Impact of diabetes on caregiver stress in patients with Alzheimer's disease: data from the ICTUS study

2018 ◽  
Vol 30 (8) ◽  
pp. 1109-1117 ◽  
Author(s):  
Jun Li ◽  
Matteo Cesari ◽  
Natalia Del Campo ◽  
Sandrine Andrieu ◽  
Birong Dong ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Self Report ◽  
Personal Life ◽  
Diabetic Patients ◽  
Psychological Burden ◽  
Factorial Model ◽  
The Social ◽  
Significant Difference ◽  
The Impact

ABSTRACTBackground:To estimate the impact of comorbid diabetes on caregiver stress in Alzheimer's disease (AD) patients from the Impact of Cholinergic Treatment Use (ICTUS) study.Methods:Using the Data from the ICTUS study, diabetes mellitus (DM) was recorded at baseline and caregiver burden was assessed twice per year using the Zarit Burden Interview (ZBI) scale. The three-factorial model of ZBI (the effect on the social and personal life of caregivers, the psychological burden and the feelings of guilt) was adopted. Linear mixed models were used to examine the relation between DM and the scores of ZBI.Results:The present analyses were conducted on 1,264 AD subjects. A total of 156 patients (12.3%) had DM with taking antidiabetic medication and/or self-report of a history. At baseline, the caregivers of patients with or without DM had similar ZBI global scores and similar scores of three different factors of ZBI. Unadjusted and adjusted models both indicated that ZBI global score increased over a 24-month follow-up without significant effect of DM. Similarly, unadjusted model showed that DM was not determining any significant difference in the score of any factor. However, adjusted model indicated that in diabetic patients, the scores of the social and personal life of caregivers and the psychological burden increased more slowly than those in non-diabetic patients (p = 0.04 and 0.01, respectively).Conclusions:DM may affect the caregivers’ daily social and personal life and psychological burden in AD patients. It is necessary for further research.

scholarly journals The Impact of Alzheimer’s Disease and Related Dementias on Dental Care Utilization and Costs in Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 800-800
Author(s):  
Sam Li ◽  
Isaac Donkor ◽  
Liang Hong ◽  
Kevin Lu ◽  
Bei Wu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dental Care ◽  
Negative Binomial ◽  
Self Report ◽  
Care Utilization ◽  
Limited Information ◽  
Dental Care Utilization ◽  
The Impact ◽  
Care Costs

Abstract There is limited information on the impact of cognition function on dental care utilization and costs. This study used the Medicare current beneficiaries survey in 2016 and included 4,268 participants 65+. Dental care utilization and costs were measured by self-report and included preventive and treatment events. Negative binomial regression and generalized linear regression were used to examine the impact of Alzheimer’s disease (AD) and related dementia (RD) on dental care utilization and costs. We found that AD was not associated with dental care utilization, but RD was associated with a lower number of total treatment dental care visits (IRR: 0.60; 95% CI: 0.37~0.98). RD was not associated with dental care costs, but AD was associated with higher total dental care costs (estimate: 1.08; 95% CI: 0.14~2.01) and higher out-of-pocket costs (estimate: 1.25; 95% CI: 0.17~2.32). AD and RD had different impacts on different types of dental care utilization and costs. Part of a symposium sponsored by the Oral Health Interest Group.

scholarly journals Functional communication ability in frontotemporal lobar degeneration and Alzheimer's disease

2008 ◽  
Vol 2 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Isabel Albuquerque M. de Carvalho ◽  
Valéria Santoro Bahia ◽  
Leticia Lessa Mansur
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Communication ◽  
Functional Communication ◽  
Communicative Behavior ◽  
Communication Assessment ◽  
Significant Difference ◽  
Communication Ability ◽  
Close Relatives ◽  
The Impact

