Physical health in schizophrenia - what's cognition got to do with it?

2011 ◽  
Vol 26 (S2) ◽  
pp. 2152-2152
Author(s):  
B. Gallhofer ◽  
G. Sammer ◽  
B. Hanewald ◽  
Keyword(s):  
Physical Health ◽  
Negative Impact ◽  
Present Report ◽  
Treatment Strategies ◽  
Cognitive Remediation ◽  
Antipsychotic Agents ◽  
Physical Parameters ◽  
Physical Treatment ◽  
Mental Load ◽  
Executive Skills

Patients suffering from schizophrenia are usually treated with antipsychotic agents posing a threat both to their cognitive and physical skills. Anticholinergic and antihistaminic side effects are well known to have a negative impact on mental as well as physical health and pose a major hazard regarding progress in reintegration.Strategies changing the fate of patients have moved away from just dampening dopaminergic noise in the limbic system. Nowadays, the new focus is on cognitive remediation. The centre of these efforts is to enhance strategic and executive skills and thereby alter patients' motivation to take their life into their own hands again.The present report aims at presenting evidence from both physical treatment strategies with the power to enhance hippocampal circuit capacity as well as cognitive remediation tools with the the aim of augmenting executive skills by rewiring cognitive circuitry in the brain.Preliminary results demonstrate not only improved processing of mental load found with fMRI measured circuitry connectivity, but they also point to the improvement of physical parameters taken in a continuous clinical context.The reasons for these favourable findings are not straight forward and trivial, but they seem to be the result of complex interaction between various factors. The latter are to be pursued in a large cohort and presented at a later point in time.

scholarly journals Dermatillomania: Strategies for Developing Protective Biomaterials/Cloth

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 341
Author(s):  
Priusha Ravipati ◽  
Bice Conti ◽  
Enrica Chiesa ◽  
Karine Andrieux
Keyword(s):  
Alternative Treatment ◽  
Negative Impact ◽  
Treatment Strategies ◽  
Current Treatment ◽  
Primary Objective ◽  
Neuropsychiatric Disorder ◽  
Physical Barrier ◽  
Physical Treatment ◽  
Pubmed Database ◽  
Prevention Of Infections

Dermatillomania or skin picking disorder (SPD) is a chronic, recurrent, and treatment resistant neuropsychiatric disorder with an underestimated prevalence that has a concerning negative impact on an individual’s health and quality of life. The current treatment strategies focus on behavioral and pharmacological therapies that are not very effective. Thus, the primary objective of this review is to provide an introduction to SPD and discuss its current treatment strategies as well as to propose biomaterial-based physical barrier strategies as a supporting or alternative treatment. To this end, searches were conducted within the PubMed database and Google Scholar, and the results obtained were organized and presented as per the following categories: prevalence, etiology, consequences, diagnostic criteria, and treatment strategies. Furthermore, special attention was provided to alternative treatment strategies and biomaterial-based physical treatment strategies. A total of six products with the potential to be applied as physical barrier strategies in supporting SPD treatment were shortlisted and discussed. The results indicated that SPD is a complex, underestimated, and underemphasized neuropsychiatric disorder that needs heightened attention, especially with regard to its treatment and care. Moreover, the high synergistic potential of biomaterials and nanosystems in this area remains to be explored. Certain strategies that are already being utilized for wound healing can also be further exploited, particularly as far as the prevention of infections is concerned.

scholarly journals Relationships between Physical and Social Behavioural Changes and the Mental Status of Homebound Residents in Hong Kong during the COVID-19 Pandemic

2020 ◽  
Vol 17 (18) ◽  
pp. 6653
Author(s):  
Ben Y. F. Fong ◽  
Martin C. S. Wong ◽  
Vincent T. S. Law ◽  
Man Fung Lo ◽  
Tommy K. C. Ng ◽  
...  
Keyword(s):  
Mental Health ◽  
Hong Kong ◽  
Physical Health ◽  
Negative Impact ◽  
Severe Depression ◽  
Social Contact ◽  
Well Being ◽  
Full Time ◽  
Online Questionnaire ◽  
Physical Strain

