scholarly journals Increased serum ferritin levels are independently associated with carotid atherosclerosis in women

2017 ◽  
Vol 117 (11) ◽  
pp. 1623-1630 ◽  
Author(s):  
Haiyan Xu ◽  
Yanqi Song ◽  
Jing Xu ◽  
Yeqing Gu ◽  
Qing Zhang ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Dietary Patterns ◽  
Carotid Atherosclerosis ◽  
Adult Population ◽  
Multiple Logistic Regression Analysis ◽  
Positive Association ◽  
Cross Sectional ◽  
Ferritin Concentration ◽  
Carotid Plaques ◽  
Serum Ferritin Concentration

AbstractPrevious studies have supported the theory that there is a positive association between ferritin and carotid atherosclerosis in Western people. Diet plays an important role in determining serum ferritin concentration. Asian dietary patterns are different from Western dietary patterns, implying that there may be a difference in the association of ferritin with carotid atherosclerosis between Asian and Western people. However, few studies focus on the association between ferritin and carotid atherosclerosis among Asians. The aim of this study was to investigate how serum ferritin levels are associated with carotid atherosclerosis in an Asian adult population. A cross-sectional assessment was performed in 8302 adults in Tianjin, China. Carotid intima-media thickness (IMT) and plaques were assessed using ultrasonography, and serum ferritin was measured using the protein chip-chemiluminescence method. Multiple logistic regression analysis was used to examine the association between quartiles of serum ferritin concentration and carotid atherosclerosis. In the present study, the overall prevalence of IMT and carotid plaques in participants is 29·2 and 22·7 %, respectively. In women, after adjustments for potentially confounding factors, the OR of IMT and carotid plaques by increasing serum ferritin quartiles were 1·00, 1·39 (95 % CI 0·98–1·99), 1·39 (95 % CI 0·99–1·97), 1·81 (95 % CI 1·30–2·55) (Pfor trend<0·001) and 1·00, 1·24 (95 % CI 0·89–1·73), 1·18 (95 % CI 0·85–1·65), 1·59 (95 % CI 1·15–2·20) (Pfor trend<0·01), respectively. However, no association was found between serum ferritin and carotid atherosclerosis in men. The study demonstrated that increased serum ferritin levels are independently associated with IMT and carotid plaques in Asian women but not in Asian men.

scholarly journals Iron deficiency in patients with cancer: a prospective cross-sectional study

2021 ◽  
pp. bmjspcare-2021-002913
Author(s):  
Elisabeth Luporsi ◽  
Anthony Turpin ◽  
Vincent Massard ◽  
Sophie Morin ◽  
Bruno Chauffert ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Serum Ferritin ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Malignant Tumours ◽  
Cross Sectional ◽  
Ferritin Concentration ◽  
Patients With Cancer ◽  
Serum Ferritin Concentration ◽  
Registration Number

BackgroundDespite the deleterious consequences of iron deficiency (ID) in patients with cancer, underdiagnosis is frequent. The CARENFER study aimed to assess the prevalence of ID using both serum ferritin concentration and transferrin coefficient saturation (iron-saturation of transferrin, TSAT) index, as well as ID anaemia in patients with cancer.MethodsThis prospective cross-sectional study was conducted in 15 oncology units in France in 2019. All patients present in the medical unit during the 2-week study period, regardless of the type of tumour (solid or haematological) and treatment, were eligible. Serum ferritin concentration, TSAT index and haemoglobin level were determined. ID and ID-associated anaemia were defined according to European Society of Medical Oncology 2018 Guidelines: ID was defined either as ferritin <100 µg/L (absolute ID) or as ferritin ≥100 µg/L and TSAT <20% (functional ID).ResultsA total of 1221 patients with different types of solid malignant tumours were analysed: median age 64 years; 89.4% under treatment for their cancer, mainly by chemotherapy (75.4%). Overall, ID was found in 57.9% (55.1–60.6) of patients. Among them, functional ID accounted for 64% of cases. ID anaemia was reported in 21.8% (19.6–24.2) of all patients with cancer. ID was highly prevalent in untreated (75/130, 57.4%) and non-anaemic (419/775, 54.1%) patients.ConclusionThis study highlights the high prevalence of ID in patients with cancer, whether or not associated with anaemia or treatment. These results emphasise the need to a better detection and management of ID in cancer, thereby optimising overall patient care.Trial registration numberClinicalTrials.gov Identifier: NCT03924271.

scholarly journals Relationship Between Dietary Patterns and Carotid Atherosclerosis Among People Aged 50 Years or Older: A Population-Based Study in China

