Current status of the wide-range (10–1500eV) spherical grating monochromator beamline at SRRC

Author(s):  
L.J. Lai ◽  
P.C. Tseng ◽  
Y.W. Yang ◽  
S.C. Chung ◽  
Y.F. Song ◽  
...  
2019 ◽  
Vol 20 (12) ◽  
pp. 1227-1243
Author(s):  
Hina Qamar ◽  
Sumbul Rehman ◽  
D.K. Chauhan

Cancer is the second leading cause of morbidity and mortality worldwide. Although chemotherapy and radiotherapy enhance the survival rate of cancerous patients but they have several acute toxic effects. Therefore, there is a need to search for new anticancer agents having better efficacy and lesser side effects. In this regard, herbal treatment is found to be a safe method for treating and preventing cancer. Here, an attempt has been made to screen some less explored medicinal plants like Ammania baccifera, Asclepias curassavica, Azadarichta indica, Butea monosperma, Croton tiglium, Hedera nepalensis, Jatropha curcas, Momordica charantia, Moringa oleifera, Psidium guajava, etc. having potent anticancer activity with minimum cytotoxic value (IC50 >3μM) and lesser or negligible toxicity. They are rich in active phytochemicals with a wide range of drug targets. In this study, these medicinal plants were evaluated for dose-dependent cytotoxicological studies via in vitro MTT assay and in vivo tumor models along with some more plants which are reported to have IC50 value in the range of 0.019-0.528 mg/ml. The findings indicate that these plants inhibit tumor growth by their antiproliferative, pro-apoptotic, anti-metastatic and anti-angiogenic molecular targets. They are widely used because of their easy availability, affordable price and having no or sometimes minimal side effects. This review provides a baseline for the discovery of anticancer drugs from medicinal plants having minimum cytotoxic value with minimal side effects and establishment of their analogues for the welfare of mankind.


2019 ◽  
Vol 20 (1_suppl) ◽  
pp. 38-44
Author(s):  
Mizuya Fukasawa

At the second Dialysis Access Symposium held in Nagoya, Japan, a proposal was made to investigate the differences in vascular access methods used in different countries. In this article, we describe the management of vascular access in Japan. The Japanese population is rapidly aging, and the proportion of elderly patients on dialysis is also increasing. There were 325,000 dialysis patients in Japan at the end of 2015, of whom 65.1% were aged 65 years or above. The number of patients with diabetic nephropathy or nephrosclerosis as the underlying condition is also increasing, whereas the number with chronic glomerulonephritis is steadily decreasing. The Japanese health insurance system enables patients to undergo medical treatment at almost no out-of-pocket cost. Percutaneous transluminal angioplasty suffers from a severe device lag compared with other countries, but although there are limitations on permitted devices, the use of those that have been authorized is covered by medical insurance. One important point that is unique to Japan is that vascular access is performed and managed by doctors involved in dialysis across a wide range of disciplines, including nephrologists, surgeons, and urologists. This may be one factor contributing to the good survival prognosis of Japanese dialysis patients.


Coatings ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 611
Author(s):  
Waldemar Gawron ◽  
Jan Sobieski ◽  
Tetiana Manyk ◽  
Małgorzata Kopytko ◽  
Paweł Madejczyk ◽  
...  

This paper presents the current status of medium-wave infrared (MWIR) detectors at the Military University of Technology’s Institute of Applied Physics and VIGO System S.A. The metal–organic chemical vapor deposition (MOCVD) technique is a very convenient tool for the deposition of HgCdTe epilayers, with a wide range of compositions, used for uncooled infrared detectors. Good compositional and thickness uniformity was achieved on epilayers grown on 2-in-diameter, low-cost (100) GaAs wafers. Most growth was performed on substrates, which were misoriented from (100) by between 2° and 4° in order to minimize growth defects. The large lattice mismatch between GaAs and HgCdTe required the usage of a CdTe buffer layer. The CdTe (111) B buffer layer growth was enforced by suitable nucleation procedure, based on (100) GaAs substrate annealing in a Te-rich atmosphere prior to the buffer deposition. Secondary-ion mass spectrometry (SIMS) showed that ethyl iodide (EI) and tris(dimethylamino)arsenic (TDMAAs) were stable donor and acceptor dopants, respectively. Fully doped (111) HgCdTe heterostructures were grown in order to investigate the devices’ performance in the 3–5 µm infrared band. The uniqueness of the presented technology manifests in a lack of the necessity of time-consuming and troublesome ex situ annealing.


