Prospective Study of Polygenic Risk, Protective Factors, and Incident Depression Following Combat Deployment in US Army Soldiers

AbstractBackgroundWhereas genetic susceptibility increases risk for major depressive disorder (MDD), non-genetic protective factors may mitigate this risk. In a large-scale prospective study of US Army soldiers, we examined whether trait resilience and/or unit cohesion could buffer against the onset of MDD following combat deployment, even in soldiers at high polygenic risk.MethodsData were analyzed from 4,182 soldiers of European ancestry assessed before and after their deployment to Afghanistan. Incident MDD was defined as no MDD episode at predeployment, followed by a MDD episode following deployment. Polygenic risk scores were constructed from the largest available MDD genome-wide association study. We first examined main effects of the MDD PRS and each protective factor on incident MDD. We then tested effects of each protective factor on incident MDD across strata of polygenic risk.ResultsPolygenic risk showed a dose-response relationship to depression, such that soldiers at high polygenic risk had greatest odds for incident MDD. Both unit cohesion and trait resilience were prospectively associated with reduced risk for incident MDD. Notably, the protective effect of unit cohesion persisted even in soldiers at highest polygenic risk.ConclusionsPolygenic risk was associated with new-onset MDD in deployed soldiers. However, unit cohesion—an index of perceived support and morale—was protective against incident MDD even among those at highest genetic risk, and may represent a potent target for promoting resilience in vulnerable soldiers. Findings illustrate the value of combining genomic and environmental data in a prospective design to identify robust protective factors for mental health.

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Prospective study of polygenic risk, protective factors, and incident depression following combat deployment in US Army soldiers

Psychological Medicine ◽

10.1017/s0033291719000527 ◽

2019 ◽

Vol 50 (5) ◽

pp. 737-745 ◽

Cited By ~ 3

Author(s):

Karmel W. Choi ◽

Chia-Yen Chen ◽

Robert J. Ursano ◽

Xiaoying Sun ◽

Sonia Jain ◽

...

Keyword(s):

Protective Factors ◽

Prospective Study ◽

Large Scale ◽

Protective Factor ◽

Polygenic Risk ◽

Us Army ◽

Combat Deployment ◽

Army Soldiers ◽

Trait Resilience ◽

Unit Cohesion

AbstractBackgroundWhereas genetic susceptibility increases the risk for major depressive disorder (MDD), non-genetic protective factors may mitigate this risk. In a large-scale prospective study of US Army soldiers, we examined whether trait resilience and/or unit cohesion could protect against the onset of MDD following combat deployment, even in soldiers at high polygenic risk.MethodsData were analyzed from 3079 soldiers of European ancestry assessed before and after their deployment to Afghanistan. Incident MDD was defined as no MDD episode at pre-deployment, followed by a MDD episode following deployment. Polygenic risk scores were constructed from a large-scale genome-wide association study of major depression. We first examined the main effects of the MDD PRS and each protective factor on incident MDD. We then tested the effects of each protective factor on incident MDD across strata of polygenic risk.ResultsPolygenic risk showed a dose–response relationship to depression, such that soldiers at high polygenic risk had greatest odds for incident MDD. Both unit cohesion and trait resilience were prospectively associated with reduced risk for incident MDD. Notably, the protective effect of unit cohesion persisted even in soldiers at highest polygenic risk.ConclusionsPolygenic risk was associated with new-onset MDD in deployed soldiers. However, unit cohesion – an index of perceived support and morale – was protective against incident MDD even among those at highest genetic risk, and may represent a potent target for promoting resilience in vulnerable soldiers. Findings illustrate the value of combining genomic and environmental data in a prospective design to identify robust protective factors for mental health.