2021 ◽  
Vol 8 ◽  
Author(s):  
Yunyun Liu ◽  
Xuena Wang ◽  
Qing Zhang ◽  
Ge Meng ◽  
Li Liu ◽  
...  
Keyword(s):  
Dietary Patterns ◽  
Dietary Pattern ◽  
Carotid Atherosclerosis ◽  
Adult Population ◽  
Intima Media Thickness ◽  
Dietary Intakes ◽  
Cross Sectional ◽  
Media Thickness ◽  
Significant Difference ◽  
The Relationship

Background: The relationship between dietary patterns and atherosclerosis is inconclusive. Usually, diets vary greatly among different regions due to cultural differences and lifestyles. Few studies to date based on a Chinese population have investigated the relationship between dietary patterns and the formation of atherosclerosis in carotid arteries. We aimed to investigate whether dietary patterns were related to carotid atherosclerosis among an adult population in Tianjin, China.Methods: This cross-sectional study included a total of 2,346 participants aged 50 years or older (mean: 59.7 ± 6.29 years). Dietary intakes were assessed using a validated 81-item semiquantitative food frequency questionnaire, and factor analysis was used to identify dietary patterns. Carotid atherosclerosis was defined as a common carotid artery intima-media thickness ≥1.0 mm or plaques, or a carotid bifurcation intima-media thickness ≥1.2 mm. Multiple logistic regression models were used to explore the relationship between dietary patterns and carotid atherosclerosis.Results: Three factors were determined: “health” dietary pattern (factor 1), “traditional Tianjin” dietary pattern (factor 2), and “sweets” dietary pattern (factor 3). The multivariable-adjusted odds ratios (95% CI) of carotid atherosclerosis for the increasing quartiles of the sweets dietary pattern scores in women were as follows: 1.00 (reference), 1.33 (0.91, 1.97), 1.21 (0.82, 1.79), 1.64 (1.08, 2.51) (p for trend &lt;0.05). No significant difference was found between any dietary pattern and carotid atherosclerosis in men.Conclusion: Greater adherence to “sweets” dietary patterns was positively related to a higher prevalence of carotid atherosclerosis in women aged 50 or older. No relationship was found between any dietary pattern and carotid atherosclerosis in men. Further prospective studies are warranted to test this finding in other populations.

scholarly journals Dietary patterns and their association with sociodemographic factors in Lithuanian adult population

Medicina ◽  
2008 ◽  
Vol 44 (10) ◽  
pp. 799 ◽  
Author(s):  
Vilma Kriaučionienė ◽  
Janina Petkevičienė ◽  
Jūratė Klumbienė
Keyword(s):  
Dietary Patterns ◽  
Rural Areas ◽  
Adult Population ◽  
Positive Association ◽  
Sociodemographic Factors ◽  
Cross Sectional ◽  
Men And Women ◽  
Level Of Education ◽  
Healthy Nutrition ◽  
Major Factors

The aim of the study was to determine the association between dietary patterns and sociodemographic factors using the data of Lithuanian health behavior monitoring. Material and methods. In 1998–2004, four cross-sectional surveys were carried out within the FINBALT HEALTH MONITOR project. For every survey, a random sample of 3000 Lithuanians aged 20–64 years was taken from the National Population Register by mailed questionnaires. The response rates varied from 61.7% to 74.4%. Factor analysis was employed in order to reduce the number of food items. Four main factors were defined: “light food,” “sweets,” “heavy food,” and “cereals” factors. The associations between dietary patterns and sociodemographic factors were examined by applying a logistic regression analysis. Results. Four major factors accounted for 45.9% of the total variance in food intake in men and 46.5% in women. The “sweets” factor was inversely associated with age both in men and women. A strong positive association was found between age and the “cereals” factor. Men and women with a higher level of education were more likely to follow “light food” and “sweets” pattern and less likely “heavy food” if compared with people with a lower level of education. The odds of consuming “light food” were higher in cities than in rural areas. Married men and women were more likely to follow “heavy food” pattern compared to unmarried. Conclusion. This study identified four main dietary patterns in Lithuanian population. Dietary patterns of people with a higher level of education and inhabitants of cities are closer to the recommendations on healthy nutrition.

