Integrative molecular phylogeography in the context of infectious diseases on the human-animal interface

Parasitology ◽  
2012 ◽  
Vol 139 (14) ◽  
pp. 1939-1951 ◽  
Author(s):  
REBECCA R. GRAY ◽  
MARCO SALEMI
Keyword(s):  
Infectious Diseases ◽  
Disease Transmission ◽  
Habitat Destruction ◽  
Food Sources ◽  
Animal Origin ◽  
Effective Control ◽  
Past Century ◽  
Long Distance ◽  
Live Animal ◽  
Molecular Phylogeography

SUMMARYThe rate of new emerging infectious diseases entering the human population has increased over the past century, with pathogens originating from animals or from products of animal origin accounting for the vast majority. Primary risk factors for the emergence and spread of emerging zoonoses include expansion and intensification of animal agriculture and long-distance live animal transport, live animal markets, bushmeat consumption and habitat destruction. Developing effective control strategies is contingent upon the ability to test causative hypotheses of disease transmission within a statistical framework. Broadly speaking, molecular phylogeography offers a framework in which specific hypotheses regarding pathogen gene flow and dispersal within an ecological context can be compared. A number of different methods has been developed for this application. Here, our intent is firstly to discuss the application of a wide variety of statistically based methods (including Bayesian reconstruction, network parsimony analysis and regression) to specific viruses (influenza, salmon anaemia virus, foot and mouth disease and Rift Valley Fever) that have been associated with animal farming/movements; and secondly to place them in the larger framework of the threat of potential zoonotic events as well as the economic and biosecurity implications of pathogen outbreaks among our animal food sources.

Multiple airflow patterns in human microenvironment and the influence on short-distance airborne cross-infection – A review

2021 ◽  
pp. 1420326X2110485
Author(s):  
Peter V Nielsen ◽  
Chunwen Xu
Keyword(s):  
Disease Transmission ◽  
Short Distance ◽  
Flow Fields ◽  
Cross Infection ◽  
Transmission Risk ◽  
Effective Control ◽  
Complex Flow ◽  
Long Distance ◽  
Physiological Factors ◽  
Flow Interactions

The global spread of the coronavirus disease 2019 (COVID-19) has increased the demand of effective control of the disease transmission between people, especially when they are in close distance between each other. The microenvironment between the people in short distance contains multiple airflow patterns that directly affect the disease transmission. By understanding and respecting this special localized environment, the airborne cross-infection at both short and long distance can be minimized. This paper gives an overview of the flow fields in human microenvironment. The exhalation flow from different respiratory activities, e.g. normal breathing, speaking, coughing or sneezing is considered as a part of the microenvironment. The dynamics of the exhalation flow and the contained droplets or aerosols are summarized from previous studies. The factors influencing the flow fields in human microenvironment are discussed, including both the physiological factors of the occupants and the environmental factors in the ventilated context (macroenvironment). Effective control of these influencing factors can be helpful to mitigate airborne transmission risk between individuals. This paper highlights the importance of better understanding of the dynamics and transmission routes of the expelled virus-laden droplets or aerosols, which are largely affected by complex flow interactions in human microenvironment.

scholarly journals Disease and the dynamics of extinction

2012 ◽  
Vol 367 (1604) ◽  
pp. 2828-2839 ◽  
Author(s):  
Hamish McCallum
Keyword(s):  
Infectious Diseases ◽  
Disease Transmission ◽  
Management Strategies ◽  
Host Density ◽  
Habitat Destruction ◽  
Broad Host Range ◽  
Tasmanian Devil ◽  
Management Options ◽  
Reservoir Species ◽  
Devil Facial Tumour Disease

Invading infectious diseases can, in theory, lead to the extinction of host populations, particularly if reservoir species are present or if disease transmission is frequency-dependent. The number of historic or prehistoric extinctions that can unequivocally be attributed to infectious disease is relatively small, but gathering firm evidence in retrospect is extremely difficult. Amphibian chytridiomycosis and Tasmanian devil facial tumour disease (DFTD) are two very different infectious diseases that are currently threatening to cause extinctions in Australia. These provide an unusual opportunity to investigate the processes of disease-induced extinction and possible management strategies. Both diseases are apparently recent in origin. Tasmanian DFTD is entirely host-specific but potentially able to cause extinction because transmission depends weakly, if at all, on host density. Amphibian chytridiomycosis has a broad host range but is highly pathogenic only to some populations of some species. At present, both diseases can only be managed by attempting to isolate individuals or populations from disease. Management options to accelerate the process of evolution of host resistance or tolerance are being investigated in both cases. Anthropogenic changes including movement of diseases and hosts, habitat destruction and fragmentation and climate change are likely to increase emerging disease threats to biodiversity and it is critical to further develop strategies to manage these threats.