In Hong Kong, social distancing has been adopted in order to minimise the spread of COVID-19. This study aims to examine the changes in physical health, mental health, and social well-being experienced by local residents who were homebound during the pandemic. An online questionnaire in both Chinese and English versions was completed by 590 eligible participants from 24 April to 13 May 2020. The questionnaire found that individuals aged 18 to 25 years spent more time resting and relaxing but experienced more physical strain. Working status was associated with social contact, with participants working full-time jobs scoring higher in “maintaining social communication via electronic means” and “avoiding social activities outside the home”. Additionally, approximately one third of the participants (29.7%) had moderate to severe depression, and participants aged 18 to 25 were found to have higher scores in PHQ-9. Changes in physical health and social contact were significantly associated with developing depressive symptoms. From the results, it is clear that the COVID-19 pandemic has the potential to exert a negative impact on the mental health status of individuals.

scholarly journals MODERN TECHNOLOGIES OF MARKETING INTELLIGENCE

2019 ◽  
Vol 4 (20) ◽  
pp. 116-124
Author(s):  
Oksana Makara ◽  
Alla Lialiuk ◽  
Yurii Panasiuk
Keyword(s):  
Physical Health ◽  
Negative Impact ◽  
Web Analytics ◽  
Direct Identification ◽  
Methodological Basis ◽  
Private Data ◽  
The Social ◽  
Marketing Intelligence ◽  
Modern Technologies

The purpose of the article is to explore the use of the latest technologies in marketing intelligence, and to offer a vision of its use without harming the social and physical health of consumers. The methodological basis of the research was foreign and domestic publications and analytical reviews on the problems of marketing intelligence using web analytics. The proposed approaches can be taken into account by the marketing services of domestic enterprises when conducting marketing intelligence. An example of Google Analytics examines the technology of marketing intelligence. It is concluded that the beginning of development of open methods of processing private data of users without their direct identification is positive. which would limit the interference with the privacy of people, leaving marketing intelligence possible, and would prevent its negative impact on people's lives.  

scholarly journals Inappropriate Nasopharyngeal Sampling for SARS-CoV-2 Detection Is a Relevant Cause of False-Negative Reports

2020 ◽  
Vol 163 (3) ◽  
pp. 459-461 ◽  
Author(s):  
Antonio Piras ◽  
Davide Rizzo ◽  
Sergio Uzzau ◽  
Giacomo De Riu ◽  
Salvatore Rubino ◽  
...  
Keyword(s):  
Nasal Obstruction ◽  
Negative Impact ◽  
Present Report ◽  
False Negative ◽  
Nasopharyngeal Swab ◽  
Rt Pcr ◽  
Radiologic Findings ◽  
Negative Findings ◽  
Current Outbreak ◽  
Polymerase Chain

Reverse transcriptase polymerase chain reaction (RT-PCR) detection of SARS-CoV-2 mRNA on nasopharyngeal swab is the standard for diagnosing active COVID-19 disease in asymptomatic cases and in symptomatic patients without the typical radiologic findings. For the present COVID-19 outbreak in Italy, we describe 4 symptomatic patients with negative RT-PCR results at the first nasopharyngeal swab, which became positive when collected a few hours later by an otolaryngologist. All the patients showed nasal obstruction. The present report suggests that inadequate nasopharyngeal sampling performed by untrained operators in the presence of nasal obstruction can be a relevant case of false-negative findings at RT-PCR, with a clear negative impact on the efforts to contain the current outbreak.

