scholarly journals The Relationship between Kidney Shear Wave Speed Measured Using the Elastpq Technique and Different Biomarkers of Chronic Kidney Disease

2017 ◽  
Vol 43 ◽  
pp. S210
Author(s):  
Flaviu Bob ◽  
Iulia Grosu ◽  
Ioan Sporea ◽  
Romulus Timar ◽  
Alina Popescu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Shear Wave ◽  
Wave Speed ◽  
Shear Wave Speed ◽  
The Relationship

Basic investigation on identification of tissue composition based on propagation speeds of longitudinal and shear waves

2021 ◽  
Author(s):  
Naotaka NITTA ◽  
Toshikatsu Washio ◽  
Tomokazu Numano
Keyword(s):  
Shear Wave ◽  
Wave Speed ◽  
Shear Wave Elastography ◽  
Disease Detection ◽  
Good Sensitivity ◽  
Tissue Composition ◽  
Tissue Properties ◽  
Shear Wave Speed ◽  
Longitudinal And Shear Waves ◽  
The Relationship

Abstract The elastic modulus of tissue as a useful biomarker of disease detection can be quantitatively evaluated based on shear wave speed (SWS) measurements in shear wave elastography. Although the longitudinal wave speed (LWS) is also expected to be a promising biomarker for disease detection, the elasticity is not always dominant because the LWS is affected by the bulk modulus. In other words, LWS and SWS may reflect different tissue properties. Therefore, in this study, based on the improvement in LWS measurement, the relationship between the composition of a phantom mixed with agar and glycerol and ultrasonically measured LWS and SWS was investigated. The LWS had a good sensitivity in detecting glycerol, while the SWS had a good sensitivity in detecting agar. The calculated Poisson's ratio had a better sensitivity in detecting agar. In conclusion, a simultaneous measurement of LWS and SWS may help identify the tissue composition.

scholarly journals Association between albuminuria and thyroid function in patients with chronic kidney disease

Endocrine ◽  
2021 ◽  
Author(s):  
Walter Reinhardt ◽  
Nils Mülling ◽  
Stefan Behrendt ◽  
Sven Benson ◽  
Sebastian Dolff ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Thyroid Function ◽  
Filtration Rate ◽  
Creatinine Ratio ◽  
Protein Loss ◽  
Reverse T3 ◽  
Thyroid Antibody ◽  
Hormone Status ◽  
The Relationship

Abstract Purpose The relationship between proteinuria and thyroid function remains controversial in patients with chronic kidney disease (CKD). We prospectively investigated the association between kidney and thyroid function in thyroid antibody-negative patients through all CKD stages. Methods We enrolled 184 nondialysis patients (mean age: 63.1 ± 16.9 years) without previous thyroid disease or thyroid-specific antibodies. Kidney function was assessed by estimating the glomerular filtration rate (eGFR) classified according KDIGO (CKD G1–5). Kidney damage was assessed by albuminuria (albumin-to-creatinine ratio, ACR) and classified as mild, moderate, or severe (ACR1: <300, ACR2: 300–3000, and ACR3: 3000 mg/g). To evaluate thyroid function, TSH, T4, fT4, T3, fT3, reverse T3 (rT3), and thyroxine-binding globulin (TBG) were measured. Results rT3 concentrations correlated negatively with albuminuria (r = −0.286, p < 0.001) and were significantly lower in patients with severe albuminuria than in those with mild or moderate albuminuria (ACR3: 0.28 vs. ACR2: 0.32 vs. ACR1: 0.36 nmol/l, p < 0.001). The severity of albuminuria revealed no impact on TSH, fT4, T3, fT3, and TBG. EGFR correlated with increasing T4, fT4, T3, fT3, and TBG (T4: r = 0.289, p < 0.01; fT4: r = 0.196, p < 0.01; T3: r = 0.408, p < 0.01; fT3: r = 0.390, p < 0.01) but not with rT3. Conclusions In thyroid antibody-negative patients presenting advanced CKD (stages 4 and 5), even severe kidney protein loss failed to influence thyroid hormone status. However, albuminuria severity correlated negatively with rT3, which was significantly lower in patients with albuminuria in the nephrotic range.

