Evaluation of thyroid function in lithium-naive bipolar patients

1999 ◽  
Vol 14 (6) ◽  
pp. 341-345 ◽  
Author(s):  
J. Valle ◽  
J.L. Ayuso-Gutierrez ◽  
A. Abril ◽  
J.L. Ayuso-Mateos
Keyword(s):  
Thyroid Function ◽  
Bipolar Affective Disorder ◽  
Rapid Cycling ◽  
Course Of Illness ◽  
Duration Of Illness ◽  
Bipolar Ii ◽  
Significant Difference ◽  
High Prevalence ◽  
Bipolar Patients ◽  
Tsh Levels

SummaryA high prevalence of thyroid hypofunction has been found in bipolar patients. However, the samples used in previous studies included a high percentage of patients in treatment with lithium and carbamazepine. Since the use of these drugs may explain the high prevalence of thyroid disturbances found in bipolar patients, we designed the present study to assess thyroid function in a sample of bipolar patients who had not been treated previously with lithium or carbamazepine. Patients included in the sample met Research Diagnostic Criteria for bipolar affective disorder. Assessment included determination of serum levels for total tyroxine (T4), total triiodothyronine (T3), and thyrotropin both basally and in response to infusion of 500 mg of Protilerin. The rate of thyroid hypofunction in the total sample (9.2%) was considerably lower than that reported in other studies with bipolar patients undergoing lithium therapy. Five patients (9.2%) showed some thyroid hyperfuncion parameter. Our results do not show significant differences in thyroid function indices between long-term and short-term duration of illness, between outpatients and inpatients, between high and low number of episodes, and between rapid- and non-rapid-cycling cases. Comparison between bipolar I and bipolar II patients shows a statistically significant difference in the values of TSH levels, with the bipolar II group having a higher mean value. Our data suggest that thyroid dysfunction is not related to gender, duration of illness, number of episodes, or rapid-cycling course of illness. The higher TRH-stimulated TSH levels in the bipolar II group could be considered a differential biological feature.

Treatment-Resistant Bipolar Disorder: A Comparison of Rapid Cyclers and Nonrapid Cyclers

CNS Spectrums ◽  
2003 ◽  
Vol 8 (12) ◽  
pp. 948-952 ◽  
Author(s):  
Dong Vo ◽  
David L. Dunner
Keyword(s):  
Lithium Treatment ◽  
Tertiary Care ◽  
Care Facility ◽  
Treatment Resistance ◽  
Rapid Cycling ◽  
Treatment Resistant ◽  
Tertiary Care Facility ◽  
Significant Difference ◽  
Persistent Depression ◽  
Bipolar Patients

ABSTRACTBackground: We investigated clinical factors to determine their relationship to treatment resistance among bipolar patients who had a consultation at a tertiary care facility.Methods: Patients were separated into two categories: rapid-cycling disorders and nonrapid-cycling disorders. We hypothesized that there would be less usage of lithium carbonate among nonrapid-cycling treatment-resistant patients than among rapid cyclers and also that there would be higher rates of comorbidity seen among nonrapid-cycling than rapid-cycling patients in order to account for these particular patients being treatment resistant.Findings: Continued recyling and persistent depression characterized rapid cyclers, whereas persistent depression characterized nonrapid cyclers. Less than 30% of patients had adequate lithium treatment and there was no significant difference comparing rapid cyclers with non-rapid cyclers. Rates of comorbidity were also not significantly different between these groups. We also assessed a number of other factors.Conclusion: Some of these factors were significant, but when a Bonferonni correction was applied, these significant differences were not maintained. The study of treatment resistance among nonrapid-cycling bipolar patients merits further research.

scholarly journals EVALUATION OF THYROID FUNCTION TEST IN OBESE PATIENTS

2016 ◽  
Vol 9 (9) ◽  
pp. 353 ◽  
Author(s):  
Faazila Fathima ◽  
Preetha P
Keyword(s):  
Thyroid Function ◽  
Thyroid Function Test ◽  
Thyroid Stimulating Hormone ◽  
Obese Patients ◽  
Obese People ◽  
Hormone Synthesis ◽  
Significant Difference ◽  
Function Test ◽  
Tsh Levels ◽  
Paired T Test