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A Descriptive Study of US Army Soldiers Referred to, Evaluated By And Enrolled In The Army Substance Abuse Program, 1988-2003

PsycEXTRA Dataset ◽

10.1037/e574032006-001 ◽

2006 ◽

Author(s):

Ilyssa E. Hollander ◽

Nicole S. Bell ◽

Margaret Phillips ◽

Paul J. Amoroso ◽

Les MacFarling

Keyword(s):

Substance Abuse ◽

Descriptive Study ◽

Us Army ◽

Substance Abuse Program ◽

Army Soldiers

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HARGA DIRI REMAJA DAN POLA ASUH ORANGTUA SEBAGAI FAKTOR PROTEKTIF IDE BUNUH DIRI

Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal ◽

10.32583/pskm.9.3.2019.301-310 ◽

2019 ◽

Vol 9 (3) ◽

pp. 301-310

Author(s):

Nirmala Fajar Pertiwi ◽

Ice Yulia Wardani

Keyword(s):

High School ◽

Suicidal Ideation ◽

Protective Factors ◽

Correlation Coefficient ◽

Parenting Style ◽

Random Sampling ◽

Protective Factor ◽

Nursing Intervention ◽

Self Esteem ◽

Emotional Instability

Remaja yang tidak mampu menghadapi tekanan akan membawanya pada ketidakstabilan emosional dan cenderung melakukan berbagai perilaku berbahaya hingga bunuh diri. Bunuh diri memiliki faktor protektif berupa harga diri tinggi karena dapat memberikan kualitas psikologis positif. Faktor protektif ide bunuh diri lainnya yaitu pola asuh yang seimbang antara dimensi penerimaan dan pengendalian atau disebut pola asuh otoritatif. Penelitian ini bertujuan untuk mengetahui hubungan harga diri dan pola asuh orangtua dengan ide bunuh diri pada remaja SMA. Desain penelitian ini menggunakan deskriptif korelatif dan pendekatan secara chross-sectional. Penelitian ini memiliki responden sejumlah 322 remaja di SMA yang dipilih dengan teknik proportional random sampling. Terdapat hubungan yang kuat dan arah negatifantara harga diri dengan ide bunuh diri dengan koefisien korelasi -0,876, yang berarti bahwa semakin rendah harga diri yang dimiliki remaja maka semakin tinggi ide bunuh diri. Terdapat hubungan dengan kekuatan sedangdan arah negatif antara pola asuh orangtua dengan ide bunuh diri dengan koefisien korelasi -0,365, artinya apabila pola asuh orangtua mengarah pada otoritatif maka ide bunuh diri akan semakin rendah, dan sebaliknya apabila pola asuh orangtua mengarah pada otoritarian maka ide bunuh diri akan semakin tinggi. Penelitian ini diharapkan dapat meningkatkan intervensi keperawatan jiwa dalammengidentifikasi ide bunuh diri pada remaja, serta meningkatkan wawasan remaja dan guru terkait faktor protektif ide bunuh diri. Kata kunci: faktor proteksi, harga diri,ide bunuh diri,dan pola asuh orangtua SELF-SELF-PRICE AND PARENT'S PATTERN AS SELF-KILLING IDEAS PROTECTIVE FACTORS ABSTRACT Teenagers who do not cope well under pressure will lead them to emotional instability and tend to perform a variety of malicious behavior or commit to suicide. Suicidial Ideation has protective factor such as high self esteem, because it can provide positive psychological qualities.Other protective factor is parenting style that contain balance between the dimensions of acceptance and control, also called authoritative. This study aims to determine the relationship of self-esteem and parenting Stylewith Suicidial Ideation in high school adolescents. This study used descriptive correlative and cross-sectional approach. This study has a number of 322 respondents, that are high school adolescents selected by proportional random sampling technique. There is strong relationshipwith negative directionbetween self-esteem with suicidal ideationand the correlation coefficient is -0,876, which means that the if adolescent’s self-esteem is lower so suicidal ideation will be higher. There is moderate relationshipwith negative direction between parenting style with suicidal ideation and the correlation coefficient is -0,365, which means that if parenting style is authoritative so suicidal ideation will be lower, and if parenting style is authoritarian so suicidal ideation will be higher.This study can be used to improve nursing intervention in identify suicidal ideation, and also to improve teenager’s and teacher’s knowledge about protective factors of suicidal ideation. Keywords: parenting style, protective factor,self-esteem and suicidal ideation