scholarly journals Spatial variations in Achilles tendon shear wave speed

2014 ◽  
Vol 47 (11) ◽  
pp. 2685-2692 ◽  
Author(s):  
Ryan J. DeWall ◽  
Laura C. Slane ◽  
Kenneth S. Lee ◽  
Darryl G. Thelen
Keyword(s):  
Achilles Tendon ◽  
Shear Wave ◽  
Wave Speed ◽  
Spatial Variations ◽  
Shear Wave Speed

Measured temperature and pressure dependence of Vp and Vs in compacted, polycrystalline sI methane and sII methane–ethane hydrate

2003 ◽  
Vol 81 (1-2) ◽  
pp. 47-53 ◽  
Author(s):  
M B Helgerud ◽  
W F Waite ◽  
S H Kirby ◽  
A Nur
Keyword(s):  
High Pressure ◽  
Shear Wave ◽  
Pressure Dependence ◽  
Gas Hydrate ◽  
Pressure Vessel ◽  
Wave Speed ◽  
Measured Temperature ◽  
Shear Wave Speed ◽  
Temperature And Pressure ◽  
Fixed End

We report on compressional- and shear-wave-speed measurements made on compacted polycrystalline sI methane and sII methane–ethane hydrate. The gas hydrate samples are synthesized directly in the measurement apparatus by warming granulated ice to 17°C in the presence of a clathrate-forming gas at high pressure (methane for sI, 90.2% methane, 9.8% ethane for sII). Porosity is eliminated after hydrate synthesis by compacting the sample in the synthesis pressure vessel between a hydraulic ram and a fixed end-plug, both containing shear-wave transducers. Wave-speed measurements are made between –20 and 15°C and 0 to 105 MPa applied piston pressure. PACS No.: 61.60Lj

Abstract 211: Variation of NEDD4L is Associated with Hypertension in Chinese Hans Chronic Kidney Disease Patients

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Cheng Wang ◽  
Jun Zhang ◽  
Cuicui Li ◽  
Wenyu Gong ◽  
Tanqi Lou
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Logistic Regression ◽  
Kidney Disease ◽  
Blood Pressure Monitoring ◽  
Multivariate Logistic Regression Analysis ◽  
Multivariate Logistic Regression ◽  
Functional Studies ◽  
Chi Squared ◽  
The Relationship

Background: Neural precursor cell expressed developmentally down-regulated 4-like (NEDD4L) is a candidate gene for hypertension, and carriers of an intact NEDD4L C2-domain,encoded by the NEDD4L rs4149601 (G/A) GG genotype, together with the C-allele of the NEDD4L rs2288774 (C/T) polymorphism have been found be associated with hypertension both in African Americans and whites. However, there is no data on the relationship between polymorphism of NEDD4L rs4149601 and rs2288774 and hypertension in Chinese chronic kidney disease (CKD) patients. The purpose of the current study was to investigate the relationship between the variation of NEDD4L rs4149601, rs2288774 and hypertension in CKD patients. Methods: A total of 546 Chines Hans CKD patients were enrolled in our study. The SNPs were genotyped using PCR-based techniques. All patients underwent ambulatory blood pressure monitoring, and clinical data were also collected. Multivariate logistic regression analysis was used to identify the relationship between polymorphisms and hypertension. Results: 506 patients carried GG/GA genotype and 30 carried AA genotype. Rs4149601 AA genotype carriers had significantly higher rate of hypertension (68.3% vs 46.2%, P = 0.022) than GG/GA genotype carriers by Chi-squared test. AA genotype carriers also had a higher day-time and bedtime systolic blood pressure (142±16 vs 135±23, P=0.036; 137±18 vs 127±13, P=0.022, respectively) when compared with GG/GA genotype carriers. AA genotype [OR= 3.08, 95% CI (1.06-9.80)], lowever eGFR [OR=0.98, 95% CI (0.97-0.99)], older age [OR=1.03, 95% CI (1.01-1.05)] were independently associated with hypertension in CKD patients by multivariate logistic regression. However, No difference was found in blood pressure with rs2288774 TT/TC/CC genotypes, and no difference was found in the incidence of hypertension among patients with three genotypes. Conclusions: Our results suggested 4149601AA genotype of NEDD4L may be associated with hypertension in CKD patients, and further genetic and functional studies are required to understand its role in the manifestation of hypertension in Chinese CKD patients.

