scholarly journals Vitamin D status and its determinants in children and adults among families in late summer in Denmark

2014 ◽  
Vol 112 (5) ◽  
pp. 776-784 ◽  
Author(s):  
Katja H. Madsen ◽  
Lone B. Rasmussen ◽  
Heddie Mejborn ◽  
Elisabeth W. Andersen ◽  
Christian Mølgaard ◽  
...  
Keyword(s):  
Vitamin D ◽  
Geometric Mean ◽  
Late Summer ◽  
Cross Sectional Study ◽  
Dietary Vitamin ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Related Factors ◽  
Cross Sectional ◽  
The Impact

The impact of the familial relationship on vitamin D status has not been investigated previously. The objective of the present cross-sectional study was to assess serum 25-hydroxyvitamin D (25(OH)D) concentration and its determinants in children and adults among families in late summer in Denmark (56°N). Data obtained from 755 apparently healthy children (4–17 years) and adults (18–60 years) recruited as families (n 200) in the VitmaD study were analysed. Blood samples were collected in September–October, and serum 25(OH)D concentration was measured by liquid chromatography–tandem MS. Information on potential determinants was obtained using questionnaires. The geometric mean serum 25(OH)D concentration was 72·1 (interquartile range 61·5–86·7) nmol/l (range 9–162 nmol/l), with 9 % of the subjects having 25(OH)D concentrations < 50 nmol/l. The intra-family correlation was 0·27 in all subjects, 0·24 in the adults and 0·42 in the children. Serum 25(OH)D concentration was negatively associated with BMI (P< 0·001) and positively associated with dietary vitamin D intake (P= 0·008), multivitamin use (P= 0·019), solarium use (P= 0·006), outdoor stay (P= 0·001), sun preference (P= 0·002) and sun vacation (P< 0·001), but was not associated with lifestyle-related factors in the adults when these were assessed together with the other determinants. In conclusion, the majority of children and adults among the families had serum 25(OH)D concentrations >50 nmol/l in late summer in Denmark. Both dietary and sun-related factors were determinants of vitamin D status and the familial component was stronger for the children than for the adults.

Vitamin D Status in Irish Children and Adolescents

2014 ◽  
Vol 53 (14) ◽  
pp. 1345-1351 ◽  
Author(s):  
Aoife Carroll ◽  
Chike Onwuneme ◽  
Malachi J. McKenna ◽  
Philip D. Mayne ◽  
Eleanor J. Molloy ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Formula Milk ◽  
Cross Sectional ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Mean ◽  
Vitamin D Supplements

Background. Vitamin D has important skeletal and extraskeletal roles but those living at northerly latitudes are at risk of suboptimal levels because of reduced sunlight exposure. Aim. To describe the vitamin D status of Irish children and identify factors predictive of vitamin D status. Methods. A prospective cross sectional study was undertaken over a 12 month period. Two hundred and fifty two healthy children attending for minor medical or surgical procedures were recruited. All had 25-hydroxyvitamin D (25OHD), parathyroid hormone and bone profiles measured. Results. The mean (standard deviation) for 25OHD was 51(25) nmol/L (20.4 (10) ng/mL). Forty-five percent had levels >50 nmol/L (20 ng/mL). The following variables were significantly associated with 25OHD levels >50 nmol/L (20 ng/mL): sample drawn in April-September, use of vitamin D supplements, consumption of formula milk, and non-African ethnicity. Conclusion. More than half of the children in this study had 25OHD levels less than 50 nmol/L (20 ng/mL). Vitamin D status was significantly improved by augmented oral vitamin D intake.

scholarly journals Vitamin D status in pre-school children in rural Nepal

2015 ◽  
Vol 19 (3) ◽  
pp. 470-476 ◽  
Author(s):  
Diana Avagyan ◽  
Sudan Prasad Neupane ◽  
Thomas E Gundersen ◽  
Ahmed A Madar
Keyword(s):  
Vitamin D ◽  
School Children ◽  
Sun Exposure ◽  
Hypovitaminosis D ◽  
Sociodemographic Factors ◽  
Cross Sectional Study ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Rural Nepal

AbstractObjectiveVitamin D plays a major role in Ca and bone metabolism, and its extraskeletal functions are being appraised. Although inadequate vitamin D concentrations have been reported in populations worldwide, too little is known about vitamin D status and its determinants among children in developing countries. We aimed to determine vitamin D status and its determinants in Nepalese children of pre-school age.DesignA community-based, cross-sectional study.SettingRural Nepal at latitude 27·39°N.SubjectsHealthy children (n280) aged 12–60 months, selected randomly from the records of a vitamin A supplementation programme. Blood samples were collected using the dried blood spot technique and analysed for serum 25-hydroxyvitamin D (s-25(OH)D) concentration using liquid chromatography–tandem mass spectrometry. Ca intake and background variables were assessed with a structured questionnaire.ResultsHypovitaminosis D, defined as s-25(OH)D concentration less than 50 nmol/l, was found in 91·1 % of the children. S-25(OH)D concentration was not related to gender, socio-economic indicators, sun exposure or nutritional status. Currently breast-fed children had higher s-25(OH)D concentrations (36·4 (sd13·2) nmol/l) than those who were not (28·6 (sd9·8) nmol/l,P<0·001). Adjustment for sociodemographic factors did not alter the results.ConclusionThere is widespread vitamin D deficiency among pre-school children in a rural area of Nepal. In our sample, sociodemographic factors did not affect the vitamin D status of children, but prolonged breast-feeding was associated with higher s-25(OH)D concentrations. Further research is required to investigate the health consequences of poor vitamin D status for this population.