ABSTRACTObjective: To evaluate thyroid function in 20-50 aged obese people. As obesity is a widespread problem today, knowledge about the factors affectingor influencing it is important. Little is known about the changes in thyroid function obese people. Influence on thyroid hormone synthesis has beenproposed.Methods: Thyroid function test was done for 30 obese and 30 nonobese people, and their thyroid-stimulating hormone (TSH) levels were compared.Results: Using paired t-test, we found that there is a statistically significant difference between TSH levels in obese and nonobese people at p<0.001.Keywords: Thyroid, Obese, Nonobese, Thyroid function test.

Manic-depressive illness — I: clinical characteristics of bipolar disorder subtypes

1992 ◽  
Vol 9 (1) ◽  
pp. 6-9 ◽  
Author(s):  
Patrick McKeon ◽  
Patrick Manley ◽  
Gregory Swanwick
Keyword(s):  
Bipolar Disorder ◽  
Family History ◽  
Age Of Onset ◽  
Rapid Cycling ◽  
Manic Depressive Illness ◽  
Bipolar Ii ◽  
History Of ◽  
Bipolar Patients ◽  
Depressive Episodes ◽  
Manic Patients

AbstractThe clinical and demographic features of 100 bipolar disorder patients, who were categorised into bipolar I, bipolar II, unipolar mania and rapid cycling groups, and who were further classified on the basis of the sequence of occurrence of the manic and depressive episodes within each cycle, are compared. Bipolar I (including unipolar manic) patients, 77% of whom had a sequence of moods where mania preceded depression (Mania-Depression – normothymic Interval: M.D.I.) constituted 69% of the total sample. Six per cent were classified as bipolar II and 25% has a rapid cycling disorder. Patients who had an M.D.I. sequence of moods, whether rapid or non-rapid cycling, had a younger age of onset, a higher male:female ratio and a stronger family history of bipolar disorder than patients whose depression preceded mania (D.M.I.). Unipolar manic patients, 12% of the sample, had a comparable age of onset, a greater family history of bipolarity and more frequent hospitalisations than the bipolar I-M.D.I. group. Rapid cycling patients had a lower mean serum thyroxine concentration than the non-rapid cycling bipolar disorder patients. This study supports the rationale for distinguishing bipolar patients with an M.D.I, sequence from those with a D.M.I, pattern and rapid cyclers from non-rapid cyclers.

Assessment of Thyroid Function in COVID-19 Patients

2021 ◽  
Author(s):  
Ali Hasan Mohammed ◽  
Araz Muhammed Yousif ◽  
Samir Anwar Jabbar ◽  
Parween Abdulsamad Ismail
Keyword(s):  
Polymerase Chain Reaction ◽  
Thyroid Function ◽  
Thyroid Disease ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Significant Difference ◽  
High Prevalence ◽  
The World ◽  
History Of ◽  
Polymerase Chain

Since the egression of the coronavirus 2019 (COVID-19) disease, more than 200 countries and areas around the world were affected. To the present, it is not clear whether COVID-19 has effects on thyroid function or not. The aim of the current study was to assess thyroid function in COVID-19 patients with history of thyroid disease and those without such a history and to find out the thyroid disturbance in both groups. The present study involved 86 COVID-19 affected patients admitted BioLab and the Balsam Hospital, Erbil/ Iraq between January and April 2021. Confirmation of COVID-19 infection all patients by Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) of nasopharyngeal swabs. Thyroid hormones, and thyrotropin (TSH) level was analyzed and assessed. Most of the participants (88.4%) had normal T3 level, and there was no significant difference (p = 0.069) between those with normal T3, TPO and with no history of thyroid disease and those with such a history and/or high TPO. T4 levels of the participants with no history of thyroid disease and normal TPO did not differ significantly (p =0.725) from those with a history of thyroid disease and/or high TPO. Regarding the level of TSH, there was significant difference (p<0.001) between the two fore mentioned groups. There is high prevalence of subclinical hypothyroidism in the COVID-19 patients with family history of thyroid disease and high TPO antibody level.

