On-chip integrated multiple microelectromechanical resonators to enable the local heating, mixing and viscosity sensing for chemical reactions in a droplet

Experimental results for nanosecond electromagnetic impulses (NEMI) impact on precious metals leaching process from sulphidic ores are presented. A possibility of an intensification of leaching process of Au, Ag, Cu is established. The extraction of silver increases by 70 %, gold – by 40 %. The samples of sulphidic ores from the pit of JSC NPF "Bashkir gold mining company" are taken as objects of research. The use of economic electronic generators is suggested herein. They create impulses of 1 nanosecond, the front of 0.1 nanoseconds, amplitude of 6-15 kV impulses, 1 kHz frequency of repetition, consumed power from an electric network is less than 100 W. Energy in one impulse is 10–3 J. The pulse field changes the valence of metals of impurity towards decrease. It changes the current of chemical reactions in a mineral matrix. The local heating of the precious metals interspersed particles and destruction of a mineral matrix are also possible.

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On-chip manipulation of local heating and nanoparticle motion

2017 International Conference on Optical MEMS and Nanophotonics (OMN) ◽

10.1109/omn.2017.8051510 ◽

2017 ◽

Author(s):

Roshni Biswas ◽

Ningfeng Huang ◽

Aravind Krishnan ◽

Luis J. Martinez ◽

Ahmed Morsy ◽

...

Keyword(s):

Local Heating ◽

On Chip

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Release and Detection of microRNA by Combining Magnetic Hyperthermia and Electrochemistry Modules on a Microfluidic Chip

Sensors ◽

10.3390/s21010185 ◽

2020 ◽

Vol 21 (1) ◽

pp. 185

Author(s):

Marie-Charlotte Horny ◽

Vincent Dupuis ◽

Jean-Michel Siaugue ◽

Jean Gamby

Keyword(s):

Microfluidic Chip ◽

Local Heating ◽

Electrochemical Techniques ◽

Magnetic Hyperthermia ◽

Microrna Target ◽

Ferrite Core ◽

Shell Nanoparticles ◽

Lab On Chip ◽

Biological Target ◽

On Chip

The heating of a biologic solution is a crucial part in an amplification process such as the catalytic detection of a biological target. However, in many situations, heating must be limited in microfluidic devices, as high temperatures can cause the denaturation of the chip components. Local heating through magnetic hyperthermia on magnetic nano-objects has opened the doors to numerous improvements, such as for oncology where a reduced heating allows the synergy of chemotherapy and thermotherapy. Here we report on the design and implementation of a lab on chip without global heating of samples. It takes advantage of the extreme efficiency of DNA-modified superparamagnetic core–shell nanoparticles to capture complementary sequences (microRNA-target), uses magnetic hyperthermia to locally release these targets, and detects them through electrochemical techniques using ultra-sensitive channel DNA-modified ultramicroelectrodes. The combination of magnetic hyperthermia and microfluidics coupled with on-chip electrochemistry opens the way to a drastic reduction in the time devoted to the steps of extraction, amplification and nucleic acids detection. The originality comes from the design and microfabrication of the microfluidic chip suitable to its insertion in the millimetric gap of toric inductance with a ferrite core.

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UHV-TEM studies of laser-induced damage

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100087471 ◽

1991 ◽

Vol 49 ◽

pp. 632-633

Author(s):

T.S. Savage ◽

R. Ai ◽

D. Dunn ◽

L.D. Marks

Keyword(s):

Surface Science ◽

Rapid Heating ◽

Local Heating ◽

Routine Practice ◽

Transmission Electron ◽

Northwestern University ◽

Laser Induced Damage ◽

Set Up ◽

Focusing Lens ◽

Diffusion Of Impurities

The use of lasers for surface annealing, heating and/or damage has become a routine practice in the study of materials. Lasers have been closely looked at as an annealing technique for silicon and other semiconductors. They allow for local heating from a beam which can be focused and tuned to different wavelengths for specific tasks. Pulsed dye lasers allow for short, quick bursts which can allow the sample to be rapidly heated and quenched. This short, rapid heating period may be important for cases where diffusion of impurities or dopants may not be desirable.At Northwestern University, a Candela SLL - 250 pulsed dye laser, with a maximum power of 1 Joule/pulse over 350 - 400 nanoseconds, has been set up in conjunction with a Hitachi UHV-H9000 transmission electron microscope. The laser beam is introduced into the surface science chamber through a series of mirrors, a focusing lens and a six inch quartz window.

