Assessment of Impacts on the Lung of Long-term Exposure to Copper-Containing Dust at a Copper Smelter - Historical Spirometry Data, Examination via Body Plethysmography and Inflammatory Biomarkers in Blood and Sputum

The intervention with the Mediterranean diet (MD) pattern has evidenced short-term anti-inflammatory effects, but little is known about its long-term anti-inflammatory properties at molecular level. This study aims to investigate the 3-year effect of MD interventions compared to low-fat diet (LFD) on changes on inflammatory biomarkers related to atherosclerosis in a free-living population with a high-risk of cardiovascular disease (CD). Participants (n = 285) in the PREDIMED trial were randomly assigned into three intervention groups: MD with extra-virgin olive oil (EVOO) or MD-Nuts, and a LFD. Fourteen plasma inflammatory biomarkers were determined by Luminex assays. An additional pilot study of gene expression (GE) was determined by RT-PCR in 35 participants. After 3 years, both MDs showed a significant reduction in the plasma levels of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, hs-CRP, MCP-1, MIP-1β, RANTES, and ENA78 (p < 0.05; all). The decreased levels of IL-1β, IL-6, IL-8, and TNF-α after MD significantly differed from those in the LFD (p < 0.05). No significant changes were observed at the gene level after MD interventions, however, the GE of CXCR2 and CXCR3 tended to increase in the control LFD group (p = 0.09). This study supports the implementation of MD as a healthy long-term dietary pattern in the prevention of CD in populations at high cardiovascular risk.

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Anti-Inflammatory Effects of the Mediterranean Diet in the Early and Late Stages of Atheroma Plaque Development

Mediators of Inflammation ◽

10.1155/2017/3674390 ◽

2017 ◽

Vol 2017 ◽

pp. 1-12 ◽

Cited By ~ 34

Author(s):

Rosa Casas ◽

Mireia Urpi-Sardà ◽

Emilio Sacanella ◽

Sara Arranz ◽

Dolores Corella ◽

...

Keyword(s):

Mediterranean Diet ◽

Plasma Concentrations ◽

Virgin Olive Oil ◽

Extra Virgin Olive Oil ◽

Inflammatory Biomarkers ◽

Elderly Persons ◽

Long Term Effects ◽

Plaque Development ◽

Atheroma Plaque

Objective.To evaluate the long-term effects of a Mediterranean diet (MeDiet) intervention on the plasma concentrations of inflammatory and plaque stability-related molecules in elderly people at high risk for cardiovascular disease.Design and Setting. 66 participants from primary care centers affiliated with the Hospital Clinic of Barcelona were randomized into 3 groups: MeDiet plus extra virgin olive oil (EVOO) or nuts and a low-fat diet (LFD). At baseline and at 3 and 5 years, we evaluated the changes in the plasma concentrations of 24 inflammatory biomarkers related to the different stages of the atherosclerotic process by Luminex®.Results.At 3 and 5 years, both MeDiet groups showed a significant reduction of IL-6, IL-8, MCP-1, and MIP-1β(P<0.05; all) compared to LFD. IL-1β, IL-5, IL-7, IL-12p70, IL-18, TNF-α, IFN-γ, GCSF, GMCSF, and ENA78 (P<0.05; all) only decreased in the MeDiet+EVOO group and E-selectin and sVCAM-1 (P<0.05; both) in the MeDiet+nuts group.Conclusions. Long-term adherence to MeDiet decreases the plasma concentrations of inflammatory biomarkers related to different steps of atheroma plaque development in elderly persons at high cardiovascular risk.