The zoonotic potential of bat-borne coronaviruses

2020 ◽  
Vol 4 (4) ◽  
pp. 365-381
Author(s):  
Ny Anjara Fifi Ravelomanantsoa ◽  
Sarah Guth ◽  
Angelo Andrianiaina ◽  
Santino Andry ◽  
Anecia Gentles ◽  
...  
Keyword(s):  
Genetic Material ◽  
Field Research ◽  
Sympatric Species ◽  
Animal Origin ◽  
Mammalian Host ◽  
Past Century ◽  
The Past ◽  
Novel Host ◽  
Horseshoe Bat ◽  
Human Infections

Seven zoonoses — human infections of animal origin — have emerged from the Coronaviridae family in the past century, including three viruses responsible for significant human mortality (SARS-CoV, MERS-CoV, and SARS-CoV-2) in the past twenty years alone. These three viruses, in addition to two older CoV zoonoses (HCoV-229E and HCoV-NL63) are believed to be originally derived from wild bat reservoir species. We review the molecular biology of the bat-derived Alpha- and Betacoronavirus genera, highlighting features that contribute to their potential for cross-species emergence, including the use of well-conserved mammalian host cell machinery for cell entry and a unique capacity for adaptation to novel host environments after host switching. The adaptive capacity of coronaviruses largely results from their large genomes, which reduce the risk of deleterious mutational errors and facilitate range-expanding recombination events by offering heightened redundancy in essential genetic material. Large CoV genomes are made possible by the unique proofreading capacity encoded for their RNA-dependent polymerase. We find that bat-borne SARS-related coronaviruses in the subgenus Sarbecovirus, the source clade for SARS-CoV and SARS-CoV-2, present a particularly poignant pandemic threat, due to the extraordinary viral genetic diversity represented among several sympatric species of their horseshoe bat hosts. To date, Sarbecovirus surveillance has been almost entirely restricted to China. More vigorous field research efforts tracking the circulation of Sarbecoviruses specifically and Betacoronaviruses more generally is needed across a broader global range if we are to avoid future repeats of the COVID-19 pandemic.

Perbedaan Metode Three Compartement Sink dengan Air Panas dan Larutan Klorin terhadap Angka Kuman Alat Makan di RSU Queen Latifa

2017 ◽  
Vol 19 (2) ◽  
pp. 126-130
Author(s):  
Rifatun Hasanah ◽  
Setyowati Setyowati ◽  
Noor Tifauzah
Keyword(s):  
Infectious Diseases ◽  
Confidence Level ◽  
Disease Transmission ◽  
T Test ◽  
Hot Water ◽  
Independent Test ◽  
The Difference ◽  
Hospital Use

Background:One of the efforts in preventing congenital food disease is by washing the cutlery perfectly. The cutlery used by patients with infectious diseases should be noted more, because it has a risk in disease transmission through cutlery. The process of washing the cutlery for infected patients in Queen Latifa Hospital use three compartement sink method with hot water, while the three compartement sink method with clorine solvent has never been tested. Purpose: Research was to determine the difference in the number of germs in the tool was washed using three compartement sink method with hot water and with clorine solvent. Method:Types of research is experiment with rancangan percobaan acak kelompok (RAK). The object of this research is 4 plates and 4 bowls. The number of experimental units in this research were 2 treatments x 2 cutlery x 2 checks x 2 reapetitions = 16 experimental units. The analysis used independent t-test with 95% confidence level. Result :The average number of germs in the cutlery washed using the three compartment sink method with hot water was 1 x 101 cfu / cm2, whereas with chlorine solvent is 0.2 cfu / cm2. Independent test t-test shows p = 0.049 which means the hypothesis is accepted. onclusion : There are differences in the number of germs in the washing cutlery using the three compartment sink method with hot water and with chlorine solvent.   Keywords: number of germs, cutlery, three compartment sink

Perbedaan Metode Three Compartement Sink dengan Air Panas dan Larutan Klorin terhadap Angka Kuman Alat Makan di RSU Queen Latifa

2017 ◽  
Vol 19 (2) ◽  
pp. 126
Author(s):  
Rifatun Hasanah ◽  
Setyowati Setyowati ◽  
Noor Tifauzah
Keyword(s):  
Infectious Diseases ◽  
Confidence Level ◽  
Disease Transmission ◽  
T Test ◽  
Hot Water ◽  
Independent Test ◽  
The Difference ◽  
Hospital Use

