scholarly journals Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers

2019 ◽  
Vol 50 (5) ◽  
pp. 737-745 ◽  
Author(s):  
Karmel W. Choi ◽  
Chia-Yen Chen ◽  
Robert J. Ursano ◽  
Xiaoying Sun ◽  
Sonia Jain ◽  
...  
Keyword(s):  
Protective Factors ◽  
Prospective Study ◽  
Large Scale ◽  
Protective Factor ◽  
Polygenic Risk ◽  
Us Army ◽  
Combat Deployment ◽  
Army Soldiers ◽  
Trait Resilience ◽  
Unit Cohesion

AbstractBackgroundWhereas genetic susceptibility increases the risk for major depressive disorder (MDD), non-genetic protective factors may mitigate this risk. In a large-scale prospective study of US Army soldiers, we examined whether trait resilience and/or unit cohesion could protect against the onset of MDD following combat deployment, even in soldiers at high polygenic risk.MethodsData were analyzed from 3079 soldiers of European ancestry assessed before and after their deployment to Afghanistan. Incident MDD was defined as no MDD episode at pre-deployment, followed by a MDD episode following deployment. Polygenic risk scores were constructed from a large-scale genome-wide association study of major depression. We first examined the main effects of the MDD PRS and each protective factor on incident MDD. We then tested the effects of each protective factor on incident MDD across strata of polygenic risk.ResultsPolygenic risk showed a dose–response relationship to depression, such that soldiers at high polygenic risk had greatest odds for incident MDD. Both unit cohesion and trait resilience were prospectively associated with reduced risk for incident MDD. Notably, the protective effect of unit cohesion persisted even in soldiers at highest polygenic risk.ConclusionsPolygenic risk was associated with new-onset MDD in deployed soldiers. However, unit cohesion – an index of perceived support and morale – was protective against incident MDD even among those at highest genetic risk, and may represent a potent target for promoting resilience in vulnerable soldiers. Findings illustrate the value of combining genomic and environmental data in a prospective design to identify robust protective factors for mental health.

scholarly journals Prospective Study of Polygenic Risk, Protective Factors, and Incident Depression Following Combat Deployment in US Army Soldiers

2018 ◽  
Author(s):  
Karmel W. Choi ◽  
Chia-Yen Chen ◽  
Robert J. Ursano ◽  
Xiaoying Sun ◽  
Sonia Jain ◽  
...  
Keyword(s):  
Protective Factors ◽  
Prospective Study ◽  
Protective Factor ◽  
European Ancestry ◽  
Polygenic Risk ◽  
Us Army ◽  
Combat Deployment ◽  
Army Soldiers ◽  
Trait Resilience ◽  
Unit Cohesion

AbstractBackgroundWhereas genetic susceptibility increases risk for major depressive disorder (MDD), non-genetic protective factors may mitigate this risk. In a large-scale prospective study of US Army soldiers, we examined whether trait resilience and/or unit cohesion could buffer against the onset of MDD following combat deployment, even in soldiers at high polygenic risk.MethodsData were analyzed from 4,182 soldiers of European ancestry assessed before and after their deployment to Afghanistan. Incident MDD was defined as no MDD episode at predeployment, followed by a MDD episode following deployment. Polygenic risk scores were constructed from the largest available MDD genome-wide association study. We first examined main effects of the MDD PRS and each protective factor on incident MDD. We then tested effects of each protective factor on incident MDD across strata of polygenic risk.ResultsPolygenic risk showed a dose-response relationship to depression, such that soldiers at high polygenic risk had greatest odds for incident MDD. Both unit cohesion and trait resilience were prospectively associated with reduced risk for incident MDD. Notably, the protective effect of unit cohesion persisted even in soldiers at highest polygenic risk.ConclusionsPolygenic risk was associated with new-onset MDD in deployed soldiers. However, unit cohesion—an index of perceived support and morale—was protective against incident MDD even among those at highest genetic risk, and may represent a potent target for promoting resilience in vulnerable soldiers. Findings illustrate the value of combining genomic and environmental data in a prospective design to identify robust protective factors for mental health.