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Long-term dynamic of forest vegetation after reduction of copper smelter emissions

Russian Journal of Ecology ◽

10.1134/s1067413614060150 ◽

2014 ◽

Vol 45 (6) ◽

pp. 498-507 ◽

Cited By ~ 33

Author(s):

E. L. Vorobeichik ◽

M. R. Trubina ◽

E. V. Khantemirova ◽

I. E. Bergman

Keyword(s):

Copper Smelter ◽

Forest Vegetation ◽

Smelter Emissions

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Effects of Flaxseed Interventions on Circulating Inflammatory Biomarkers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Advances in Nutrition ◽

10.1093/advances/nmz048 ◽

2019 ◽

Vol 10 (6) ◽

pp. 1108-1119 ◽

Cited By ~ 7

Author(s):

Mehran Rahimlou ◽

Nasrin Banaie Jahromi ◽

Nazila Hasanyani ◽

Amirhossein Ramezani Ahmadi

Keyword(s):

Weighted Mean Difference ◽

Meta Analysis ◽

High Sensitivity ◽

Inflammatory Biomarkers ◽

Inflammatory Factors ◽

Reactive Protein ◽

Hs Crp ◽

Meta Analyses ◽

Different Doses

ABSTRACT There have been various clinical studies on the effect of flaxseed-derived products on circulating inflammatory biomarkers, but the findings from these are contradictory. The aim of the present study was to clarify any association. A comprehensive literature search was conducted from inception to May 2018. From the eligible trials, 32 articles describing studies conducted on adults aged 18–70 y were selected for the meta-analysis. Meta-analyses using the random-effects model were performed to investigate the data and results showed significant effects of flaxseed intake on circulating high-sensitivity CRP (hs-CRP) [weighted mean difference (WMD) = −0.75; 95% CI: −1.19, −0.30; P < 0.001] and TNFα (WMD = −0.38; 95% CI: −0.75,–0.01; P = 0.04). However, no significant changes were found in IL6 concentration (WMD = −0.24; 95% CI: –0.70, 0.21; P = 0.28) and C-reactive protein (CRP) (WMD = −0.34; 95% CI:–0.89, 0.20; P = 0.22). Moreover, by eliminating 1 of the studies from the sensitivity analysis, changes in IL6 concentration were significant (WMD = −0.44; 95% CI: –0.81, –0.08). The changes in inflammatory biomarkers were dependent on study design (parallel or crossover), supplement type (flaxseed, flaxseed oil, or lignan), study quality (high or low), and participants’ age and BMI. According to this meta-analysis, flaxseed significantly reduced circulating concentrations of hs-CRP and TNFα, but did not affect IL6 and CRP. Further research is needed to examine the effect of different doses and long-term benefits of flaxseed and its derivatives on inflammatory factors.

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Cardiovascular and Inflammatory Biomarkers to Predict Short- and Long-Term Survival in Community-acquired Pneumonia

American Journal of Respiratory and Critical Care Medicine ◽

10.1164/rccm.201003-0415oc ◽

2010 ◽

Vol 182 (11) ◽

pp. 1426-1434 ◽

Cited By ~ 126

Author(s):

Stefan Krüger ◽

Santiago Ewig ◽

Sven Giersdorf ◽

Oliver Hartmann ◽

Norbert Suttorp ◽

...

Keyword(s):

Community Acquired Pneumonia ◽

Inflammatory Biomarkers ◽

Term Survival ◽

Long Term Survival ◽

Short And Long Term

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Emission of SO2 and SO42- from copper smelter and its influence on the level of total s in soil and moss in Bor and the surroundings

Hemijska industrija ◽

10.2298/hemind131003018s ◽

2015 ◽

Vol 69 (1) ◽

pp. 51-58 ◽

Cited By ~ 3

Author(s):

Snezana Serbula ◽

Dragana Ţivkovic ◽

Ana Radojevic ◽

Tanja Kalinovic ◽

Jelena Kalinovic

Keyword(s):

