Epidemiological and clinical characteristics of the first 500 confirmed COVID-19 inpatients in a tertiary infectious disease referral hospital in Manila, Philippines

Abstract Background The Philippines has been one of the most affected COVID-19 countries in the Western Pacific region, but there are limited data on COVID-19-related mortality and associated factors from this setting. We aimed to describe the epidemiological and clinical characteristics and associations with mortality among COVID-19-confirmed individuals admitted to an infectious diseases referral hospital in Metro Manila. Main text This was a single-centre retrospective analysis including the first 500 laboratory-confirmed COVID-19 individuals admitted to San Lazaro Hospital, Metro Manila, Philippines, from January to October 2020. We extracted clinical data and examined epidemiological and clinical characteristics and factors associated with in-hospital mortality. Of the 500 individuals, 133 (26.6%) were healthcare workers (HCW) and 367 (73.4%) were non-HCW, with HCW more likely presenting with milder symptoms. Non-HCW admissions were more likely to have at least one underlying disease (51.6% vs. 40.0%; p = 0.002), with hypertension (35.4%), diabetes (17.4%), and tuberculosis (8.2%) being the most common. Sixty-one (12.2%) died, comprising 1 HCW and 60 non-HCW (0.7% vs. 16.3%; p < 0.001). Among the non-HCW, no death occurred for the 0–10 years age group, but deaths were recorded across all other age groups. Compared to those who recovered, individuals who died were more likely to be older (p < 0.001), male (p = 0.015), report difficulty of breathing (p < 0.001), be HIV positive (p = 0.008), be intubated (p < 0.001), categorised as severe or critical (p < 0.001), have a shorter mean hospital stay (p < 0.001), or have an additional diagnosis of pneumonia (p < 0.001) or ARDS (p < 0.001). Conclusion Our analysis reflected significant differences in characteristics, symptomatology, and outcomes between healthcare and non-healthcare workers. Despite the unique mix of cohorts, our results support the country’s national guideline on COVID-19 vaccination which prioritises healthcare workers, the elderly, and people with comorbidities and immunodeficiency states.

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Trend of fall-related mortality among the elderly

Revista da Escola de Enfermagem da USP ◽

10.1590/1980-220x-reeusp-2020-0069 ◽

2021 ◽

Vol 55 ◽

Author(s):

Yara Cristina Martins Monteiro ◽

Maria Aparecida da Silva Vieira ◽

Priscila Valverde de Oliveira Vitorino ◽

Silvio José de Queiroz ◽

Gabriela Moreira Policena ◽

...

Keyword(s):

Time Series ◽

Information System ◽

Elderly Population ◽

Temporal Trend ◽

Preventive Measures ◽

Age Groups ◽

The Elderly ◽

Death Rates ◽

Variation Rate ◽

Related Mortality

ABSTRACT Objective: To analyze the temporal trend of fall-related mortality in elderly in Brazil from 2008 to 2016. Method: Study of time series of rates of fall-related mortality according to CID-10 from 2008 to 2016. Data from the Mortality Information System on death registers of people ≥ 60 living in Brazil were used. The specific rates of fall-related mortality among the elderly were calculated through the ratio between the number of deaths and the elderly population of that year and region. The populational information was obtained from the 2000 and 2010 censuses. The variation rate and temporal trend were obtained through linear regression (p < 0.05). Results: The fall-related deaths among the elderly aged ≥ 60 amounted to 72,234 (31.2%). Falls from the same level were the most frequent (53.8%) and death rates in all ages ranged from 29.7 to 44.7 per 100,000 elders. Fall-related deaths increased with age. Conclusion: There was a growing trend of fall-related deaths among elderly in all age groups, an event which is avoidable through the adoption of preventive measures. The high rates and growing trend of fall-related deaths, as well as the aging of the Brazilian population, suggest that public policies for protecting the elderly must be prioritized.

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Osteosarcoma in Adolescents and Young Adults

Cells ◽

10.3390/cells10102684 ◽

2021 ◽

Vol 10 (10) ◽

pp. 2684

Author(s):

Jun Ah Lee ◽

Jiwon Lim ◽

Hye Young Jin ◽

Meerim Park ◽

Hyeon Jin Park ◽

...

