Central inhibitory dysfunctions in neuropathic pain: What is the relationship between basic science and clinical practice?

1997 ◽  
Vol 20 (3) ◽  
pp. 465-465
Author(s):  
Philip J. Siddall
Keyword(s):  
Nervous System ◽  
Neuropathic Pain ◽  
Clinical Practice ◽  
Clinical Application ◽  
Basic Science ◽  
Aminobutyric Acid ◽  
Inhibitory Mechanisms ◽  
Clinical Conditions ◽  
Relationship Of ◽  
The Relationship

The possible dysfunction of γ aminobutyric acid (GABA) and opioid inhibitory mechanisms following central and peripheral nervous system injury is an important and potentially useful finding. However, effective clinical application must take into account the specific characteristics of the models used in the studies and the relationship of these models to specific clinical conditions. [dickenson; wiesenfeld-hallin et al.]

Electroencephalography in Clinical Practice

PEDIATRICS ◽  
1953 ◽  
Vol 12 (3) ◽  
pp. 337-337
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Practice ◽  
Historical Background ◽  
Reasonable Accuracy ◽  
The Central Nervous System ◽  
Technical Details ◽  
Psychiatric Conditions ◽  
Relationship Of ◽  
The Relationship

In a compact yet clear manner, this book discusses the uses and limitations of encephalography in the diagnosis, study and treatment of diseases of the central nervous system. Technical details, controversial matter, and interpretative record evaluations are offered in as simplified a manner as is possible, and consistent with reasonable accuracy. In addition to short descriptions of the pertinent historical background, basic neurophysiology involved and general technics, the book also includes chapters on the relationship of the EEG to epilepsy, neurologic and neurosurgical problems, and psychiatric conditions.

scholarly journals Investigation of the Correlation between Postherpetic Itch and Neuropathic Pain over Time

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Rie Ishikawa ◽  
Masako Iseki ◽  
Rie Koga ◽  
Eiichi Inada
Keyword(s):  
Neuropathic Pain ◽  
Herpes Zoster ◽  
Pain Intensity ◽  
Visual Analog Scale ◽  
Analog Scale ◽  
Paindetect Questionnaire ◽  
Relationship Of ◽  
The Relationship ◽  
Over Time

Postherpetic itch (PHI), or herpes zoster itch, is an intractable and poorly understood disease. We targeted 94 herpes zoster patients to investigate their pain and itch intensities at three separate stages of the condition (acute, subacute, and chronic). We used painDETECT questionnaire (PDQ) scores to investigate the correlation between PHI and neuropathic pain. Seventy-six patients were able to complete follow-up surveys. The prevalence of PHI was 47/76 (62%), 28/76 (37%), and 34/76 (45%) at the acute, subacute, and chronic stages, respectively. PHI manifestation times and patterns varied. We investigated the relationship of PHI with neuropathic pain using the visual analog scale (VAS), which is a measure of pain intensity, and the PDQ, which is a questionnaire used to evaluate the elements of neuropathic pain. The VAS and PDQ scores did not differ significantly between PHI-positive and PHI-negative patients. A large neuropathic component was not found for herpes zoster itch, suggesting that neuropathic pain treatments may not able to adequately control the itch. Accordingly, we suggest that a more PHI-focused therapy is required to address this condition.

Clinical Translation, Ethics, and Policy

2021 ◽  
Author(s):  
Jonathan Kimmelman
Keyword(s):  
Clinical Practice ◽  
Conceptual Framework ◽  
Linear Process ◽  
Clinical Translation ◽  
Ethical Aspects ◽  
New Treatments ◽  
Relationship Of ◽  
The Relationship ◽  
Translation Ethics

Many representations of clinical translation present it as a linear process by which bench discoveries are advanced into clinical practice. The present chapter offers a conceptual framework that highlights distinctive ethical aspects of clinical translation. The framework understands clinical translation as a process not so much as developing new treatments but rather generating evidence on how to use (and how not to use) new as well as old interventions. It also emphasizes attending to the relationship of different studies with each other and the importance of coordinating different studies with each other. The model presented here foregrounds the role of coordination in realizing societal objectives of clinical translation at minimal burden and cost for patients and study volunteers.