Anosmia: Differential Diagnosis, Evaluation, and Management

2017 ◽  
Vol 31 (1) ◽  
pp. e3-e7 ◽  
Author(s):  
George A. Scangas ◽  
Benjamin S. Bleier
Keyword(s):  
Differential Diagnosis ◽  
Negative Impact ◽  
Treatment Strategies ◽  
Communication Disorders ◽  
The United States ◽  
Current Treatment ◽  
Olfactory Dysfunction ◽  
Olfactory Testing ◽  
Smell Disorders

The ability to scrutinize our surroundings remains heavily dependent on the sense of smell. From the ability to detect dangerous situations such as fires to the recollection of a fond memory triggered by an odor, the advantages of an intact olfactory system cannot be overstated. Outcomes studies have highlighted the profound negative impact of anosmia and parosmia on the overall quality of life. The National Institute on Deafness and Other Communication Disorders estimates that ∼1.4% of the United States population experiences chronic olfactory dysfunction and smell loss. Efforts have focused on improving both the diagnosis of olfactory dysfunction through olfactory testing and improved reporting of treatment outcomes of olfactory training. The purpose of this article was to review the differential diagnosis, workup, and current treatment strategies of anosmia and smell disorders.

scholarly journals Valuing the health of the support worker in the aged care sector

2016 ◽  
Vol 37 (5) ◽  
pp. 1006-1024 ◽  
Author(s):  
ESTHER GEORGE ◽  
LEIGH HALE ◽  
JENNIFER ANGELO
Keyword(s):  
Physical Health ◽  
Time Pressure ◽  
Negative Impact ◽  
Physical Nature ◽  
Aged Care ◽  
Structured Interviews ◽  
Support Worker ◽  
Community Based ◽  
Health Support ◽  
Care Support

AbstractThis study explored aged care support workers’ perceptions of how their health was influenced by their job, highlighting similarities and differences of those working in community-based and institution-based care. Support workers working in two institution-based and three community-based aged care organisations were invited to participate. Semi-structured interviews were undertaken with ten participants. Open-ended questions probed participants’ perceptions of their health as it related to their work. Data were analysed with the General Inductive Approach. Four central themes were identified, many of which related to mental, as opposed to physical health. ‘Love of the job’ described various sources of satisfaction for participants. These factors commonly overrode the negative aspects. ‘Stress’ encompassed the negative influences on all aspects of health. ‘Support’ described the positive influences on health, which supported participants in their job. ‘Physicality’ described the physical nature of the job and the positive and negative impact this had on participants’ health. Support workers perform numerous tasks, which often impact upon their health. Aspects of the job that may impact the health of the worker are improved communication and support from management, as well as recognition for support workers’ contribution to society. These could be targeted to enhance support worker health. Additional training and reduced time pressure may also represent aspects for improvement, to optimise support workers’ physical health.

Effects of concurrent training on physical health and performance

2018 ◽  
Vol 14 (1) ◽  
pp. 63-68 ◽  
Author(s):  
P. Jha ◽  
S. Khurana ◽  
K. Ali ◽  
I. Ahmad ◽  
S. Verma
Keyword(s):  
Physical Health ◽  
Intervention Studies ◽  
Primary Objective ◽  
Concurrent Training ◽  
Physical Parameters ◽  
Cross Sectional ◽  
And Performance ◽  
Insight Into

The primary objective of this narrative review was to evaluate the current literature and to provide further insight into the role of concurrent training on various components of physical health or performance. Literature was obtained by electronic searches of databases using specific keywords. Combined effect of training sessions proved to be as beneficial as drug interactions. Results from cross-sectional, longitudinal, and intervention studies are reviewed and discussed with main focus on physical parameters, such as body composition, physiological parameters, molecular adaptation, athlete’s perspective, order of execution, interference phenomena and recovery. In conclusion, concurrent resistance and endurance training is an effective method for enhancing overall fitness as well as improving quality of life.

scholarly journals Feasibility and Safety of 3-Weekly Carboplatin/Paclitaxel Regimen in Advanced Squamous cell Carcinoma of the Anal Canal

2021 ◽  
pp. 1-5
Author(s):  
Abraão Dornellas ◽  
Abraão Dornellas ◽  
Renata C. Bonadio ◽  
Priscila M. G. Moraes ◽  
Maria I. Braghiroli ◽  
...  
Keyword(s):  
Adverse Events ◽  
Cox Regression ◽  
Negative Impact ◽  
Multivariable Analysis ◽  
Treatment Strategies ◽  
Complete Response ◽  
Median Number ◽  
Rank Test ◽  
Hiv Positive ◽  
Serious Adverse Events

