Gynaecological and Obstetric Comorbidities in Patients with Bipolar Disorder: A Systematic Review

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
J. Bobes ◽  
J.M. Montes ◽  
J. Mostaza ◽  
F. Rico-Villademoros ◽  
E. Vieta ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Retrospective Study ◽  
Placenta Previa ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Medline Search ◽  
Increased Risk ◽  
Retrospective Cohort Studies

Objective:To synthesize the available knowledge on gynaecological and obstetric comorbidities in patients with bipolar disorder (BD).Methods:Relevant studies were identified by a MEDLINE search from 1966 to January 2008, and supplemented by a manual review of reference lists of the articles identified and previous review articles. We included studies with any design, in patients with BD as diagnosed by any criteria, with sample size ≥30 patients, and reporting any measure of frequency or association as regards the comorbidities. When available, priority was given to comparative studies.Results:We identified 4 studies: 3 were comparative; 1 was cross-sectional and 3 were retrospective cohort studies; 1 was population-based study; and 4 used a convenience sample. A retrospective study reported an increased risk of pregnancy complications in patients with BD (OR1.23, 95%CI 1.06-1.44) but not of labor/delivery or neonatal complications; as compared to controls, patients with BD had an increased risk of placenta previa (OR2.04, 95% CI 1.11-3.73), antepartum hemorrhage (OR 1.66, 95%CI 1.15-2.39), and drug side-effects (OR 3.94, 95%CI 1.46-10.62). In another retrospective study, patients with BD had an increased risk of endometriosis (OR: 1.93, 95%CI 1.37-2.70), inflammatory disease of ovary (OR 2.17, 95%CI 1.84-2.57), and disorders of menstruation (OR 1.79, 95%CI 1.56-2.05). In a cross-sectional study, gynaecological disorders were more common in patients with BD than in patients with schizophrenia (4% vs 1.3%).Conclusion:Although the information is scanty, available data suggest that patients with BD might have an increased risk of gynaecological and obstetric comorbidities/complications.

scholarly journals Clinical manifestations of chikungunya among university professors and staff in Santo Domingo, the Dominican Republic

2017 ◽  
Vol 41 ◽  
pp. 1 ◽  
Author(s):  
Michael A Zingman ◽  
Amarilis Then Paulino ◽  
Matilde Peguero Payano
Keyword(s):  
Dominican Republic ◽  
Longitudinal Research ◽  
Clinical Manifestations ◽  
Population Based ◽  
Cross Sectional Study ◽  
Santo Domingo ◽  
Phase Duration ◽  
Cross Sectional ◽  
University Professors ◽  
Convenience Sample

Objective. To further characterize chikungunya virus infection and its associated clinical manifestations, using a sample of university professors and staff in Santo Domingo, the Dominican Republic. Methods. A cross-sectional study with quota sampling by department was performed to obtain a convenience sample of professors (n = 736) and staff (n = 499) at the Universidad Autónoma de Santo Domingo. Surveys were used to collect demographic and infection data during the fall term of 2014. Univariate and bivariate analyses were carried out to quantify infection and clinical manifestation prevalence and to assess relationships of these outcomes with age, sex, and acute phase duration. Results. Of 1 236 participants, 49% reported infection (professors = 41%; staff = 61%). Of these, 53% also reported the presence of chronic effects, largely arthralgia (48%). Significant relationships were observed between reported infection and sex (P = 0.023), age (P < 0.001), and occupation (P < 0.001). More headache (P = 0.008) and edema (P < 0.001) in females, more headache (P = 0.005) in younger subjects, and more myalgia (P = 0.006) in those with longer acute symptoms were found. Additionally, more chronic arthralgia (P < 0.001; P = 0.003) and chronic edema (P < 0.001; P = 0.001) in females and older subjects, and more chronic myalgia (P = 0.041) and chronic edema (P = 0.037) in those with longer acute symptoms were observed. Conclusions. To the authors knowledge, this is the first population-based chikungunya prevalence study in the Dominican Republic, and the first to explore clinical manifestations in a university setting. The findings reflect results from studies following the 2005 – 2006 Reunion Island outbreak: prevalence of infection and chronic arthralgia, as well as associations with sex, age, and acute intensity. Longitudinal research can provide further insight into these effects.

scholarly journals Blunted Diurnal Cortisol Pattern Is Associated With Frailty: A Cross-Sectional Study of 745 Participants Aged 65 to 90 Years