Association between Serum Ferritin Concentration and Perihaematoma Oedema Volume in Patients with Supratentorial Spontaneous Intracerebral Haemorrhage

2019 ◽  
Vol 8 (2) ◽  
pp. 77-86
Author(s):  
Ahsan Mohammed Hafiz ◽  
Md Sumon Rana ◽  
KM Tarikul Islam ◽  
Milton Kumer Saha ◽  
Md Atikur Rahman ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Mean Value ◽  
Motor Deficit ◽  
College Hospital ◽  
Cross Sectional ◽  
Ferritin Concentration ◽  
Female Ratio ◽  
Mortality And Morbidity ◽  
Medical College ◽  
Serum Ferritin Concentration

Background: Stroke (ischaemic & haemorrhagic) is a major cause of mortality and morbidity in the developed as well as in the developing countries. Perihaematoma oedema and haematoma expansion are two important points to be considered when deciding outcome of patients with ICH. Brain damage due to haematoma may be irreversible but the injury from perihaematoma oedema may be reversible. It has been seen that S. ferritin is the most reliable indicator of body iron. Treatment with iron chelators may give better outcome after ICH. Objective: This study was under taken to assess the association between serum ferritin and relative perihaematoma oedema volume. Methodology: This study was a cross sectional observational study that was conducted in the Departments of Neurosurgery & Neurology, Bangabandhu Sheikh Mujib Medical University (BSMMU) and Dhaka Medical College Hospital (DMCH) from 1st March, 2014 till 30th September, 2015 on 32 patients (32) who fulfilled the selection criteria were enrolled in this study. Results: In this study, male female ratio was 1:1 and the mean age was 56±15 years. Most of the ICH patients fell in the age group between 41-60 years (53%). During admission, grade-1 (GCS 3- 8) level of consciousness was reported among 45% of patients. All the patients in this study presented with motor deficit that include hemiplegia 20 (62.5%) and hemiparesis 12 (37.5%). Mean value of serum ferritin was found elevated on day 4 (344±406 μg/L) in comparison to day 1 (213.4±123.5μg/ L). Mean value of relative perihaematoma oedema was elevated on day 4 (4±2.7) than day 1 (1.9±1) but it was not statistically significant. Conclusion: In this study after statistical analysis by Pearson’s correlation test we found that there was no significant association between serum ferritin concentration and relative perihaematoma oedema on day-1 and day-4. Bang. J Neurosurgery 2019; 8(2): 77-86

scholarly journals Serum ferritin concentration in Gaucher's disease.

BMJ ◽  
1983 ◽  
Vol 286 (6381) ◽  
pp. 1864-1864 ◽  
Author(s):  
M A Morgan ◽  
A V Hoffbrand ◽  
M Laulicht ◽  
W Luck ◽  
S Knowles
Keyword(s):  
Serum Ferritin ◽  
Gaucher's Disease ◽  
Gaucher’S Disease ◽  
Ferritin Concentration ◽  
Serum Ferritin Concentration

scholarly journals Association of Dietary and Lifestyle Inflammation Score With Metabolic Syndrome in a Sample of Iranian Adults

2021 ◽  
Vol 8 ◽  
Author(s):  
Fatemeh Dehghani Firouzabadi ◽  
Ahmad Jayedi ◽  
Elaheh Asgari ◽  
Zahra Akbarzadeh ◽  
Nasim Janbozorgi ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Adult Population ◽  
Positive Association ◽  
Population Based ◽  
Cross Sectional Study ◽  
Significant Positive Association ◽  
Cross Sectional ◽  
General Adult Population ◽  
Education Status ◽  
Inflammation Score

Objective: We aimed to evaluate the association between the dietary and lifestyle inflammation score (DLIS) and metabolic syndrome (MetS) and its components in a sample of Iranian adults.Design: Population-based cross-sectional study.Setting: General adult population living in Tehran, Iran.Subjects: We included 827 adult men and women with an age range of 18–59 years who were referred to health centers in different districts of Tehran, Iran. Dietary intake was assessed by a semiquantitative food frequency questionnaire with 168 items. The DLIS was calculated based on four components, including dietary inflammation score, physical activity, cigarette smoking, and general obesity. Higher DLIS represents a more proinflammatory diet and lifestyle. The odds ratio (OR) and 95% confidence interval (CI) of the MetS across quartiles of the DLIS was calculated by using logistic regression analysis, controlling for age, sex, energy intake, marital status, education status, and occupation.Results: A total of 827 participants (31% men) were included, with a mean age of 44.7 ± 10.7 years. The prevalence of the MetS was 30.5%. The DLIS ranged between −2.35 and +3.19 (mean ± SD: 0.54 ± 1.09). There was a significant positive association between the DLIS and odds of MetS (OR fourthvs.thefirstquartile: 1.57, 95% CI: 1.01–2.45) in the fully adjusted model.Conclusion: Our results showed a significant positive association between the DLIS and odds of MetS. The results of the present crosssectional study suggested that having a more proinflammatory lifestyle can be associated with MetS. More prospective studies are needed to confirm the findings.