A Descriptive Study of US Army Soldiers Referred to, Evaluated By And Enrolled In The Army Substance Abuse Program, 1988-2003

2006 ◽  
Author(s):  
Ilyssa E. Hollander ◽  
Nicole S. Bell ◽  
Margaret Phillips ◽  
Paul J. Amoroso ◽  
Les MacFarling
Keyword(s):  
Substance Abuse ◽  
Descriptive Study ◽  
Us Army ◽  
Substance Abuse Program ◽  
Army Soldiers

HARGA DIRI REMAJA DAN POLA ASUH ORANGTUA SEBAGAI FAKTOR PROTEKTIF IDE BUNUH DIRI

2019 ◽  
Vol 9 (3) ◽  
pp. 301-310
Author(s):  
Nirmala Fajar Pertiwi ◽  
Ice Yulia Wardani
Keyword(s):  
High School ◽  
Suicidal Ideation ◽  
Protective Factors ◽  
Correlation Coefficient ◽  
Parenting Style ◽  
Random Sampling ◽  
Protective Factor ◽  
Nursing Intervention ◽  
Self Esteem ◽  
Emotional Instability

Remaja yang tidak mampu menghadapi tekanan akan membawanya pada ketidakstabilan emosional dan cenderung melakukan berbagai perilaku berbahaya hingga bunuh diri. Bunuh diri memiliki faktor protektif berupa harga diri tinggi karena dapat memberikan kualitas psikologis positif. Faktor protektif ide bunuh diri lainnya yaitu pola asuh yang seimbang antara dimensi penerimaan dan pengendalian atau disebut pola asuh otoritatif. Penelitian ini bertujuan untuk mengetahui hubungan harga diri dan pola asuh orangtua dengan ide bunuh diri pada remaja SMA. Desain penelitian ini menggunakan deskriptif korelatif dan pendekatan secara chross-sectional. Penelitian ini memiliki responden sejumlah 322 remaja di SMA yang dipilih dengan teknik proportional random sampling. Terdapat hubungan yang kuat dan arah negatifantara harga diri dengan ide bunuh diri dengan koefisien korelasi -0,876, yang berarti bahwa semakin rendah harga diri yang dimiliki remaja maka semakin tinggi ide bunuh diri. Terdapat hubungan dengan kekuatan sedangdan arah negatif antara pola asuh orangtua dengan ide bunuh diri dengan koefisien korelasi -0,365, artinya apabila pola asuh orangtua mengarah pada otoritatif maka ide bunuh diri akan semakin rendah, dan sebaliknya apabila pola asuh orangtua mengarah pada otoritarian maka ide bunuh diri akan semakin tinggi. Penelitian ini diharapkan dapat meningkatkan intervensi keperawatan jiwa dalammengidentifikasi ide bunuh diri pada remaja, serta meningkatkan wawasan remaja dan guru terkait faktor protektif ide bunuh diri.   Kata kunci: faktor proteksi, harga diri,ide bunuh diri,dan pola asuh orangtua   SELF-SELF-PRICE AND PARENT'S PATTERN AS SELF-KILLING IDEAS PROTECTIVE FACTORS   ABSTRACT Teenagers who do not cope well under pressure will lead them to emotional instability and tend to perform a variety of malicious behavior or commit to suicide. Suicidial Ideation has protective factor such as high self esteem, because it can provide positive psychological qualities.Other protective factor is parenting style that contain balance between the dimensions of acceptance and control, also called authoritative. This study aims to determine the relationship of self-esteem and parenting Stylewith Suicidial Ideation in high school adolescents. This study used descriptive correlative and cross-sectional approach. This study has a number of 322 respondents, that are high school adolescents selected by proportional random sampling technique. There is strong relationshipwith negative directionbetween self-esteem with suicidal ideationand the correlation coefficient is -0,876, which means that the if adolescent’s self-esteem is lower so suicidal ideation will be higher. There is moderate relationshipwith negative direction between parenting style with suicidal ideation and the correlation coefficient is -0,365, which means that if parenting style is authoritative so suicidal ideation will be lower, and if parenting style is authoritarian so suicidal ideation will be higher.This study can be used to improve nursing intervention in identify suicidal ideation, and also to improve teenager’s and teacher’s knowledge about protective factors of suicidal ideation.   Keywords: parenting style, protective factor,self-esteem and suicidal ideation