2017 ◽  
Vol 474 (17) ◽  
pp. 2953-2976 ◽  
Author(s):  
Lasse Stach ◽  
Paul S. Freemont

The AAA+ (ATPases associated with diverse cellular activities) ATPase p97 is essential to a wide range of cellular functions, including endoplasmic reticulum-associated degradation, membrane fusion, NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) activation and chromatin-associated processes, which are regulated by ubiquitination. p97 acts downstream from ubiquitin signaling events and utilizes the energy from ATP hydrolysis to extract its substrate proteins from cellular structures or multiprotein complexes. A multitude of p97 cofactors have evolved which are essential to p97 function. Ubiquitin-interacting domains and p97-binding domains combine to form bi-functional cofactors, whose complexes with p97 enable the enzyme to interact with a wide range of ubiquitinated substrates. A set of mutations in p97 have been shown to cause the multisystem proteinopathy inclusion body myopathy associated with Paget's disease of bone and frontotemporal dementia. In addition, p97 inhibition has been identified as a promising approach to provoke proteotoxic stress in tumors. In this review, we will describe the cellular processes governed by p97, how the cofactors interact with both p97 and its ubiquitinated substrates, p97 enzymology and the current status in developing p97 inhibitors for cancer therapy.


Sensors ◽  
2020 ◽  
Vol 20 (20) ◽  
pp. 5826
Author(s):  
Yinming Zhao ◽  
Yang Liu ◽  
Yongqian Li ◽  
Qun Hao

Resistance strain force sensors have been applied to monitor the strains in various parts and structures for industrial use. Here, we review the working principles, structural forms, and fabrication processes for resistance strain gauges. In particular, we focus on recent developments in resistance stress transfer for resistance strain force sensors and the creep effect due to sustained loads and/or temperature variations. Various error compensation methods to reduce the creep effect are analyzed to develop a metrology standard for resistance strain force sensors. Additionally, the current status of carbon nanotubes (CNTs), silicon carbide (SiC), gallium nitride (GaN), and other wide band gap semiconductors for a wide range of strain sensors are reviewed. The technical requirements and key issues of resistance strain force sensors for future applications are presented.


2013 ◽  
Vol 12 (10) ◽  
pp. 1199 ◽  
Author(s):  
Maxime Legros ◽  
Egide G. Karuranga ◽  
Marie-France Lebouc ◽  
Muhammad Mohiuddin

This paper seeks to examine the evolution of determinants under scrutiny by academics publishing on performance of ethnic companies in Organisation for Economic Co-operation and Development (OECD) countries. Using the systematic literature review method, we first provide a descriptive analysis of articles gathered, and then make an in-depth examination of the determinants focused on. A database of 40 papers published between 2002 and 2011 was collected the topic was precise enough to yield only a few articles from a wide range of journals. We provide a systemized summary of the current status of this body of work, examine areas where research is lacking, and explain why further study of the role of cultural and ethical values as determinants of ethnic entrepreneurship is critical.


Author(s):  
Anayatullah Khan ◽  
Anuradha Mishra ◽  
Syed Misbahul Hasan ◽  
Afreen Usmani ◽  
Mohd Ubaid ◽  
...  

