scholarly journals The effect of selection on brain and body size association in rats

1984 ◽  
Vol 43 (3) ◽  
pp. 289-298 ◽  
Author(s):  
William R. Atchley
Keyword(s):  
Body Weight ◽  
Body Size ◽  
Weight Gain ◽  
Brain Size ◽  
Body Weight Gain ◽  
Genetic Correlations ◽  
Considerable Change ◽  
Evolutionary Divergence ◽  
Significant Divergence

SUMMARYChanges in brain size, body size and their co variance are reported from a long-term replicated directional selection experiment on body weight gain in rats. Two strains had been selected for increased and two for decreased weight gain between 3 and 9 weeks of age, and there were two randomly selected control lines. Selection produced significant changes in body weight in all selected lines. Divergence from the controls occurred in brain size in those strains selected for increased weight gain; no significant divergence was found for the strains selected for decreased weight gain. Divergence among unselected control lines suggests that genetic drift occurred in expression of brain size. Sexual dimorphism in response to selection results from sex differences in heritabilities and genetic correlations in relevant traits. In spite of considerable change in body size and brain size, no significant change in their covariation occurred either between the selection lines or between sexes. The relevance of these results to a brain and body size ‘scaling effect’ during evolutionary divergence is discussed.

scholarly journals Combined Deletion of Y1, Y2, and Y4 Receptors Prevents Hypothalamic Neuropeptide Y Overexpression-Induced Hyperinsulinemia despite Persistence of Hyperphagia and Obesity

Endocrinology ◽  
2006 ◽  
Vol 147 (11) ◽  
pp. 5094-5101 ◽  
Author(s):  
En-Ju D. Lin ◽  
Amanda Sainsbury ◽  
Nicola J. Lee ◽  
Dana Boey ◽  
Michelle Couzens ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Neuropeptide Y ◽  
Energy Homeostasis ◽  
Viral Vector ◽  
Body Weight Gain ◽  
Hormonal Changes ◽  
Obesity Syndrome ◽  
Y Receptors

Neuropeptide Y (NPY) is a key regulator of energy homeostasis and is implicated in the development of obesity and type 2 diabetes. Whereas it is known that hypothalamic administration of exogenous NPY peptides leads to increased body weight gain, hyperphagia, and many hormonal and metabolic changes characteristic of an obesity syndrome, the Y receptor(s) mediating these effects is disputed and unclear. To investigate the role of different Y receptors in the NPY-induced obesity syndrome, we used recombinant adeno-associated viral vector to overexpress NPY in mice deficient of selective single or multiple Y receptors (including Y1, Y2, and Y4). Results from this study demonstrated that long-term hypothalamic overexpression of NPY lead to marked hyperphagia, hypogonadism, body weight gain, enhanced adipose tissue accumulation, hyperinsulinemia, and other hormonal changes characteristic of an obesity syndrome. NPY-induced hyperphagia, hypogonadism, and obesity syndrome persisted in all genotypes studied (Y1−/−, Y2−/−, Y2Y4−/−, and Y1Y2Y4−/− mice). However, triple deletion of Y1, Y2, and Y4 receptors prevented NPY-induced hyperinsulinemia. These findings suggest that Y1, Y2, and Y4 receptors under this condition are not crucially involved in NPY’s hyperphagic, hypogonadal, and obesogenic effects, but they are responsible for the central regulation of circulating insulin levels by NPY.

Early nutritional changes induce sexually dimorphic long-term effects on body weight gain and the response to sucrose intake in adult rats

Metabolism ◽  
2012 ◽  
Vol 61 (6) ◽  
pp. 812-822 ◽  
Author(s):  
Esther Fuente-Martín ◽  
Miriam Granado ◽  
Cristina García-Cáceres ◽  
Miguel A. Sanchez-Garrido ◽  
Laura M. Frago ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Sexually Dimorphic ◽  
Sucrose Intake ◽  
Long Term Effects ◽  
Adult Rats ◽  
Nutritional Changes

Long-term reductions in GH, insulin-like growth factor-I and body weight gain in rats treated neonatally with antibodies to rat GH

1990 ◽  
Vol 124 (3) ◽  
pp. 381-386 ◽  
Author(s):  
M. J. Gardner ◽  
D. J. Flint
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Growth Factor ◽  
Body Weight Gain ◽  
Female Rats ◽  
Serum Prolactin ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

ABSTRACT Treatment of neonatal rats on days 2–5 with antibodies against rat GH (rGH) markedly reduced body weight gain and serum concentrations of insulin-like growth factor-I for 6–8 weeks in both females and males, after which weight gain normalized without evidence of catch-up growth. There were no significant effects on serum prolactin, tri-iodothyronine or corticosterone. Testis and ovarian weights were reduced, although only in proportion to body size. In females, but not males, the treated rats, though lighter, had increased fat deposition in the parametrial depot. Pituitary weight was considerably reduced over 100 days later, as was the pituitary content of GH, but not prolactin. The response to GH-releasing factor of both male and female rats was also greatly reduced at this time. Taken together with the fact that these rGH antibodies can bind directly to somatotrophs, we propose that the long-term effects of the antibodies are induced by specific somatotroph destruction. Journal of Endocrinology (1990) 124, 381–386