Activities and risk factors associated with fall-related injuries among US Army soldiers

2020 ◽  
pp. bmjmilitary-2020-001564
Author(s):  
Raina D Brooks ◽  
T Grier ◽  
B H Jones ◽  
M C Chervak
Keyword(s):  
Risk Factors ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Physically Active ◽  
Us Army ◽  
Factors Associated ◽  
Younger Age ◽  
Near Falls ◽  
Independent Risk Factors ◽  
Army Soldiers

IntroductionFalls/near falls are the second leading cause of hospitalisation and outpatient visits among US Army soldiers. While numerous studies have evaluated fall-related or near fall-related injuries among elderly adults, few have evaluated this association among young adults. The objective of this study is to describe the characteristics and risk factors associated with fall-related or near fall-related injuries among male US Army soldiers.MethodsThis is a cross-sectional study of male US Army Airborne Division soldiers (n=5187). Electronic surveys captured demographic, lifestyle, physical training (PT), fitness and injury data during spring/summer of 2016. Multiple logistic regression was used to identify independent risk factors of fall-related or near fall-related injuries, adjusting for potential confounders.ResultsPrimary findings indicated that activities and risk factors associated with fall-related or near fall-related injuries among soldiers included younger age (≤35 years), holding a job that required minimal lifting activities, slower 2-mile run times and not running during personal PT.ConclusionsThe findings from this study suggest that male US Army soldiers and other physically active men may benefit from (1) obtaining and/or maintaining higher aerobic endurance and muscular strength, and (2) training focused on preventing fall-related injuries during PT, road marching and sports/recreational activities. Moreover, prevention strategies and education should further target younger soldiers (≤35 years old), as younger age is not modifiable.

Wireless parathyroid detection device using autofluorescence and smart glasses: A preliminary study

2021 ◽  
pp. 1-9
Author(s):  
Chang Hwan Ryu ◽  
Jungirl Seok ◽  
Yu Lim Choi ◽  
Seok-ki Kim ◽  
Yuh-Seog Jung ◽  
...  
Keyword(s):  
Prospective Study ◽  
Large Scale ◽  
Video Recording ◽  
Controlled Study ◽  
Autofluorescence Imaging ◽  
Agreement Rate ◽  
Smart Glasses ◽  
Practical Effect ◽  
Preliminary Study ◽  
Positive Agreement

BACKGROUND: Autofluorescence imaging technology has been utilized for preserving or identifying parathyroid glands (PTGs) during thyroid surgery. We developed a wireless PTGs detection device linked with smart glasses that allows for real-time video recording and screen switching according to the light source. OBJECTIVE: This study aimed to confirm the feasibility of the device and whether it would help preserve the PTG during the surgery. METHODS: This prospective study was conducted in 30 patients with 66 PTGs. The device’s agreement with the physician’s judgment was evaluated, and we determined how many PTGs were preserved from thyroidectomy. RESULTS: The positive agreement rate for PTGs detection between the surgeon and device was 70.9%. Inadvertent parathyroidectomy was identified in surgical specimens of 6 patients (20%). No PTG was removed when it was confirmed by the device (0/39). Of the 27 glands not detected by the device, there was inadvertent removal of 6 PTGs. CONCLUSIONS: PTGs can be preserved successfully when the detection of them by the device is consistent with the surgeon’s discretion. A large-scale controlled study is necessary to demonstrate the practical effect of this device on hypoparathyroidism after thyroidectomy.