scholarly journals Musculoskeletal Health in Active Ambulatory Men with Cerebral Palsy and the Impact of Vitamin D

2021 ◽  
Author(s):  
Christina Kate Langley ◽  
Gladys Leopoldine Onambélé-Pearson ◽  
David Thomas Sims ◽  
Ayser Hussain ◽  
Aidan John Buffey ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cerebral Palsy ◽  
Body Mass ◽  
Dietary Vitamin ◽  
Vitamin D Status ◽  
Musculoskeletal Health ◽  
Food Diary ◽  
Cross Sectional ◽  
Z Scores ◽  
The Impact

Abstract Purpose: 1) To determine the contribution of diet, time spent outdoors and habitual physical activity (PA) on vitamin D status in men with cerebral palsy (CP) compared to age matched controls (TDC) without neurological impairment. 2) To determine the role of vitamin D on musculoskeletal health, morphology and function in men with CP compared to TDC.Materials and methods: A cross-sectional comparison study where, twenty-four active, ambulant men with CP aged 21.0±1.4 years (Gross Motor Function Classification Score I-II) and 24 healthy TDC aged 25.3±3.1 years completed in vivo assessment of musculoskeletal health, including: Vastus Lateralis anatomical cross-sectional area (VL ACSA), isometric knee extension maximal voluntary contraction (KE iMVC), 10m-sprint, vertical jumps (VJ), radius and tibia bones T and Z scores. Assessments of vitamin D status through venous samples of serum 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone, dietary vitamin D intake from food diary and total sun exposure via questionnaire were also taken. Results: Men with CP had 40.5% weaker KE iMVC, 23.7% smaller VL ACSA, 22.2% lower VJ, 14.6% lower KE iMVC/VL ACSA ratio, 22.4% lower KE iMVC/body mass (BM) ratio and 25.1% lower KE iMVC/lean body mass (LBM) ratio (all p<0.05). Radius T and Z scores were 1.75 and 1.57 standard deviations lower than TDC, respectively (p<0.05), whereas neither tibia T nor Z scores showed any difference compared to TDC (p>0.05). 25(OH)D was not different between groups, and 90.9% of men with CP and 91.7% of TDC had low 25(OH)D levels when compared to current UK recommendations. 25(OH)D was positively associated with KE iMVC/LBM ratio in men with CP (r = 0.500, p=0.020), but not in TDC (r = 0.281, p=0.104).Conclusion: Musculoskeletal outcomes in men with CP were lower than TDC and despite there being no difference in levels of 25(OH)D between the groups, 25 (OH)D was associated with strength (KE iMVC/LBM) in the CP group, but not TDC. The findings suggest a greater sensitivity to low vitamin D in men with CP with regards to bone and muscle content and functional outcomes.

scholarly journals Factors influencing the vitamin D status of 10-year-old urban South African children

2010 ◽  
Vol 14 (2) ◽  
pp. 334-339 ◽  
Author(s):  
Machuene A Poopedi ◽  
Shane A Norris ◽  
John M Pettifor
Keyword(s):  
Vitamin D ◽  
Bone Health ◽  
Cross Sectional Study ◽  
Vitamin D Supplementation ◽  
Healthy Children ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
White Children ◽  
Hydroxyvitamin D ◽  
Total Fat

AbstractObjectiveAssessment of vitamin D status in a cohort of healthy 10-year-old urban children and the factors that influence vitamin D status in these children.DesignA cross-sectional study. Blood samples were collected across four seasons of the year for the biochemical determination of serum 25-hydroxyvitamin D [25(OH)D]. Anthropometric measurements (height and weight), BMI and total fat and lean mass (determined by the dual energy X-ray absorptiometry) were measured. 25(OH)D concentrations were assessed by chemiluminescent assay.SettingStudy of children in the Greater Johannesburg area of South Africa who form the Bone Health sub-cohort of the longitudinal Birth to Twenty cohort.SubjectsThree hundred and eighty-five children who form the Bone Health sub-cohort of the longitudinal Birth to Twenty cohort.ResultsWhite children had significantly higher 25(OH)D than their black peers (120·0 (sd 36·6) nmol/l v. 93·3 (sd 34·0) nmol/l, respectively). Seasonal variations in 25(OH)D levels were found only in white children, with 25(OH)D levels being significantly higher in white than in black children during the autumn and summer months. In multiple regression analysis, season, ethnicity, sex and total fat mass were the factors found to have an influence on 25(OH)D. Vitamin D deficiency (7 %) and insufficiency (19 %) were uncommon among the 10-year-old children.ConclusionsVitamin D supplementation or fortification is not warranted in healthy children living in Johannesburg. However, further studies need to confirm this in other regions of the country, especially in those living further south and with less sunshine during the winter months.