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Surface reactions observed by photoemission electron microscopy (PEEM)

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100121831 ◽

1992 ◽

Vol 50 (1) ◽

pp. 286-287

Author(s):

H.H. Rotermund

Keyword(s):

Electron Microscopy ◽

Electron Microscope ◽

Work Function ◽

Chemical Reactions ◽

Reaction Diffusion ◽

Dynamic Processes ◽

Clean Surface ◽

Crystal Surfaces ◽

Single Crystal Surfaces ◽

Photoemission Electron

Chemical reactions at a surface will in most cases show a measurable influence on the work function of the clean surface. This change of the work function δφ can be used to image the local distributions of the investigated reaction,.if one of the reacting partners is adsorbed at the surface in form of islands of sufficient size (Δ>0.2μm). These can than be visualized via a photoemission electron microscope (PEEM). Changes of φ as low as 2 meV give already a change in the total intensity of a PEEM picture. To achieve reasonable contrast for an image several 10 meV of δφ are needed. Dynamic processes as surface diffusion of CO or O on single crystal surfaces as well as reaction / diffusion fronts have been observed in real time and space.

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Microwaves: Application in Electron Microscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100158248 ◽

1990 ◽

Vol 48 (3) ◽

pp. 140-141

Author(s):

Anthony S-Y Leong ◽

David W Gove

Keyword(s):

Electron Microscopy ◽

Light Microscopy ◽

Chemical Reactions ◽

Electromagnetic Waves ◽

Tissue Fixation ◽

Primary Method ◽

Dipolar Molecules ◽

Wide Range ◽

Time Required ◽

Cryostat Sections

Microwaves (MW) are electromagnetic waves which are commonly generated at a frequency of 2.45 GHz. When dipolar molecules such as water, the polar side chains of proteins and other molecules with an uneven distribution of electrical charge are exposed to such non-ionizing radiation, they oscillate through 180° at a rate of 2,450 million cycles/s. This rapid kinetic movement results in accelerated chemical reactions and produces instantaneous heat. MWs have recently been applied to a wide range of procedures for light microscopy. MWs generated by domestic ovens have been used as a primary method of tissue fixation, it has been applied to the various stages of tissue processing as well as to a wide variety of staining procedures. This use of MWs has not only resulted in drastic reductions in the time required for tissue fixation, processing and staining, but have also produced better cytologic images in cryostat sections, and more importantly, have resulted in better preservation of cellular antigens.

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Fine structure and properties of defects in naturally occurring silicates and oxides

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100175430 ◽

1990 ◽

Vol 48 (4) ◽

pp. 460-461

Author(s):

David R. Veblen

Keyword(s):

Chemical Reactions ◽

High Resolution Electron Microscopy ◽

Extended Defects ◽

Single Chain ◽

Naturally Occurring ◽

Resolution Electron ◽

Fine Structures ◽

Image Simulations ◽

Similar Crystal Structure

Extended defects and interfaces control many processes in rock-forming minerals, from chemical reactions to rock deformation. In many cases, it is not the average structure of a defect or interface that is most important, but rather the structure of defect terminations or offsets in an interface. One of the major thrusts of high-resolution electron microscopy in the earth sciences has been to identify the role of defect fine structures in reactions and to determine the structures of such features. This paper will review studies using HREM and image simulations to determine the structures of defects in silicate and oxide minerals and present several examples of the role of defects in mineral chemical reactions. In some cases, the geological occurrence can be used to constrain the diffusional properties of defects.The simplest reactions in minerals involve exsolution (precipitation) of one mineral from another with a similar crystal structure, and pyroxenes (single-chain silicates) provide a good example. Although conventional TEM studies have led to a basic understanding of this sort of phase separation in pyroxenes via spinodal decomposition or nucleation and growth, HREM has provided a much more detailed appreciation of the processes involved.

