Secular trends in the prevalence of major and subthreshold depression among 55–64-year olds over 20 years

2017 ◽  
Vol 48 (11) ◽  
pp. 1824-1834 ◽  
Author(s):  
Hans W. Jeuring ◽  
Hannie C. Comijs ◽  
Dorly J. H. Deeg ◽  
Max L. Stek ◽  
Martijn Huisman ◽  
...  
Keyword(s):  
Multinomial Logistic Regression ◽  
Functional Limitations ◽  
Population Based ◽  
Secular Trends ◽  
Subthreshold Depression ◽  
Birth Cohorts ◽  
Screening Design ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Psychosocial Conditions

AbstractBackgroundStudying secular trends in the exposure to risk and protective factors of depression and whether these trends are associated with secular trends in the prevalence of depression is important to estimate future healthcare demands and to identify targets for prevention.MethodsThree birth cohorts of 55–64-year olds from the population-based Longitudinal Aging Study Amsterdam were examined using identical methods in 1992 (n = 944), 2002 (n = 964) and 2012 (n = 957). A two-stage screening design was used to identify subthreshold depression (SUBD) and major depressive disorder (MDD). Multinomial logistic regression analyses were used to identify secular trends in depression prevalence and to identify factors from the biopsychosocial domains of functioning that were associated with these trends.ResultsCompared with 1992, MDD became more prevalent in 2002 (OR 1.90, 95% CI 1.10–3.28, p = 0.022) and 2012 (OR 1.80, 95% CI 1.03–3.14, p = 0.039). This was largely attributable to an increase in the prevalence of chronic diseases and functional limitations. Socioeconomic and psychosocial improvements, including an increase in labor market participation, social support and mastery, hampered MDD rates to rise more and were also associated with a 32% decline of SUBD-rates in 2012 as compared with 2002 (OR 0.68, 95% CI 0.48–0.96, p = 0.03).ConclusionsAmong late middle-aged adults, there is a substantial net increase of MDD, which is associated with deteriorating physical health. If morbidity and disability continue to increase, a further expansion of MDD rates may be expected. Improving socioeconomic and psychosocial conditions may benefit public health, as these factors were protective against a higher prevalence of both MDD and SUBD.

scholarly journals Psychosocial and Health-Related Factors Associated With Discordance Between 13-Year Trajectories of Self-Reported Functional Limitations and Performance-Based Physical Functioning in Old Age

2019 ◽  
Vol 32 (9) ◽  
pp. 1084-1097
Author(s):  
Almar A. L. Kok ◽  
Marieke J. Henstra ◽  
Nathalie van der Velde ◽  
Didi Rhebergen ◽  
Natasja M. van Schoor
Keyword(s):  
Physical Functioning ◽  
Latent Class ◽  
Multinomial Logistic Regression ◽  
Functional Limitations ◽  
Population Based ◽  
Related Factors ◽  
Factors Associated ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
And Performance

Objective: The objective of this study was to examine correlates of discordance between 13-year trajectories of self-reported functional limitations and performance-based physical functioning in older adults. Method: We included 2,135 participants from the population-based Longitudinal Aging Study Amsterdam, the Netherlands, followed across 1995-2008. Self-reported functional limitations included six (instrumental) activities of daily living. Performance-based functioning was a composite of four tests. We used latent class growth analysis and multinomial logistic regression to examine discordance and its correlates. Results: Patterns of discordance and concordance (41% concordance, 46% “overestimation” of daily functioning, 13% “underestimation”) appeared to be persistent over 13 years. Older age, male sex, cognitive impairment, absence of pain, and light alcohol use were associated with overestimation. Younger age, female sex, and lower self-rated health were associated with underestimation. Discussion: Factors associated with overestimation partly differ from those associated with underestimation. Factors that are highly stable over time are particularly good indicators of persistent discordance.

The long-term outcome of subthreshold depression in later life

2016 ◽  
Vol 46 (13) ◽  
pp. 2855-2865 ◽  
Author(s):  
H. W. Jeuring ◽  
M. Huisman ◽  
H. C. Comijs ◽  
M. L. Stek ◽  
A. T. F. Beekman
Keyword(s):  
At Risk ◽  
High Body Mass Index ◽  
Later Life ◽  
Subthreshold Depression ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Screening Design ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study