Introduction: Anal cancer is a rare disease, and there is a lack of phase 3 studies in the advanced setting. Currently, the standard treatment is based on interAACT phase 2 study using Carboplatin (C) (AUC 5, D1q28) plus Paclitaxel (P) (80 mg/m2, D1,8,15q28). This study demonstrated a median OS of 20m, a response rate of 59% and serious adverse events in 36% of patients (pts). However, this regimen requires more infusions and hospital visits than a 3-weekly CP regimen, resulting in high social and financial cost. Objective: To retrospectively access safety and efficacy of treatment with 3-weekly CP in advanced SCCA. Methods: We performed a single-center retrospective analysis of patients (pts) who received first-line treatment with 3-weekly CP for inoperable locally recurrent or metastatic SCCA between Jun/2011 and Jun/2018. Study data were collected using REDCap®. Survival analyses were estimated with the Kaplan-Meier method and compared by log-rank test. Prognostic factors were evaluated by Cox regression. Results: 47 patients were included. Median age was 57 years, 60% (n=28) were female and 21% (n=10) HIV positive.16% (n=7) had metastatic disease at diagnosis. The majority of pts (n=42) were treated with paclitaxel (P) 175 mg/m2 plus carboplatin (C) AUC 5 every 3 weeks. The median number of cycles was 4 and dose reduction by toxicity was necessary for 30% (n=14). Grade 3/4 adverse events were neutropenia 19% (n=9), anemia 4% (n=2), fatigue 4% (n=2), neuropathy 2% (n=1). Two pts had interruption due to toxicity and no treatment-related death. 64% of patients benefited from treatment, 4% with complete response. The median overall survival (OS) was 10 months(m). In a multivariable analysis, HIV-positive (HIV+) status (HR 3.1; 95%CI 1.8-8.4; p 0.001) and ECOG 2/3 (HR 3.9; 95%CI 1.2-8.1; p 0.01) showed a negative impact on OS. Median OS was 16m for HIV- vs 4m for HIV+ group; and 20m for ECOG 0/1 vs 4m for ECOG 2/3. Conclusion: The present study suggests that 3-weekly CP has similar outcomes to the InterAACT regimen. Nevertheless, pts who are HIV+ or have ECOG 2/3 had poor outcomes and other treatment strategies should be studied for these pts.

scholarly journals Diagnosis and treatment of Charcot arthropathy in diabetic patients

2021 ◽  
Vol 64 (8) ◽  
pp. 543-550
Author(s):  
Jae Jung Jeong
Keyword(s):  
Negative Impact ◽  
Financial Burden ◽  
Late Complication ◽  
Treatment Strategies ◽  
Sensory Neuropathy ◽  
Diabetic Patients ◽  
Foot And Ankle ◽  
Charcot Joint ◽  
Appropriate Treatment ◽  
Joint Dislocations

Background: Charcot joint or neurogenic arthropathy in diabetes is a late complication invading the foot and ankle that results in dislocation, instability, and deformity of the affected area. Sensory neuropathy leads to numbness and malalignment of the foot and ankle or inadequate post-traumatic response, which results in progressive fractures, multiple joint dislocations, ulcerations, osteomyelitis, and amputation. Because of such serious consequences, understanding of pathophysiology is important in determining treatment strategies. Early diagnosis and appropriate treatment can prevent this destructive process.Current Concepts: The number of adults diabetic patients continuously increases. Health care and life expectancy will continue to improve with the development of medicine. As a result, the incidence of diabetes-related complications will increase. Diabetic Charcot joint will have a serious negative impact on the quality of life and financial burden on the diabetic patients. The goal of treatment for Charcot joint is not to build a normal foot, but to make a stable plantigrade foot that can be worn shoes. Therefore, it would be most important to understand the progress and characteristics of the disease and to develop an appropriate plan in order to select the appropriate treatment method.Discussion and Conclusion: Understanding Charcot joint and familiarization with its appropriate treatment should reduce the number of the cases of diabetic Charcot joint patients with disabilities or amputations.

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