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Polygenic risk score and risk of monoclonal B-cell lymphocytosis in caucasians and risk of chronic lymphocytic leukemia (CLL) in African Americans

Leukemia ◽

10.1038/s41375-021-01344-9 ◽

2021 ◽

Author(s):

Geffen Kleinstern ◽

J. Brice Weinberg ◽

Sameer A. Parikh ◽

Esteban Braggio ◽

Sara J. Achenbach ◽

...

Keyword(s):

Environmental Factors ◽

B Cell ◽

Risk Score ◽

Genetic Factors ◽

Strong Predictor ◽

Lymphocytic Leukemia ◽

European Ancestry ◽

Polygenic Risk Score ◽

Polygenic Risk ◽

C Statistic

AbstractMonoclonal B-cell lymphocytosis (MBL) is a precursor to CLL. Other than age, sex, and CLL family-history, little is known about factors associated with MBL risk. A polygenic-risk-score (PRS) of 41 CLL-susceptibility variants has been found to be associated with CLL risk among individuals of European-ancestry(EA). Here, we evaluate these variants, the PRS, and environmental factors for MBL risk. We also evaluate these variants and the CLL-PRS among African-American (AA) and EA-CLL cases and controls. Our study included 560 EA MBLs, 869 CLLs (696 EA/173 AA), and 2866 controls (2631 EA/235 AA). We used logistic regression, adjusting for age and sex, to estimate odds ratios (OR) and 95% confidence intervals within each race. We found significant associations with MBL risk among 21 of 41 variants and with the CLL-PRS (OR = 1.86, P = 1.9 × 10−29, c-statistic = 0.72). Little evidence of any association between MBL risk and environmental factors was observed. We observed significant associations of the CLL-PRS with EA-CLL risk (OR = 2.53, P = 4.0 × 10−63, c-statistic = 0.77) and AA-CLL risk (OR = 1.76, P = 5.1 × 10−5, c-statistic = 0.62). Inherited genetic factors and not environmental are associated with MBL risk. In particular, the CLL-PRS is a strong predictor for both risk of MBL and EA-CLL, but less so for AA-CLL supporting the need for further work in this population.

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Activities and risk factors associated with fall-related injuries among US Army soldiers

BMJ Military Health ◽

10.1136/bmjmilitary-2020-001564 ◽

2020 ◽

pp. bmjmilitary-2020-001564

Author(s):

Raina D Brooks ◽

T Grier ◽

B H Jones ◽

M C Chervak

Keyword(s):

Risk Factors ◽

Cross Sectional Study ◽

Cross Sectional ◽

Physically Active ◽

Us Army ◽

Factors Associated ◽

Younger Age ◽

Near Falls ◽

Independent Risk Factors ◽

Army Soldiers

IntroductionFalls/near falls are the second leading cause of hospitalisation and outpatient visits among US Army soldiers. While numerous studies have evaluated fall-related or near fall-related injuries among elderly adults, few have evaluated this association among young adults. The objective of this study is to describe the characteristics and risk factors associated with fall-related or near fall-related injuries among male US Army soldiers.MethodsThis is a cross-sectional study of male US Army Airborne Division soldiers (n=5187). Electronic surveys captured demographic, lifestyle, physical training (PT), fitness and injury data during spring/summer of 2016. Multiple logistic regression was used to identify independent risk factors of fall-related or near fall-related injuries, adjusting for potential confounders.ResultsPrimary findings indicated that activities and risk factors associated with fall-related or near fall-related injuries among soldiers included younger age (≤35 years), holding a job that required minimal lifting activities, slower 2-mile run times and not running during personal PT.ConclusionsThe findings from this study suggest that male US Army soldiers and other physically active men may benefit from (1) obtaining and/or maintaining higher aerobic endurance and muscular strength, and (2) training focused on preventing fall-related injuries during PT, road marching and sports/recreational activities. Moreover, prevention strategies and education should further target younger soldiers (≤35 years old), as younger age is not modifiable.