BackgroundSubthreshold depression (SUBD) in later life is common and important as prodromal state and prominent risk factor in the development of major depressive disorder (MDD). Indicated prevention can reduce the incidence of MDD among people with SUBD substantially, but needs to be targeted to those that are truly at risk of developing MDD.MethodN = 341 eligible participants with SUBD were included from the first (1992/1993), second (1995/1996) and third (1998/1999) cycle from the Longitudinal Aging Study Amsterdam (LASA) by using a two-stage screening design. LASA is an ongoing prospective cohort study in The Netherlands among the older population (55–85 years). At baseline (1992/1993) N = 3107 participants were interviewed and follow-up cycles were conducted every 3 years until 2008/2009, resulting in maximal 17 years of observational period. The proportion of people that developed MDD, remained SUBD, or recovered from SUBD was measured and Cox proportional regression analyses were performed to investigate 29 putative predictors of MDD and recovery from SUBD.ResultsN = 153 (44.9%) recovered from SUBD, N = 138 (40.5%) remained chronically SUBD, and N = 50 (14.7%) developed MDD (incidence rate 15.1/1000 person-years). Women, high neuroticism, more chronic diseases, high body mass index, smoking and less social support predicted conversion to MDD. Men, low neuroticism and absence of pain predicted recovery from SUBD.ConclusionsAlthough older people with SUBD are clearly at risk of developing MDD, the majority did not, even after a long and thorough follow-up. Given the risk factors that were uncovered, targeting and prevention of MDD in those at very high risk is feasible.

scholarly journals Frailty Changes Predict Mortality in 4 Longitudinal Studies of Aging

2020 ◽  
Author(s):  
Erwin Stolz ◽  
Emiel O Hoogendijk ◽  
Hannes Mayerl ◽  
Wolfgang Freidl
Keyword(s):  
Mortality Risk ◽  
Clinical Decision Making ◽  
Frailty Index ◽  
Credible Interval ◽  
Clinical Decision ◽  
Population Based ◽  
Time To Event Data ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Longitudinal Aging Study

Abstract Background Baseline frailty index (FI) values have been shown to predict mortality among older adults, but little is known about the effects of changes in FI on mortality. Methods In a coordinated approach, we analyzed data from 4 population-based cohorts: the Health and Retirement Study (HRS), the Survey of Health, Ageing and Retirement in Europe (SHARE), the English Longitudinal Survey of Ageing (ELSA), and the Longitudinal Aging Study Amsterdam (LASA), comprising a total of 24 961 respondents (65+), 95 897 observations, up to 9 repeated FI assessments, and up to 23 years of mortality follow-up. The effect of time-varying FI on mortality was modeled with joint regression models for longitudinal and time-to-event data. Results Differences (of 0.01) in current FI levels (hazard ratio [HR] = 1.04, 95% credible interval [CI] = 1.03–1.05) and baseline FI levels (HR = 1.03, 95% CI = 1.03–1.05) were consistently associated with mortality across studies. Importantly, individuals with steeper FI growth also had a higher mortality risk: An increase in annual FI growth by 0.01 was associated with an increased mortality risk of HR = 1.56 (95% CI = 1.49–1.63) in HRS, HR = 1.24 (95% CI = 1.13–1.35) in SHARE, HR = 1.40 (95% CI = 1.25–1.52) in ELSA, and HR = 1.71 (95% CI = 1.46–2.01) in LASA. Conclusions FI changes predicted mortality independently of baseline FI differences. Repeated assessment of frailty and individual’s frailty trajectory could provide a means to anticipate further health deterioration and mortality and could thus support clinical decision making.

scholarly journals Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals

2011 ◽  
Vol 165 (4) ◽  
pp. 545-554 ◽  
Author(s):  
Renate T de Jongh ◽  
Paul Lips ◽  
Natasja M van Schoor ◽  
Kelly J Rijs ◽  
Dorly J H Deeg ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Subclinical Hypothyroidism ◽  
Population Based ◽  
Thyroid Disorders ◽  
Older Individuals ◽  
Cross Sectional ◽  
Thyroid Medication ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Subclinical Thyroid Disorders

ObjectiveTo what extent endogenous subclinical thyroid disorders contribute to impaired physical and cognitive function, depression, and mortality in older individuals remains a matter of debate.DesignA population-based, prospective cohort of the Longitudinal Aging Study Amsterdam.MethodsTSH and, if necessary, thyroxine and triiodothyronine levels were measured in individuals aged 65 years or older. Participants were classified according to clinical categories of thyroid function. Participants with overt thyroid disease or use of thyroid medication were excluded, leaving 1219 participants for analyses. Outcome measures were physical and cognitive function, depressive symptoms (cross-sectional), and mortality (longitudinal)ResultsSixty-four (5.3%) individuals had subclinical hypothyroidism and 34 (2.8%) individuals had subclinical hyperthyroidism. Compared with euthyroidism (n=1121), subclinical hypo-, and hyper-thyroidism were not significantly associated with impairment of physical or cognitive function, or depression. On the contrary, participants with subclinical hypothyroidism did less often report more than one activity limitation (odds ratio 0.44, 95% confidence interval (CI) 0.22–0.86). After a median follow-up of 10.7 years, 601 participants were deceased. Subclinical hypo- and hyper-thyroidism were not associated with increased overall mortality risk (hazard ratio 0.89, 95% CI 0.59–1.35 and 0.69, 95% CI 0.40–1.20 respectively).ConclusionsThis study does not support disadvantageous effects of subclinical thyroid disorders on physical or cognitive function, depression, or mortality in an older population.

