Schistosoma mansoni: a histological study of migration in the laboratory mouse

Parasitology ◽  
1979 ◽  
Vol 79 (1) ◽  
pp. 49-62 ◽  
Author(s):  
P.R. Wheater ◽  
R. A. Wilson
Keyword(s):  
Blood Flow ◽  
Schistosoma Mansoni ◽  
Pulmonary Circulation ◽  
Histological Study ◽  
Laboratory Mouse ◽  
Tissue Responses ◽  
Migratory Route ◽  
Specific Tissue ◽  
Mammal Host ◽  
Histopathological Evidence

SUMMARYQuantitative histological methods were applied in a study of the migratory route of schistosomula within the definitive mammal host. The observations are consistent with an entirely intravascular mode of migration in the direction of blood flow. They do not support a trans-diaphragm route. Schistosomula can be identified in low numbers in systemic organs, in the left side of the heart and in the venous compartment of the pulmonary circulation. They were not observed penetrating the diaphragm or the capsule of the liver. No histopathological evidence was found to suggest that the tissue responses of previously unexposed hosts affect migrating schistosomula at any stage during migration. These non-specific tissue responses were marked only in the skin phase of migration.

Tissue Reaction to Subcutaneous Implantation of SuperEBA (Reinforced Zinc Oxide Cement) Used as Root-End Filling Material: A Histological Study in Rats

2016 ◽  
Vol 695 ◽  
pp. 247-251
Author(s):  
Alexandru Andrei Iliescu ◽  
Cristian Marian Petcu ◽  
Ileana Cristiana Petcu ◽  
Irina Maria Gheorghiu ◽  
Andrei Iliescu ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Histological Study ◽  
Tissue Reaction ◽  
Tissue Response ◽  
Successful Outcome ◽  
Filling Material ◽  
Clinical Value ◽  
Filling Materials ◽  
Retrograde Filling ◽  
Specific Tissue

The retrograde filling is a critical step to a successful outcome of the endodontic surgery. Despite the progress in the technology of novel root-end filling materials, zinc oxide-eugenol cement superEBA is still preserving its clinical value on long-term basis. The study aimed to reconsider the tissue response to the initial irritating effect of this material. Silicon tubes filled with superEBA were subcutaneously implanted for 120 days in white Wistar rats which were afterwards sacrificed. The connective tissue surrounding the superEBA implants revealed fibroblast proliferation and a definite reparatory process without inflammatory reaction. A non-specific tissue healing in progress around the implants, without calcifications, necrosis, and apoptosis was also described after 4 months. SuperEBA proved on animal model that its cytotoxicity is reducing gradually in time until no adverse reaction is observed. The reduced content in eugenol compared to other surgical zinc oxide cements and the benefic effect of o-ethoxybenzoic acid are the support to reconsider SuperEBA as a biocompatible retrograde filling material.

scholarly journals Heterogeneity of blood flow: impact of age on muscle specific tissue perfusion during exercise

2014 ◽  
Vol 592 (8) ◽  
pp. 1729-1730 ◽  
Author(s):  
Joel D. Trinity ◽  
Gwenael Layec ◽  
Joshua F. Lee
Keyword(s):  
Blood Flow ◽  
Tissue Perfusion ◽  
Specific Tissue

Pattern of blood flow in the pulmonary veins of the dog

1965 ◽  
Vol 20 (6) ◽  
pp. 1118-1128 ◽  
Author(s):  
Eugene Morkin ◽  
John A. Collins ◽  
Harold S. Goldman ◽  
Alfred P. Fishman
Keyword(s):  
Blood Flow ◽  
Pulmonary Circulation ◽  
Pulmonary Veins ◽  
Electromagnetic Flowmeter ◽  
Sine Wave ◽  
Left Ventricular ◽  
Mean Flow ◽  
Venous Flow ◽  
Pulmonary Venous Flow ◽  
Atrial Contraction