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Effects of Modified Foodservice Practices in Military Dining Facilities on Ad Libitum Nutritional Intake of US Army Soldiers

Journal of the Academy of Nutrition and Dietetics ◽

10.1016/j.jand.2013.01.005 ◽

2013 ◽

Vol 113 (7) ◽

pp. 920-927 ◽

Cited By ~ 23

Author(s):

Aaron P. Crombie ◽

LesLee K. Funderburk ◽

Tracey J. Smith ◽

Susan M. McGraw ◽

Leila A. Walker ◽

...

Keyword(s):

Nutritional Intake ◽

Us Army ◽

Ad Libitum ◽

Army Soldiers

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General v. specific vulnerabilities: polygenic risk scores and higher-order psychopathology dimensions in the Adolescent Brain Cognitive Development (ABCD) Study

Psychological Medicine ◽

10.1017/s0033291721003639 ◽

2021 ◽

pp. 1-10

Author(s):

Monika A. Waszczuk ◽

Jiaju Miao ◽

Anna R. Docherty ◽

Andrey A. Shabalin ◽

Katherine G. Jonas ◽

...

Keyword(s):

Clinical Practice ◽

Behavioral Problems ◽

Mental Health Problems ◽

Chronic Back Pain ◽

European Ancestry ◽

Risk Scores ◽

General Factor ◽

Childhood Psychopathology ◽

Polygenic Risk ◽

Partial Correlations

Abstract Background Polygenic risk scores (PRSs) capture genetic vulnerability to psychiatric conditions. However, PRSs are often associated with multiple mental health problems in children, complicating their use in research and clinical practice. The current study is the first to systematically test which PRSs associate broadly with all forms of childhood psychopathology, and which PRSs are more specific to one or a handful of forms of psychopathology. Methods The sample consisted of 4717 unrelated children (mean age = 9.92, s.d. = 0.62; 47.1% female; all European ancestry). Psychopathology was conceptualized hierarchically as empirically derived general factor (p-factor) and five specific factors: externalizing, internalizing, neurodevelopmental, somatoform, and detachment. Partial correlations explored associations between psychopathology factors and 22 psychopathology-related PRSs. Regressions tested which level of the psychopathology hierarchy was most strongly associated with each PRS. Results Thirteen PRSs were significantly associated with the general factor, most prominently Chronic Multisite Pain-PRS (r = 0.098), ADHD-PRS (r = 0.079), and Depression-PRS (r = 0.078). After adjusting for the general factor, Depression-PRS, Neuroticism-PRS, PTSD-PRS, Insomnia-PRS, Chronic Back Pain-PRS, and Autism-PRS were not associated with lower order factors. Conversely, several externalizing PRSs, including Adventurousness-PRS and Disinhibition-PRS, remained associated with the externalizing factor (|r| = 0.040–0.058). The ADHD-PRS remained uniquely associated with the neurodevelopmental factor (r = 062). Conclusions PRSs developed to predict vulnerability to emotional difficulties and chronic pain generally captured genetic risk for all forms of childhood psychopathology. PRSs developed to predict vulnerability to externalizing difficulties, e.g. disinhibition, tended to be more specific in predicting behavioral problems. The results may inform translation of existing PRSs to pediatric research and future clinical practice.