Abstract Functional communication is crucial for independent and efficient communicative behavior in response to every day activities. In the course of dementia progression, cognitive losses may impair these abilities. For this reason, functional communication assessment should be part of a formal assessment to quantify and qualify the impact of deficiency on patients' lives. Objective: To compare functional communication abilities in fronto-temporal lobar degeneration (FLTD) and Alzheimer's disease (AD). Methods: Six AD patients (mean age: 82.50±2.66 years; mean education: 5.67±3.61 years), and eight FTLD patients (mean age: 57.13±9.63 years; mean education: 10.86±6.91 years) had their close relatives answer the Functional Assessment of Communication Skills for Adults (Asha-facs) . Statistical analyses correlated the performance on each of the Asha-facs domains (social communication, communication of basic needs; reading, writing, number concept and daily planning) between both groups. Results: Analyses showed that functional communication was similar for AD and FTLD patients. Only two items had statistical difference, namely 'Comprehension of inference' (AD 6.7±1.33; FTLD 2.43±2.30, p=0.017) and 'capacity to make basic money transactions' (AD 2.17±2.04; FTLD 4.00±0.90, p=0.044). Comparison among the four domains' mean scores revealed no significant difference. Conclusion: The Asha-facs is a useful instrument to characterize functional communication abilities in both FTLD and AD. Nevertheless, the analysis presented for this sample showed that the Asha-facs could not discriminate which aspects of the FTLD and AD differed.

scholarly journals Home-Based Care for People with Alzheimer’s Disease and Related Dementias (ADRD) during COVID-19 Pandemic: From Challenges to Solutions

2020 ◽  
Vol 17 (24) ◽  
pp. 9303
Author(s):  
Atiqur sm-Rahman ◽  
Chih Hung Lo ◽  
Azra Ramic ◽  
Yasmin Jahan
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Supporting Evidence ◽  
Psychological Issues ◽  
Home Based ◽  
The Social ◽  
Novel Coronavirus ◽  
Home Based Care ◽  
The Impact

There has been supporting evidence that older adults with underlying health conditions form the majority of the fatal cases in the current novel coronavirus disease (COVID-19) pandemic. While the impact of COVID-19 is affecting the general public, it is clear that these distressful experiences will be magnified in older adults, particularly people living with Alzheimer’s disease and related dementia (ADRD), making them the most vulnerable group during this time. People with differing degrees of ADRD are especially susceptible to the virus, not only because of their difficulties in assessing the threat or remembering the safety measures, but also because of the likelihood to be subject to other risk factors, such as lack of proper care and psychological issues. Therefore, in this article, we will discuss the challenges related to home-based care for people with ADRD during a pandemic and propose a formulation of systematic solutions to address these challenges and to alleviate the social and economic impact resulting from the crisis.

Performance of healthy elderly with Alzheimer's disease at an early stage in executive function and language

2011 ◽  
Vol 26 (S2) ◽  
pp. 498-498
Author(s):  
M.T. Santos ◽  
G.C. Couto ◽  
J.C. Achieri ◽  
C.A. Júnior
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Stage ◽  
The Elderly ◽  
Screening Tests ◽  
Healthy Elderly ◽  
Initial Stage ◽  
Significant Difference ◽  
Common Causes ◽  
The Impact

Dementia are increasingly prevalent in population. The most common causes of dementia is Alzheimer's disease (AD). Screening tests have been used for the premature diagnosis of Alzheimer Disease (AD), specifically in the executive functions and language, which are compromised at an initial stage. However, the necessity standardized means and validated for our middle, to show oneself a pressing subject.ObjectiveTo analyze the impact of the length of sentences in the abstraction of proverbs in the Screening Test for Alzheimer's disease with Proverbs (TRDAP), healthy elderly and with Alzheimer's disease at early stage.MethodSurvey document in the database, analyzing the responses of the elderly (abstract or concrete interpretation of proverbs), relating the length of sentences (sayings) of stage B of TRDAP with the diagnosis of Alzheimer's disease and the interference of age and schooling.ResultsHealthy older people showed greater capacity for abstraction than those with AD. There was Significant differences, in the sayings 1 (p = 0.033) and 2 (p = 0.001), corresponding to lower sentences, which did not occur with the proverb 3. As for age no verified significant difference among the healthy and only saying 3 in AD patients, however schooling differenced the healthy.ConclusionElderly with Alzheimer's disease at an initial stage have lower performance in the comprehension of ambiguous sentences, interpretation and abstraction of proverbs, corroborating with the data of the literature. The size of these sentences appears to be inversely proportional to the correctness of interpretation in elderly patients with and without AD.

