles Hulme
Keyword(s):  
Down Syndrome ◽  
Learning To Read ◽  
New Words ◽  
Phonological Knowledge

From sound to syntax: phonological constraints on children's lexical categorization of new words

2008 ◽  
Vol 36 (5) ◽  
pp. 967-997 ◽  
Author(s):  
STANKA A. FITNEVA ◽  
MORTEN H. CHRISTIANSEN ◽  
PADRAIC MONAGHAN
Keyword(s):  
French Language ◽  
French Immersion ◽  
Extensive Experience ◽  
New Words ◽  
Phonological Knowledge ◽  
English Speaking ◽  
Language Environment ◽  
Computational Analyses ◽  
The Relationship

ABSTRACTTwo studies examined the role of phonological cues in the lexical categorization of new words when children could also rely on learning by exclusion and whether the role of phonology depends on extensive experience with a language. Phonological cues were assessed via phonological typicality – an aggregate measure of the relationship between the phonology of a word and the phonology of words in the same lexical class. Experiment 1 showed that when monolingual English-speaking seven-year-olds could rely on learning by exclusion, phonological typicality only affected their initial inferences about the words. Consistent with recent computational analyses, phonological cues had stronger impact on the processing of verb-like than noun-like items. Experiment 2 revealed an impact of French on the performance of seven-year-olds in French immersion when tested in a French language environment. Thus, phonological knowledge may affect lexical categorization even in the absence of extensive experience.

scholarly journals Characterization of Caenorhabditis elegans Homologs of the Down Syndrome Candidate Gene DYRK1A

Genetics ◽  
2003 ◽  
Vol 163 (2) ◽  
pp. 571-580 ◽  
Author(s):  
William B Raich ◽  
Celine Moorman ◽  
Clay O Lacefield ◽  
Jonah Lehrer ◽  
Dusan Bartsch ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Caenorhabditis Elegans ◽  
Trisomy 21 ◽  
Gene Dosage ◽  
Inducible Promoters ◽  
C Elegans ◽  
Dual Specificity ◽  
Specificity Protein

Abstract The pathology of trisomy 21/Down syndrome includes cognitive and memory deficits. Increased expression of the dual-specificity protein kinase DYRK1A kinase (DYRK1A) appears to play a significant role in the neuropathology of Down syndrome. To shed light on the cellular role of DYRK1A and related genes we identified three DYRK/minibrain-like genes in the genome sequence of Caenorhabditis elegans, termed mbk-1, mbk-2, and hpk-1. We found these genes to be widely expressed and to localize to distinct subcellular compartments. We isolated deletion alleles in all three genes and show that loss of mbk-1, the gene most closely related to DYRK1A, causes no obvious defects, while another gene, mbk-2, is essential for viability. The overexpression of DYRK1A in Down syndrome led us to examine the effects of overexpression of its C. elegans ortholog mbk-1. We found that animals containing additional copies of the mbk-1 gene display behavioral defects in chemotaxis toward volatile chemoattractants and that the extent of these defects correlates with mbk-1 gene dosage. Using tissue-specific and inducible promoters, we show that additional copies of mbk-1 can impair olfaction cell-autonomously in mature, fully differentiated neurons and that this impairment is reversible. Our results suggest that increased gene dosage of human DYRK1A in trisomy 21 may disrupt the function of fully differentiated neurons and that this disruption is reversible.

Neurobiological Elements of Cognitive Dysfunction in Down Syndrome: Exploring the Role of APP

2012 ◽  
Vol 71 (5) ◽  
pp. 403-409 ◽  
Author(s):  
Martha Millan Sanchez ◽  
Sietske N. Heyn ◽  
Devsmita Das ◽  
Sarah Moghadam ◽  
Kara J. Martin ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cognitive Dysfunction

scholarly journals ICTs and Music in Generic Learning Disabilities

2017 ◽  
Vol 12 (04) ◽  
pp. 101 ◽  
Author(s):  
Paraskevi Theodorou ◽  
Athanasios Drigas
Keyword(s):  
Learning Disabilities ◽  
Down Syndrome ◽  
Cerebral Palsy ◽  
Disruptive Behavior ◽  
Information And Communication Technologies ◽  
Communication Technologies ◽  
Digital Music ◽  
Information And Communication ◽  
Role Of Information

The purpose of this paper is to review the most representative studies of the last decade (2006-2015) which deal with the combination of technology and music and concern individuals with Generic learning disabilities. Particularly, the areas of needs in this paper are divided to the following categories: Depression/ disruptive behavior, Down syndrome, Intellectual disa¬bilities, Cerebral palsy and Severe/Profound disa-bilities. It is also underlined the important role of Information and Communication Technologies (ICTs) and digital music tools in promoting musical participation and as-sisting students with the pre-referred disa-bilities.

scholarly journals Polymorphisms inHSD17B1: Early Onset and Increased Risk of Alzheimer’s Disease in Women with Down Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Joseph H. Lee ◽  
Susan Gurney ◽  
Deborah Pang ◽  
Alexis Temkin ◽  
Naeun Park ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Age At Onset ◽  
Nucleotide Polymorphisms ◽  
Risk Alleles ◽  
Increased Risk ◽  
Estrogen Activity ◽  
Intron 4