Domestic violence in a sample of Egyptian female psychiatric patients(pilot study)

2011 ◽  
Vol 26 (S2) ◽  
pp. 1657-1657
Author(s):  
H. Dessoki ◽  
M. El Batrawy ◽  
M. Shaheen ◽  
N. Sabry
Keyword(s):  
Domestic Violence ◽  
Battered Women ◽  
Psychiatric Patients ◽  
Statistical Significance ◽  
Bipolar Affective Disorder ◽  
Depression Scale ◽  
Control Group ◽  
Significant Difference ◽  
History Of ◽  
Bipolar Patients

Domestic violence is one of the most pervasive of all social problems, Domestic violence for women is violence perpetrated within relationships; this violence is much serious than violence perpetrated by a stranger.The hypothesis of this work is that domestic violence is a general health problem and not present particularly in psychiatric patients, the study aims at studying domestic violence in married female psychiatric patients. Sixty Egyptian married females were included, 20 of them had the I.C.D.-10 diagnosis of bipolar affective disorder, 20 neurotic disorders and 20 control group. All groups were clinically and psychometrically assessed using clinical psychiatric sheet of Kasr El-Aini hospital. Those who reported history of domestic violence were subjected to: Zung self rating depression scale, locus of control, Esyenck Personality Questionnaire (E.P.Q) and a specially designed questionnaire to assess intimacy/abuse, and wives’ perception of husbands characters.The results reveal no statistically significant difference between the 3 groups concerning the domestic violence or the degree of abuse. A significant relation was found between domestic violence and history of child abuse. Battered women of patient group were more depressed than control group with no statistical significance, while neurotic patients were significantly more depressed (87%) than bipolar patients (50%) and control group (57.1%)((p < 0.05). Significant higher scores were found in neurotic patients on EPQ neuroticism scale.ConclusionDomestic violence occurring in female psychiatric patients is not higher than normal. In addition, despite abuse, Egyptian wives tend to see their husbands positively.

scholarly journals DO BIPOLAR PATIENTS LACK MIND READING; AN ATTEMPT TO ASSESS THROUGH PICTURE SEQUENCING TASK

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Anant Kumar Rathi ◽  
Sandeep Sharma ◽  
Kamal Kumar Verma ◽  
Divya Bishnoi
Keyword(s):  
Theory Of Mind ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
False Belief ◽  
Mind Reading ◽  
Previous Evidence ◽  
Significant Difference ◽  
Icd 10 ◽  
Bipolar Patients ◽  
Sequencing Task

Background: This paper reports the performance of ICD-10 diagnosed Bipolar affective disorder (BPAD) patients on a well recognised measure of theory of mind (ToM) that commonly elicits  group related differences in schizophrenia research. Aims: (1) To assess Theory of mind in patients of Bipolar Affective Disorder.                                   (2)  To examine effect of mood on Theory of Mind. Method: Three groups were formed namely Control, BPAD (M) and BPAD (D). Each group was socio-demographically suitably matched and had 30 participants. Active symptomatology was assessed by using YMRS and MADRS in BPAD(M) and BPAD(D) cases respectively. Theory of mind was calculated using Landon and Clotheart (1999) Picture Sequencing Task. Results: Relative to controls, bipolar patients performed significantly worse on the ToM relevant false belief script in picture sequencing task but not on other types of task stories. No significant difference was observed in the ToM performance between the phase of bipolarity. Conclusion: The results support previous evidence of ToM deficit in BPAD and indicate a potential endophenotypic overlap in the phenomenology of both Schizophrenia and BPAD. Keywords: Theory of Mind, YMRS, MADRS, Picture Sequence Task

scholarly journals High Prevalence of Anti Thyroid Antibodies in an Albanian Cohort of Patients

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A830-A831
Author(s):  
Dorina Minxuri ◽  
Anila Mitre ◽  
Silva Bino ◽  
Ina Toska ◽  
Ina Mulla
Keyword(s):  
Thyroid Function ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Thyroid Disorders ◽  
Thyroid Antibodies ◽  
Positive Group ◽  
Normal Thyroid ◽  
Normal Thyroid Function ◽  
Significant Difference ◽  
High Prevalence

