scholarly journals “Essential Collaborators”: Locating Middle Eastern Geneticists in the Global Scientific Infrastructure, 1950s–1970s

2018 ◽  
Vol 60 (1) ◽  
pp. 119-149 ◽  
Author(s):  
Elise K. Burton

AbstractIn the aftermath of World War II, a new international infrastructure based on United Nations agencies took charge of coordinating global biomedical research. Through this infrastructure, European and American geneticists hoped to collect and test blood samples from human populations across the world to understand processes of human heredity and evolution and trace the historical migrations of different groups. They relied heavily on local scientific workers to help them identify and access populations of interest, although they did not always acknowledge the critical role non-Western collaborators played in their studies. Using scientific publications, personal correspondence, and oral histories, I investigate the collaborative relationships between Western scientists, their counterparts in the Middle East, and the human subjects of genetic research. I comparatively examine the experiences of Israeli and Iranian scientists and physicians engaged in genetic anthropology and medical genetics between the mid-1950s and the late 1970s, noting how they both applied nationalist historical narratives to their genetic data and struggled to establish the value of their local knowledge and scientific labor. I argue that the Israeli and Iranian experience of transnational scientific collaboration is representative of how Western scientists relegated their collaborators from “developing” regions to a subordinate positionality as collection agents or native informants. Meanwhile, within their own countries, the elite professional identity of Israeli and Iranian scientists granted them the authority to manipulate their research subjects, who often belonged to marginalized minority communities, and to interpret their biology and history within contexts of Jewish and Persian nationalism.

Author(s):  
Lawrence A. Zeidman

Eighty years ago the greatest mass murder of human beings of all time occurred in Nazi occupied Europe. This began with the mass extermination of patients with neurologic and psychiatric disorders that rendered them “useless eaters” to Hitler’s regime. The neuropsychiatric profession was systematically “cleansed” beginning in 1933, but racism and eugenics had infiltrated the specialty in the decades before that. With the installation of Nazi-principled neuroscientists, mass forced sterilization was enacted, which slowed down by the start of World War II and the advent of patient murder. But the murder of roughly 275,000 patients by the end of the war was not enough. The patients’ brains and neurologic body parts were stored and used in scientific publications both during and long after the war. Also, patients themselves were used in unethical ways for epilepsy and multiple sclerosis experiments. Relatively few neuroscientists resisted the Nazis, with some success in the occupied countries. Most neuroscientists involved in unethical actions continued their careers unscathed after the war. Few answered for their actions in a professional or criminal sense, and few repented. The legacy of such a depraved era in the history of neuroscience and medical ethics is that codes exist by which patients and research subjects are protected from harm. But this protection is possibly subject to political extremes and only by understanding the horrible past can our profession police itself. Individual neuroscientists can protect patients and colleagues if they are aware of the dangers of a utilitarian, unethical, and uncompassionate mindset.


1993 ◽  
Vol 8 (S1) ◽  
pp. S11-S14 ◽  
Author(s):  
Eric A. Davis ◽  
Ronald F. Maio

The atrocities committed by Nazi physicians and scientists, in the name of furthering medical science, is an appalling page of the history of medical research. In the wake of World War II, the scientific community strived to develop regulations to guard against future abuses in medical research. However, a particularly sobering thought is that the atrocities in Germany were being carried out in a country that had specific regulations for protecting human research subjects: Nazi Germany was the only European country to have such regulations. A more in-depth look at these regulations reveals institutional or department heads were held accountable, but not the individual researcher. The lesson from this analysis is clear: individual investigators must bear the responsibility of conducting ethical research. Governmental regulations and Institutional Review Boards never can replace investigators who are advocates for the protection of human subjects.The purpose of this paper is to address issues broadly regarding ethics and prehospital research, with a focus on the topic of informed consent.


2019 ◽  
Vol 133 (22) ◽  
pp. 2283-2299
Author(s):  
Apabrita Ayan Das ◽  
Devasmita Chakravarty ◽  
Debmalya Bhunia ◽  
Surajit Ghosh ◽  
Prakash C. Mandal ◽  
...  