Background/Aims. Genetic variants that affect estrogen activity may influence the risk of Alzheimer's disease (AD). In women with Down syndrome, we examined the relation of polymorphisms in hydroxysteroid-17beta-dehydrogenase (HSD17B1) to age at onset and risk of AD.HSD17B1encodes the enzyme 17β-hydroxysteroid dehydrogenase (HSD1), which catalyzes the conversion of estrone to estradiol.Methods. Two hundred and thirty-eight women with DS, nondemented at baseline, 31–78 years of age, were followed at 14–18-month intervals for 4.5 years. Women were genotyped for 5 haplotype-tagging single-nucleotide polymorphisms (SNPs) in theHSD17B1gene region, and their association with incident AD was examined.Results. Age at onset was earlier, and risk of AD was elevated from two- to threefold among women homozygous for the minor allele at 3 SNPs in intron 4 (rs676387), exon 6 (rs605059), and exon 4 inCOASY(rs598126). Carriers of the haplotype TCC, based on the risk alleles for these three SNPs, had an almost twofold increased risk of developing AD (hazard ratio = 1.8, 95% CI, 1.1–3.1).Conclusion. These findings support experimental and clinical studies of the neuroprotective role of estrogen.

scholarly journals COMPOUND NOUNS IN GERMAN LANGUAGE

2020 ◽  
Vol 1 (10(78)) ◽  
pp. 124-127
Author(s):  
Svitlana Korol
Keyword(s):  
Component Composition ◽  
Word Formation ◽  
Regular Growth ◽  
German Language ◽  
New Words ◽  
Plural Form ◽  
Compound Nouns ◽  
Object Of Study ◽  
Relationship Of

The article deals with one of the most common types of word formation in German as word compounding. Compound nouns have become the object of study, as this part of the language leads the way in the formation of new words in this way. The relevance of the research is reinforced by the fact that German compound nouns differ by their multicomponent structure and are in the process of regular growth of their numbers, so they are attracting the attention of Germanists of different generations continuously. The study has examined the nature of the component composition of composites, the types of bonding between components, the types of constituent components, the role of the connecting element, the syllable’s accentuation of components of the compound noun etc. The compound can be built from nouns, adjectives, verbs or an invariable element (prepositions). There is no limit of the number of the associated words. The last word in the compound always determines the gender and plural form of the compound noun. The connectors or linking elements in existing German compound words often correspond to old case endings (e.g., plural, genitive). These endings expressed the relationship of the compound parts to one another. The article considers the causes of the formation of complex nouns. Compounds make the German language more flexible. In general, compounds are used to convey more information in one word and for reasons of language economy. Special attention deserves such a phenomenon as Denglish. This is the mashing of words from the two languages to create new hybrid words.

scholarly journals Dyslexia: An overview

2011 ◽  
Vol 70 (2) ◽  
Author(s):  
S. O. Wajuihian ◽  
K. S. Naidoo
Keyword(s):  
Developmental Disorder ◽  
Imaging Techniques ◽  
Neural Pathways ◽  
Learning Disorder ◽  
Conventional Instruction ◽  
Management Options ◽  
Learning To Read ◽  
Neuro Imaging ◽  
Sociocultural Background

Dyslexia is a neuro-developmental disorder characterized by difficulties in learning to read despite conventional instruction, adequate intelligence and a balanced sociocultural background.  Dyslexia is the most common type of learning disorder.  Reading difficulties affect a child’s academic achievement.  As primary eye care practitioners, optometrists have a role in attending to patients who may present with symptoms indicative of dyslexia, therefore an understanding of dyslexia will be beneficial to the optometrist.  This paper presents an overview of dyslexia and discusses its prevalence, aetiology, classifications, neural pathways involved in reading, theories, neuro-imaging techniques and management options. The role of optometry in the multidisciplinary management of dyslexia is discussed.  (S Afr Optom 2011 70(2) 89-98)

scholarly journals The Role of Sensorial Integration in Motor Development in Children with Down Syndrome

GYMNASIUM ◽  
2019 ◽  
Vol XIX (1) ◽  
pp. 42
Author(s):  
Mihaela Anghel
Keyword(s):  
Down Syndrome ◽  
Motor Development ◽  
Sensory Stimulation ◽  
Sensory Stimuli ◽  
Children With Down Syndrome ◽  
Combination Strategies ◽  
Sensory Motor ◽  
Syndrome Child

One of the reasons behind the choice of the topic is that this problem of sensory-motor development in children with physical and mental deficiencies, especially in children with Down syndrome, is not sufficiently known and studied, sensory-motor development representing an important factor in their physical and social development. The reason I chose this theme and the theoretical basis from which I started was to improve the psychomotor behaviors through sensory stimulation. The assumptions we went into the research were: 1. If we use different sensory combination strategies, the Down Syndrome will be able to compensate for the psycho-motor disorders; 2. If we apply sensory stimuli to the Down Syndrome child, then there will be ameliorations of the underlying motor conduction. The research presents a case study of a 6 year and six mouth old child diagnosed with Down syndrome. The location of the study was carried out at the "Delfinul" day center of the Betania Association.

scholarly journals The role of social workers for children with down syndrome and their families.

2018 ◽  
Author(s):  
Renawati Renawati ◽  
Maulana Irfan Maulana ◽  
Meilanny Budiarty Meilanny ◽  
Budhi Wibhawa Budhi ◽  
Nurlina Apsari Nurlina
Keyword(s):  
Down Syndrome ◽  
Social Workers ◽  
Children With Down Syndrome
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