scholarly journals Los retos de la política de dependencia en Francia = Challenges of dependency policy in France

2012 ◽  
pp. 133
Author(s):  
Eguzki Urteaga
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Security ◽  
Baby Boomers ◽  
Private Insurance ◽  
Disabled Persons ◽  
Advanced Age ◽  
The Social ◽  
The Impact

Resumen<br /><br />El riesgo de dependencia, que concierne a las personas mayores y discapacitadas, despierta un interés creciente entre los responsables políticos y se constatan unos avances significativos en esta materia: adecuación de los instrumentos de financiación, modernización de los centros y de los servicios de ayuda domiciliaria, mejora de la integración de estas personas, etc. Pero, el incremento de las necesidades cuando la generación de los baby-boomers llegará a una edad avanzada plantea la cuestión de la sostenibilidad del gasto, del impacto sobre las familias que supone la atención de una persona dependiente así como la de los medios específicos que es preciso movilizar para las personas que padecen la enfermedad de Alzheimer. El debate en torno al “quinto riesgo” gira sobre su naturaleza con respecto a los demás riesgos cubiertos por la Seguridad social, la población concernida, la parte que incumbe al público, a los hogares y a los seguros en la financiación. Ante esta situación, existen dos posibilidades en cuanto a la financiación de la dependencia: la primera caracterizada por el mantenimiento de una parte mayoritaria de la solidaridad colectiva, mientras que la segunda privilegia la solicitación del seguro privado y del seguro de previsión.<br /><br />Abstract<br /><br />The risk of dependency, which concerns the major and disabled persons, generates an increasing interest between the politicians and a few significant advances are observed in this matter: adequacy of the instruments of financing, modernization of the centers and services of domiciliary help, improvement of the integration of these persons, etc. But, the increase of the needs when the generation of the baby-boomers will come to an advanced age raises the question of the sustainability of the expense, the impact on the families that the attention of one dependent person supposes as well as the specific means that is precise to mobilize for the persons who suffer Alzheimer's disease. The debate concerning the "fifth risk" turns on his nature comparing with other risks covered by the social security, the concerned population, part that is incumbent on public, to the families and to the insurances in the financing. In front of this situation, two possibilities exist for the financing of the dependency: the first one characterized by the maintenance of a majority part of the collective solidarity, whereas the second one favours the solicitation of the private insurance and the insurance of forecast.

scholarly journals The Impact of Diet Type on Weight Loss in Patients with Alzheimer’s Disease

2021 ◽  
Vol 36 ◽  
pp. 153331752110448
Author(s):  
Tomiyo Nakamura
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Weight Loss ◽  
Nutritional Assessment ◽  
Mini Nutritional Assessment ◽  
Care Hospital ◽  
Term Care ◽  
Significant Difference ◽  
The Impact ◽  
Diet Type

Objectives: To compare differences in weight loss in patients with Alzheimer’s disease on normal, diabetic, or texture-modified diets. Methods: This prospective interventional study examined the data of patients with Alzheimer’s disease who were admitted to a long-term care hospital in Japan from February to April 2013. Dietary elements and weight loss over a 3-month period were examined. Results: Of the 75 patients examined, 6 were on a normal diet, 10 were on a diabetic diet, and 59 were on a texture-modified diet. Weight loss was significantly associated with body weight, Mini Nutritional Assessment®, and diet type. In the non-malnourished patients, there was a significant difference between the three types of diets in terms of eating rate and weight loss. Conclusion: Diet type was independently associated with weight loss in patients with Alzheimer’s disease. Research using larger sample sizes is necessary to eliminate the differences between these diet types.