Background:One of the efforts in preventing congenital food disease is by washing the cutlery perfectly. The cutlery used by patients with infectious diseases should be noted more, because it has a risk in disease transmission through cutlery. The process of washing the cutlery for infected patients in Queen Latifa Hospital use three compartement sink method with hot water, while the three compartement sink method with clorine solvent has never been tested. Purpose: Research was to determine the difference in the number of germs in the tool was washed using three compartement sink method with hot water and with clorine solvent. Method:Types of research is experiment with rancangan percobaan acak kelompok (RAK). The object of this research is 4 plates and 4 bowls. The number of experimental units in this research were 2 treatments x 2 cutlery x 2 checks x 2 reapetitions = 16 experimental units. The analysis used independent t-test with 95% confidence level. Result :The average number of germs in the cutlery washed using the three compartment sink method with hot water was 1 x 101 cfu / cm2, whereas with chlorine solvent is 0.2 cfu / cm2. Independent test t-test shows p = 0.049 which means the hypothesis is accepted. Conclusion : There are differences in the number of germs in the washing cutlery using the three compartment sink method with hot water and with chlorine solvent.

Spatial-temporal transmission dynamics and control of infectious diseases: Ebola virus disease (EVD) as a case study

2018 ◽  
Author(s):  
Cécile Viboud ◽  
Hélène Broutin ◽  
Gerardo Chowell
Keyword(s):  
Infectious Diseases ◽  
Disease Transmission ◽  
Ebola Virus ◽  
Temporal Dynamics ◽  
Virus Disease ◽  
Spatial Dynamics ◽  
Childhood Diseases ◽  
Middle Income ◽  
Theoretical Concepts ◽  
Dynamics And Control

Disentangling the spatial-temporal dynamics of infectious disease transmission is important to address issues of disease persistence, epidemic growth and optimal control. In this chapter, we review key concepts relating to the spatial-temporal dynamics of infectious diseases in meta-populations, whereby geographically separate subpopulations are connected by migration or mobility rates. We review the dynamics of colonization, persistence and extinction of emerging and recurrent pathogens in meta-populations; the role of demographic and environmental factors; and geographic heterogeneity in epidemic growth rate. We illustrate theoretical concepts by reviewing the spatial dynamics of childhood diseases and other acute infections in low- and middle-income countries, and provide a detailed description of the spatial-temporal dynamics of the 2014–16 Ebola epidemic in West Africa. We further discuss how increased availability of empirical data and recent methodological developments provide a deeper mechanistic understanding of transmission processes in space and time, and make recommendations for future work.

Communicable and Other Infectious Diseases

2020 ◽  
Author(s):  
Markus Frischhut
Keyword(s):  
Public Health ◽  
European Union ◽  
Infectious Diseases ◽  
Disease Transmission ◽  
Eu Law ◽  
The European Union ◽  
Ethical Perspective ◽  
Health Measures ◽  
Environment Agency ◽  
And Control

This chapter discusses the most important features of EU law on infectious diseases. Communicable diseases not only cross borders, they also often require measures that cross different areas of policy because of different vectors for disease transmission. The relevant EU law cannot be attributed to one sectoral policy only, and thus various EU agencies participate in protecting public health. The key agency is the European Centre for Disease Prevention and Control. Other important agencies include the European Environment Agency; European Food Safety Authority; and the Consumers, Health, Agriculture and Food Executive Agency. However, while integration at the EU level has facilitated protection of the public's health, it also has created potential conflicts among the different objectives of the European Union. The internal market promotes the free movement of products, but public health measures can require restrictions of trade. Other conflicts can arise if protective public health measures conflict with individual human rights. The chapter then considers risk assessment and the different tools of risk management used in dealing with the challenges of infectious diseases. It also turns to the external and ethical perspective and the role the European Union takes in global health.

scholarly journals Urban Vulnerability Assessment for Pandemic Surveillance—The COVID-19 Case in Bogotá, Colombia

2021 ◽  
Vol 13 (6) ◽  
pp. 3402
Author(s):  
Jeisson Prieto ◽  
Rafael Malagón ◽  
Jonatan Gomez ◽  
Elizabeth León
Keyword(s):  
Vulnerability Assessment ◽  
Disease Transmission ◽  
Urban Areas ◽  
A Priori ◽  
Vulnerability Index ◽  
Past Century ◽  
Vulnerability Factors ◽  
Early Assessment ◽  
Global Citizens ◽  
Urban Vulnerability