Effects of Modified Foodservice Practices in Military Dining Facilities on Ad Libitum Nutritional Intake of US Army Soldiers

2013 ◽  
Vol 113 (7) ◽  
pp. 920-927 ◽  
Author(s):  
Aaron P. Crombie ◽  
LesLee K. Funderburk ◽  
Tracey J. Smith ◽  
Susan M. McGraw ◽  
Leila A. Walker ◽  
...  
Keyword(s):  
Nutritional Intake ◽  
Us Army ◽  
Ad Libitum ◽  
Army Soldiers

PERILAKU BERESIKO DAN FAKTOR PELINDUNG PENGGUNAAN TEMBAKAU SINTETIS PADA KOMUNITAS CJ

2021 ◽  
Vol 3 (2) ◽  
pp. 78-91
Author(s):  
Yunita Anggraeni ◽  
Sitti Muthia Maghfirah Massinai ◽  
Rahma Dilla Arnanda
Keyword(s):  
Protective Factors ◽  
Drug Users ◽  
Protective Factor ◽  
Risk And Protective Factors ◽  
Community Collaboration ◽  
Community Members ◽  
The Social ◽  
The Individual ◽  
Calming Effect ◽  
The Impact

ABSTRACTSynthetic tobacco is a type of drug produced from tobacco mixed with chemical liquids. Synthetic tobacco produces a calming effect, daydreaming, hallucinations, and unconsciousness. In some individuals there is resistance to chemicals, resulting in dizziness, vomiting and unconsciousness. The basic ingredients of tobacco make synthetic tobacco difficult to distinguish from ordinary tobacco. So that the impact on the prevention and eradication of drugs is increasingly difficult. The CJ community is a community of drug users who have used synthetic tobacco for 5 months. This study aimed to determine the risk and protective factors of synthetic tobacco use in the CJ community. This research was a qualitative study on the case of the CJ community with the direct involvement of researchers in the community. The result of the research was an analysis description of the risk and protective factors in the CJ community. Medically dangerous side effects have not been communicated to users in the CJ community. Awareness of the future and responsibility are protective factors that motivate community members to stop using drugs. This research showed that the use of synthetic tobacco type drugs can be more harmful to individuals and the environment. The impact on the individual physically and psychologically will affect the individual's difficulty in interacting with the social environment. There is a need for socialization and education that takes into account various aspects of society so that prevention can take place effectively. The results of the research can become the basis for providing intervention designs with community collaboration as agents of change.Key Word: Synthetic Tobacco, Risk Factor, Protective Factor, Drugs User ABSTRAKTembakau sintetis merupakan jenis narkoba yang dihasilkan dari tembakau yang dicampur dengan cairan kimia. Tembakau sintetis menghasilkan efek tenang, melamun, halusinasi, dan tidak sadarkan diri. Pada beberapa individu terdapat penolakan terhadap zat kimia, berakibat pusing, muntah dan tidak sadarkan diri. Bahan dasar tembakau membuat tembakau sintetis sulit dibedakan dengan tembakau biasa. Sehingga berdampak kepada pencegahan dan pemberantasan narkoba yang semakin sulit. Komunitas CJ merupakan komunitas pengguna narkoba yang sudah menggunakan tembakau sintetis selama 5 bulan. Penelitian ini bertujuan untuk mengetahui risk and protective factor penggunaan tembakau sintetis pada komunitas CJ. Penelitian ini merupakan studi kualitatif pada kasus komunitas CJ dengan keterlibatan langsung peneliti pada komunitas. Hasil penelitian berupa deskripsi analisis dari risk and protective factor pada komunitas CJ. Efek samping yang berbahaya secara medis belum tersosialisasikan kepada para pengguna di komunitas CJ. Kesadaran mengenai masa depan dan tanggung jawab menjadi faktor protektif yang memotivasi anggota komunitas untuk berhenti menggunakan narkoba. Penelitian ini menunjukan bahwa penggunaan narkoba jenis tembakau sintetis dapat lebih berbahaya bagi individu dan lingkungan. Dampak kepada individu secara fisik dan psikologis akan mempengaruhi kesulitan individu berinteraksi dengan lingkungan sosial. Perlu adanya sosialisasi dan edukasi yang memperhatikan berbagai aspek di masyarakat agar pencegahan dapat berlangsung dengan efektif. Hasil penelitian dapat menjadi landasan dalam memberikan rancangan intervensi dengan kolaborasi masyarakat sebagai agen perubahan.Kata Kunci: Tembakau Sintetis, Faktor Risiko, Faktor Protektif, Pengguna Narkoba

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