P-413: Correction of Vitamin D and parathyroid hormone concentration (PTH) in patients with acute hip fracture and low 25 hydroxy-vitamin D. Results at 3 months by a replenishment protocol

2015 ◽  
Vol 6 ◽  
pp. S142-S143
Author(s):  
R. Menéndez ◽  
T. Alarcon ◽  
J.I. González-Montalvo ◽  
P. Gotor ◽  
I. Martín-Maestre
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Hip Fracture ◽  
Hormone Concentration ◽  
25 Hydroxy Vitamin D

scholarly journals Association between serum vitamin B6concentration and risk of osteoporosis in the middle-aged and older people in China: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. e028129 ◽  
Author(s):  
Jing Wang ◽  
Lin Chen ◽  
Yan Zhang ◽  
Chen-guang Li ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Type I Collagen ◽  
Bone Turnover Marker ◽  
Serum Vitamin ◽  
Type I ◽  
Hormone Concentration ◽  
Mineral Density ◽  
Cross Sectional ◽  
25 Hydroxy Vitamin D

ObjectiveTo determine the relationship between serum vitamin B6(Vit B6) concentration and the status of bone mineral density and identify the relationship between serum Vit B6 and bone metabolism parameters in middle-aged and older people in China.DesignThe present study was a cross-sectional study within the framework of an ongoing prospective population-based cohort study.Setting and participantsA total of 1829 residents (men ≥50 years and women ≥45 years) from two subdistricts were recruited from July 2015 to February 2016 in Shanghai, China.MeasuresRecruited residents were grouped (control, osteopenia and osteoporosis) according to their lumbar spine bone mineral density, measured through dual-energy X-ray absorptiometry. Serum Vit B6concentrations, bone turnover marker concentrations and calcium and phosphorus metabolism parameters were assessed.ResultsNo significant linear trend between serum Vit B6concentrations and lumbar bone mass was observed in the men. In the women, the average osteoporosis risk was 61% higher at serum Vit B6concentrations of <19.2 μg/L than at those of >26.9 μg/L (OR 1.61, 95% CI 1.00 to 2.58). However, there was no significance after controlling of serum 25-hydroxy-vitamin D concentration and parathyroid hormone concentration, respectively. In the osteoporotic women, the serum Vit B6concentration was significantly negatively correlated to concentrations of bone turnover marker including N-terminal propeptide of type I collagen, β-C-terminal telopeptide of type I collagen and osteocalcin. It was also positively related to the serum 25-hydroxy-vitamin D concentration and inversely related to the serum parathyroid hormone concentration.ConclusionsA relatively low serum Vit B6concentration, even in the normal range, may be a risk factor for osteoporosis in postmenopausal women, which is dependent on serum 25-hydroxy-vitamin D concentration and parathyroid hormone concentration.Trial registration numberNCT02958020; Post-results.

scholarly journals Parathyroid Hormone in Pregnancy: Vitamin D and Other Determinants

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 360
Author(s):  
Ola Hysaj ◽  
Patricia Marqués-Gallego ◽  
Aline Richard ◽  
Magdeldin Elgizouli ◽  
Alexandra Nieters ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Inflection Point ◽  
Demographic Data ◽  
Late Pregnancy ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
25 Hydroxy Vitamin D ◽  
Maximal Suppression

We aimed to assess the parathyroid hormone (PTH) concentration in pregnant women at the beginning of pregnancy (1st trimester) and within days before delivery (3rd trimester) and evaluate its determinants. From September 2014 through December 2015 in a cross-sectional study, 204 women in the 1st trimester of pregnancy and 203 women in the 3rd trimester of pregnancy were recruited. Blood samples were collected to measure PTH and circulating 25-hydroxy-vitamin D (25(OH)D) concentrations. Lifestyle and demographic data were collected using a questionnaire. Serum 25(OH)D and PTH were inversely correlated in both early and late pregnancy. Our analyses suggest that in the 3rd trimester of pregnancy, a 25(OH)D level of 18.9 ng/mL (47.3 nmol/L) could serve as an inflection point for the maximal suppression of PTH. Statistically significant determinants of PTH concentrations in multiple regression were 25(OH)D concentrations, season, multiparity and education of the partner (all p < 0.05) in early pregnancy. In late pregnancy, 25(OH)D concentrations and country of origin were statistically significant determinants of PTH concentrations (all p < 0.05). These factors and their effect on PTH appear to be vastly determined by 25(OH)D; however, they might also affect PTH through other mechanisms besides 25(OH)D.

scholarly journals Falsely Elevated 25-Hydroxy-Vitamin D Levels in Patients with Hypercalcemia