scholarly journals Age and Spinal Disease Correlate to Albumin and Vitamin D Status

2021 ◽  
pp. 219256822098256
Author(s):  
Anderson Gomes Marin ◽  
Raphael de Rezende Pratali ◽  
Samuel Machado Marin ◽  
Carlos Fernando Pereira da Silva Herrero
Keyword(s):  
Vitamin D ◽  
Nutritional Status ◽  
Age Groups ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Surgical Approaches ◽  
Albumin Concentration ◽  
Vitamin D Status ◽  
Cross Sectional ◽  
Epidemiological Profile

Study Design: Cross-sectional study. Objectives: Thus, this study aimed to assess the epidemiological profile of a patient sample that underwent spinal surgery regarding their nutritional and vitamin D status. Methods: Serum albumin and vitamin D (25-hydroxyvitamin D) levels were measured in patients with different spinal surgical approaches and various pathologies at a single institution. 112 patients were retrospectively identified for inclusion and stratified by age into 4 age groups and by pathology. The nutritional status of the patients was classified in vitamin D inadequacy (< 30ng/mL), vitamin D deficiency (<20ng/mL), and hypoalbuminemia (<3.5g/dL). Data was analyzed comparing vitamin D, and albumin means considering gender, age group, and pathologies. Results: Twenty-eight (25.2%) patients had hypoalbuminemia. There was no difference between gender (p = 0.988); there was a significant decrease in albumin concentration increasing the age (p < 0.001). The prevalence of hypoalbuminemia was significantly higher in patients with trauma, tumor and infection than in those patients with degenerative and deformity diseases (p = 0.003). The prevalence of vitamin D inadequacy was 33.7%, and that of deficiency was 62.2%, while severe deficiency (< 10 ng/mL) in 16.3%. The vitamin D concentration was significantly different among the pathologies (P = 0.047), the lower concentration occurring in patients with tumor. Conclusion: Older patients, as well as patients with tumor and infectious pathologies, seem to have a higher prevalence of hypoalbuminemia, inferring malnutrition. There was a low epidemic level of vitamin D concentration, almost all patients presenting some degree of hypovitaminosis D, independent of age, gender and nutritional status.

scholarly journals High prevalence of peripheral neuropathy in multiple myeloma patients and the impact of vitamin D levels, a cross-sectional study

2021 ◽  
Author(s):  
B. E. Oortgiesen ◽  
J. A. Kroes ◽  
P. Scholtens ◽  
J. Hoogland ◽  
P. Dannenberg - de Keijzer ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Vitamin D ◽  
Peripheral Neuropathy ◽  
Hypovitaminosis D ◽  
Cross Sectional Study ◽  
Clinical Trial Registration ◽  
Cross Sectional ◽  
Validated Questionnaire ◽  
Vitamin D Levels ◽  
The Impact

Abstract Purpose Peripheral neuropathy (PN) is common in patients with multiple myeloma (MM). We hypothesized that the relationship between hypovitaminosis D and PN described in diabetes mellitus patients may also be present in MM patients. Methods To study this potential association, we assessed the incidence of hypovitaminosis D (vitamin D < 75 nmol/L [= 30 ng/mL]) in smouldering and active MM patients in two Dutch hospitals. Furthermore, a validated questionnaire was used to distinguish different PN grades. Results Of the 120 patients included between January 2017 and August 2018, 84% had an inadequate vitamin D level (median vitamin D level 49.5 nmol/L [IQR 34–65 nmol/L]; mean age: 68 years [SD ± 7.7]; males: 58%). PN was reported by 69% of patients (n = 83); however, of these 83 patients, PN was not documented in the medical records of 52%. An association was found between lower vitamin D levels and higher incidence of PN in the total population (P = 0.035), and in the active MM patients (P = 0.016). Conclusion This multi-centre cohort study showed that PN and hypovitaminosis D are common in MM patients, and addressing low vitamin D levels in the treatment of MM patients might be beneficial in reducing the risk of PN. More attention for PN is warranted, as PN is underreported by clinicians. Further research is needed to fully understand the implications of vitamin D in the development of PN in patients with MM. Clinical trial registration Netherland Trial Register NL5835, date of registration July 28, 2016

scholarly journals Vitamin D status and associated metabolic risk factors among North Korean refugees in South Korea: a cross-sectional study

BMJ Open ◽  
2015 ◽  
Vol 5 (11) ◽  
pp. e009140 ◽  
Author(s):  
Kyeong Jin Kim ◽  
Yoon Jung Kim ◽  
Sun Hwa Kim ◽  
Jee Hyun An ◽  
Hye Jin Yoo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
South Korea ◽  
Cross Sectional Study ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Vitamin D Status ◽  
Sectional Study ◽  
Cross Sectional ◽  
North Korean Refugees
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