Keyword(s):

Young Adults ◽

Young Children ◽

Clinical Characteristics ◽

Local Treatment ◽

Age Groups ◽

The Elderly ◽

Adolescents And Young Adults ◽

Dependent Manner ◽

Female Ratio ◽

Male To Female

The epidemiology of osteosarcoma in adolescents and young adults (AYA) remains unclear. We aimed to assess and compare the clinical features of osteosarcoma between AYA and other age groups. We retrieved osteosarcoma cases diagnosed between 1999 and 2017 from the Korea Central Cancer Registry. We compared survival trends and clinical characteristics between AYA and other age groups. AYA comprised 43.3% (1309/3022) of the osteosarcoma cases. Compared to other age groups, the male-to-female ratio was highest in AYA (1.61:1). The proportion of tumors located in an extremity was 80.3% in AYA, which was lower than in young children (92.5%) or pubertal children (93.8%) but higher than in adults (55.7%) or the elderly (47.5%). As for treatments, 71.2% of AYA received local treatment and systemic chemotherapy, and 28.8% received only local treatment (surgery: 261, radiotherapy: 9, surgery and radiotherapy: 5). The 5-year overall survival (OS) was lower in AYA (68%) than in young children (78%) or pubertal children (73%) but higher than in adults (47%) or the elderly (25%). When AYA were divided into five subgroups by age, patients aged 15–19 years constituted the largest proportion (45.4%, n = 594). Additionally, the proportion of patients with a non-extremity tumor increased in an age-dependent manner, from 10.3% in AYA aged 15–19 years to 35.3% in AYA aged 35–39 years. OS did not significantly differ among the different age subgroups of AYA. The clinical characteristics and OS of the AYA were more similar to those of children than to those of adults. There is a need for cooperation between pediatric and adult oncologists for effective osteosarcoma treatment in AYA.

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COVID-19 Screening for Healthcare Workers in a Tertiary Infectious Diseases Referral Hospital in Manila, the Philippines

American Journal of Tropical Medicine and Hygiene ◽

10.4269/ajtmh.20-0715 ◽

2020 ◽

Vol 103 (3) ◽

pp. 1211-1214 ◽

Cited By ~ 1

Author(s):

Annavi Marie G. Villanueva ◽

Jezreel Lazaro ◽

Ana Ria Sayo ◽

Su Myat Han ◽

Tatsuya Ukawa ◽

...

Keyword(s):

Infectious Diseases ◽

Healthcare Workers ◽

The Philippines ◽

Referral Hospital

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Transplant in Chronic Lymphocytic Leukemia: To Do It or Not and If So, When and How?

American Society of Clinical Oncology Educational Book ◽

10.14694/edbook_am.2012.32.224 ◽

2012 ◽

pp. 399-404

Author(s):

John G. Gribben

Keyword(s):

Chronic Lymphocytic Leukemia ◽

Treatment Options ◽

The Elderly ◽

Underlying Disease ◽

Lymphocytic Leukemia ◽

Major Focus ◽

Hematopoietic Stem ◽

Graft Versus Host ◽

Graft Versus Leukemia ◽

Related Mortality

Overview: Most patients with chronic lymphocytic leukemia (CLL) have an indolent clinical course, but the disease remains incurable with standard therapy and the prognosis is dismal for those patients with disease refractory to available treatment options. The only potentially curative treatment is allogeneic hematopoietic stem cell transplantation (SCT), but since CLL is a disease of elderly patients, few patients are candidates for myeloablative allogeneic SCT. Although autologous SCT is feasible and has low treatment-related mortality, it is not curative. The widespread adoption of reduced-intensity conditioning (RIC) allogeneic SCT has made this approach applicable to the elderly patient population with CLL. This approach relies on the documented graft-versus-leukemia (GVL) effect and is strong in CLL. Steps to further decrease the morbidity and mortality of the RIC SCT and in particular to reduce the incidence of chronic extensive graft-versus-host disease (GVHD) remain a major focus. Many potential treatments are available for CLL, and appropriate patient selection and SCT timing remain controversial and the focus of ongoing clinical trials. The use of SCT must always be weighed against the risk of the underlying disease, particularly in a setting where improvements in treatment are leading to improved outcome. The major challenge remains how to identify which patients with CLL merit this approach and where in the treatment course this treatment can be applied optimally.

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Prevalence of Coronavirus Disease 2019 Infection and Outcomes Among Symptomatic Healthcare Workers in Seattle, Washington

Clinical Infectious Diseases ◽

10.1093/cid/ciaa761 ◽

2020 ◽

Vol 71 (10) ◽

pp. 2702-2707 ◽

Cited By ~ 7

Author(s):

Nandita S Mani ◽

Jehan Z Budak ◽

Kristine F Lan ◽

Chloe Bryson-Cahn ◽

Allison Zelikoff ◽

...

