scholarly journals Longitudinal, population-based cohort study of prenatal influenza vaccination and influenza infection in childhood

Vaccine ◽  
2022 ◽  
Author(s):  
Damien Foo ◽  
Mohinder Sarna ◽  
Gavin Pereira ◽  
Hannah C. Moore ◽  
Annette K. Regan
2016 ◽  
Vol 62 (10) ◽  
pp. 1221-1227 ◽  
Author(s):  
Annette K. Regan ◽  
Hannah C. Moore ◽  
Nicholas de Klerk ◽  
Saad B. Omer ◽  
Geoffrey Shellam ◽  
...  

2017 ◽  
Vol 232 ◽  
pp. 315-323 ◽  
Author(s):  
Ju-Chi Liu ◽  
Ta-Jung Wang ◽  
Li-Chin Sung ◽  
Pai-Feng Kao ◽  
Tsung-Yeh Yang ◽  
...  

Oncotarget ◽  
2017 ◽  
Vol 8 (68) ◽  
pp. 112697-112711 ◽  
Author(s):  
Pai-Feng Kao ◽  
Ju-Chi Liu ◽  
Yi-Ping Hsu ◽  
Li-Chin Sung ◽  
Tsung-Yeh Yang ◽  
...  

PLoS ONE ◽  
2012 ◽  
Vol 7 (12) ◽  
pp. e51734 ◽  
Author(s):  
Cormac J. Sammon ◽  
Julia Snowball ◽  
Anita McGrogan ◽  
Corinne S. de Vries

BMJ Open ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. e041577 ◽  
Author(s):  
Angel Vila-Córcoles ◽  
Olga Ochoa-Gondar ◽  
Eva M. Satué-Gracia ◽  
Cristina Torrente-Fraga ◽  
Frederic Gomez-Bertomeu ◽  
...  

ObjectiveTo investigate possible relationships between pre-existing medical conditions (including common comorbidities and chronic medications) and risk for suffering COVID-19 disease in middle-aged and older adults.DesignPopulation-based retrospective cohort study.SettingTwelve primary care centres (PCCs) in Tarragona (Spain).Participants79 083 people (77 676 community-dwelling and 1407 nursing-home residents), who were all individuals aged >50 years affiliated to the 12 participating PCCs.OutcomesBaseline cohort characteristics (age, sex, vaccinations, comorbidities and chronic medications) were established at study start (1st. March 2020) and primary outcome was time to COVID-19 confirmed by PCR among cohort members throughout the epidemic period (from 1st. March 2020 to 23rd. May 2020). Risk for suffering COVID-19 was evaluated by Cox regression, estimating multivariable HRs adjusted for age, sex, comorbidities and medications use.ResultsDuring the study period, 2324 cohort members were PCR-tested, with 1944 negative and 380 positive results, which means an incidence of 480.5 PCR-confirmed COVID-19 cases per 100 000 persons-period. Assessing the total study cohort, only age (HR 1.02; 95% CI 1.01 to 1.03; p=0.002), nursing-home residence (HR 21.83; 95% CI 16.66 to 28.61; p<0.001) and receiving diuretics (HR 1.35; 95% CI 1.04 to 1.76; p=0.026) appeared independently associated with increased risk. Smoking (HR 0.62; 95% CI 0.41 to 0.93; p=0.022), ACE inhibitors (HR 0.68; 95% CI 0.47 to 0.99; p=0.046) and antihistamine (HR 0.47; 95% CI 0.22 to 1.01; p=0.052) were associated with a lower risk. Among community-dwelling individuals, cancer (HR 1.52; 95% CI 1.03 to 2.24; p=0.035), chronic respiratory disease (HR 1.82; 95% CI 1.08 to 3.07; p=0.025) and cardiac disease (HR 1.53; 95% CI 1.06 to 2.19; p=0.021) emerged to be also associated with an increased risk. Receiving ACE inhibitors (HR 0.66; 95% CI 0.44 to 0.99; p=0.046) and influenza vaccination (HR 0.63; 95% CI 0.44 to 0.91; p=0.012) was associated with decreased risk.ConclusionAge, nursing-home residence and multiple comorbidities appear predisposing for COVID-19. Conversely, receiving ACE inhibitors, antihistamine and influenza vaccination could be protective, which should be closely investigated in further studies specifically focused on these concerns.


Author(s):  
Laura Ruiz Azcona ◽  
Miguel Roman-Rodriguez ◽  
Montserrat Llort Bove ◽  
Job FM van Boven ◽  
Miguel Santibáñez Margüello

To determine the prevalence of influenza vaccination in chronic obstructive pulmonary disease (COPD) patients and its effect on COPD exacerbations, we conducted a retrospective population-based cohort study analyzing real-life data. We included all registered COPD patients ≥40 years old using respiratory medication during the study period (2012–2013). Influenza vaccination during the 2012/2013 campaign was the parameter studied. Moderate and severe exacerbations during 2013 were the dependent outcome variables. Logistic regression adjusting for age, gender, concomitant asthma diagnosis, COPD severity, smoking status, number of moderate and severe exacerbations the previous year, and comorbidities was performed, and 59.6% of the patients received seasonal influenza vaccination. The percentage of patients with exacerbations was higher among those vaccinated. Influenza vaccination had a statistically significantly negative (non-protective) crude effect favoring the risk of severe exacerbations: OR: 1.20 (95% CI; 1.05–1.37). This association diminished and lost statistical significance after adjustment: aOR: 0.93 (95% CI; 0.74–1.18). The protective effect in the analysis restricted to the epidemic period was not significant: aOR: 0.82 (95% CI; 0.58–1.16). We concluded that prevalence of influenza vaccination was suboptimal. In contrast with most of the available evidence, our results did not support a protective effect of influenza vaccination on the risk of admission for COPD exacerbation.


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