2014 ◽  
Vol 99 (3) ◽  
pp. E464-E468 ◽  
Author(s):  
Hamimatunnisa Johar ◽  
Rebecca T. Emeny ◽  
Martin Bidlingmaier ◽  
Martin Reincke ◽  
Barbara Thorand ◽  
...  
Keyword(s):  
Salivary Cortisol ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Cortisol Reactivity ◽  
Diurnal Cortisol ◽  
Frailty Status ◽  
Increased Risk ◽  
Cortisol Levels ◽  
Study Participants

Background: The role of neuroendocrine alterations in the etiology of frailty syndrome is still poorly understood. Hypothalamic-pituitary-adrenal axis dysregulation is a plausible candidate pathway contributing to frailty. Thus, we sought to examine the associations of diurnal cortisol secretion with frailty in older adults. Methods: A cross-sectional analysis was conducted among 745 study participants (age 65–90 years, mean age 75.1 years) of the population-based KORA Age study. Associations between salivary cortisol measures at awakening (morning 1 [M1]), 30 minutes after awakening (M2), and evening (E) and frailty criteria were determined. Results: Lower cortisol levels in the first morning sample (M1) (P = .18) and M2 (P = .14) and increased E levels (P = .004) were observed in prefrail (35.17%, n = 262) and frail (3.36%, n = 25) individuals, in a dose-response manner. Frailty was strongly associated with smaller ratios of morning to evening levels; M1 to E ratio (P = .02) and M2 to E ratio (P = .003). Higher evening cortisol levels were associated with a 24% increased risk of a prefrail state (odds ratio, 1.22; 95% confidence interval, 1.03–1.44). A smaller morning to evening ratio was associated with an increased risk of low grip strength (1.42, 1.09–1.86) and gait speed (1.31, 1.02–1.68). Conclusion: Frailty status is associated with blunted cortisol reactivity as demonstrated by lower morning and higher evening salivary cortisol levels.

scholarly journals Prevalence and Clinical Features of Atopic Dermatitis in China

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Xin Wang ◽  
Lin-Feng Li ◽  
Da-yu Zhao ◽  
Yi-wei Shen
Keyword(s):  
Atopic Dermatitis ◽  
Bacterial Infection ◽  
Clinical Features ◽  
Population Based ◽  
Cross Sectional Study ◽  
Morbidity Rate ◽  
Cross Sectional ◽  
Increased Risk ◽  
Tertiary Hospitals ◽  
History Of

Background. The epidemiology of atopic dermatitis (AD) in Chinese outpatients is yet to be clarified.Objectives. To investigate population-based prevalence and clinical features of AD in Chinese outpatients.Methods. A multicenter cross-sectional study was conducted in outpatients with eczema or dermatitis from 39 tertiary hospitals in 15 provinces.Results. This study included 682 patients diagnosed with AD, with the mean age of28.8±20.1years and the median course of5.3±6.9years. AD patients had more severe itching (30.4% versus 13.8%,p<0.001) and clinically suspected bacterial infection (21.7% versus 16.1%,p<0.001) than those of other types of dermatitis. Older patients were more susceptible to have a history of flexion dermatitis (p<0.001), bacterial infection (p=0.005), and severe itching (p<0.001). Outpatients with clinically suspected bacterial infection had 3.53-fold increased risk of AD than those without it (p<0.001). The morbidity rate of AD in the (20–25°N) region is 2.86 times higher than that in the (40–45°N) region [OR (95% CI): 0.352 (0.241–0.514),p<0.001].Conclusions. AD is characterized by unique clinical/demographic features. Bacterial infection and latitude region may have an impact on the incidence of AD in China.

scholarly journals Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults

2020 ◽  
Author(s):  
Yun Qiu ◽  
Qi Zhao ◽  
Yian Gu ◽  
Na Wang ◽  
Yuting Yu ◽  
...  
Keyword(s):  
Renal Function ◽  
Risk Factor ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Chinese Adults ◽  
Cross Sectional ◽  
Logistic Regression Models ◽  
Hypertriglyceridemic Waist ◽  
Increased Risk