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PERILAKU BERESIKO DAN FAKTOR PELINDUNG PENGGUNAAN TEMBAKAU SINTETIS PADA KOMUNITAS CJ

Journal of Community Mental Health and Public Policy ◽

10.51602/cmhp.v3i2.56 ◽

2021 ◽

Vol 3 (2) ◽

pp. 78-91

Author(s):

Yunita Anggraeni ◽

Sitti Muthia Maghfirah Massinai ◽

Rahma Dilla Arnanda

Keyword(s):

Protective Factors ◽

Drug Users ◽

Protective Factor ◽

Risk And Protective Factors ◽

Community Collaboration ◽

Community Members ◽

The Social ◽

The Individual ◽

Calming Effect ◽

The Impact

ABSTRACTSynthetic tobacco is a type of drug produced from tobacco mixed with chemical liquids. Synthetic tobacco produces a calming effect, daydreaming, hallucinations, and unconsciousness. In some individuals there is resistance to chemicals, resulting in dizziness, vomiting and unconsciousness. The basic ingredients of tobacco make synthetic tobacco difficult to distinguish from ordinary tobacco. So that the impact on the prevention and eradication of drugs is increasingly difficult. The CJ community is a community of drug users who have used synthetic tobacco for 5 months. This study aimed to determine the risk and protective factors of synthetic tobacco use in the CJ community. This research was a qualitative study on the case of the CJ community with the direct involvement of researchers in the community. The result of the research was an analysis description of the risk and protective factors in the CJ community. Medically dangerous side effects have not been communicated to users in the CJ community. Awareness of the future and responsibility are protective factors that motivate community members to stop using drugs. This research showed that the use of synthetic tobacco type drugs can be more harmful to individuals and the environment. The impact on the individual physically and psychologically will affect the individual's difficulty in interacting with the social environment. There is a need for socialization and education that takes into account various aspects of society so that prevention can take place effectively. The results of the research can become the basis for providing intervention designs with community collaboration as agents of change.Key Word: Synthetic Tobacco, Risk Factor, Protective Factor, Drugs User ABSTRAKTembakau sintetis merupakan jenis narkoba yang dihasilkan dari tembakau yang dicampur dengan cairan kimia. Tembakau sintetis menghasilkan efek tenang, melamun, halusinasi, dan tidak sadarkan diri. Pada beberapa individu terdapat penolakan terhadap zat kimia, berakibat pusing, muntah dan tidak sadarkan diri. Bahan dasar tembakau membuat tembakau sintetis sulit dibedakan dengan tembakau biasa. Sehingga berdampak kepada pencegahan dan pemberantasan narkoba yang semakin sulit. Komunitas CJ merupakan komunitas pengguna narkoba yang sudah menggunakan tembakau sintetis selama 5 bulan. Penelitian ini bertujuan untuk mengetahui risk and protective factor penggunaan tembakau sintetis pada komunitas CJ. Penelitian ini merupakan studi kualitatif pada kasus komunitas CJ dengan keterlibatan langsung peneliti pada komunitas. Hasil penelitian berupa deskripsi analisis dari risk and protective factor pada komunitas CJ. Efek samping yang berbahaya secara medis belum tersosialisasikan kepada para pengguna di komunitas CJ. Kesadaran mengenai masa depan dan tanggung jawab menjadi faktor protektif yang memotivasi anggota komunitas untuk berhenti menggunakan narkoba. Penelitian ini menunjukan bahwa penggunaan narkoba jenis tembakau sintetis dapat lebih berbahaya bagi individu dan lingkungan. Dampak kepada individu secara fisik dan psikologis akan mempengaruhi kesulitan individu berinteraksi dengan lingkungan sosial. Perlu adanya sosialisasi dan edukasi yang memperhatikan berbagai aspek di masyarakat agar pencegahan dapat berlangsung dengan efektif. Hasil penelitian dapat menjadi landasan dalam memberikan rancangan intervensi dengan kolaborasi masyarakat sebagai agen perubahan.Kata Kunci: Tembakau Sintetis, Faktor Risiko, Faktor Protektif, Pengguna Narkoba

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