Sulphur Dioxide ◽

Copper Smelter ◽

Rural Site ◽

Industrial Zone ◽

Wet And Dry Deposition ◽

Atmospheric Depositions ◽

Measurement Results ◽

Rural Zone ◽

Copper Ores

Bor and the surroundings (Eastern Serbia) have been known for exploitation and processing of sulphide copper ores for more than 100 years. Emissions of waste gases and particulate matter rich in heavy metals are characteristic for pyrometallurgical production of copper. Long-term measurement results (2005-2008) indicate an increased sulphur dioxide level in the urban-industrial zone of Bor since it is closest to the copper smelter which is a dominant source of air pollution in the studied area. Average annual sulphur dioxide concentrations at four measuring sites in the urban-industrial zone exceeded the maximum allowable value of 50 ?g/m3. However the maximum allowable value of the total atmospheric depositions (200 mg/m2/day on an annual basis) exceeded only at two of 15 measuring sites in the urban-industrial and rural zone. The highest annual deposition rate of sulphates from deposition was detected in the urban-industrial zone. Since the maximum permitted value for sulphates is not defined by the Serbian Regulations, the extent of the pollution cannot be discussed. Since the environment can continuously be polluted through the wet and dry deposition, biomonitoring by moss was conducted, which revealed significantly higher concentrations of total sulphur in moss in the urban-industrial zone, compared to the background zone. The obtained results confirm the reliability of moss as a bioindicator of ambient pollution. Higher total S concentration in soil samples was noted at the rural site (Ostrelj) located in the close vicinity of two tailing ponds.

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Novel inflammatory biomarkers after long-term left ventricular assist device implantation

10.22541/au.159863474.42942000 ◽

2020 ◽

Author(s):

Martin Holek ◽

Jiri Kettner ◽

Janka Franekova ◽

Antonin Jabor ◽

Marian Pindak ◽

...

Keyword(s):

Left Ventricular Assist Device ◽

Ventricular Assist Device ◽

Left Ventricular ◽

Inflammatory Biomarkers ◽

Assist Device ◽

Ventricular Assist ◽

Device Implantation ◽

Left Ventricular Assist

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P6597Long-term impact of catheter ablation on growth differentiation factor-15 and neutrophil-lymphocyte ratio in paroxysmal atrial fibrillation

European Heart Journal ◽

10.1093/eurheartj/ehz746.1185 ◽

2019 ◽

Vol 40 (Supplement_1) ◽

Author(s):

K Bin Waleed ◽

Y L Xia ◽

L J Gao ◽

Y Xiaomeng ◽

G Tse ◽

...

Keyword(s):

Atrial Fibrillation ◽

Catheter Ablation ◽

Sinus Rhythm ◽

Inflammatory Biomarkers ◽

Growth Differentiation Factor 15 ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Differentiation Factor ◽

Significant Difference

Abstract Background There is increasing evidence that inflammatory biomarkers growth differentiation factor 15 (GDF-15) and neutrophil-lymphocyte ratio (NLR) appear to be associated with stroke and adverse cardiovascular events in patients with atrial fibrillation (AF). However, long-term impact of catheter ablation (CA) on GDF-15 and NLR is still unknown. Objective To evaluate the long-term change in GDF-15 and NLR after CA in paroxysmal AF patients. Methods A total of 58 paroxysmal AF patients were consecutively enrolled to perform CA. The inflammatory biomarkers GDF-15 and NLR were measured at baseline and 6-months postablation. Results All patients except one could complete 6-Months follow up. Fifty (87.7%) patients maintained sinus rhythm (SR group) and seven (12.3%) patients sustained AF recurrence (AFR group). No significant difference was noted in clinical and procedural characteristics between two groups (p>0.05), except mean fluoroscopy time (minutes 22±11.7 vs. 13±5.3, p=0.001) significantly longer in AFR than SR group. The GDF-15 (pg/ml 195±57 vs. 216±88, p=0.398), and NLR (% 1.8 (1.3–3) vs. 2.6 (1.4–3.4), p=0.395) were comparable at baseline in both SR and AFR groups respectively. At 6-months postablation, GDF-15 (pg/ml 133±41 vs. 195±57, p<0.001), and NLR (% 1.6 (1.1–2) vs. 1.8 (1.3–3), p=0.004) were significant deceased compared to baseline levels in SR group. However, GDF-15 (pg/ml 139±86 vs. 216±88, p=0.064), and NLR (% 1.6 (1.2–3) vs. 2.6 (1.4–3.4), p=0.398) biomarkers remained comparable to baseline level in AFR group (p>0.05) Conclusion Inflammatory biomarkers; GDF-15 and NLR significantly decreased at long-term on successful maintenance of sinus rhythm by CA in paroxysmal AF patients. Acknowledgement/Funding None

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