Abstract Background: The hypertriglyceridemic waist (HTGW) phenotype has been suggested as a risk factor for chronic kidney disease (CKD), but evidence on relationship of triglyceride waist phenotypes with estimated glomerular filtration rate (eGFR) status and severity is limited. Our aim was to explore the association of triglyceride waist phenotypes with reduced eGFR and various decreased eGFR stages among Chinese adults.Methods: A population-based, cross-sectional study was conducted among Chinese participants aged 20-74 years during June 2016 to December 2017 in Shanghai, China. An eGFR value below 60 mL/min/1.73 m2 was defined as Decreased eGFR. The HTGW phenotype was defined as a triglycerides (TG) level ≥1.7 mmol/L and a waist circumference (WC) ≥90 cm for men and ≥80 cm for women. We examined the association of triglyceride waist phenotypes with decreased eGFR risk using the weighted logistic regression models.Results: A total of 31,296 adults were included in this study. Compared with normal TG level/normal WC (NTNW) phenotype, normal TG level/enlarged WC (NTGW), elevated TG level/normal WC (HTNW), elevated TG level/enlarged WC (HTGW) were associated with the increased risk of decreased eGFR, with an multivariable-adjusted ORs (95% CI) of 1.77 (1.42-2.20), 1.48 (1.16-1.90), and 2.30 (1.80-2.93), respectively. These positive associations between triglyceride waist phenotypes and decreased eGFR risk remained across almost all the subgroups, including sex, age, BMI, T2DM, and hypertension. NTGW, HTNW, and HTGW phenotype were consistently positively associated with the risk of mildly and moderately decreased eGFR, but not with severely decreased eGFR risk.Conclusions: HTGW was consistently associated with the increased risk of decreased eGFR and various decreased eGFR stages except for severely decreased eGFR. The findings imply that HTGW may be an important risk factor for renal dysfunction or an indicator for prevention and control aiming to reduce renal function decline.

scholarly journals Hormonal, metabolic and nutritional alterations in smokers: emergency for smoking abstinence

2013 ◽  
Vol 62 (4) ◽  
pp. 261-267 ◽  
Author(s):  
Gláucia Renata Souza Rodrigues ◽  
Marcela Melquíades ◽  
Maria Alvim Leite ◽  
Maíra Barros Louro ◽  
Carmen Perches ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Cross Sectional Study ◽  
The Body ◽  
University Hospital ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Fasting Glycemia ◽  
Increased Risk ◽  
The University

OBJECTIVE: To evaluate the biochemical and nutritional status of smokers in treatment for smoking cessation and its association with anthropometric parameters. METHODS: This is a cross-sectional study with convenience sample. Adult smokers were assessed at the start of treatment in the Interdisciplinary Center for Tobacco Research and Intervention of the University Hospital of the Federal University of Juiz de Fora (CIPIT/HU-UFJF). We evaluated the body mass index (BMI), conicity index (CI); waist circumference (WC), percentage of body fat (%BF), fasting glycemia, cortisol, insulin, total cholesterol (TC), LDL-c, HDL-c, triglycerides (TG) and metabolic syndrome (MS). RESULTS: Most participants (52.2%) had MS and high cardiovascular risk. The fasting glycemia was abnormal in 30.4%. There was a significant positive correlation between BMI and WC (r = 0.90; p = 0.0001), %BF (r = 0.79; p = 0.0001), CI (r = 0.65; p = 0.0001), glycemia (r = 0.42; p = 0.04) and TG (r = 0.47; p = 0.002). The CI presented positive correction with insulin (r = 0.60; p = 0.001), glycemia (r = 0.55; p = 0.007), TG (r = 0.54; p = 0.008) and %BF (r = 0.43; p = 0.004). Patients with longer duration of smoking had a higher risk of developing MS (OR = 9.6, p = 0.016). CONCLUSION: The smokers evaluated had increased risk for developing MS, especially those with longer duration of smoking, requiring urgent smoking cessation.

The prevalence and influencing factors of anemia among pre-pregnant women in mainland China: A large population-based, cross-sectional study

2021 ◽  
pp. 1-31
Author(s):  
Jun Zhao ◽  
Xiaoyue Zhu ◽  
Qiaoyun Dai ◽  
Xiang Hong ◽  
Hongguang Zhang ◽  
...  
Keyword(s):  
Public Health ◽  
Pregnant Women ◽  
Population Based ◽  
Cross Sectional Study ◽  
Blood Type ◽  
Chinese Government ◽  
Severe Anemia ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk

Abstract Anemia is a global public health problem affecting women worldwide, and reproductive-age women are at increased risk. We conducted a population-based cross-sectional study analyzing the prevalence of overall anemia and anemia according to severity in Chinese pre-pregnant women to update current knowledge on anemia epidemiology. Based on the National Free Preconception Check-up Projects supported by the Chinese government, 5,679,782 women participating in this project in 2017 were included in this study. The cyanmethemoglobin method was applied to assess hemoglobin concentrations. Univariate and multivariate logistic regressions were applied for associated factors. The prevalence of anemia among Chinese pre-pregnant women was 21.64% (mild anemia: 14.10%, moderate anemia: 7.17%, severe anemia: 0.37%). The prevalence of overall and severe anemia was the highest in Tibet and the lowest in Beijing among 31 provinces. Women’s age, region, ethnic origin, educational level, occupation, and pregnancy history were all correlated with anemia. Women with B blood type (aOR=0.89), higher BMIs (overweight: aOR=0.84; obesity: aOR=0.70), and alcohol consumption (aOR=0.69) were less likely to have anemia, while those with rhesus negative blood type (aOR=1.10), history of anemia (aOR=2.60), older age at menarche (aOR=1.19), heavy menstrual blood loss (aOR=1.39), longer menstrual period (aOR=1.09) and shorter menstrual cycle (aOR=1.08) were more likely to suffer from anemia. Meat or egg eaters were not significantly associated with severe anemia. Anemia is of moderate public health significance among Chinese pre-pregnant women. Interventions should be considered to prevent anemia to the greatest extent possible to avoid potential harm in this population.

