Vaccination Data When the Outbreak Happens: A Qualitative Evaluation of Oregon’s Rapid Response Tool

2019 ◽  
Vol 13 (4) ◽  
pp. 682-685
Author(s):  
Andrew W. Osborn ◽  
Lee R. Peters
Keyword(s):  
Strong Support ◽  
Disease Outbreaks ◽  
Qualitative Evaluation ◽  
Population Data ◽  
Rapid Response ◽  
Outbreak Response ◽  
Immunization Information System ◽  
Further Development ◽  
Zip Code ◽  
Prototype Instrument

ABSTRACTObjectiveImmunization data are vital to support responses to vaccine-preventable disease outbreaks. The Oregon Immunization Program developed a unique prototype instrument—the Rapid Response Tool (RRT)—that provides population data to local responders within 2 hours of a request. Data outputs include vaccination coverage by age group and zip code; percentages of students with nonmedical exemptions to vaccination requirements, by school; and current, comprehensive lists of local vaccination providers.MethodsThe RRT was demonstrated to staff at 7 Oregon counties and feedback was solicited via comments and a structured survey.ResultsThe RRT received strong support. Attendees identified several uses for RRT data, including outbreak response and ongoing intervention efforts, and they pointed to areas for further development.ConclusionsThe success of the RRT demonstrations illustrates that a well-populated immunization information system can contribute to preparedness work well beyond current standards. (Disaster Med Public Health Preparedness. 2019;13:682–685)

scholarly journals Evaluation of the Nipah epidemic containment and multisectoral involvement in Kerala using an appropriate management framework

2020 ◽  
Vol 7 (7) ◽  
pp. 2813
Author(s):  
Asma A. Rahim ◽  
Sujina C. Muthukutty ◽  
Sabitha R. Jacob ◽  
Rini Ravindran ◽  
Jayakrishnan Thayyil ◽  
...  
Keyword(s):  
Health Personnel ◽  
Viral Infections ◽  
Nipah Virus ◽  
Disease Outbreaks ◽  
State Level ◽  
The State ◽  
Contact Tracing ◽  
Outbreak Response ◽  
Management Framework ◽  
The Government

Kozhikode district of North Kerala, India witnessed an outbreak of Nipah virus (NiV) in the month of May 2018. Two adjacent districts were affected leaving 17 patients dead out of the 19 confirmed. United Nations and WHO lauded the expeditious response of the state’s health system in the diagnosis and containment of the outbreak which was unprecedented. The authors being in the contact tracing and surveillance operation district team, had kept a record of timeline of events and actions at the state level, compiled the news clippings and tracked events. In the absence of an end‑of‑epidemic report for reference, these records served as a valuable tool for the present review. We used the Management science for health frame work tool (MSH framework) to evaluate the district and state coordinated actions which helped in curbing the outbreak. Though NiV outbreak in South India (2018) had similar epidemiological features to previous disease outbreaks, it stands out as the one to be detected and contained in a short span of time. As health personnel working in the government medical college of an affected district and directly involved in contact tracing operations and containment measures, exploring and sharing, what worked and how, in the context of multidisciplinary response and recovery attempts of the outbreak in the state may be beneficial to public health personnel and policy makers. This management framework may be replicated in the national and international context, particularly in South East Asian region under threat of emerging viral infections like COVID-19, lacking specific epidemic management frameworks for outbreak response and containment.

scholarly journals Satellite imagery technology in public health: analysis of site catchment areas for assessment of poliovirus circulation in Nigeria and Niger

2016 ◽  
Vol 11 (3) ◽  
Author(s):  
Marina Takane ◽  
Shizu Yabe ◽  
Yumiko Tateshita ◽  
Yusuke Kobayashi ◽  
Akihiko Hino ◽  
...  
Keyword(s):  
Population Size ◽  
Population Data ◽  
Sewage Water ◽  
Small Scale ◽  
Surface Model ◽  
Environmental Surveillance ◽  
Outbreak Response ◽  
Catchment Areas ◽  
Elevation Model ◽  
Selection Of

Environmental surveillance supplements the surveillance of acute flaccid paralysis by monitoring wastewater for poliovirus circulation. Building on previous work, we analysed wastewater flow to optimise selection and placement of sampling sites with higher digital surface model (DSM) resolution. The newly developed 5-m mesh DSM from the panchromatic, remote-sensing instruments for stereo mapping on-board the Japanese advanced land observing satellite was used to estimate catchment areas and flow of sewage water based on terrain topography. Optimal sampling sites for environmental surveillance were identified to maximise sensitivity to poliovirus circulation. Population data were overlaid to prioritise selection of catchment areas with dense populations. The results for Kano City, Nigeria were compared with an analysis based on existing 30- and 90-m mesh digital elevation model (DEM). Analysis based on 5-m mesh DSM was also conducted for three cities in Niger to prioritise the selection of new sites. The analysis demonstrated the feasibility of using DSMs to estimate catchment areas and population size for programme planning and outbreak response with respect to polio. Alternative sampling points in Kano City that would cover a greater population size have been identified and potential sampling sites in Niger are proposed. Comparison with lower-resolution DEMs suggests that the use of a 5-m mesh DSMs would be useful where the terrain is flat or includes small-scale topographic changes not captured by 30-m data searches.

