scholarly journals Contact With the Workplace During Long-Term Sickness Absence and Worker Expectations of Return to Work

2015 ◽  
Vol 10 ◽  
Author(s):  
John Selander ◽  
Åsa Tjulin ◽  
Ulrika Müssener ◽  
Kerstin Ekberg
Keyword(s):  
Return To Work ◽  
Sickness Absence ◽  
Multivariate Logistic Regression Model ◽  
Health Unit ◽  
Multivariate Logistic Regression ◽  
The Social ◽  
Union Representative ◽  
Quality Of Contact

Since long-term sickness absence constitutes a problem in most western countries, research that can facilitate return to work (RTW) is important. Today there is evidence that the social context at the workplace has a significant impact on return to work. The dual aims of the study was firstly to investigate the pattern and quality of contact between employees on long-term sick leave and different actors at the workplace, and secondly to investigate whether contacts with the workplace were associated with expectations regarding return to work. An explorative method and descriptive design was used for the first aim. For the second aim, the data was analysed in a multivariate logistic regression model. The results show that employees had frequent and, in most cases, appreciated contact with their supervisor and co-workers. Contact with other workplace actors; that is, the occupational health unit, the union representative, and the human resources department, were less frequent. Employees who experienced the contact as supportive and constructive were far more positive and optimistic than others regarding return to work. It is concluded that supervisors and co-workers should be aware that they play a significant role in the return-to-work process, and that quality of contact is what matters.

Economic Impact of Lifestyle Behaviour and Quality of Sleep on Long-Term Sickness Absence

2019 ◽  
Author(s):  
Noora Kanerva ◽  
Paulus Torkki ◽  
Ossi Rahkonen ◽  
Johanna Pekkala ◽  
Olli Pietiläinen ◽  
...  
Keyword(s):  
Economic Impact ◽  
Sickness Absence ◽  
Quality Of Sleep ◽  
Lifestyle Behaviour

scholarly journals Perceived Impeding Factors for Return-to-Work after Long-Term Sickness Absence Due to Major Depressive Disorder: A Concept Mapping Approach

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85038 ◽  
Author(s):  
Gabe de Vries ◽  
Hiske L. Hees ◽  
Maarten W. J. Koeter ◽  
Suzanne E. Lagerveld ◽  
Aart H. Schene
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Return To Work ◽  
Concept Mapping ◽  
Sickness Absence ◽  
Major Depressive ◽  
Mapping Approach

Identification of characteristics associated with long-term survival in patients with metastatic urothelial carcinoma (mUC) who received durvalumab (D) with or without tremelimumab (T) in clinical studies.

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 441-441
Author(s):  
Marie Alt ◽  
Carlos Stecca ◽  
Shaum Kabadi ◽  
Benga Kazeem ◽  
Srikala S. Sridhar
Keyword(s):  
Logistic Regression ◽  
Phase I ◽  
Regression Model ◽  
Clinical Studies ◽  
Logistic Regression Model ◽  
Multivariate Logistic Regression Model ◽  
Multivariate Logistic Regression ◽  
Term Survival ◽  
Long Term Survival