The pattern of blood flow in the large pulmonary veins was studied in dogs by chronic implantation of sine-wave electromagnetic flowmeters and cineangiographic observations. These revealed that: 1) pulmonary venous flow is continuous and pulsatile with peak rate of flow of approximately twice the mean flow; 2) the initial rapid increase in venous flow occurs 0.10 sec after the onset of ventricular systole, reaching a peak at the time of closure of the A-V valves; 3) left atrial contraction produces a fleeting slowing or reversal of flow; and 4) respiratory variations in pulmonary venous flow follow those in pulmonary arterial flow, beat by beat. The genesis of phasic pulmonary venous flow was investigated by analysis of pressure and flow curves from the two sides of the heart, by consideration of the energy required for left ventricular filling, and by reconstruction of the pulmonary venous flow pulse using a mathematical model of the pulmonary circulation. These three lines of evidence are consistent in indicating that the transmitted right ventricular pressure is the major determinant of the pulmonary venous flow pattern in the dog. pulsatile pulmonary venous flow; pulmonary venous flow; pulmonary circulation; ventricular suction; respiration on pulmonary circulation; pulmonary venous angiography; pulmonary veno-atrial junctions; electromagnetic flowmeter; cineangiography Submitted on November 16, 1964

scholarly journals Hypercapnia Regulates Gene Expression and Tissue Function

2020 ◽  
Vol 11 ◽  
Author(s):  
Masahiko Shigemura ◽  
Lynn C. Welch ◽  
Jacob I. Sznajder
Keyword(s):  
Gene Expression ◽  
Lung Diseases ◽  
Transcriptional Response ◽  
Cell Types ◽  
Chronic Lung Diseases ◽  
Tissue Responses ◽  
Mammalian Tissues ◽  
Specific Tissue ◽  
Different Cell Types ◽  
Alveolar Gas Exchange

Carbon dioxide (CO2) is produced in eukaryotic cells primarily during aerobic respiration, resulting in higher CO2 levels in mammalian tissues than those in the atmosphere. CO2 like other gaseous molecules such as oxygen and nitric oxide, is sensed by cells and contributes to cellular and organismal physiology. In humans, elevation of CO2 levels in tissues and the bloodstream (hypercapnia) occurs during impaired alveolar gas exchange in patients with severe acute and chronic lung diseases. Advances in understanding of the biology of high CO2 effects reveal that the changes in CO2 levels are sensed in cells resulting in specific tissue responses. There is accumulating evidence on the transcriptional response to elevated CO2 levels that alters gene expression and activates signaling pathways with consequences for cellular and tissue functions. The nature of hypercapnia-responsive transcriptional regulation is an emerging area of research, as the responses to hypercapnia in different cell types, tissues, and species are not fully understood. Here, we review the current understanding of hypercapnia effects on gene transcription and consequent cellular and tissue functions.

scholarly journals Host cell adhesion to Schistosoma mansoni larvae in the peritoneal cavity of naive mice: histological and scanning electron microscopic studies

1993 ◽  
Vol 35 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Alan Lane de Melo ◽  
Conceição Ribeiro da Silva Machado ◽  
Leógenes Horácio Pereira
Keyword(s):  
Cell Adhesion ◽  
Schistosoma Mansoni ◽  
Host Cell ◽  
Peritoneal Cavity ◽  
Mononuclear Cells ◽  
Close Contact ◽  
Histological Study ◽  
Electron Microscopic ◽  
Microscopic Studies ◽  
Scanning Electron

Cercariae of Schistosoma mansoni inoculated into the peritoneal cavity of naive mice induced host cell adhesion to their surface, but after 90 minutes the number of adherent cells sharply decreased. The cell detachment is progressive and simultaneous to the cercaria-schistosomule transformation. The histological study showed mainly neutrophils in close contact with the larvae. Mononuclear cells and some eosinophils were occasionally seen surrounding the adherent neutrophils. The scanning electron microscopy showed cells displaying twisted microvilli and several microplicae contacting or spreading over the larval surface, and larvae completely surrounded by clusters of cells. These results suggest that the neutrophils recognize molecules on the cercarial surface which induce their spreading