Abstract Objectives The increasing demand for herbal drugs for the human application is causing a growing demand for the cultivation of Medicinal Plants. This demand has developed because of cost-effective, plant-derived products rather than commercially available synthetic drugs. Cucumis sativus Linn. (Ver. Kheera) is a vegetable climber, species belongs to family Cucurbitaceae This species has a wide range of medicinal and biological applications thanks to its richness in carbohydrate, proteins, minerals (calcium, iron, magnesium, phosphorus, potassium, zinc) and secondary metabolites like alkaloids, tannins, flavonoids, saponins, and phenolic compounds These phytoconstituents may be responsible for allied therapeutic application. So, C. sativus possess wider applications for preventing certain ailments. Content The literature in various national and international journals and reports pertaining to the medicinal and nutritional uses were reviewed. The result revealed the current therapeutic applications of C. sativus whole plants other than the nutritional value. C. sativus pharmacological action includes antioxidant, anti-diabetic, UV protectant, hepatoprotective, gastroprotective, anti-helminthic, wound healing, antimicrobial, and anticancer. So, it could be useful for both preventive and additive therapy along with modern medicine for the better management of certain disorders. Summary and Outlook This review furnishes updated information about the phytoconstituents and their medicinal applications so that it can pose a path for the young researchers to do future findings.


2021 ◽  
Author(s):  
Pablo Lorente ◽  

<p>The Mediterranean Sea is considered a relevant geostrategic region and a prominent climate change hot spot. This semi-enclosed basin has been the subject of abundant studies due to its vulnerability to sea-level rise and other coastal hazards. With the steady advent of new technologies, a growing wealth of observational data are nowadays available to efficiently monitor the sea state and properly respond to socio-ecological challenges and stakeholder needs, thereby strengthening the community resilience at multiple scales.</p><p>Nowadays, High-Frequency radar (HFR) is a worldwide consolidated land-based remote sensing technology since it provides, concurrently and in near real time, fine-resolution maps of the surface circulation along with (increasingly) wave and wind information over broad coastal areas. HFR systems present a wide range of practical applications: maritime safety, oil spill emergencies, energy production, management of extreme coastal hazards. Consequently, they have become an essential component of coastal ocean observatories since they offer a unique dynamical framework that complement conventional in-situ observing platforms. Likewise, within the frame of the Copernicus Marine Environment Monitoring Service (CMEMS), HFR are valuable assets that play a key pivotal role in both the effective monitoring of coastal areas and the rigorous skill assessment of operational ocean forecasting systems.</p><p>The present work aims to show a panoramic overview not only of the current status of diverse Mediterranean HFR systems, but also of the coordinated joint efforts between many multi-disciplinary institutions to establish a permanent HFR monitoring network in the Mediterranean, aligned with European and global initiatives. In this context, it is worth highlighting that many of the Mediterranean HFR systems are already integrated into the European HFR Node, which acts as central focal point for data collection, homogenization, quality assurance and dissemination and promotes networking between EU infrastructures and the Global HFR network.</p><p>Furthermore, priority challenges tied to the implementation of a long-term, fully integrated, sustainable operational Mediterranean HFR network are described. This includes aspects related to the setting up of such a system within the broader framework of the European Ocean Observing System (EOOS), and a long-term financial support required to preserve the infrastructure core service already implemented. Apart from the technological challenges, the enhancing of the HFR data discovery and access, the boosting of the data usage as well as the research integration must be achieved by building synergies among academia, management agencies, state government offices, intermediate and end users. This would guarantee a coordinated development of tailored products that meet the societal needs and foster user uptake, serving the marine industry with dedicated smart innovative services, along with the promotion of strategic planning and informed decision-making in the marine environment.</p>


2020 ◽  
Vol 9 (5) ◽  
pp. 69 ◽  
Author(s):  
Dag Øivind Madsen

Agile is one of the most popular contemporary management concepts and buzzwords. This paper provides an in-depth examination of the influence of the Agile concept on the discourse, thinking and practices of organizations worldwide. The paper traces the emergence and evolution of the Agile concept from inception to the present by synthesizing findings from a wide range of academic and practitioner-oriented sources. Overall, the picture that emerges from the analysis is that the Agile concept has grown considerably in popularity and has become one of the most dominant concepts in public management discourse. The popularization of Agile has, to a large extent, been driven by an active supply-side made up of actors such as consultants, coaches, and trainers. Another finding is that the Agile concept has evolved considerably over time, from its initial presentation as a narrow and specialized concept rooted in the software development community to a much broader and general approach applicable across nearly all types of organizations and industries. The broadening of the concept has led to neologisms such as Agile Marketing, Agile Government, and Agile Management. The paper ends with reflections on the current status of Agile and some speculation about the concept’s likely future trajectory.


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