Keyword(s):

United States ◽

Healthcare Workers ◽

Clinical Characteristics ◽

The United States ◽

Limited Data ◽

Healthcare Workforce ◽

Increased Risk ◽

Using Data ◽

The University

Abstract Background Healthcare workers (HCWs) who serve on the front lines of the coronavirus disease 2019 (COVID-19) pandemic have been at increased risk for infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in some settings. Healthcare-acquired infection has been reported in similar epidemics, but there are limited data on the prevalence of COVID-19 among HCWs and their associated clinical outcomes in the United States. Methods We established 2 high-throughput employee testing centers in Seattle, Washington, with drive-through and walk-through options for symptomatic employees in the University of Washington Medicine system and its affiliated organizations. Using data from these testing centers, we report the prevalence of SARS-CoV-2 infection among symptomatic employees and describe the clinical characteristics and outcomes among employees with COVID-19. Results Between 12 March 2020 and 23 April 2020, 3477 symptomatic employees were tested for COVID-19 at 2 employee testing centers; 185 (5.3%) employees tested positive for COVID-19. The prevalence of SARS-CoV-2 was similar when comparing frontline HCWs (5.2%) with nonfrontline staff (5.5%). Among 174 positive employees reached for follow-up at least 14 days after diagnosis, 6 reported COVID-related hospitalization; all recovered. Conclusions During the study period, we observed that the prevalence of positive SARS-CoV-2 tests among symptomatic HCWs was comparable to that of symptomatic nonfrontline staff. Reliable and rapid access to testing for employees is essential to preserve the health, safety, and availability of the healthcare workforce during this pandemic and to facilitate the rapid return of SARS-CoV-2–negative employees to work.

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COVID-19 Susceptibility, Mortality, and Length of hospitalization based on age-sex composition: Evidence from Davao Region Philippines

10.1101/2021.06.20.21259222 ◽

2021 ◽

Author(s):

Roel Ceballos

Keyword(s):

Age Groups ◽

Senior Citizen ◽

Case Fatality ◽

The Elderly ◽

The Philippines ◽

Human Society ◽

Sex Composition ◽

Medical Resources ◽

Department Of Health ◽

Nonparametric Statistical

The coronavirus disease is spreading continuously worldwide with an unprecedented amount of impact on every human society. In order to reduce the risks of infections and mortality, several interventions such as mobility restrictions for different age groups and vaccination prioritization programs are implemented in the Philippines. Identifying age-sex composition with greater susceptibility, longer hospitalization, and higher fatality is useful to guide the targeted intervention and establish risk stratification for patients infected with COVID-19 within communities and localities. Furthermore, it is also helpful in the allocation of medical resources and assessment of vaccination priority. We analyzed the COVID-19 data provided by the Davao Center for Health Development of the Department of Health Davao Region in the Philippines. The dataset contains records of COVID-19 cases reported from March 2020 to April 2021. Methods that were used include descriptive statistics, graphical presentations, and nonparametric statistical methods. The study reveals that male children and female senior citizens are the most susceptible age-sex composition while male senior citizen is the subgroup with the highest case fatality and mortality. Furthermore, regardless of sex groups, the senior citizen is the subgroup with the longest hospitalization. Susceptibility due to exposure should be included as a criterion in determining the age-sex compositions for vaccination priority against COVID-19 and other potentially deadly viruses. Further, Proper planning and allocation of medical resources for the elderly should be prioritized in the provincial levels.

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SARS-CoV-2 Among Military and Civilian Patients, Metro Manila, Philippines

Military Medicine ◽

10.1093/milmed/usaa525 ◽

2020 ◽

Author(s):

John Mark Velasco ◽

Fatima Claire Navarro ◽

Paula Corazon Diones ◽

Vicente Villa ◽

Maria Theresa Valderama ◽

...

Keyword(s):

Old Age ◽

Age Groups ◽

The Philippines ◽

Sequencing Analysis ◽

Military Population ◽

First Case ◽

Metro Manila ◽

The Government ◽

Military Patients ◽

The Military

ABSTRACT Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) belonging to the family Coronaviridae and genus Betacoronavirus is the causative agent of COVID-19 disease and was first identified in Wuhan, China. SARS-CoV-2 spread globally with >28 million cases and 911,000 deaths recorded worldwide as of September 12, 2020. The Philippines reported the first case of community transmission on March 5, 2020, and despite the government imposing one of the longest and strictest lockdowns in Southeast Asia, the number of confirmed COVID-19 cases still surged with >250,000 cases and 4,000 deaths reported as of September 12, 2020. It is important to estimate the burden and impact of SARS-CoV-2 on the military population since this can affect the military readiness. Materials and Methods Nasopharyngeal and oropharyngeal swabs were collected and SARS-CoV-2 real-time RT-PCR testing was performed on the samples. Phylogenetic analysis was performed using sequences from 23 SARS-CoV-2-positive specimens from this study and sequences retrieved from GenBank and GISAID databases. Results From April 14 to August 15, 2020, a total of 12,432 specimens were tested with 763 (6%) unique individuals testing positive for SARS-CoV-2 by rRT-PCR. In the military population, majority of the patients who were tested (80%) and those who tested positive for SARS-CoV-2 (86%) were male. Military and civilian status was available for 7,672 patients with 515/5,042 (10%) positive among military patients and 248/2,630 (9%) positive among civilian patients. Both military and civilian populations had the highest case counts of SARS-CoV-2-positive cases in the 21- to 30- and 31- to 40-year-old age groups, while the 71- to 80-year-old age group had the highest proportion (18%) of SARS-CoV-2-positive cases. Sequencing analysis showed 19 different variants in the 23 genomes. Twenty of the 23 genomes were classified under clade GR/B1.1, 2 genomes were classified under clade GR/B1.1.28, and 1 genome was classified under Clade O/B.6. Twenty-two of the 23 sequences collected after June 25, 2020, contained the D614G mutation. Conclusion We describe here the results of SARS-CoV-2 testing for military and civilian patients and personnel. The 21- to 30- and 31- to 40-year-old age groups had the highest case counts of SARS-CoV-2-positive cases. Sequencing results showed the presence of the D614G mutation in the spike protein in a majority of specimens collected from the end of June to July 2020.