Diagnosis of liver fibrosis based on quantification of factors associated with shear wave speed

Choonpa Igaku ◽  
2021 ◽  
Author(s):  
Hiroko IIJIMA ◽  
Toshifumi TADA ◽  
Hiroyuki HACHIYA ◽  
Takashi NISHIMURA ◽  
Junko NISHIMURA ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Shear Wave ◽  
Wave Speed ◽  
Shear Wave Speed ◽  
Factors Associated

scholarly journals The relationship between serum uric acid and chronic kidney disease among Appalachian adults

2010 ◽  
Vol 25 (11) ◽  
pp. 3593-3599 ◽  
Author(s):  
L. Cain ◽  
A. Shankar ◽  
A. M. Ducatman ◽  
K. Steenland
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Serum Uric Acid ◽  
The Relationship

scholarly journals Association between gut dysbiosis and chronic kidney disease: a narrative review of the literature

2021 ◽  
Vol 49 (10) ◽  
pp. 030006052110532
Author(s):  
Zhe Feng ◽  
Ting Wang ◽  
Sheng Dong ◽  
Hongli Jiang ◽  
Jianzhong Zhang ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Communicable Disease ◽  
Treatment Options ◽  
Narrative Review ◽  
Gut Dysbiosis ◽  
Significant Burden ◽  
Intestinal Ecology ◽  
The Relationship ◽  
Non Communicable Disease

Chronic kidney disease (CKD) is a serious non-communicable disease that poses a significant burden on healthcare and society. It is essential to devise new strategies to better treat patients with CKD. Research has illustrated that gut dysbiosis, describing an abnormal intestinal ecology, is closely associated with CKD. In this narrative review, we summarized the evidence of their mutual relationship and discussed the potential treatment options to correct gut dysbiosis in patients with CKD. Gut dysbiosis significantly increases the risk of CKD, especially in the older population. Gut dysbiosis also plays a role in CKD complications, such as hypertension, cardiovascular events, and cognitive dysfunction. The relationship between gut dysbiosis and CKD is bidirectional, and CKD itself can lead to changes in gut microecology. The usual therapies for CKD can also increase the incidence of gut dysbiosis. Meanwhile, probiotics and antibiotics are generally used to correct gut dysbiosis. Further studies are required to elaborate the association between gut dysbiosis and CKD, and more treatment options should be explored to prevent CKD in patients with gut dysbiosis.

scholarly journals A national analysis of risk for potential chronic kidney disease of unknown etiology in Ecuador

2020 ◽  
Vol 5 (2) ◽  
Author(s):  
Rachel Sippy ◽  
Martín Lotto ◽  
Abigail Bideaux ◽  
Irene Torres ◽  
Sriram Narsipur ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Land Surface ◽  
Maximum Temperature ◽  
Unknown Etiology ◽  
Younger Adults ◽  
Agricultural Industry ◽  
Mean Temperature ◽  
National Analysis ◽  
The Relationship

An increase of chronic kidney disease (CKD) has affected many tropical countries but with an atypical presentation. This illness, known as Chronic Kidney Disease of Unknown Etiology (CKDu), presents in younger adults without the typical comorbidities for CKD, often among those working in agricultural production. The cause of disease is unknown but temperature, heat stress, or dehydration are thought to contribute to the development of this condition. There is no information on whether anyone in Ecuador is affected by this illness. We describe CKD rates in Ecuador and hypothesize that CKD is impacted by temperature and the agricultural industry in Ecuador. Using publicly available data from the Instituto Nacional de Estadísticas y Censos from the years 2010—2015, we describe the rate of CKD among adults aged 20—45 in each province, as well as the agricultural industry across Ecuador. We combined this information with land surface temperature and used a Poisson mixed effects model to assess the relationship between mean temperature, maximum temperature and agricultural industry with CKD rates among adults aged 20—49 in each province. We found that the CKD rate is increasing in this age group over 2010—2015 (p=0.017), and in 2015, CKD rates were highest in Pastaza. Our spatial analysis found that both mean temperature and proportion of population in agriculture were positively associated with CKD rate by province in 2014 and 2015. This preliminary analysis shows that temperature and agricultural industry are associated with CKD rates among adults aged 20—49. While this association does not definitively show the presence of CKDu, it provides evidence to support further investigation of this illness in Ecuador.

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