2020 ◽  
Vol 2020 ◽  
pp. 1-3
Author(s):  
Moon Kyung Choi ◽  
Prapaipan Putthapiban ◽  
Patamaporn Lekprasert
Keyword(s):  
Multiple Myeloma ◽  
Vitamin D ◽  
Parathyroid Hormone ◽  
Diagnostic Workup ◽  
Laboratory Measurement ◽  
Clinical Scenario ◽  
Detailed History ◽  
Commercial Laboratory ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D

Symptomatic hypercalcemia is a commonly encountered clinical scenario. Though it is important to collect detailed history to find clinical clues connecting to the etiology of hypercalcemia, the diagnostic workup of hypercalcemia depends heavily on laboratory analysis. Accurate measurement of the parathyroid hormone and vitamin D levels is essential. However, commercial laboratory measurement of vitamin D levels can be erroneous in the setting of abundant paraprotein in the serum. One of the most common conditions that can cause an increased amount of paraproteins is multiple myeloma. We report 2 cases of falsely elevated 25-hydroxy-vitamin D levels in patients presenting with hypercalcemia and an underlying diagnosis of MM.

Serum 25 – hydroxy – vitamin D and parathyroid hormone in adult inhabitans of Lapland

1983 ◽  
Vol 104 (3_Supplc) ◽  
pp. S23-S24
Author(s):  
C. Lamberg–Allardt ◽  
A. Dessypris ◽  
B.A. Lamberg
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
25 Hydroxy Vitamin D

scholarly journals 48 * VITAMIN D, PARATHYROID HORMONE AND LENGTH OF STAY IN HIP FRACTURE PATIENTS

2015 ◽  
Vol 44 (suppl 1) ◽  
pp. i12-i13
Author(s):  
M. Popescu ◽  
M. Zertalis ◽  
D. East ◽  
A. Butler-Manuel ◽  
R. Woledge ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Hip Fracture ◽  
Length Of Stay

Parathyroid hormone-ionized calcium dynamics over the first year of life

2016 ◽  
Vol 29 (6) ◽  
Author(s):  
Atul K. Sharma ◽  
Sina Gallo ◽  
Catherine A. Vanstone ◽  
Sherry Agellon ◽  
Mary L’Abbé ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Repeated Measures ◽  
Negative Relationship ◽  
Ionized Calcium ◽  
First Year ◽  
Calcium Dynamics ◽  
Hormone Concentration ◽  
Ancillary Study ◽  
First Year Of Life

AbstractIonized calcium (iCa) is believed to be the principle determinant of parathyroid hormone concentration (PTH). However, previous studies contained few infants.This ancillary study from our vitamin DNo significant correlations were observed between iCa and PTH at individual visits (p>0.2). After accounting for repeated measures, PTH decreased with increasing iCa (slope –5.25; 95% confidence intervals (CI) –8.78 to –1.73), decreased with increasing 25(OH)D (slope –0.006; 95% CI –0.009 to –0.002, and increased with later visits (6–12 months, p<0.001),We observed a weak negative relationship between iCa and PTH and an increase with age consistent with physiologic maturation.

scholarly journals Vitamin D Status and Its Association with Parathyroid Hormone Concentration in Brazilians

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Juliana Sálvio Martins ◽  
Magda de Oliveira Palhares ◽  
Octávio Cury Mayrink Teixeira ◽  
Mariana Gontijo Ramos
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Clinical Analysis ◽  
Vital Role ◽  
Vitamin D Status ◽  
Hormone Concentration ◽  
High Prevalence ◽  
Analysis Laboratory ◽  
Hormonal Action ◽  
Different Populations

Vitamins are organic compounds that play a vital role in the control of metabolic processes. The D complex is considered a nutrient with a hormonal action and has an important participation in the constant maintenance of serum and extracellular calcium levels. The present study aims to analyze the results of 105.588 vitamin D (25(OH)D) measurements obtained from a database from a clinical analysis laboratory in Brazil, between the years of 2011 and 2013. The values of 25(OH)D were correlated with age, gender, and values of PTH. The results show a high prevalence of values of 25(OH)D considered inadequate, characterizing 76% of the studied population. It was observed that 26,5% of the individuals had deficiency and 49,5% had insufficiency of vitamin D. It was also shown that there was a negative correlation between 25(OH)D and PTH levels. In conclusion, this study is in accordance with others that show a high prevalence of vitamin D deficiency in different populations and alerts us for the importance of these measurements and analysis in clinical practice and as a base for diagnosis and treatment of hypovitaminosis.

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