Does Apolipoprotein E Influence Learning and Memory in the Nondemented Oldest Old?

2001 ◽  
Vol 13 (4) ◽  
pp. 451-459 ◽  
Author(s):  
Anne Salo ◽  
Raija Ylikoski ◽  
Auli Verkkoniemi ◽  
Tuomo Polvikoski ◽  
Kati Juva ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Learning And Memory ◽  
Verbal Fluency ◽  
Oldest Old ◽  
Very Elderly ◽  
Object Memory ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
Relationship Of ◽  
The Relationship

The objective of this study was to analyze the relationship of the apolipoprotein E (apoE) ε4 and ε2 alleles to learning and memory performances in the nondemented oldest old. Forty-six nondemented persons aged 85 years or over from a randomly selected group of 128 subjects in Vantaa, Finland, were studied. ApoE genotyping was performed using the minisequencing technique. A structured clinical examination and interview were carried out. The test variables studied were learning and memory scores (from the Fuld Object-Memory Evaluation), verbal fluency, and conceptualization (the Similarities subtest of the WAIS-R). We compared apoE-ε4 carriers to noncarriers and apoE-ε2 carriers to noncarrirs. No statistically significant differences were found in any of the test variables. The results failed to confirm the hypotheses that poor cognitive performance is associated with the apoE-ε4 allele and good performance with the apoE-ε2 allele in the oldest old. This suggests that the apoE alleles do not have a detectable relationship to learning and memory in nondemented very elderly people.

Apolipoprotein E genotype and major depression in a community of older adults. The Cache County Study

2003 ◽  
Vol 33 (3) ◽  
pp. 541-547 ◽  
Author(s):  
D. C. STEFFENS ◽  
M. C. NORTON ◽  
A. D. HART ◽  
I. SKOOG ◽  
C. CORCORAN ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Late Onset ◽  
Allelic Variation ◽  
Genetic Locus ◽  
Significant Interaction Effect ◽  
Ε4 Allele ◽  
Cache County ◽  
Relationship Of ◽  
The Relationship

Background. The role of allelic variation in APOE, the genetic locus for apolipoprotein E, in geriatric depression is poorly understood. There are conflicting reports as to an association between the ε4 allele and depression in late life.Method. Using a community based study of non-demented elders in Cache County, Utah, that included many very old individuals, we examined the relationship between APOE and late-onset (age >60) depression, with particular attention to possible age effects.Results. There was no overall association between APOE and depression. However, there was a significant interaction effect of APOE and age such that the relationship of late-onset depression with respect to presence of the ε4 allele was larger among those 80 and older compared with those below age 80. Consistent with previous studies, women were more likely to experience late-onset depression than men.Conclusions. Because we excluded prevalent cases of dementia, this pattern of relative risk with age may reflect the appearance of depressive symptoms as a prodrome of Alzheimer's disease or vascular dementia. Longitudinal studies should help to confirm or refute this explanation of the data.

scholarly journals Modification of the Relationship of the Apolipoprotein E ε4 Allele to the Risk of Alzheimer Disease and Neurofibrillary Tangle Density by Sleep

2013 ◽  
Vol 70 (12) ◽  
pp. 1544 ◽  
Author(s):  
Andrew S. P. Lim ◽  
Lei Yu ◽  
Matthew Kowgier ◽  
Julie A. Schneider ◽  
Aron S. Buchman ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Neurofibrillary Tangle ◽  
Ε4 Allele ◽  
Relationship Of ◽  
The Relationship

Cognitive asymmetries associated with apolipoprotein E genotype in patients with Alzheimer's disease

2003 ◽  
Vol 9 (5) ◽  
pp. 751-759 ◽  
Author(s):  
MICHAEL J. FINTON ◽  
JOHN A. LUCAS ◽  
JULIE D. RIPPETH ◽  
DARYL L. BOHAC ◽  
GLENN E. SMITH ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Apolipoprotein E ◽  
Cognitive Performance ◽  
Cognitive Abilities ◽  
Apoe Genotype ◽  
Unique Contribution ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
The Relationship