441 Background: Immune checkpoint inhibitors (ICI) have changed the landscape of mUC, yet outcomes are variable as some patients (pts) do not respond to treatment while others have a durable response. To optimally select pts who may derive benefit from ICIs, predictive factors are required. This retrospective, post-hoc analysis evaluated pt characteristics to determine differences between short and long-term survivors among pts with mUC who received D (anti–PD-L1) with or without T (anti–CTLA-4) in two clinical studies. Methods: Pts with platinum-refractory mUC who received D monotherapy in the phase I/II study 1108 (10 mg/kg Q2W, up to 12 mo) or D+T in the phase I study 10 (D at 20 mg/kg + T at 1 mg/kg Q4W for 4 mo, then D at 10 mg/kg Q2W for 12 mo) were included. Pt characteristics, tumor characteristics, radiological assessments, and biological assessments were collected. The primary outcome measure was long-term overall survival (OS). Pts were categorized as OS ≥2 yrs (from 1st dose of study drug) or OS <2 yrs. A univariate analysis was conducted on each baseline characteristic to assess independent associations with long-term OS; a multivariate logistic regression model was employed including each variable with a p-value ≤0.1 as factors or covariates. Results: A total of 367 pts with mUC were included in the analysis: 88 (24.0%) had OS ≥2 yrs (range: 2.09–4.99) and 279 (76.0%) had OS <2 yrs (range: 0.03–1.98). Pts with OS ≥2 yrs had a significantly higher objective response rates than those with OS <2 yrs (71.6% vs 5.7%; p<0.0001) and a significantly longer duration of response (median 2.3 yrs vs 0.39 yrs; p<0.0001). The characteristics included in the multivariate logistic regression model are listed in the Table. Long-term OS was significantly associated with ECOG PS, PD-L1 status, baseline hemoglobin level, and baseline absolute neutrophils count. Conclusions: Our analyses show that several characteristics, including tumor response to treatment, are associated with long-term OS for pts with mUC treated with D or D+T. Further investigation into these and other characteristics may provide additional insights into long-term survival outcomes with ICIs. [Table: see text]

Facial transplantation: historical developments and future directions

2015 ◽  
Vol 129 (3) ◽  
pp. 206-211 ◽  
Author(s):  
G L Garrett ◽  
I Beegun ◽  
A D'souza
Keyword(s):  
Functional Outcomes ◽  
Ethical Issues ◽  
Infectious Complications ◽  
Future Directions ◽  
Facial Transplantation ◽  
The Social ◽  
Bibliographic Search ◽  
Historical Developments

AbstractObjective:To present the clinical outcomes obtained by the first facial transplant teams worldwide, reviewing current practice and addressing controversies.Methods:A bibliographic search of Medline and Embase databases was performed, and a comparative analysis of all articles published from 1980 to the present was conducted. Two independent investigators screened the manuscripts in accordance with pre-defined criteria.Results:A total of 12 partial and 5 full facial transplants were recorded in the literature. Procedures included partial and near-total facial myocutaneous flaps, and complex osteomyocutaneous grafts. Fifteen patients had fully vascularised grafts, and two patients died of transplant-related and infectious complications.Conclusion:Facial transplantation can restore quality of life and enable the social re-integration of recipients. Results published by the first facial transplant teams are promising. However, long-term reports of aesthetic and functional outcomes are needed to more precisely define outcomes. In addition, significant technical, medical and ethical issues remain to be solved.

scholarly journals Long-term change in health-related quality of life in patients with asthma

2019 ◽  
Vol 28 (6) ◽  
pp. 708-714
Author(s):  
N. L. Perel’man ◽  
V. P. Kolosov
Keyword(s):  
Quality Of Life ◽  
Emotional Disorders ◽  
Asthma Control ◽  
Social Activity ◽  
Anxiety And Depression ◽  
Cold Air ◽  
The Social ◽  
Activity Domain

