Serum C-reactive protein levels predict regional brain responses to noxious cold stimulation of the hand in chronic whiplash associated disorders

2016 ◽  
Vol 11 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Michele Sterling ◽  
Jessica Head ◽  
Peter J. Cabot ◽  
Michael Farrell
Keyword(s):  
Inflammatory Biomarkers ◽  
Pain Processing ◽  
C Reactive Protein ◽  
Cold Stimulation ◽  
Cold Pain ◽  
Reactive Protein ◽  
Tnf Α ◽  
Whiplash Associated Disorders ◽  
Chronic Whiplash ◽  
Stimulation Of

AbstractBackground and aimsWhiplash Associated Disorders (WAD) are a costly health burden. The condition is characterised by sensory disturbances such as widespread hyperalgesia likely indicative of central hyperexcitability. Recently elevated levels of pro-inflammatory biomarkers have also found in acute and chronic WAD. The aim of this cross-sectional study was to investigate the relationship between inflammatory biomarkers and pain processing in people with persistent whiplash associated disorders (WAD).MethodsTwenty one participants with chronic whiplash (>3 months) were recruited. Venous blood samples were collected and assays performed for C-reactive protein (CRP) and TNF-α. Blood oxygen level-dependent (BOLD) contrast images of the brain were acquired with a Siemens 1.5T MRI scanner during repeated 24 s stimulus blocks of innocuous or painful stimuli (thumbnail pressure and cold stimulation of dorsum of hand) separated by 36 s inter-stimulus intervals. Stimulus intensities used during scanning were at the level of participants’ thresholds for moderate pain. Parameter estimates representing BOLD signal increases during painful events from each participant were tested for associations with inflammatory biomarkers.ResultsClinically relevant levels of CRP and TNF-α were found in 33% and 38% of participants. Levels of CRP showed a positive correlation with levels of cold pain activation in brain regions including the anterior insula, posterior parietal cortex, caudate and thalamus (pcorrected < 0.05). Levels of TNF-α were not related to activation levels during either noxious pressure or cold. Pressure pain activations also did not show a relationship with CRP levels.ConclusionsShared variance between inflammation and increased levels of regional pain-related activation in people with persistent whiplash symptoms is apparent for cold, but not pressure stimuli.ImplicationsThe results highlight cold pain processing as an important aspect of whiplash chronicity, although the implications of this modality-specific effect are not readily apparent.

Utility of serial measurement of biomarkers of cardiovascular stress and inflammation in systolic dysfunction

EP Europace ◽  
2020 ◽  
Vol 22 (7) ◽  
pp. 1044-1053
Author(s):  
Daniel P Morin ◽  
Ronald Chong-Yik ◽  
Sudarone Thihalolipavan ◽  
Yoaav S Krauthammer ◽  
Michael L Bernard ◽  
...  
Keyword(s):  
Time Dependent ◽  
Inflammatory Biomarkers ◽  
Left Ventricular Ejection ◽  
Time Varying ◽  
Laboratory Measurements ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Tnf Α ◽  
Ambulatory Patients ◽  
Over Time

Abstract Aims Evidence links markers of systemic inflammation and heart failure (HF) with ventricular arrhythmias (VA) and/or death. Biomarker levels, and the risk they indicate, may vary over time. We evaluated the utility of serial laboratory measurements of inflammatory biomarkers and HF, using time-dependent analysis. Methods and results We prospectively enrolled ambulatory patients with left ventricular ejection fraction (LVEF) ≤35% and a primary-prevention implanted cardioverter-defibrillator (ICD). Levels of established inflammatory biomarkers [C-reactive protein, erythrocyte sedimentation rate (ESR), suppression of tumourigenicity 2 (ST2), tumour necrosis factor alpha (TNF-α)] and brain natriuretic peptide (BNP) were assessed at 3-month intervals for 1 year. We assessed relationships between biomarkers modelled as time-dependent variables, VA, and death. Among 196 patients (66±14 years, LVEF 23±8%), 33 experienced VA, and 18 died. Using only baseline values, BNP predicted VA, and both BNP and ST2 predicted death. Using serial measurements at 3-month intervals, time-varying BNP independently predicted VA, and time-varying ST2 independently predicted death. C-statistic analysis revealed no significant benefit to repeated testing compared with baseline-only measurement. C-reactive protein, ESR, and TNF-α, either at baseline or over time, did not predict either endpoint. Conclusion In stable ambulatory patients with systolic cardiomyopathy and an ICD, BNP predicts ventricular tachyarrhythmia, and ST2 predicts death. Repeated laboratory measurements over a year’s time do not improve risk stratification beyond baseline measurement alone. Clinical Trial Registration Clinicaltrials.gov NCT01892462 (https://clinicaltrials.gov/ct2/show/NCT01892462).