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Point-Cathode Electron Gun Using Electron-Beam Bombardment for Cathode Tip Heating

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100179749 ◽

1990 ◽

Vol 48 (1) ◽

pp. 198-199

Author(s):

Ryo Iiyoshi ◽

Susumu Maruse ◽

Hideo Takematsu

Keyword(s):

Electron Beam ◽

Tungsten Wire ◽

Local Heating ◽

Electron Gun ◽

Original Position ◽

Beam Power ◽

Radius Of Curvature ◽

High Brightness ◽

Beam Focusing ◽

Time Operation

Point cathode electron gun with high brightness and long cathode life has been developed. In this gun, a straightened tungsten wire is used as the point cathode, and the tip is locally heated to higher temperatures by electron beam bombardment. The high brightness operation and some findings on the local heating are presented.Gun construction is shown in Fig.l. Small heater assembly (annular electron gun: 5 keV, 1 mA) is set inside the Wehnelt electrode. The heater provides a disk-shaped bombarding electron beam focusing onto the cathode tip. The cathode is the tungsten wire of 0.1 mm in diameter. The tip temperature is raised to the melting point (3,650 K) at the beam power of 5 W, without any serious problem of secondary electrons for the gun operation. Figure 2 shows the cathode after a long time operation at high temperatures, or high brightnesses. Evaporation occurs at the tip, and the tip part retains a conical shape. The cathode can be used for a long period of time. The tip apex keeps the radius of curvature of 0.4 μm at 3,000 K and 0.3 μm at 3,200 K. The gun provides the stable beam up to the brightness of 6.4×106 A/cm2sr (3,150 K) at the accelerating voltage of 50 kV. At 3.4×l06 A/cm2sr (3,040 K), the tip recedes at a slow rate (26 μm/h), so that the effect can be offset by adjusting the Wehnelt bias voltage. The tip temperature is decreased as the tip moves out from the original position, but it can be kept at constant by increasing the bombarding beam power. This way of operation is possible for 10 h. A stepwise movement of the cathode is enough for the subsequent operation. Higher brightness operations with the rapid receding rates of the tip may be improved by a continuous movement of the wire cathode during the operations. Figure 3 shows the relation between the beam brightness, the tip receding rate by evaporation (αis the half-angle of the tip cone), and the cathode life per unit length, as a function of the cathode temperature. The working life of the point cathode is greatly improved by the local heating.

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Gut microbiome a promising target for management of respiratory diseases

Biochemical Journal ◽

10.1042/bcj20200426 ◽

2020 ◽

Vol 477 (14) ◽

pp. 2679-2696

Author(s):

Riddhi Trivedi ◽

Kalyani Barve

Keyword(s):

Respiratory Diseases ◽

New Technology ◽

Bacterial Flora ◽

Systemic Circulation ◽

The Body ◽

Lung Pathology ◽

Promising Target ◽

Current Therapies ◽

Intestinal Microbial Flora ◽

On Chip

The intestinal microbial flora has risen to be one of the important etiological factors in the development of diseases like colorectal cancer, obesity, diabetes, inflammatory bowel disease, anxiety and Parkinson's. The emergence of the association between bacterial flora and lungs led to the discovery of the gut–lung axis. Dysbiosis of several species of colonic bacteria such as Firmicutes and Bacteroidetes and transfer of these bacteria from gut to lungs via lymphatic and systemic circulation are associated with several respiratory diseases such as lung cancer, asthma, tuberculosis, cystic fibrosis, etc. Current therapies for dysbiosis include use of probiotics, prebiotics and synbiotics to restore the balance between various species of beneficial bacteria. Various approaches like nanotechnology and microencapsulation have been explored to increase the permeability and viability of probiotics in the body. The need of the day is comprehensive study of mechanisms behind dysbiosis, translocation of microbiota from gut to lung through various channels and new technology for evaluating treatment to correct this dysbiosis which in turn can be used to manage various respiratory diseases. Microfluidics and organ on chip model are emerging technologies that can satisfy these needs. This review gives an overview of colonic commensals in lung pathology and novel systems that help in alleviating symptoms of lung diseases. We have also hypothesized new models to help in understanding bacterial pathways involved in the gut–lung axis as well as act as a futuristic approach in finding treatment of respiratory diseases caused by dysbiosis.

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