Abstract Introduction: Albania is classified as iodine deficient region and endemic goiter in this country has been a concern for public health. A salt iodization program has been implemented in Albania since 2008. Most of regions still remain with a mild or moderate iodine deficiency there are no studies on prevalence of thyroid autoimmune disorders. The purpose of this study was to assess thyroid function and the presence of thyroid antibodies in subjects that were not previously diagnosed or treated for thyroid disorders. Methods: This is a cross-sectional study performed in a cohort of patients in Albania during a 2 year period (january 2018-january 2020). We assessed the prevalence of thyroid function disorders and presence of thyroid antibodies in 5047 subjects (81% females and 19% males). Individuals previously diagnosed or treated for thyroid disease were excluded from the study. TSH, Free T4, total T3, Anti TPO(thyroid peroxidase) and anti TG (thyroglobulin) were measured with electrochemiluminescence method with Cobas 6000 Roche Diagnostics. We calculated the frequency of thyroid antibodies and the abnormal thyroid function. Statistical analysis was performed to see if there was a difference between individuals with positive antibodies and those negative for antibodies. Results: 91 % (4596) of subjects resulted euthyroid. We found a low prevalence of overt thyroid dysfunction (hyperthyroidism 0.48% and hypothyroidism 1.69%). The rates of subclinical hypothyroidism and hyperthyroidism were 5.5% and 1.4% respectively. The prevalence of positive thyroid antibodies, at least one of them was 28% in females and 14% in males (2:1 ratio). 97.3 % of subjects who testet negative for antibodies had normal thyroid function compared to 73.5% in antibodies positive group. There was a significant difference for subclinical hypothyroidism and other thyroid disorders between antibodies positive group and antibodies negative group (p value &lt;0.0000119% of individuals(from 5047 examined) had normal thyroid function and resulted positive for anti TPO or anti TG. Conclusions: Undiagnosed biochemical thyroid dysfunctions were common in subjects living in a mild to moderate iodine-deficient area especially subclinical hypothyroidism. TSH level correlated well with the presence of antibodies resulting in significant difference in thyroid function between 2 groups. We found a high prevalence (19%) of thyroid antibodies in euthyroid subjects. TPO antibodies in euthyroid subjects can be used to identify subjects with increased risk for hypothyroidism such as women who are pregnant (to predict first trimester or postpartum thyroid dysfunction), patients with other autoimmune diseases, subjects on drugs like amiodarone or relatives of patients with autoimmune thyroid diseases.

scholarly journals The results of neonatal TSH screening do not agree with indicators of the optimal iodine status of pregnant women in the Republic of Georgia

2018 ◽  
Vol 14 (2) ◽  
pp. 81-85 ◽  
Author(s):  
Nelli Barnabishvilli ◽  
Gregory A. Gerasimov ◽  
Teimuraz Azikuri
Keyword(s):  
Iodine Deficiency ◽  
Endemic Goiter ◽  
Thyroid Stimulating Hormone ◽  
Capital City ◽  
Iodine Nutrition ◽  
Iodine Status ◽  
Significant Difference ◽  
High Prevalence ◽  
The Republic ◽  
Tsh Levels

Background. Georgia historically was a country with moderate to severe iodine deficiency and high prevalence of endemic goiter. A representative countrywide iodine survey conducted in Georgia in 2017 confirmed optimal iodine nutrition of the population with median UIC 298 mcg/L in SAC and 211 mcg/L in PW. Aim. The aim of this study was to assess status of iodine nutrition of population in Georgia. Methods. The assesement based on the proportion of neonatal Thyroid-Stimulating Hormone (TSH) levels >5mIU/L from 2009 to 2015 and compare these data with the results of direct assessment of iodine status made during the 2017 national survey. Results. From 2009 to 2015 the proportion of newborns with TSH >20 mIU/L decreased threefold: from 0.45 to 0.15%. This trend was observed in all regions of the country with significant difference between the capital city and Western in Eastern parts of the country. There has been also significant reduction of the prevalence of TSH >5 mIU/L in Georgia from 4.46% in 2009 to 3.5% in 2015. However, only in Tbilisi the frequency of elevated TSH was below 3% – the cutoff level for adequate iodine nutrition. In other regions (Western and Eastern Georgia) prevalence of TSH >5 mIU/L was 3.8% and 4.4% respectively that could be falsely interpreted as mild iodine deficiency. Conclusions. Although neonatal TSH is useful to detect moderate to severe iodine deficiency, it should be cautiously recommended for the evaluation of iodine status in iodine sufficient to mildly iodine deficient regions.