RELATIONSHIP BETWEEN HBA1C LEVELS AND INFLAMMATORY BIOMARKERS (C - REACTIVE PROTEIN, IL6 AND TNF-ALPHA) AMONG TYPE 2 DIABETES MELLITUS-KHARTOUM- SUDAN

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Maha Ali Omer ◽  
Abdalla E Ali
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Inflammatory Biomarkers ◽  
Tnf Alpha ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Tnf Α ◽  
Hba1c Levels

Introduction: World most prevalence disease, is diabetes mellitus, with countless causes, it on increasing, genetic, lifestyle, infections could all be contributors as causative agents especially type 2 diabetes mellitus, increase inflammatory biomarkers plays extremely critical and vital role in progression of type 2 diabetes mellitus. So this study aimed to assess glycated hemoglobin levels and inflammatory biomarkers among T2DM and find such correlation and compare data with healthy control. Method: Cross-sectional case control study among 100 case group T2DM and 100 healthy subjects as control group, HbA1c and inflammatory biomarkers, C-reactive protein, IL6 and TNF-alpha were measured for study groups. Enzyme linked immunoassay (ELISA) used for measurement of inflammatory biomarkers TNF-α, CRP, IL6 and Cystatin C. while HbA1c assessed by ichroma device. Result:  HbA1c, C-reactive protein, IL6 and TNF-alpha were increased among T2DM patients than healthy subjects, giving increased significant difference for each, as p value <0.05. Pearson’s correlation of HbA1c with each of measured parameters showed that HbA1c has positive correlation with inflammatory biomarkers TNF-α. (R= 0.812** P=0.00), CRP(R= 0.527** P=0.00), IL6, (R= 0.778** P=0.00) and Cystatin C (R= 0.884** P=0.00) respectively. Conclusion: higher levels of inflammatory biomarkers associate with increase with glycated hemoglobin, Improvement of glycemic control reduce risk markers for development of diabetic complications. Key words: HbA1c Levels and inflammatory biomarkers, tumor necrosis factor, interleukin 6.

Relationship between Proliferative Diabetic Retinopathy and Inflammatory Markers in Patients with Type 1 Diabetes in Brazil: A Nested Case Control Study

2020 ◽  
Vol 243 (6) ◽  
pp. 471-478
Author(s):  
Laura Gomes Nunes Melo ◽  
Paulo Henrique Morales ◽  
Karla Rezende Guerra Drummond ◽  
Deborah Conte Santos ◽  
Marcela Haas Pizarro ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Inflammatory Biomarkers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Tnf Α ◽  
Control Study

<b><i>Introduction:</i></b> This study examined the relationship between proliferative diabetic retinopathy (PDR) and serum levels of C-reactive protein, VEGF, TNF-α, and IL-6 inflammatory biomarkers, related to the pathophysiology of diabetic retinopathy. <b><i>Methods:</i></b> This cross-sectional, case control study comprised 240 patients with type 1 diabetes (80 cases with PDR and 160 controls without diabetic retinopathy) who were matched for gender and duration of diabetes. <b><i>Results:</i></b> C-reactive protein was the only inflammatory biomarker that was positively related to PDR (OR 1.96; 95% CI 1.01–3.78, <i>p</i> = 0.0045). We also noted an association between high glycated hemoglobin levels, the use of angiotensin-converting enzyme inhibitor, low glomerular filtration rate, and PDR. <b><i>Conclusion:</i></b> Patients with higher levels of C-reactive protein are more likely to present with PDR. We did not find a link between serum levels of VEGF, TNF-α, or IL-6 and PDR. The function of inflammatory biomarkers in PDR must be addressed in further studies.

scholarly journals Perfil de biomarcadores inflamatórios dos pacientes com pneumonia de um hospital no alto sertão paraibano / Profile of inflammatory biomarkers of patients with pneumonia in a hospital in the upper sertão of Paraíba

2021 ◽  
Vol 15 (57) ◽  
pp. 391-406
Author(s):  
Kamilla Zenóbya Ferreira Nóbrega de Souza ◽  
Elisangela Vilar De Assis ◽  
Marcelo Rodrigues Bacci
Keyword(s):  
Tumor Necrosis Factor ◽  
Kidney Disease ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Inflammatory Biomarkers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Tnf Α ◽  
Acute Kidney Disease ◽  
Necrosis Factor