scholarly journals Impact of depressive symptoms on outcome of Alzheimer's disease

2010 ◽  
Vol 4 (4) ◽  
pp. 346-352 ◽  
Author(s):  
Anita de Paula Eduardo Garavello ◽  
Regina Miksian Magaldi ◽  
Sérgio Márcio Pacheco Paschoal ◽  
Wilson Jacob Filho
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Depressive Symptoms ◽  
The Elderly ◽  
Functional Evaluation ◽  
Depression Group ◽  
Significant Difference ◽  
The Impact ◽  
Group D

Abstract There is no consensus in the medical literature about the impact of depressive symptoms on the evolution of Alzheimer's disease (AD). Objective: To compare the evolution of AD patients, with and without depressive symptoms, in terms of cognition, functionality and caregiver stress. Methods: The study entailed 2 stages: an initial retrospective stage involving review of medical charts of patients with mild and moderate AD. Patients were divided according to the presence or absence of depressive symptoms, defined by medical interview and questions on depressed mood from the CAMDEX (Cambridge Examination for Mental Disorders of the Elderly) and Neuropsychiatric Inventory (NPI). Twenty-nine patients were evaluated, 37.9% with depression (Group D+) and 62.1% without depression (Group D-). The groups were compared regarding demographic and medical characteristics, cognitive and functional performance, presence of apathy as a separate symptom, and caregiver stress, using standardized tests and questionnaires. In the second transversal step, the same tools were reapplied after 2 to 4 years of follow-up, and evolution for the two groups was compared. Results: The two groups were highly homogeneous in demographic and clinic characteristics, as well as in length of follow-up, and presented no significant difference in cognitive or functional evaluation at the time of diagnoses or after follow-up. Only caregiver stress was greater in Group D+ at the two time points (p<0.001). Conclusions: No differences in the evolution of AD patients with or without depressive symptoms were evident. Nevertheless, these symptoms were associated to emotional burden of caregivers.

scholarly journals Evaluation of the Effect of Resistance Exercise and Donepezil on Some Neurotrophin-Induced Changes in Gene Expression and Trk Receptors in the Hippocampus of Rats with Alzheimer’s Disease

2021 ◽  
Vol 12 (3) ◽  
Author(s):  
Gholamhasan Jafarzadeh ◽  
Asieh Sadat Mousavian ◽  
Saeid Shakerian
Keyword(s):  
Gene Expression ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Resistance Exercise ◽  
Intraventricular Injection ◽  
Trk Receptors ◽  
Male Adult ◽  
Significant Difference ◽  
And Control ◽  
The Impact

Objectives: This study aimed to evaluate the impact of resistance exercise and donepezil on some neurotrophins gene expression and Trk receptors in the hippocampus of rats with Alzheimer’s disease (AD). Methods: In this study, 32 male adult Wistar rats (mean weight: 230 - 280 g) were assigned into two groups of AD and control. The control and AD groups received normal saline and streptozotocin (STZ) through intraventricular injection, respectively. Then, six subgroups were considered: (1) control rest (Con); (2) control exercise (Con-Exe); (3) Alzheimer’s rest (Alz); (4) Alzheimer’s exercise (Alz-Exe); (5) Alzheimer’s donepezil (Alz-Don); and (6) Alzheimer’s donepezil-exercise (Alz-Don-Exe). Donepezil was fed daily at a dose of 1.5 mg/kg to the treated groups. The three subgroups of exercising rats received exercises for eight weeks (three times a week). Each day, the resting groups were managed to decrease stress impacts. Twenty-four hours after the last session of exercise by the eighth week, deep anesthesia was applied, and the rats' heads were severed. Results: Considering an error rate below 5% (P < 0.05) and a confidence of more than 95%, a significant difference was observed in BDNF, NT3, NGF, TrkA, and TrkB values between exercising and donepezil-exercise rats compared to AD group. These values were considerably greater for donepezil-exercising Alzheimer’s group. Besides, the donepezil group was not significantly different from the Alzheimer’s group. Conclusions: Although the use of donepezil alone did not significantly increase the expression of the studied genes, the concomitant use of the drug and resistance training significantly increased the expression levels.