The relationship between apolipoprotein E (apoE) genotype and cognitive performance was examined in 200 patients with probable Alzheimer's disease (AD). Differences between composite measures of verbal and nonverbal functioning were used to define asymmetric patterns of cognition. Patients who were homozygous for apoE ε4 demonstrated relatively worse nonverbal as compared to verbal cognitive ability. In contrast, participants who were heterozygous for apoE ε4 or who possessed no ε4 allele demonstrated relatively equivalent verbal and nonverbal cognitive abilities. Although age and dementia severity also contributed to these patterns, apoE genotype appears to have a significant unique contribution to cognitive performance in these individuals. The ε4 allele may thus be associated with a specific neurocognitive phenotype among patients with AD, with the overall pattern of cognitive asymmetry dependent upon ε4 dose. (JINS, 2003, 9, 751–759.)

scholarly journals Relationship of Depression and function of Attention, Planning and Verbal Learning and Memory

2019 ◽  
Vol 8 (9) ◽  
pp. 214-225
Author(s):  
Nongmeikapam Premika Devi
Keyword(s):  
Learning And Memory ◽  
Verbal Learning ◽  
Education Level ◽  
Auditory Verbal Learning ◽  
And Function ◽  
Age Range ◽  
Relationship Of ◽  
The Relationship ◽  
Minimum Education ◽  
Hiv Aids

The present study examines the relationship of depression and the neuropsychologicalfunction of attention, planning and auditory verbal learning and memory among individualswith HIV/AIDS. 200 subjects who were HIV/AIDS positive (100 males and 100 females) andwere within age range of 20 to 50 years and minimum education level of 8th standard weretaken. The result indicates that Depression slows down the performance of attention; alsodepression most likely decreases the function of auditory verbal learning and memory

Differences Between APOE Carriers and Non-APOE Carriers on Neurocognitive Tests: Jensen Effects?

2018 ◽  
Vol 33 (6) ◽  
pp. 353-361 ◽  
Author(s):  
Jan te Nijenhuis ◽  
Kyu Yeong Choi ◽  
Yu Yong Choi ◽  
Jang Jae Lee ◽  
Eun Hyun Seo ◽  
...  
Keyword(s):  
Older Adults ◽  
At Risk ◽  
Risk Factor ◽  
Apolipoprotein E ◽  
Test Scores ◽  
General Intelligence ◽  
Apoe Ε4 ◽  
Neurocognitive Tests ◽  
Ε4 Allele ◽  
The Difference

Background: Being a carrier of the apolipoprotein E (APOE) ε4 allele is a clear risk factor for development of Alzheimer’s disease (AD). On some neurocognitive tests, there are smaller differences between carriers and noncarriers, while other tests show larger differences. Aims: We explore whether the size of the difference between carriers and noncarriers is a function of how well the tests measure general intelligence, so whether there are Jensen effects. Methods: We used the method of correlated vectors on 441 Korean older adults at risk for AD and 44 with AD. Results: Correlations between APOE carriership and test scores ranged from −.05 to .11 (normal), and −.23 to .54 (AD). The differences between carriers and noncarriers were Jensen effects: r = .31 and r = .54, respectively. Conclusion: A composite neurocognitive score may show a clearer contrast between APOE carriers and noncarriers than a large number of scores of single neurocognitive tests.

O3-10-01: DIFFERENT EFFECTS OF APOE ε4 ALLELE ON THE RELATIONSHIP BETWEEN TAU AND β-AMYLOID IN EARLY-ONSET AND LATE-ONSET ALZHEIMER DISEASE

2006 ◽  
Vol 14 (7S_Part_19) ◽  
pp. P1039-P1040
Author(s):  
Young Noh ◽  
Tae Sung Lim ◽  
Sang-Yoon Lee ◽  
Kee Hyung Park ◽  
Dong Jin Shin ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Early Onset ◽  
Late Onset ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
Β Amyloid ◽  
The Relationship

scholarly journals Metabolic syndrome is associated with poor cognition: a population-based study of 70-year-olds without dementia