Objetivo: Avaliar alterações no perfil de biomarcadores (proteína C reativa, fator de necrose tumoral, interleucina 6 e creatinina) em pacientes com pneumonia, durante o período de internação segundo a sobrevivência ou óbito, relacionando a gravidade do quadro de pneumonia ou indicativo de desenvolvimento de doença renal aguda em pacientes com pneumonia. Método: Foi realizado um estudo prospectivo com 47 pacientes que foram internados com pneumonia, no município de Cajazeiras, PB. Foram realizadas análises laboratoriais para quantificação sérica de creatinina, proteína C reativa, IL-6 e TNF- α. Resultados: Foram analisados segundo o teste de Mann-Whitney e o teste de correlação de Spearman. Foram consideradas diferenças significativas quando p0,05. Observou-se que os níveis de creatinina, proteína C reativa, IL-6 e TNF-α estavam mais elevados no grupo dos pacientes com pneumonia que vieram a óbito.  Os pacientes com pneumonia e doença renal aguda, do grupo que foram a óbito apresentaram maiores níveis de creatinina e IL-6. Para esse o grupo, os níveis de creatinina, TNF-α e IL-6 apresentaram correlação diretamente proporcionais ao escore da escala de CURB-65. Conclusão: Sugere-se que biomarcadores inflamatórios podem ser utilizados no monitoramento de agravo no quadro clínico da doença.Palavras-chave: Creatinina. Fator de Necrose Tumoral Alfa. Interleucina-6. Pneumonia. Proteína C-reativa. Abstract: The aim of this study was to evaluate changes in the profile of biomarkers (C-reactive protein, tumor necrosis factor, interleukin 6 and creatinine) in patients with pneumonia, during the hospitalization period, according to survival or death, relating the severity of pneumonia or indicative of development of acute kidney disease in patients with pneumonia. A prospective study was carried out with 47 patients who were hospitalized with pneumonia in the city of Cajazeiras, Paraíba. Laboratory analyzes were performed to quantify serum creatinine, C-reactive protein, IL-6 and TNF-α. Results were analyzed using the Mann-Whitney test and the Spearman correlation test. Significant differences were considered when p0.05. It was observed that the levels of creatinine, C-reactive protein, IL-6 and TNF-α were higher in the group of patients with pneumonia who died. Patients with pneumonia and acute kidney disease from the group who died had higher levels of creatinine and IL-6. For this group, creatinine, TNF-α and IL-6 levels correlated directly proportional to the CURB-65 scale score. It is suggested that inflammatory biomarkers can be used to monitor the disease's clinical condition. Keywords: Creatinine. Tumor Necrosis Factor Alpha. Interleukin-6. Pneumonia. C-reactive protein.

scholarly journals Effect of Grape Juice Ingestion on Plasma Inflammatory Biomarkers in Overweight and Insulin Resistance Women

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1128-1128
Author(s):  
Bruna Jardim Quintanilha ◽  
Vinícius Cooper Capetini ◽  
Geni Rodrigues Sampaio ◽  
Marcelo Rogero
Keyword(s):  
Insulin Resistance ◽  
Intervention Study ◽  
Grape Juice ◽  
Inflammatory Biomarkers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Funding Sources ◽  
Food Research ◽  
Tnf Α ◽  
Study Population

Abstract Objectives To investigate the effect of grape juice ingestion in the inflammatory process in overweight and insulin resistance women. Methods An intervention study was conducted, in which, for 4 weeks, the volunteers ingested 500 mL of grape juice daily. Blood samples were collected at baseline and 2 and 4 weeks after the beginning of the grape juice ingestion. The study population consisted of healthy women (n = 20), aged between 18 and 40 years, and body mass index classified as overweight (25–29.9 kg/m²). Lipid profile and plasma glucose, insulin, leptin, adiponectin, inflammatory biomarkers (IL-10, IL-6, TNF-α, C-reactive protein, MCP-1, VCAM-1, and ICAM-1) levels were analyzed. Food consumption was evaluated by the analysis of three 24 hours recalls collected at all times. Results The intake of grape juice promoted a significant increased (P &lt; 0.05) in plasma triacylglycerols levels after 4 weeks of ingestion in comparison to the baseline. The intervention with grape juice significantly reduced plasma sICAM-1 levels after 4 weeks in comparison to the baseline. Conclusions Grape juice reduced a biomarker related to endothelial dysfunction in overweight and insulin resistance women. Funding Sources Food Research Center (FoRC), Sao Paulo Research Foundation (FAPESP).