scholarly journals PREVALENCE OF HYPERTENSION IN ADULT POPULATION OF HAYATABAD PESHAWAR

1969 ◽  
Vol 5 (1) ◽  
pp. 644-647
Author(s):  
SARA GUL ◽  
ATIF HUSSAIN ◽  
KASHIF UR REHMAN KHALIL ◽  
IMRANULLAH ◽  
MUHAMMAD ISHTIAQ ◽  
...  
Keyword(s):  
Communicable Disease ◽  
Adult Population ◽  
Positive Association ◽  
Developed Countries ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Study Results ◽  
History Of ◽  
Study Population

BACKGROUND: Hypertension is one of the common non communicable disease and is reported to beprevalent in 20% to 50% of the adult population, hypertension is one of the major contributor ofmortality and morbidity in developing and developed countries. The cross-sectional descriptive studywas formulated to find the prevalence and to assess different etiological factors of hypertension.MATERIAL & METHODS: This cross-sectional study among 400 adults of age 25-75 years wasconducted in months of June to December 2014 in Phase 5, Hayatabad Peshawar. A detailed structuredproforma having important questions was used to collect important data regarding various variables.RESULTS: Our study results showed that 22.75% of the study people were hypertensive i.e. 10.25% ofmales and 12.5% of females; and the prevalence of hypertension showed positive association withadvancing age. Out of all respondents; 60.25% were males while 39.75% were females; 28.5% weresmokers; 5.25% consume predominantly meat; 32.5% were obese & overweight; 36.75% checked theirB.P regularly; and 19.75% had positive history of hypertension in family.CONCLUSION: We conclude that hypertension prevalence was high among our study population andwas associated with various modifiable and non modifiable risk factors thus population based preventivestrategies are needed to control and prevent hypertension.KEY WORDS: Hypertension, Age, Diet, Smokers, Hayatabad, Peshawar.

scholarly journals Serum ferritin levels are associated with carotid atherosclerosis in Chinese postmenopausal women: the Shanghai Changfeng Study

2015 ◽  
Vol 114 (7) ◽  
pp. 1064-1071 ◽  
Author(s):  
Hui Ma ◽  
Huandong Lin ◽  
Yu Hu ◽  
Xiaoming Li ◽  
Wanyuan He ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Serum Ferritin ◽  
Carotid Atherosclerosis ◽  
Ferritin Level ◽  
Oral Glucose ◽  
Model Assessment ◽  
Cvd Risk ◽  
Carotid Plaques ◽  
Increased Risk ◽  
Fourth Quartile

Postmenopausal women are at increased risk of CVD: the increased serum ferritin level may be involved in the pathogenesis. The aim of the present study is to investigate the relationship of ferritin and carotid atherosclerosis in postmenopausal women. A total of 1178 postmenopausal women (mean age, 60·8 years) were enrolled from the Changfeng Study. A standard interview, anthropometric measurements and laboratory analyses were performed for each participant. Bilateral CIMT (carotid intima–media thickness) were measured using ultrasonography, and the presence of carotid plaques was assessed. Serum ferritin was measured using electrochemiluminescence immunoassay. The results showed that serum ferritin was 181·9 (sd 65·8) ng/ml in the postmenopausal women. Multivariate, linear, stepwise regression analysis demonstrated that age (standardised β = 0·233, P< 0·001), alanine transaminase (standardised β = 0·194, P< 0·001), log homeostasis model assessment index for insulin resistance (standardised β = 0·181, P< 0·001), TAG (standardised β = 0·083, P= 0·003), Hb (standardised β = 0·080, P= 0·004) and PPG (2-h glucose levels following a 75-g oral glucose challenge) (standardised β = 0·079, P= 0·004) were independently associated with serum ferritin. Compared with the ferritin level of subjects in the first quartile, that in the fourth quartile had greater CIMT, and higher prevalence of carotid plaque. After adjusting for conventional CVD risk factors, Hb, leucocytes, log urine albumin:creatinine ratio and liver function, the ferritin level of postmenopausal women in the fourth quartile had a 1·587-fold increased risk of carotid plaques relative to those in the lowest quartile. In conclusion, these results suggest that serum ferritin is independently and positively associated with carotid atherosclerosis in postmenopausal women and that ferritin may be implicated in atherosclerosis.

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