scholarly journals Serum IGF1, metabolic syndrome, and incident cardiovascular disease in older people: a population-based study

2013 ◽  
Vol 168 (3) ◽  
pp. 393-401 ◽  
Author(s):  
Christa C van Bunderen ◽  
Mirjam M Oosterwerff ◽  
Natasja M van Schoor ◽  
Dorly J H Deeg ◽  
Paul Lips ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Older People ◽  
Population Based ◽  
Mortality Data ◽  
The Metabolic Syndrome ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Definition Of ◽  
Relationship Of ◽  
The Relationship

ObjectiveHigh as well as low levels of IGF1 have been associated with cardiovascular diseases (CVD). The relationship of IGF1 with (components of) the metabolic syndrome could help to clarify this controversy. The aims of this study were: i) to investigate the association of IGF1 concentration with prevalent (components of) the metabolic syndrome; and ii) to examine the role of (components of) the metabolic syndrome in the relationship between IGF1 and incident CVD during 11 years of follow-up.MethodsData were used from the Longitudinal Aging Study Amsterdam, a cohort study in a representative sample of the Dutch older population (≥65 years). Data were available in 1258 subjects. Metabolic syndrome was determined using the definition of the US National Cholesterol Education Program Adult Treatment Panel III. CVD were ascertained by self-reports and mortality data.ResultsLevels of IGF1 in the fourth quintile were associated with prevalent metabolic syndrome compared with the lowest quintile (odds ratio: 1.59, 95% confidence interval (CI) 1.09–2.33). The middle up to the highest quintile of IGF1 was positively associated with high triglycerides in women. Metabolic syndrome was not a mediator in the U-shaped relationship of IGF1 with CVD. Both subjects without the metabolic syndrome and low IGF1 levels (hazard ratio (HR) 1.75, 95% CI 1.12–2.71) and subjects with the metabolic syndrome and high IGF1 levels (HR 2.28, 95% CI 1.21–4.28) demonstrated increased risks of CVD.ConclusionsIn older people, high-normal IGF1 levels are associated with prevalent metabolic syndrome and high triglycerides. Furthermore, this study suggests the presence of different pathomechanisms for both low and high IGF1 levels and incident CVD.

scholarly journals Self-Reported Impact of the COVID-19 Pandemic on Nutrition and Physical Activity Behaviour in Dutch Older Adults Living Independently

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3708 ◽  
Author(s):  
Marjolein Visser ◽  
Laura A. Schaap ◽  
Hanneke A. H. Wijnhoven
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Negative Impact ◽  
Functional Limitations ◽  
Physical Activity Behaviour ◽  
Household Composition ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Nutrition And Physical Activity ◽  
Activity Behaviour

The aim was to explore the self-reported impact of the COVID-19 pandemic on nutrition and physical activity behaviour in Dutch older adults and to identify subgroups most susceptible to this impact. Participants (N = 1119, aged 62–98 y, 52.8% female) of the Longitudinal Aging Study Amsterdam living independently completed a COVID-19 questionnaire. Questions on diagnosis, quarantine and hospitalization were asked, as well as impact of the pandemic on ten nutrition and physical activity behaviours. Associations of pre-COVID-19 assessed characteristics (age, sex, region, household composition, self-rated health, BMI, physical activity, functional limitations) with reported impact were tested using logistic regression analyses. About half of the sample (48.3–54.3%) reported a decrease in physical activity and exercise due to the pandemic. An impact on nutritional behaviour predisposing to overnutrition (e.g., snacking more) was reported by 20.3–32.4%. In contrast, 6.9–15.1% reported an impact on behaviour predisposing to undernutrition (e.g., skipping warm meals). Those who had been in quarantine (n = 123) more often reported a negative impact. Subgroups with higher risk of impact could be identified. This study shows a negative impact of the COVID-19 pandemic on nutrition and physical activity behaviour of many older adults, which may increase their risk of malnutrition, frailty, sarcopenia and disability.

scholarly journals The effects of environmental context and personal resources on depressive symptomatology in older age: a test of the Lawton model

2000 ◽  
Vol 20 (2) ◽  
pp. 183-202 ◽  
Author(s):  
C. P. M. KNIPSCHEER ◽  
M. I. BROESE VAN GROENOU ◽  
G. J. F. LEENE ◽  
A. T. F. BEEKMAN ◽  
D. J. H. DEEG
Keyword(s):  
Older Adults ◽  
Functional Status ◽  
Depressive Symptomatology ◽  
Functional Limitations ◽  
Strong Association ◽  
Empirical Support ◽  
Hierarchical Regression ◽  
Proactive Behaviour ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study