Corrigenda for vol. 80, Cover legend

1996 ◽  
Vol 80 (6) ◽  
pp. 2254-2254
Keyword(s):  
Blood Flow ◽  
Shear Stress ◽  
Wall Shear Stress ◽  
Network Topology ◽  
Pulmonary Circulation ◽  
Pressure Flow ◽  
Pulsatile Pressure ◽  
Volume Relationship ◽  
Pressure Volume Relationship ◽  
Pulse Waves

Cover legend: In the cover legend for the March and April issues, the starting sentence "Pulsatile pressure-volume relationship..." should read instead "Pulsatile pressure-flow relationship..." Cover legend is reprinted below. Cover: Pulsatile pressure-flow relationship, input impedance, encodes network topology, geometry, and design via reflected pulse waves from distributed branching sites in the pulmonary circulation. Network design is a system property conferring a susceptibility to modulate the amplitude of wall shear stress in vessles with the distribution of blood flow. (From Bennett et al. J. Appl. Physiol. 80: 1033-1056, 1996)

Influence of pulmonary blood flow on management and outcome

2011 ◽  
Keyword(s):  
Blood Flow ◽  
Heart Disease ◽  
Pulmonary Circulation ◽  
Early Life ◽  
Pulmonary Blood Flow ◽  
Venous Blood ◽  
Cyanotic Heart Disease ◽  
Capillary Membrane ◽  
Pulmonary Vascular Development ◽  
Alveolar Capillary

Introduction 50Pulmonary vascular development in early life 50Cyanotic heart disease and pulmonary blood flow 52Delivery of systemic venous blood to the alveolar capillary membrane to allow release of waste CO2 and uptake of O2 depends on the integrity of the pulmonary circulation. Too little blood flow to the lungs and the patient is hypoxic; too much and the lungs become oedematous....

Thermal recovery after passage of the pulmonary circulation assessed by deconvolution

1988 ◽  
Vol 64 (3) ◽  
pp. 1210-1216 ◽  
Author(s):  
J. Bock ◽  
P. Deuflhard ◽  
A. Hoeft ◽  
H. Korb ◽  
H. G. Wolpers ◽  
...  
Keyword(s):  
Blood Flow ◽  
Pulmonary Circulation ◽  
Thermal Recovery ◽  
Base Line ◽  
Indocyanine Green Dye ◽  
Cold Blood ◽  
Finite Integral ◽  
Pulmonary Arterial ◽  
Extravascular Compartment

For indicator-dilution studies, complete thermal recovery after passage of heat through the pulmonary circulation would be desirable. However, the results in the literature obtained by extrapolation techniques are inconsistent. To overcome problems of the extrapolation approach, transport functions of the pulmonary circulation (including the left heart) were computed by deconvolution of pulmonary arterial and aortic pairs of thermodilution curves after central venous indicator injection (10 ml of an ice-cold blood indocyanine green dye mixture). Thermal recovery was determined as the finite integral of the transport function. Thirteen mongrel dogs under piritramid-N2O anesthesia were examined under base-line conditions, in orthostasis to alter the distribution of pulmonary blood flow (9 dogs), and in oleic acid edema (8 dogs). Using the deconvolution approach, thermal recovery was 0.97 ± 0.04 under base-line conditions, 0.96 ± 0.03 in orthostasis, and 0.96 ± 0.05 in pulmonary edema. Thermal recovery determined from extrapolated dilution curves was greater than 100% in all groups, a physically impossible finding. It is concluded that thermal recovery is incomplete but insensitive with respect to the distribution of blood flow and to the size of the extravascular compartment. Monoexponential extrapolation is unsuited for the determination of thermal recovery.

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