scholarly journals Qualitative Evaluation of Causes for Routine Salmonella Monitoring False-Positive Test Results in Dutch Poultry Breeding Flocks

2021 ◽  
Vol 9 (11) ◽  
pp. 2215
Author(s):  
Eduardo Costa ◽  
Armin Elbers ◽  
Miriam Koene ◽  
Andre Steentjes ◽  
Henk Wisselink ◽  
...  
Keyword(s):  
False Positive ◽  
Good Reason ◽  
Monitoring Program ◽  
Competent Authority ◽  
Qualitative Evaluation ◽  
Population Data ◽  
Cross Contamination ◽  
Test Results ◽  
False Positive Test ◽  
The Eu

The Salmonella monitoring program, as outlined in the EU Commission regulation 200/2010, asks for repeated sampling in order to ascertain progress in achievement of the EU target. According to Article 2.2.2.2.c of this regulation, the competent authority may decide to do a resample and retest when it has reasons to question the results of initial testing. In the Netherlands, the competent authorities have been resampling and retesting all initial positive samplings for several years because of doubts about false positive initial test results. An analysis of population data in the period 2015–2019 indicates that 48% of initial samplings at the farm were classified as false positive after resampling and retesting by the competent authorities. A qualitative analysis, assessing factors that could be associated with the occurrence of false positives, indicates that cross-contamination during the sampling process by the poultry farmer is probably the most likely source. Cross-contamination of samples during transport from the farm to the laboratory and/or cross-contamination at the laboratory are also considered possible sources. Given the slightly non-optimal system-specificity of the Salmonella monitoring program, there is good reason to make, or consider, standard resampling and retesting of initial positive results by the competent veterinary authorities possible within the EU.

scholarly journals Surveillance System Evaluations Provide Evidence to Improve Public Health Practice

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Beverley J. Paterson ◽  
David N. Durrheim
Keyword(s):  
Public Health ◽  
Public Health Practice ◽  
Disease Outbreaks ◽  
Surveillance Systems ◽  
Health Practice ◽  
Outbreak Response ◽  
Local Public Health ◽  
Infectious Disease Outbreaks ◽  
The Pacific ◽  
Surveillance Practice

Surveillance evaluations of surveillance systems should provide evidence to improve public health practice. In response to surveillance evaluation findings amongst Pacific Island Countries and Territories that identified a critical need to better equip local public health officials with skills to rapidly appropriately respond to suspected infectious disease outbreaks across the Pacific, the RAPID (Response and Analysis for Pacific Infectious Diseases) project was implemented to strengthen capacity in surveillance, epidemiology and outbreak response. The RAPID project is a notable example of how evidence gathered through a surveillance evaluation can be used to improve public health surveillance practice.

scholarly journals COVID-19 Outbreak in Africa: Lessons and Insights from the West African Ebola Virus Disease Epidemics

2020 ◽  
Vol 8 (3) ◽  
pp. 96-99
Author(s):  
Oluwafolajimi Adetoye Adesanya
Keyword(s):  
Ebola Virus ◽  
Democratic Republic Of Congo ◽  
Virus Disease ◽  
Disease Outbreaks ◽  
Ebola Virus Disease ◽  
African Continent ◽  
Outbreak Response ◽  
African Countries ◽  
Response Strategies ◽  
Past Experiences

Over the years, the African continent has had to battle several outbreaks of infectious diseases in different countries. Some of the most deadly were the Ebola virus disease (EVD) outbreaks that occurred in West Africa between 2014 and 2016 affecting Guinea, Liberia, and Sierra Leone and, more recently, from 2018 to 2020 in the Democratic Republic of Congo (DRC). In the era of the COVID-19 pandemic, it is important that as a continent, we draw lessons and insights from our past experiences to guide outbreak response strategies being deployed to curb the latest onslaught. The Ebola outbreaks have shown that disease outbreaks should not be seen only as medical emergencies, but as full blown humanitarian crises, because oftentimes, their socio-economic impacts are more devastating than the more obvious cost to life. In this mini-review, we explore the possible humanitarian costs of the COVID-19 pandemic on the African continent by looking through the lens of our past experiences with the EVD outbreaks, highlighting how the current pandemic could significantly affect the African economy, food security, and vulnerable demographics, like children and the sexual and reproductive health and rights of women and girls. We then proffer recommendations that could be instrumental in preventing a double tragedy involving the devastating health consequences of the virus itself and the deadly fallout from its multi-sectoral knock-on effects in African countries. Keywords: COVID-19, SARS-CoV-2, Ebola Virus Disease, Coronavirus.