2021 ◽  
Author(s):  
Anna Marseglia ◽  
Alexander Darin-Mattsson ◽  
Johan Skoog ◽  
Lina Rydén ◽  
Timothy Hadarsson-Bodin ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Heart Disease ◽  
Executive Function ◽  
Cognitive Performance ◽  
Birth Cohort ◽  
Verbal Fluency ◽  
Apoe Genotype ◽  
Perceptual Speed ◽  
Apoe Ε4 ◽  
Ε4 Allele

Abstract Background Individual conditions of metabolic syndrome (MetS) have been related to dementia, however, their combined impact on the preclinical stage is unknown. We investigated the associations between MetS and domain-specific cognitive function as well as the role of sociodemographic, cardiovascular, and genetic factors. Methods Within the Gothenburg H70 Birth Cohort Study-Birth cohort 1944, 1131 dementia-free participants (aged 70 years) were examined during 2014-2016. MetS (central obesity plus at least two factors [reduced HDL-cholesterol, elevated triglycerides, blood pressure, or blood glucose]) was identified according to the International Diabetes Federation criteria. Five cognitive domains (memory, attention/perceptual speed, executive function, verbal fluency, visuospatial abilities) were generated after z-standardizing raw scores from ten neuropsychological tests. Education, heart disease, claudication (indicating peripheral atherosclerosis), and apolipoprotein (APOE) genotype were ascertained by trained staff. Data were analyzed with linear regression models. Results Overall, 618 participants (55%) had MetS. In multi-adjusted linear regressions, MetS was related to poorer performance in attention/perceptual speed (β -0.14 [95% CI -0.25, -0.02]), executive function (β -0.12 [95% CI -0.23, -0.01]), and verbal fluency (β -0.19 [95% CI -0.30, -0.08]). These associations were present only among individuals who did not carry any APOE-ε4 allele or were highly educated. However, among those with MetS, high education was related to better cognitive performance. MetS together with comorbid heart disease or claudication was associated with even worse cognitive performance than each alone. Conclusions MetS is associated with poor attention/perceptual speed, executive function, and verbal fluency performance. Education, APOE-ε4 allele, and comorbid cardiovascular disease influenced the observed associations.

Apolipoprotein E ε4/4 genotype limits response to dietary induction of hyperhomocysteinemia and resulting inflammatory signaling

2022 ◽  
pp. 0271678X2110690
Author(s):  
Charles E Seaks ◽  
Erica M Weekman ◽  
Tiffany L Sudduth ◽  
Kevin Xie ◽  
Brandi Wasek ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Apolipoprotein E ◽  
Late Onset ◽  
Apoe Ε4 ◽  
Perivascular Inflammation ◽  
Ε4 Allele ◽  
Barrier Breakdown ◽  
The Impact

Vascular contributions to cognitive impairment and dementia (VCID) are the second leading cause of dementia behind Alzheimer’s disease. Apolipoprotein E (ApoE) is a lipid transporting lipoprotein found within the brain and periphery. The APOE ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease and is a risk factor for VCID. Our lab has previously utilized a dietary model of hyperhomocysteinemia (HHcy) to induce VCID pathology and cognitive deficits in mice. This diet induces perivascular inflammation through cumulative oxidative damage leading to glial mediated inflammation and blood brain barrier breakdown. Here, we examine the impact of ApoE ε4 compared to ε3 alleles on the progression of VCID pathology and inflammation in our dietary model of HHcy. We report a significant resistance to HHcy induction in ε4 mice, accompanied by a number of related differences related to homocysteine (Hcy) metabolism and methylation cycle, or 1-C, metabolites. There were also significant differences in inflammatory profiles between ε3 and ε4 mice, as well as significant reduction in Serpina3n, a serine protease inhibitor associated with ApoE ε4, expression in ε4 HHcy mice relative to ε4 controls. Finally, we find evidence of pervasive sex differences within both genotypes in response to HHcy induction.

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