scholarly journals Awareness of Functional Status: People with Alzheimer’s Disease Abilities to Self-Report Impairment in Activities of Daily Living

2020 ◽  
Vol 4 (1) ◽  
pp. 405-415
Author(s):  
Paula Gasparini Emery Trindade ◽  
Raquel Luiza Santos ◽  
Aud Johannessen ◽  
Jose Pedro Simões Neto ◽  
Marcia Cristina Nascimento Dourado
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Status ◽  
Negative Impact ◽  
Demographic Data ◽  
Self Report ◽  
Structured Interviews ◽  
Functional Deficits ◽  
Qualitative Part ◽  
The Impact

Background: Awareness of functional status may underlie specific profiles and differences related to stage severity in individuals with Alzheimer’s disease (AD). Objective: This study aimed to assess self-reported experiences of awareness of functional activity in people with mild and moderate AD. Methods: This is a mixed methods approach. The qualitative part was conducted through semi-structured interviews concerning the experiences and awareness of deficits in 38 older adults with mild or moderate AD. The quantitative approach included a comparison between groups with regard to concerns of awareness and clinic and demographic data. Results: Impairment on awareness of disease and awareness of functional deficits was observed even in the mild stages of AD. There was also a noticeable progression of impairments of both kinds of awareness from mild to moderate stage of disease. The majority of participants with mild and moderate AD were partially aware of their functional deficits. Both groups of participants reported some negative impact; however, they were not able to entirely describe their functional status. Also, deficits to recognize the need for help with hygiene and general tasks were observed. Significant differences were found in awareness of need for help with general tasks and awareness of need for help with hygiene tasks. Conclusion: People with mild and moderate AD may describe their aware of the disease better than specific functional deficits, and most of them can provide some reports concerning to the impact of the disease.

scholarly journals Relationship between Dementia Severity and Behavioral and Psychological Symptoms of Dementia in Dementia with Lewy Bodies and Alzheimer's Disease Patients

2015 ◽  
Vol 5 (2) ◽  
pp. 244-252 ◽  
Author(s):  
Mamoru Hashimoto ◽  
Yusuke Yatabe ◽  
Tomohisa Ishikawa ◽  
Ryuji Fukuhara ◽  
Keiichiro Kaneda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Dementia With Lewy Bodies ◽  
Psychiatric Symptoms ◽  
Psychological Symptoms ◽  
Lewy Bodies ◽  
Clinical Dementia Rating ◽  
Significant Difference ◽  
The Impact ◽  
Behavioral And Psychological Symptoms

Background/Aims: Behavioral and psychological symptoms of dementia (BPSD) are common in the clinical manifestation of dementia. Although most patients with dementia exhibit some BPSD during the course of the illness, the association of BPSD with the stage of dementia remains unclear. It was the aim of this study to evaluate the impact of severity of dementia on the expression of BPSD in patients with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). Methods: Ninety-seven patients with DLB and 393 patients with AD were recruited from 8 dementia clinics across Japan. BPSD were assessed by the Neuropsychiatric Inventory (NPI). A relationship between BPSD and dementia stage classified by the Clinical Dementia Rating (CDR) in each type of dementia was assessed. Results: No significant difference was seen in NPI total score across CDR staging in the DLB group. On the other hand, the NPI total score significantly increased with dementia stage in the AD group. Conclusion: The relationship of dementia stage with the expression of BPSD was different according to the type of dementia. BPSD and dementia stage were correlated in AD subjects, in whom psychiatric symptoms increase as the disease progresses, but not in DLB subjects.

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