scholarly journals In vivo CRISPR-Cas gene editing with no detectable genome-wide off-target mutations

2018 ◽  
Author(s):  
Pinar Akcakaya ◽  
Maggie L. Bobbin ◽  
Jimmy A. Guo ◽  
Jose M. Lopez ◽  
M. Kendell Clement ◽  
...  
Keyword(s):  
Genome Editing ◽  
Ex Vivo ◽  
Strong Support ◽  
Guide Rna ◽  
Genome Wide ◽  
Highly Sensitive ◽  
Further Development ◽  
Target Effects ◽  
Cas Gene

CRISPR-Cas genome-editing nucleases hold substantial promise for human therapeutics1–5 but identifying unwanted off-target mutations remains an important requirement for clinical translation6, 7. For ex vivo therapeutic applications, previously published cell-based genome-wide methods provide potentially useful strategies to identify and quantify these off-target mutation sites8–12. However, a well-validated method that can reliably identify off-targets in vivo has not been described to date, leaving the question of whether and how frequently these types of mutations occur. Here we describe Verification of In Vivo Off-targets (VIVO), a highly sensitive, unbiased, and generalizable strategy that we show can robustly identify genome-wide CRISPR-Cas nuclease off-target effects in vivo. To our knowledge, these studies provide the first demonstration that CRISPR-Cas nucleases can induce substantial off-target mutations in vivo, a result we obtained using a deliberately promiscuous guide RNA (gRNA). More importantly, we used VIVO to show that appropriately designed gRNAs can direct efficient in vivo editing without inducing detectable off-target mutations. Our findings provide strong support for and should encourage further development of in vivo genome editing therapeutic strategies.

scholarly journals Outbreak analytics: a developing data science for informing the response to emerging pathogens

2019 ◽  
Vol 374 (1776) ◽  
pp. 20180276 ◽  
Author(s):  
Jonathan A. Polonsky ◽  
Amrish Baidjoe ◽  
Zhian N. Kamvar ◽  
Anne Cori ◽  
Kara Durski ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Data Science ◽  
Disease Outbreaks ◽  
Health Concern ◽  
Emerging Pathogens ◽  
Outbreak Response ◽  
Theme Issue ◽  
Effective Response ◽  
Infectious Disease Outbreaks ◽  
Challenges And Opportunities

Despite continued efforts to improve health systems worldwide, emerging pathogen epidemics remain a major public health concern. Effective response to such outbreaks relies on timely intervention, ideally informed by all available sources of data. The collection, visualization and analysis of outbreak data are becoming increasingly complex, owing to the diversity in types of data, questions and available methods to address them. Recent advances have led to the rise of outbreak analytics , an emerging data science focused on the technological and methodological aspects of the outbreak data pipeline, from collection to analysis, modelling and reporting to inform outbreak response. In this article, we assess the current state of the field. After laying out the context of outbreak response, we critically review the most common analytics components, their inter-dependencies, data requirements and the type of information they can provide to inform operations in real time. We discuss some challenges and opportunities and conclude on the potential role of outbreak analytics for improving our understanding of, and response to outbreaks of emerging pathogens. This article is part of the theme issue ‘Modelling infectious disease outbreaks in humans, animals and plants: epidemic forecasting and control‘. This theme issue is linked with the earlier issue ‘Modelling infectious disease outbreaks in humans, animals and plants: approaches and important themes’.

Communicative functions of emoji sequences on Sina Weibo

First Monday ◽  
2018 ◽  
Author(s):  
Jing Ge ◽  
Susan C. Herring
Keyword(s):  
Social Media ◽  
Strong Support ◽  
Sina Weibo ◽  
Graphical Language ◽  
Universal Language ◽  
Communicative Functions ◽  
Computer Mediated ◽  
Mediated Discourse ◽  
Media Platform ◽  
Further Development

The popular press is currently rife with speculation that emoji are becoming a global, digitally-mediated language. Sequences of emoji that function like verbal utterances potentially lend strong support to this claim. We employ computer-mediated discourse analysis to analyze the pragmatic meanings conveyed through emoji sequences and their rhetorical relations with accompanying text, focusing on posts by social media influencers and their followers on a popular Chinese social media platform. The findings show that the emoji sequences can function pragmatically like verbal utterances and form relations with textual propositions, although their usage differs from textual utterances in several respects. We also observed user innovations that make the sequences more language like, although there is not as yet a fixed grammar of emoji sequences. We characterize this emoji use as an emergent graphical language, with the caveats that it is not yet a fully-formed language and that the Chinese emoji language that is emerging is different from the English variety, and therefore emoji are not a universal language. In order to promote the further development of emoji language(s), we advance recommendations for emoji design grounded in linguistic principles.

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