On humoral factors in nervous activity

1935 ◽  
Vol 31 (6) ◽  
pp. 777-787
Author(s):  
D. S. Vorontsov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nervous Activity ◽  
Active Part ◽  
Humoral Factors ◽  
The Central Nervous System ◽  
Relationship Of ◽  
The Relationship

Not only in the peripheral working organs, irritating substances are formed, which, as we can see, take an active part in their regulation, but also in the central nervous system, in the relationship of its individual elements, such substances apparently play an important role.

scholarly journals The effect of baclofen on spontaneous and evoked behavioural expression of experimental neuropathic chronic pain

1999 ◽  
Vol 57 (3B) ◽  
pp. 753-760 ◽  
Author(s):  
TEREZINHA DE JESUS T. SANTOS ◽  
CARLOS M. DE CASTRO-COSTA ◽  
SÍLVIO D. A. GIFFONI ◽  
FRANKLIN J. C. SANTOS ◽  
RODRIGO S. N. RAMOS ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Nervous System ◽  
Neuropathic Pain ◽  
Aminobutyric Acid ◽  
Thermal Stimulus ◽  
Dependent Manner ◽  
Gamma Aminobutyric Acid ◽  
Analgesic Effects ◽  
Nociceptive Stimulus ◽  
Dose Dependent

Baclofen (beta-p-chlorophenyl-GABA) has been used in humans to treat spasticity, as well as trigeminal neuralgia. Since GABA (gamma-aminobutyric acid) has been implicated in inhibitory and analgesic effects in the nervous system, it was of interest to study the effect of baclofen in experimental neuropathic pain. With this purpose, experiments were carried out in 17 neuropathic rats with constrictive sciatic injury, as described by Bennet and Xie (1988), taking as pain parameters scratching behaviour and the latency to the thermal nociceptive stimulus. The results showed that baclofen induces, in a dose-dependent manner, significant decrease (p < 0.05) of scratching behaviour and significant increase (p < 0.05) of the latency to the nociceptive thermal stimulus. The absence of antagonism of naloxone suggested a non-participation of an opioid-mediated mechanism in this analgesic effect of baclofen on experimental neuropathic pain.

scholarly journals A virtual second opinion: Acceptability of a computer-based decision tool to assess older drivers with dementia

2019 ◽  
Vol 26 (2) ◽  
pp. 911-924
Author(s):  
Mark J Rapoport ◽  
Carla Zucchero Sarracini ◽  
Benoit M Mulsant ◽  
Dallas P Seitz ◽  
Frank Molnar ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Nurse Practitioners ◽  
Second Opinion ◽  
Decision Tool ◽  
Qualitative Thematic Analysis ◽  
Computer Based ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship ◽  
Knowledge Translation Interventions

Clinicians face challenges in deciding which older patients with dementia to report to transportation administrators. This study used a qualitative thematic analysis to understand the utility and limitations of implementing a computer-based Driving in Dementia Decision Tool in clinical practice. Thirteen physicians and eight nurse practitioners participated in an interview to discuss their experience using the tool. While many participants felt the tool provided a useful ‘virtual second opinion’, specialist physicians felt that the tool did not add value to their clinical practice. Barriers to using the Driving in Dementia Decision Tool included lack of integration with electronic medical records and inability to capture certain contextual nuances. Opinions varied about the impact of the tool on the relationship of clinicians with patients and their families. The Driving in Dementia Decision Tool was judged most useful by nurse practitioners and least useful by specialist physicians. This work highlights the importance of tailoring knowledge translation interventions to particular practices.

scholarly journals Hyperuricemia, gout and high cardiovascular risk - how to manage them in clinical practice

2019 ◽  
Vol 91 (12) ◽  
pp. 75-83
Author(s):  
V V Fomin ◽  
T E Morosova ◽  
V V Tsurko
Keyword(s):  
Cardiovascular Disease ◽  
Clinical Practice ◽  
Cardiovascular Risk ◽  
High Risk ◽  
High Cardiovascular Risk ◽  
Relationship Of ◽  
The Relationship

In recent years, the relationship of hyperuricemia and gout with a high risk of cardiovascular disease has been widely discussed. Therefore, it is important to systematically examine patients in order to diagnose comorbidities, among which cardiovascular disease and its complications occupy a leading place and consider mandatory treatment of patients with hyperuricemia and gout with high cardiovascular risk with lowering drugs, which fully reflects the provisions of the latest European recommendations for the management and treatment of patients with gout.

Autonomic Therapy in the Psychoneuroses

1939 ◽  
Vol 85 (358) ◽  
pp. 1036-1042
Author(s):  
Duncan Macmillan ◽  
H. Fischgold
Keyword(s):  
Nervous System ◽  
Autonomic Nervous System ◽  
Clinical Medicine ◽  
Detailed Knowledge ◽  
Autonomic Nervous ◽  
Relationship Of ◽  
The Relationship

Though detailed knowledge of the autonomic nervous system is comparatively recent, the initial conceptions of its nature have undergone very important modifications during the time it has been known. This is mainly due to the fact that originally the anatomical discovery was taken up by investigators in various branches of clinical medicine, physiology and pharmacology, and made a special subject for detailed research. Especially did the dualism which is so remarkable a feature of the autonomic nervous system give rise to a number of theories about the relationship of the two components.

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