Synergism Effects of Ursolic Acid Supplementation on the Levels of Irisin, C-reactive Protein, IL-6, and TNF-α During High-intensity Resistance Training in Low Activity Men

2020 ◽  
Vol 20 (2) ◽  
pp. 138-144 ◽  
Author(s):  
Ehsan Asghari ◽  
Amir Rashidlamir ◽  
Seyyed R.A. Hosseini ◽  
Mahtab Moazzami ◽  
Saeed Samarghandian ◽  
...  
Keyword(s):  
Resistance Training ◽  
Ursolic Acid ◽  
High Intensity ◽  
Plasma Levels ◽  
Group Versus ◽  
Current Data ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Tnf Α ◽  
Low Activity

Background:: Ursolic Acid (UA) is a pentacyclic triterpenoid carboxylic acid which is extracted from plants. UA may enhance the effect of Resistance Training (RT) in human. Objective: Current research was designed to show the effect of High-Intensity Resistance Training (HIRT) in the presence or absence of UA on the serum levels of irisin, CRP, IL-6 and TNF-α in the low activity men. Method:: The study included twenty-two healthy male HIRT with placebo, supplementation, and HIRT in the presence of UA supplementation. The two groups received eight-week intervention including 2 sets of 8 exercises, with 8~10 repetitions at 70~75% of 1 repetition maximum and a 2 min rest interval between sets, performed 3 times/week. Placebo or UA orally was evaluated as 1 capsule 3 times/day during 8 weeks. The subsequent factors were measured post- and preintervention: C-Reactive Protein (CRP), Irisin, Tumor Necrotic Factor (TNF-α) and Interleukin-6 (IL-6). Results:: UA supplementation significantly increased the plasma levels of irisin in the HIRT+UA group versus the HIRT+P group (p<0.05). UA treatment also dramatically decreased the plasma levels of CRP, IL-6, and TNF-α in the HIRT+UA group versus the HIRT+P group (p<0.05). Conclusion:: The current data showed that UA-induced an increase in serum irisin and reduction of CRP, IL-6, and TNF-α may have beneficial effects as a chemical for increasing of the effects of HIRT in low activity men.

The TNF-α G-308A polymorphism is associated with C-reactive protein levels: The HERITAGE Family Study

2006 ◽  
Vol 44 (5) ◽  
pp. 377-383 ◽  
Author(s):  
Hanna-Maaria Lakka ◽  
Timo A. Lakka ◽  
Tuomo Rankinen ◽  
Treva Rice ◽  
D.C. Rao ◽  
...  
Keyword(s):  
Family Study ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Tnf Α

scholarly journals Cytokine status in patients with myocardial infarction as a possible predictor of coronary atherosclerosis severity

2020 ◽  
Vol 19 (3) ◽  
pp. 2316
Author(s):  
O. V. Khlynova ◽  
E. A. Shishkina ◽  
N. I. Abgaryan
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Coronary Atherosclerosis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Coronary Artery Atherosclerosis ◽  
Tnf Α ◽  
Atherosclerosis Severity

Aim. To study the association of cytokine status with coronary atherosclerosis severity in patients with myocardial infarction (MI).Material and methods. Between 11.2018 and 07.2019, 92 patients hospitalized with MI in Perm Clinical Cardiology Dispensary were included in the study. The control group consisted of 23 patients with stable coronary artery disease. In addition to the standard examination, enzyme-linked immunosorbent assay was used to determine the levels of interleukins (IL)-6, -10, tumor necrosis factor alpha (TNF-α), C-reactive protein.Results. Significant increase in plasma IL-6, TNF-α and C-reactive protein levels in MI patients compared with the control group. The increase in the concentration of IL-6, TNF-α, as well as the IL-6/IL-10 ratio occurs in proportion to coronary atherosclerosis severity. A direct correlation of Gensini score with IL-6, TNF-α, and IL-6/IL-10 ratio was established.Conclusion. Further study of cytokine profile parameters in MI patients will help a clearer understanding pathogenesis of coronary artery atherosclerosis. An increase in concentrations of IL-6, TNF-α, and IL-6/IL-10 ratio is associated with an increase in coronary atherosclerosis severity and can be used in practice for its prediction.

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