Social cognition and bipolar disorder: A preliminary study

2017 ◽  
Vol 41 (S1) ◽  
pp. S426-S426
Author(s):  
F.D.R. Ponte ◽  
T.D.A. Cardoso ◽  
M. Kunz ◽  
A.R. Rosa
Keyword(s):  
Bipolar Disorder ◽  
Social Cognition ◽  
Clinical Outcomes ◽  
Cross Sectional Study ◽  
First Episode ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Preliminary Study ◽  
Competing Interest ◽  
Cognition Impairment

AimTo assess the clinical outcomes associated with social cognition impairment in euthymic patients with bipolar disorder.MethodIt was a cross-sectional study with convenience sample. The diagnose of bipolar disorder was performed by psychiatrist, using DSM-IV criteria, at bipolar disorder program – Hospital de Clinicas de Porto Alegre (Brazil), where the sample was recruited. The social cognition was assessed by psychologists using the Reading the Mind in the Eyes Test.ResultsWe included 46 euthymic BD patients: BD I (n = 39), women (n = 32), age (49.11 ± 13.17), and years of education (10.56 ± 3.80). Patients with social cognition impairment were not different of patients without social cognition impairment regarding socio demographic factors (gender, age, educational level, marital status, and employment status). Patients with social cognitive impairment showed higher rates of BD I patients (P = 0.036) and higher proportion of hospitalization in the first episode (P = 0.033), as compared to patients without social cognition impairment.ConclusionThis is a preliminary study demonstrating that BD patients with social cognition impairment show worse clinical outcomes. Severe BD onset seems to be an important predictor of social cognition impairment. However, more studies are needed investigating social cognition impairment in subjects with bipolar disorder.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Waist circumference as a determinant of hypertension and diabetes in Brazilian women: a population-based study

2004 ◽  
Vol 7 (5) ◽  
pp. 629-635 ◽  
Author(s):  
MTA Olinto ◽  
LC Nacul ◽  
DP Gigante ◽  
JSD Costa ◽  
AMB Menezes ◽  
...  
Keyword(s):  
Waist Circumference ◽  
Odds Ratio ◽  
Age Groups ◽  
Population Based ◽  
Cross Sectional Study ◽  
Central Adiposity ◽  
Cross Sectional ◽  
Younger Women ◽  
Increased Risk

AbstractObjective:To evaluate the role of central adiposity, as evaluated by the measurement of waist circumference (WC), as an independent risk factor for hypertension and type 2 diabetes mellitus in the setting of a developing country.Design:Population-based, cross-sectional study.Setting:A medium-sized town in southern Brazil.Participants:One thousand and ninety-five non-pregnant women, 20 to 69 years old, recruited by cluster random sampling between 1999 and 2000. Their mean WC was 85.3 cm (standard deviation 13.9 cm) and 23.3% (n = 255) were obese (body mass index >30 kg m−2). The prevalence of hypertension and diabetes was 25.6% (n = 280) and 6.2% (n = 68), respectively.Results:The risks of hypertension and diabetes were directly related to WC measurement. Women with WC > 80 cm had increased risk of hypertension (odds ratio (OR) = 6.2, P < 0.001). The association remained significant (OR = 1.04 per cm increase in WC, P = 0.02) after adjusting for confounders. The effect of WC on diabetes was modified by age. The effect was stronger in women younger than 40 years old (OR = 12.7, P = 0.016) than in those over 40 years old (OR = 2.8, P = 0.013). In the multivariate analysis, the odds ratio was 5.7 (P = 0.12) in those under 40 years old and 2.8 (P = 0.008) in older women.Conclusions:Waist circumference is an independent determinant for hypertension and diabetes in women in this population. The stronger association between WC and diabetes in younger women suggests that the validity of this indicator to assess abdominal adiposity is age-specific. Further studies should validate the usefulness of WC measurement in different age groups.

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