Abstract The role of inflammation in all phases of atherosclerotic process is well established and soluble TREM-like transcript 1 (sTLT1) is reported to be associated with chronic inflammation. Yet, no information is available about the involvement of sTLT1 in atherosclerotic cardiovascular disease. Present study was undertaken to determine the pathophysiological significance of sTLT1 in atherosclerosis by employing an observational study on human subjects (n=117) followed by experiments in human macrophages and atherosclerotic apolipoprotein E (apoE)−/− mice. Plasma level of sTLT1 was found to be significantly (P<0.05) higher in clinical (2342 ± 184 pg/ml) and subclinical cases (1773 ± 118 pg/ml) than healthy controls (461 ± 57 pg/ml). Moreover, statistical analyses further indicated that sTLT1 was not only associated with common risk factors for Coronary Artery Disease (CAD) in both clinical and subclinical groups but also strongly correlated with disease severity. Ex vivo studies on macrophages showed that sTLT1 interacts with Fcɣ receptor I (FcɣRI) to activate spleen tyrosine kinase (SYK)-mediated downstream MAP kinase signalling cascade to activate nuclear factor-κ B (NF-kB). Activation of NF-kB induces secretion of tumour necrosis factor-α (TNF-α) from macrophage cells that plays pivotal role in governing the persistence of chronic inflammation. Atherosclerotic apoE−/− mice also showed high levels of sTLT1 and TNF-α in nearly occluded aortic stage indicating the contribution of sTLT1 in inflammation. Our results clearly demonstrate that sTLT1 is clinically related to the risk factors of CAD. We also showed that binding of sTLT1 with macrophage membrane receptor, FcɣR1 initiates inflammatory signals in macrophages suggesting its critical role in thrombus development and atherosclerosis.


2020 ◽  
Vol 20 (5) ◽  
pp. 321-332
Author(s):  
Yunbo Liu ◽  
Xu Zhang ◽  
Lin Yang

Adeno-associated virus (AAV) is a promising vector for in vivo gene therapy because of its excellent safety profile and ability to mediate stable gene expression in human subjects. However, there are still numerous challenges that need to be resolved before this gene delivery vehicle is used in clinical applications, such as the inability of AAV to effectively target specific tissues, preexisting neutralizing antibodies in human populations, and a limited AAV packaging capacity. Over the past two decades, much genetic modification work has been performed with the AAV capsid gene, resulting in a large number of variants with modified characteristics, rendering AAV a versatile vector for more efficient gene therapy applications for different genetic diseases.


Galaxies ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 24
Author(s):  
Alister Graham ◽  
Katherine Kenyon ◽  
Lochlan Bull ◽  
Visura Don ◽  
Kazuki Kuhlmann

Radio astronomy commenced in earnest after World War II, with Australia keenly engaged through the Council for Scientific and Industrial Research. At this juncture, Australia’s Commonwealth Solar Observatory expanded its portfolio from primarily studying solar phenomena to conducting stellar and extragalactic research. Subsequently, in the 1950s and 1960s, astronomy gradually became taught and researched in Australian universities. However, most scientific publications from this era of growth and discovery have no country of affiliation in their header information, making it hard to find the Australian astronomy articles from this period. In 2014, we used the then-new Astrophysics Data System (ADS) tool Bumblebee to overcome this challenge and track down the Australian-led astronomy papers published during the quarter of a century after World War II, from 1945 until the lunar landing in 1969. This required knowledge of the research centres and facilities operating at the time, which are briefly summarised herein. Based on citation counts—an objective, universally-used measure of scientific impact—we report on the Australian astronomy articles which had the biggest impact. We have identified the top-ten most-cited papers, and thus also their area of research, from five consecutive time-intervals across that blossoming quarter-century of astronomy. Moreover, we have invested a substantial amount of time researching and providing a small tribute to each of the 62 scientists involved, including several trail-blazing women. Furthermore, we provide an extensive list of references and point out many interesting historical connections and anecdotes.