A pandemic devastates the lives of global citizens and causes significant economic, social, and political disruption. Evidence suggests that the likelihood of pandemics has increased over the past century because of increased global travel and integration, urbanization, and changes in land use with a profound affectation of society–nature metabolism. Further, evidence concerning the urban character of the pandemic has underlined the role of cities in disease transmission. An early assessment of the severity of infection and transmissibility can help quantify the pandemic potential and prioritize surveillance to control highly vulnerable urban areas in pandemics. In this paper, an Urban Vulnerability Assessment (UVA) methodology is proposed. UVA investigates various vulnerability factors related to pandemics to assess the vulnerability in urban areas. A vulnerability index is constructed by the aggregation of multiple vulnerability factors computed on each urban area (i.e., urban density, poverty index, informal labor, transmission routes). This methodology is useful in a-priori evaluation and development of policies and programs aimed at reducing disaster risk (DRR) at different scales (i.e., addressing urban vulnerability at national, regional, and provincial scales), under diverse scenarios of resources scarcity (i.e., short and long-term actions), and for different audiences (i.e., the general public, policy-makers, international organizations). The applicability of UVA is shown by the identification of high vulnerable areas based on publicly available data where surveillance should be prioritized in the COVID-19 pandemic in Bogotá, Colombia.

scholarly journals Dietary Intake, Nutritional Adequacy, and Food Sources of Protein and Relationships with Personal and Family Factors in Spanish Children Aged One to < 10 Years: Findings of the EsNuPI Study

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1062
Author(s):  
Casandra Madrigal ◽  
María José Soto-Méndez ◽  
Ángela Hernández-Ruiz ◽  
Teresa Valero ◽  
Federico Lara Villoslada ◽  
...  
Keyword(s):  
Dietary Protein ◽  
Total Protein ◽  
Dairy Products ◽  
Protein Intake ◽  
Meat Products ◽  
Food Sources ◽  
Animal Origin ◽  
Total Protein Intake ◽  
Fish And Shellfish ◽  
Milk And Dairy Products

Diet in the first years of life is an important factor in growth and development. Dietary protein is a critical macronutrient that provides both essential and nonessential amino acids required for sustaining all body functions and procedures, providing the structural basis to maintain life and healthy development and growth in children. In this study, our aim was to describe the total protein intake, type and food sources of protein, the adequacy to the Population Reference Intake (PRI) for protein by the European Food Safety Authority (EFSA), and the Recommended Dietary Allowance (RDA) by the Institute of Medicine (IoM). Furthermore, we analyzed whether the consumption of dairy products (including regular milk, dairy products, or adapted milk formulas) is associated with nutrient adequacy and the contribution of protein to diet and whole dietary profile in the two cohorts of the EsNuPI (in English, Nutritional Study in the Spanish Pediatric Population) study; one cohort was representative of the Spanish population from one to < 10 years old (n = 707) (Spanish reference cohort, SRS) who reported consuming all kinds of milk and one was a cohort of the same age who reported consuming adapted milk over the last year (including follow-on formula, growing up milk, toddler’s milk, and enriched and fortified milks) (n = 741) (adapted milk consumers cohort, AMS). The children of both cohorts had a high contribution from protein to total energy intake (16.79% SRS and 15.63% AMS) and a high total protein intake (60.89 g/day SRS and 53.43 g/day AMS). We observed that protein intake in Spanish children aged one to < 10 years old was above the European and international recommendations, as well as the recommended percentages for energy intakes. The main protein sources were milk and dairy products (28% SRS and 29% AMS) and meat and meat products (27% SRS and 26% AMS), followed by cereals (16% SRS and 15% AMS), fish and shellfish (8% in both cohorts), eggs (5% SRS and 6% AMS), and legumes (4% in both cohorts). In our study population, protein intake was mainly from an animal origin (meat and meat products, milk and dairy products, fish and shellfish, and eggs) rather than from a plant origin (cereals and legumes). Future studies should investigate the long-term effect of dietary protein in early childhood on growth and body composition, and whether high protein intake affects health later in life.

scholarly journals China and the global search for health security: history, vaccines, and governance

2021 ◽  
Author(s):  
Daojiong Zha
Keyword(s):  
Global Health ◽  
Final Section ◽  
Analytical Framework ◽  
Global Search ◽  
Effective Control ◽  
Past Century ◽  
Health Governance ◽  
Health Security ◽  
Core Elements ◽  
History Of

AbstractChina is a key player, not just an actor, in the global search for health security. Reiteration of this point is useful for International Relations studies, which often portray China as a factor to contend with, especially given the background of the country as the first to report the outbreak of the COVID-19 pandemic. This paper adopts an analytical framework developed through a summary of routines in Chinese engagement in global health from a practitioner’s perspective: aid, interdependence, governance and knowledge. These are the core elements in a country’s pursuit of engagement with the rest of the world. After the introduction, the second section of the paper reviews contributions from China in the history of global plague control over the past century. The third section discusses structural issues affecting access to vaccines, which are essential for bringing COVID-19 under effective control. The fourth section identifies a number of challenges China is facing in global health governance. The final section offers a few concluding thoughts, reiterating the nature of interdependence in the global search for enhancement of health security.

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