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Abstract #535: Clinical Characteristics of Primary Hyperparathyroidism Among Different Age Groups

Endocrine Practice ◽

10.1016/s1530-891x(20)44475-1 ◽

2017 ◽

Vol 23 ◽

pp. 118-119

Author(s):

Beatrice Wong ◽

Anjana Divakaran ◽

Kenneth Sluis ◽

Hyon Kim ◽

Vanessa Narwani ◽

...

Keyword(s):

Primary Hyperparathyroidism ◽

Clinical Characteristics ◽

Age Groups

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The Effects of Significant International Sports Events on Hungarian Suicide Rates

Crisis ◽

10.1027/0227-5910/a000352 ◽

2016 ◽

Vol 37 (2) ◽

pp. 148-154 ◽

Cited By ~ 2

Author(s):

Karoly Bozsonyi ◽

Peter Osvath ◽

Sandor Fekete ◽

Lajos Bálint

Keyword(s):

Significant Relationship ◽

Olympic Games ◽

Arima Model ◽

Age Groups ◽

The Elderly ◽

Intervention Analysis ◽

Middle Aged ◽

Sports Events ◽

Sport Events ◽

The Olympic Games

Abstract. Background: Several studies found a significant relationship between important sport events and suicidal behavior. Aims: We set out to investigate whether there is a significant relationship between the raw suicide rate and the most important international sports events (Olympic Games, FIFA World Cup, UEFA European Championship) in such an achievement-oriented society as the Hungarian one, where these sport events receive great attention. Method: We examined suicide cases occurring over 15,706 days between January 1, 1970, and December 31, 2012 (43 years), separately for each gender. Because of the age-specific characteristics of suicide, the effects of these sport events were analyzed for the middle-aged (30–59 years old) and the elderly (over 60 years old) generations as well as for gender-specific population groups. The role of international sport events was examined with the help of time-series intervention analysis after cyclical and seasonal components were removed. Intervention analysis was based on the ARIMA model. Results: Our results showed that only the Olympic Games had a significant effect in the middle-aged population. Neither in the older male nor in any of the female age groups was a relationship between suicide and Olympic Games detected. Conclusion: The Olympic Games seem to decrease the rate of suicide among middle-aged men, slightly but significantly.

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Older workers in the Russian labor market: Trends in employment reallocation

Voprosy Ekonomiki ◽

10.32609/0042-8736-2019-11-5-34 ◽

2019 ◽

pp. 5-34

Author(s):

Anna L. Lukyanova ◽

Rostislav I. Kapeliushnikov

Keyword(s):

Older Workers ◽

Service Sector ◽

Age Groups ◽

The Elderly ◽

Education And Health ◽

Job Opportunities ◽

Intellectual Labor ◽

Market Trends ◽

Trade Education ◽

The One

The paper analyzes changes in job opportunities of older workers in Russia in the period 2005—2017. The study uses the data from the Russian Labor Force Survey conducted by Rosstat. Changes in the occupational and industrial composition of elderly workers follow the trends pursued by other age groups: employment shifts from low- to high-skilled occupations, from physical to intellectual labor, and from material production to the service sector. We find a stronger polarization among older workers as their occupational structure is biased in favor of, on the one hand, the most and, on the other hand, the least qualified types of jobs. Employment of the elderly has fallen sharply in agriculture and manufacturing with a significant increase in trade, education, and health. Although the employment structure of older workers is generally more “traditionalist”, recent decades have witnessed its transformation in “progressive” directions, similarly to other age groups. These findings suggest that the legislated increase in the state retirement age is not likely to give rise to sizeable unemployment among the elderly. Most of them will be able to work in the occupations and industries previously dominated by young and prime-age workers.

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