2021 ◽  
Vol 9 (2) ◽  
pp. 189-204
Author(s):  
Ozum Yesiltas

This study investigates the growing influence of Middle Eastern non-state actors as agents of foreign policy and their interactions with states through an analysis of the U.S.-Kurdish relationship. Incorporating archival data and interviews with Kurdish and American policy makers, the paper analyses the factors that have affected the U.S.-Kurdish relationship from World War II to the recent Syrian crisis in the context of the mainstream theoretical approaches within the discipline of International Relations. The article concludes that the failure to formulate a coherent Kurdish policy complicates the U.S.’ Middle East strategy and contributes to outcomes unfavourable to U.S. interests in the region.  Abstract in Kurmanji Hêza ji kenaran : Pêşniyara bo siyaseteke derveyî ya hevgirtî ya Dewletên Yekbûyî yên Amerîkayê li hemberî Kurdan Ev lêkolîn tesîra her ku diçe mezin dibe ya aktorên ne-dewletî li Rojhilata Navîn wek failên siyaseta derve, digel danûstandinên wan bi dewletan re, li ser hîma tehlîla têkiliya DYA û Kurdan vedikole. Bi vehewandina daneyên arşîvî û hevdîtinên li gel siyasetmedarên kurd û amerîkî, ev nivîsar nêrînên bîrdozî yên herî berbelav di  babetaTêkiliyên Navneteweyî de bi kar tîne, ji bo ku faktorên bandor li têkiliyên DYA-Kurd ji Şerê Cîhanê yê Duyem heta qeyrana surî ya dawîn  kirine, tehlîl bike. Nivîsar bi vê encamê digihîje ku têkçûna sazkirina siyaseteke kurd a hevgirtî ji bo stratejiya DYA ya li Rojhilata Navîn zehmetiyan derdixe û netîceyên neyînî bo berjewendiyên DYA jî bi xwe re tîne. Abstract in Sorani Hêzê Sînoran: Kurdan Reyde Mesela Sîyasetê Teberî yê DYA yê ‘Pêgirewteyî’ Pê analîzê têkilîya DYA û kurdan, no cigêrayîş Rojhelato Mîyanên de tesîrê averşîyayoxî yê aktoranê bêdewletanê sey ajananê sîyasetê teberî û dewletan reyde înteraksîyonanê nê aktoran tehqîq keno. Bi dayeyanê arşîvan û roportajanê qerardaranê sîyasetî reyde, no nuşte faktoranê ke Cengê Cîhanî yê II. ra heta krîzê Sûrîye yê nikayinî têkilîya DYA û kurdan ser o tesîr kerdo, ê faktoran çarçewaya teorîyanê bingeyênan yê beşê Têkilîya Mîyanneteweyî de analîz keno. Na meqale netîce de vana ke DYA besenêkerd polîtîkayêka kurdan a pêgirewtîye virazê, na kêmanîye kî Rojhelato Mîyanên de stratejîya DYA kena têmîyan û peynîye de faydeyê xo nêreseno menfeatanê DYA yê a herême. Abstract in Zazaki Destellat le kenarewe : keysêk derbarey hawrrayî le siyasetî derewey Emerîka da beramber be Kurdekan Em nûsîne le karîgerî geşesendinî hêzwektere bê-netewekan le ser siyasetî Rojhellatî Nawerrast da dekollêtewe, legell peywendiyan legell dewlletekan da le rêgayi şirovekirdinî peywendî nêwan wîlayete yekgirtwekanî Emerîka û Kurdekan da. Be têkellkirdinî datay erşîf û çawpêketin legell siyasetmedare emerîkî û Kurdekan da, em nûsîne şirovey ew fakterane dekat ke karîgeryan le ser peywendî nêwan wîlayete yekgrtwekanî emerîka û Kurdekan da hebuh le cengî cîhanî duwemewe heta qeyranî tazey Suriya, le çwarçêwey têore berbillawekan le zanistî peywendiye nîwdewlletiyekan da. Encamî wutareke eweye ke be hoy şikesthênan le dirustkirdinî siyasetêkî yekgirtû beramber Kurdekan, astengî bo planî Wîlayete Yekgrtwekanî Emerîka le Rojhellatî Nawerrast da dirust dekat û debête hoy dirustbûnî derencamî nerênî le qazancî Wîlayete Yekgirtwekanî Emerîka le nawçeke da.