Long-term high animal protein diet reduces body weight gain and insulin secretion in diet-induced obese rats

2012 ◽  
Vol 92 (13) ◽  
pp. 2638-2643 ◽  
Author(s):  
Haiyan Chen ◽  
Yiling Wang ◽  
Lichuan Ma ◽  
Jiajun Zhao ◽  
Yinyin Li ◽  
...  
Keyword(s):  
Body Weight ◽  
Insulin Secretion ◽  
Weight Gain ◽  
Body Weight Gain ◽  
Animal Protein ◽  
Protein Diet ◽  
High Animal ◽  
Obese Rats

scholarly journals Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats

2009 ◽  
Vol 78 (8) ◽  
pp. 951-958 ◽  
Author(s):  
Edson Lucas Santos ◽  
Kely de Picoli Souza ◽  
Elton Dias da Silva ◽  
Elice Carneiro Batista ◽  
Paulo J. Forcina Martins ◽  
...  
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Life Span ◽  
Ace Inhibitor ◽  
Body Weight Gain ◽  
Term Treatment ◽  
Long Term Treatment

scholarly journals Karakteristik Kuantitatif Sapi Bali dan Sapi Simbal (Simmental X Bali) di Kecamatan Renah Pamenang Kabupaten Merangin

2021 ◽  
Vol 11 (1) ◽  
pp. 30
Author(s):  
Husni Almakmum ◽  
Depison Depison ◽  
Helmi Ediyanto
Keyword(s):  
Body Weight ◽  
Body Size ◽  
Weight Gain ◽  
Body Weight Gain ◽  
The Body ◽  
Chest Circumference ◽  
Body Measurements ◽  
Quantitative Characteristics ◽  
Bali Cattle ◽  
The Relationship

Abstract This study aimed to determine the quantitative characteristics, the determinant of body size and shape, and the correlation of body measurements and the bodyweight of Bali and Simbal cattle in Renah Pamenang, Merangin District. The survey method was used along with purposive sampling, the samples were Bali and Simbal cattle aged I1 (Incicivus 1) and not in pregnant condition, with 60 cattle consisting of 30 males and 30 females. Observed data included: body weight, body weight gain, body length, shoulder height, chest circumference, chest weight, chest width, hip height, and canon circumference were analyzed using the t-test method. The principal component analysis was used to determine the determinant of size and shape of Bali and Simbal cattle followed by the regression and correlation analysis to determine the relationship and closeness of the relationship between body measurements with body weight. The result showed that the body weight, body weight gain, and body size of Bali cattle were significantly different (P <0.05) from Simbal. The body weight, body weight gain, and body size of Bali cattle were lower than Simbal cattle. The main characteristic of size in Bali and Simbal cattle was the Chest Circumference. The dominant characteristic of shape in Bali and Simbal cattle was shoulder height. The highest correlation between body measurements and body weight in Bali and Simbal cattle was the chest circumference. Keywords: Quantitative Characteristics; Bali Cattle; Simbal Cattle.   Abstrak Penelitian ini bertujuan untuk mengetahui karakteristik kuantitatif, penciri ukuran dan bentuk tubuh, serta korelasi ukuran-ukuran tubuh dengan bobot badan sapi Bali dan Simbal di Kecamatan Renah Pamenang Kabupaten Merangin. Metode yang digunakan adalah survey dengan pengambilan sampel secara purposive sampling, yaitu sapi Bali dan Simbal, umur I1 (Incicivus 1),  dan tidak dalam keadaan bunting sebanyak 60 sampel yang terdiri dari 30 ekor jantan dan 30 ekor betina pada masing-masing bangsa. Data yang dihimpun meliputi : bobot badan, pertambahan bobot badan, panjang badan, tinggi pundak, lingkar dada, dalam  dada, lebar dada, tinggi pinggul dan lingkar kanon dianalisis menggunakan uji-t. Analisis komponen utama digunakan untuk mengetahui penciri ukuran dan bentuk tubuh sapi Bali dan Simbal kemudian dilanjutkan analisis regresi dan korelasi untuk mengetahui hubungan dan keeratan hubungan antara ukuran-ukuran tubuh dengan bobot badan. Hasil penelitian menunjukkan bahwa bobot badan, pertambahan bobot badan dan ukuran-ukuran tubuh sapi Bali berbeda nyata (P<0,05) dengan Simbal. Bobot badan, pertambahan bobot badan dan ukuran-ukuran tubuh sapi Bali lebih rendah dibandingkan Simbal. Penciri ukuran pada sapi Bali dan Simbal adalah lingkar dada. penciri bentuk pada sapi Bali dan Simbal adalah tinggi pundak. Korelasi tertinggi antara ukuran-ukuran tubuh dengan bobot badan sapi Bali dan Simbal adalah lingkar dada. Kata kunci: Karakteristik kuantitatif; Sapi Bali; Sapi Simbal

Sign in / Sign up

Export Citation Format

Share Document