The aim of this study was to investigate long-term change in health-related quality of life (HRQL) in patients with asthma in real clinical practice and in relation to emotional disorders, cooperativeness (cooperation between the patient and the physician, and adherence to treatment), and cold air-provoked bronchial hyperresponsiveness (BHR).Methods. This observational study involved 32 patients with mild to moderate asthma. The study duration was 7.5 to 10 years. HRQL was assessed using SF-36 questionnaire and Asthma Quality of Life Questionnaire (AQLQ); emotional disorders were diagnosed using Hospital Anxiety and Depression Scale (HADS). Patients’ cooperativeness assessment was based on number of a patient’s scheduled visits to a physician during the study. The asthma control level was evaluated using the Asthma Control Test (ACT).Results. A significant worsening was found in the social activity domain of HRQL in the total group of the patients. According to AQLQ, a significant improvement was seen in the activity and symptoms domains and in the total score of quality of life (QoL). Long-term pharmacological treatment of asthma decreased anxiety and depression levels. The asthma control (ACT score) increased from 13.2 ± 1.0 to 19.7 ± 1.1 (р = 0.00003). Anxiety and depression decreased in patients with high cooperativeness during the long-term follow-up, while the total QoL and the specific QoL were unchanged excluding the social activity domain. A significant worsening in the activity scale and in the emotional scale of specific QoL together with growing depression and decreasing control of asthma were found in patients with lower cooperativeness. The cold air-provoked BNR slowed down the long-term improvement in the social activity domain. The cold air-provoked BNR also decreased patient-reported evaluation of daily activity.Conclusion. The long-term basic therapy of asthma provides a positive trend in HRQL in the real clinical practice independently on worsening of the disease. Lower cooperativeness of a patient could decrease specific QoL, which, in turn, worsens the control of asthma and contributes to negative emotional background and destructive behavior.

scholarly journals Screening instruments for predicting return to work in long-term sickness absence

2016 ◽  
Vol 67 (2) ◽  
pp. 101-108 ◽  
Author(s):  
A.-M. H. Momsen ◽  
C. M. Stapelfeldt ◽  
C. V. Nielsen ◽  
M. B. D. Nielsen ◽  
R. Rugulies ◽  
...  
Keyword(s):  
Return To Work ◽  
Sickness Absence ◽  
Screening Instruments

scholarly journals Quality of Life in Young Adults With Cerebral Palsy: A Longitudinal Analysis of the SPARCLE Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Nicolas Vidart d'Egurbide Bagazgoïtia ◽  
Virginie Ehlinger ◽  
Carine Duffaut ◽  
Jérôme Fauconnier ◽  
Silke Schmidt-Schuchert ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Young Adults ◽  
Social Relationships ◽  
Young Adulthood ◽  
Associated Factors ◽  
Well Being ◽  
Psychological Well Being ◽  
The Social

Introduction: While most people with cerebral palsy (CP) will have a life expectancy similar to that of the general population, international research has primarily focused on childhood and adolescence; and knowledge about the quality of life (QoL) of young adults with CP, its trajectories, and associated factors remains scarce.Methods: This longitudinal study included young adults with CP living in five European regions and who had previously participated in the SPARCLE cohort as children and/or adolescents. Their QoL in the psychological well-being and social relationships domains was estimated using age-appropriate validated instruments (KIDSCREEN-52 in childhood/adolescence and WHOQOL-Bref in young adulthood). We used generalized linear mixed-effect models with random intercept to estimate long-term trajectories of QoL in both domains and to investigate whether severity of impairment, pain, and seizure influenced these trajectories. We sought to identify potentially different trajectories of QoL from childhood to adulthood using a shape-based clustering method.Results: In total, 164 young adults with CP aged 22–27 years participated in the study. Psychological well-being linearly decreased by 0.78 points (scale 0–100) per year (95% confidence interval (CI) −0.99 to −0.56) from childhood to young adulthood, whereas QoL in the social relationships domain increased (β coefficient 1.24, 95% CI 0.92–1.55). Severity of impairment was associated with reduced QoL in all life periods of the study (childhood, adolescence, and young adulthood): motor impairment with social relationships, and more nuancedly intellectual disability with psychological well-being and social relationships. At all periods, frequent pain significantly reduced psychological well-being, and seizures were associated with lower QoL in the social relationships domain. In both domains, we identified a group of individuals with CP who presented a reverse trajectory compared with the general QoL trajectory.Conclusion: Identification of QoL trajectories and their associated factors yields improved knowledge about the experience of individuals with CP until young adulthood. Further studies are needed to better understand the determinants that have the greatest influence on the different shapes of long-term trajectories of QoL.

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