PEDIATRICS ◽  
1957 ◽  
Vol 19 (6) ◽  
pp. 1124-1128
Author(s):  
W. T. Mustard

THIS PAPER is a general review of the development of the artificial heart-lung to facilitate open-heart surgery. At the close of World War II many centers began investigating the possibility of total cardiac bypass. Oven the past decade, pump oxygenerators of various types have become popular and recent clinical successes throughout the world have given further impetus to the study of problems posed by the artificial heart-lung apparatus. The subject divides itself into three separate parts, the first two being concerned with the maintenance of life in an experimental animal during a total cardiac bypass. One must take all the blood from the animal and return it to the animal by means of a pump. Secondly, one must oxygenate the blood before returning it. The third part of the problem confronting the surgeon is the selection of cases and correction of defects in human subjects. The pumping mechanism must duplicate as nearly as possible the action of the chambers of the heart. Pumping action must be smooth so as to prevent hemolysis and to avoid turbulence with thrombosis. It is not difficult to construct a pump with which hemolysis can be kept to relatively negligible amounts. Most of the pumps in use throughout the world give an hemolysis of less than 50 mg of hemoglobin per 100 ml of blood, which is perfectly safe. Turbulence with thrombosis can be overcome by removing valves inside the stream and placing valves outside of, rather than within the stream of blood. Furthermore, heparinization of the blood lessens the tendency to thrombosis.


2021 ◽  
pp. 104973232110611
Author(s):  
Jill Owczarzak ◽  
Katherine C. Smith

In January 2019, revisions to federal regulations that outline requirements for ethical oversight of human subjects research (The Revised Common Rule) went into effect. These revisions reflect major changes in thinking about risk and protection of research subjects. The Revised Common Rule (RCR) considerably curtails federal oversight of social and behavioral science, with most non-interventional research and “benign” behavioral interventions becoming exempt from mandated Institutional Review Board (IRB) approval, although determination of exemption remains with IRBs. As two qualitative health researchers serving on IRBs, we consider how this contraction of federal oversight dovetails with longstanding criticisms of IRB oversight of qualitative research. We explore the passage of the RCR as a point of potentially important change in procedure and principle in relation to ethical oversight of qualitative health research. We identify challenges and opportunities with these changes at the institutional, professional, and individual levels for ethical and impactful qualitative research.


2009 ◽  
Vol 24 (1) ◽  
pp. 31-43 ◽  
Author(s):  
Diane A. Riordan ◽  
Michael P. Riordan

ABSTRACT: Federal regulations require oversight of federally sponsored research involving human subjects. Universities have responded by forming Institutional Review Boards (IRBs). Although these regulations only apply to federally funded projects, universities have extended the oversight to include all projects involving human subjects. From our own experience, we observe that not all accounting faculty are aware of their responsibilities to their local boards. The sanctions for failing to follow required procedures depend on the infraction, and range from an order to cease work on the project to termination of university service for the faculty member and expulsion for the student. This report helps accounting faculty understand how the review process may affect their role as instructors and serves as encouragement to them to become familiar with the requirements of local review boards.


2020 ◽  
pp. 396-413
Author(s):  
Olive Vassell

The black British press has since its inception in 1900 been rooted in several connected struggles. They are: the push for African and Caribbean independence, and the creation of a collective cultural and political black identity based in African roots; the formation of community and belonging for largely Caribbean immigrants following the post-World War II mass migration, and the reflection and reinforcement of identity for black British-born citizens outside of white political, social, economic and cultural hegemony. However, it has not only played a pivotal role in addressing issues of liberation and community building, but also in helping to define the public discourse surrounding the definition of what it means to be both black and British, not just for blacks, but for the entire British society. This chapter examines the history of black British newspapers and periodicals through these three distinct periods of social change and the critical role they have played in each of them.


Sign in / Sign up

Export Citation Format

Share Document