This study examines the environmental and psychosocial determinants of depression in older adults. Based on Lawton's environmental docility thesis, the question is posed: is the strong association between functional limitations and depressive symptomatology affected when environmental conditions, objective and subjective efficacy, and docile or proactive behaviour are taken into account. Data were used from LASA (the Longitudinal Aging Study Amsterdam), a national survey of the population between 55 and 85 years of age, stratified by age and sex. Hierarchical regression analyses were performed on the data of 2,981 respondents. Empirical support was found for the extended Lawton model, including both environmental, efficacy and behavioural factors. In particular, living in a more urbanised area, not being able to perform heavy household tasks, having a low self-efficacy, not feeling safe, receiving help from others and having few social contacts within the neighbourhood, increase depressive symptoms in general but, in particular, when combined with lower functional status. It is concluded that both being able and feeling able to influence one's environment increases proactive behaviour and decreases depressive symptomatology in older adults with low functional status.

scholarly journals Three-year trajectories in Functional Limitations and Cognitive Decline among Dutch 75+ year olds, using nine-month intervals

2021 ◽  
Author(s):  
Maura Gardeniers ◽  
Marjolein Broese van Groenou ◽  
Erik Jan Meijboom ◽  
Martijn Huisman
Keyword(s):  
Cognitive Functioning ◽  
Physical Functioning ◽  
Functional Limitations ◽  
Future Research ◽  
Short Version ◽  
Time Intervals ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Mini Mental Status Examination ◽  
Longitudinal Aging Study

Abstract Background Using longitudinal panel data, the aim of this study was to first identify three-year trajectories in cognitive and physical functioning among Dutch older adults. And second, to identify which main characteristics were associated with these trajectories. Methods Group-based Trajectory Modelling with mortality jointly estimated was used to identify trajectories, using a scale composed of 6 Activities of Daily Living (ADL) as a measure of physical functioning, and a short version of the mini mental status examination (sMMSE) or the IQCODE as a measure of cognitive functioning. Data came from 574 Dutch adults aged 75+, collected in five nine-month measurement waves conducted between 2015 and 2018 for the Longitudinal Aging Study Amsterdam. Results Five trajectories in physical functioning were identified: ‘high’, ‘moderate’, ‘steeply declining’, ‘gradually declining’, and ‘continuously low’. People that were older, lower educated, living in an institution, or suffered from diabetes or cerebrovascular accidents were more likely to follow a low or declining physical trajectory. For cognitive functioning four trajectories were identified: a ‘high’, ‘moderate’, ‘declining’, and ‘low’ trajectory. Old age, low education, living in an institution, and heart- and lung diseases were associated with continuously low or declining cognitive functioning. Mortality risks were highest among those experiencing the continuously low functioning trajectories. Conclusions This study identified trajectories comparable to previous studies that used longer time intervals, showing the consistent presence of heterogeneity in both physical and cognitive trajectories. Co-modelling mortality resulted in bigger group sizes for the more adverse trajectories. The favourable trajectories, containing most of the participants, were mostly characterized by absence of disease, whereas trajectories showing decline did not share a common indicator. Specific chronic diseases were associated with different rates of decline, however there was no factor that was associated with all declining trajectories; future research could focus on finding such an indicator.

scholarly journals Balance in social support exchange and discontinuation of young-old’s personal relationships in three birth cohorts

2019 ◽  
Vol 36 (11-12) ◽  
pp. 3371-3388
Author(s):  
Bianca Suanet ◽  
Theo G. van Tilburg
Keyword(s):  
Social Support ◽  
Emotional Support ◽  
Coming Of Age ◽  
Personal Relationships ◽  
Birth Cohorts ◽  
Cohort Differences ◽  
Longitudinal Aging Study Amsterdam ◽  
Aging Study ◽  
Societal Changes ◽  
Early Cohort

Societal changes and an increase in personal resources are likely to have an impact on the personal relationships of cohorts coming of age. We expect that, in recent times, (1) relationships more often strike a balance in exchanged instrumental and emotional support and (2) relationships are discontinued more often when there is no balance in exchanged instrumental and emotional support, particularly among nonkin. We compare three birth cohorts from the Longitudinal Aging Study Amsterdam, aged 55–64 years at baseline (early cohort: born in 1928–1937, interviewed in 1992; middle cohort: born in 1938–1947, interviewed in 2002; late cohort: born in 1948–1957, interviewed in 2012). The results indicate that, in the middle and late birth cohorts, personal relationships are more often characterized by a balance in social support exchanges compared to the early cohort. No cohort differences in the effect of balance on relationship discontinuation are observed. The results suggest increased opportunities and preferences of young-olds to maintain balance in their personal relationships.

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