scholarly journals Influence of the first episode duration on further course of bipolar disorder

2011 ◽  
Vol 64 (9-10) ◽  
pp. 466-469 ◽  
Author(s):  
Vladimir Knezevic ◽  
Aleksandra Nedic
Keyword(s):  
Bipolar Disorder ◽  
Medical Records ◽  
First Episode ◽  
Modest Contribution ◽  
Significant Difference ◽  
High Prevalence ◽  
Episode Duration ◽  
Bipolar Patients ◽  
Treatment Prognosis

Introduction. Bipolar disorder has been continuously studied due to its high prevalence and incidence. The aim of this study was to explore the influence of duration of the first episode of bipolar disorder on the further course of this disorder. Material and Methods. The research was conducted as a retrospective-prospective, naturalistic study, which included 65 bipolar patients admitted to the hospital. We used Student?s t-test in addition to descriptive parameters, mean, median and standard deviation. We followed the 5-year course of the disorder after the first episode. Results. Having examined the medical records of the first episode and five-year follow-up of the course of the disease we found a statistically significant difference (2 vs 1.54; df=120; p<0.05) in the number of episodes following the first episode between the patients whose first episode was longer than 2 months and the patients whose first episode was shorter than 2 months. In addition, we found a statistically significant difference (55.42 vs 42.3; df=120; p<0.05) in duration of episodes that followed the first episode between the patients whose first episode was longer than 2 months and the patients whose first episode was shorter than 2 months. Discussion. Since these results are in accordance with the literature, we ought to point out the possibility of developing chronic syndromes in patients with longer first episodes. Conclusion. This study is a modest contribution to the trend of studying bipolar disorder. Better knowledge of the course would enable better treatment, prognosis and outcome of this disorder.

Prodromes, coping strategies and course of illness in bipolar affective disorder – a naturalistic study

2001 ◽  
Vol 31 (8) ◽  
pp. 1397-1402 ◽  
Author(s):  
D. LAM ◽  
G. WONG ◽  
P. SHAM
Keyword(s):  
Coping Strategies ◽  
Bipolar Affective Disorder ◽  
Manic Episode ◽  
Psychosocial Interventions ◽  
Naturalistic Study ◽  
Prodromal Stage ◽  
Prodromal Symptoms ◽  
Course Of Illness ◽  
Manic Symptoms ◽  
Bipolar Patients

Background. Psychosocial interventions for bipolar patients often include teaching patients to recognize prodromal symptoms and tackle them early. This prospective study set out to investigate which bipolar prodromal symptoms were reported frequently and reliably over a period of 18 months. Furthermore, we have also investigated which types of coping strategies were related to good outcome.Method. Forty bipolar patients were interviewed for their bipolar prodromal symptoms and their coping strategies at recruitment and 18 months later. Patients were also assessed as to whether they had experienced relapses.Results. Bipolar patients were able to report bipolar prodromal symptoms reliably. Mania prodromal symptoms tended to be behavioural symptoms. A quarter of patients reported difficulties in detecting depression prodromes, which tended to be more diverse and consisted of a mix of behavioural, cognitive and somatic symptoms. Significantly fewer patients who reported the use of behavioural coping strategies to curb excessive behaviour during the mania prodromal stage experienced a manic episode. Similarly, significantly fewer patients who reported the use of behavioural coping strategies experienced depression relapses. How well patients coped with mania prodromes predicted bipolar episodes significantly when the mood levels at baseline were controlled. Ratings of how well subjects coped with mania prodromal symptoms also predicted manic symptoms significantly at T2 when manic symptom at T1 was controlled.Conclusion. Our study suggests that bipolar patients are able to report prodromal symptoms reliably. It is advisable to teach patients to monitor their moods systematically and to promote good coping strategies.

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