Intake of B vitamins in childhood and adult life in relation to psychological distress among women in a British birth cohort

AbstractBackgroundLower levels of B vitamins (particularly folate, vitamin B12and vitamin B6) may be associated with psychological distress. Little is known about the impact of childhood nutrition on psychological distress in adult life.ObjectiveWe investigated whether prospectively measured childhood and adult dietary intakes of thiamin, riboflavin, niacin, folate, vitamin B6and vitamin B12were related to the psychological distress of women in mid-age, taking into account socio-economic, behavioural and lifestyle factors.DesignProspective data were collected from a cohort of 636 British women followed up since their birth in 1946. Participants completed a 28-item, scaled version of the General Health Questionnaire (GHQ-28) to measure psychological distress at age 53 years. Dietary intakes in childhood (at age four) were determined by 24h recall and in adulthood (at age 36, 43 and 53 years) by a 5d food record.ResultsLow dietary vitamin B12intake at age 53 was associated with higher psychological distress at that age. Women in the lowest third of vitamin B12intake in adulthood had a higher GHQ-28 score compared with those in the highest third (percentage change, adjusted regression coefficient, 21 (95% CI 3, 39)). There were no other significant associations between dietary B vitamin intake in childhood or adulthood and psychological distress in the cohort.ConclusionsOverall, there is evidence that intake of vitamin B12at age 53 is related to adult psychological distress but there is no evidence for the effects of other adult B vitamin intakes or childhood intakes on psychological distress.

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Associations between dietary intake of B-vitamins and psychological disorders among Iranian women: a cross-sectional study

Public Health Nutrition ◽

10.1017/s1368980020002943 ◽

2020 ◽

pp. 1-11

Author(s):

Hadis Mozaffari ◽

Manije Darooghegi Mofrad ◽

Pamela J Surkan ◽

Mohammadreza Askari ◽

Leila Azadbakht

Keyword(s):

Psychological Distress ◽

Dietary Intake ◽

Psychological Disorders ◽

Cross Sectional Study ◽

B Vitamins ◽

Dietary Vitamin ◽

Vitamin B ◽

Sectional Study ◽

Iranian Women ◽

Cross Sectional

Abstract Objective: B-vitamins affect brain function through multiple pathways. Given limited evidence on the relationship between dietary intake of these vitamins and psychological disorders, we examined dietary intake of vitamin B6-9-12 in relation to psychological disorders among Iranian women. Design: Cross-sectional study. Dietary intake was assessed using a valid and reliable FFQ. To assess psychological disorders, we used a version of the Depression Anxiety Stress Scale-21 validated in Iran. Setting: Ten public health centres in southern Tehran, Iran. Participants: A total of 447 female participants aged 20–50 years. Results: The median values of vitamin B6 (pyridoxine), B9 (folate) and B12 (cobalamin) were 1·30 mg/d, 313·89 µg/d and 3·99 µg/d, respectively. After adjustment for potential confounders, dietary vitamin B6 intake was associated with lower odds of depression (OR: 0·54; 95 % CI: 0·31, 0·95; Ptrend: 0·03). However, there was a positive association between dietary vitamin B12 intake with the odds of depression (OR: 2·05; 95 % CI: 1·17, 3·60; Ptrend: 0·01) and psychological distress (OR: 2·00; 95 % CI: 1·17, 3·41; Ptrend: 0·01). No association was found between vitamin B9 with any psychological disorders. Conclusions: Women with higher dietary intakes of vitamin B6 had lower likelihood of depression. However, women with higher dietary intake of vitamin B12 had higher odds of depression and psychological distress. Future prospective studies in different populations are needed to clarify whether B-vitamin deficiency is a cause or consequence of psychological disorders.

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Riboflavin Is an Important Determinant of Vitamin B-6 Status in Healthy Adults

Journal of Nutrition ◽

10.1093/jn/nxaa225 ◽

2020 ◽

Vol 150 (10) ◽

pp. 2699-2706

Author(s):

Alexandra Jungert ◽

Helene McNulty ◽

Leane Hoey ◽

Mary Ward ◽

J J Strain ◽

...

Keyword(s):

Methylenetetrahydrofolate Reductase ◽

Active Form ◽

Age Groups ◽

Healthy Adults ◽

Dietary Vitamin ◽

Vitamin B ◽

Dietary Intakes ◽

Mthfr Genotype ◽

B Vitamin ◽

Riboflavin Status

ABSTRACT Background Riboflavin is required to generate the active form of vitamin B-6 (pyridoxal 5′-phosphate; PLP) in tissues, but the relevance of this metabolic interaction for nutritional status of vitamin B-6 is unclear because riboflavin biomarkers are rarely measured in human studies. Objectives The purpose of this study was to identify the determinants of biomarkers of vitamin B-6 and riboflavin status and to examine the relationship between these nutrients in healthy adults. Methods Multiple linear regression was performed on observational data in 407 healthy adults aged 18–92 y who did not use B-vitamin supplements. Vitamin B-6 status was assessed by plasma PLP concentrations and erythrocyte glutathione reductase activation coefficient (EGRac) was used as a functional indicator of riboflavin status. Results Dietary intakes of vitamin B-6 and riboflavin were below the average requirements in 10% and 29% of participants, respectively. Suboptimal status of vitamin B-6 (PLP ≤30.0 nmol/L) was more prevalent in adults aged ≥60 y than in younger participants (i.e., 14% compared with 5%), whereas a high proportion (i.e., overall 37%) of both age groups had deficient riboflavin status (EGRac ≥1.40). In multiple regression analysis, EGRac (P = 0.019) was a significant determinant of plasma PLP, along with dietary vitamin B-6 intake (P = 0.003), age (P < 0.001), BMI (kg/m2) (P = 0.031), and methylenetetrahydrofolate reductase gene (MTHFR) genotype (P < 0.001). Significant determinants of EGRac were dietary riboflavin intake (P < 0.001), age (P < 0.001) and MTHFR genotype (P = 0.020). Plasma PLP showed a stepwise decrease across riboflavin status categories from optimal (EGRac ≤1.26) to low (EGRac 1.27–1.39) to deficient status (P = 0.001), independent of dietary vitamin B-6 intake. Conclusions The findings are consistent with the known metabolic dependency of vitamin B-6 on riboflavin status and indicate that riboflavin may be the limiting nutrient, particularly in older people, for maintaining adequate vitamin B-6 status.

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Associations of dietary B vitamins intakes with depression in adults

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000720 ◽

2021 ◽

Author(s):

Yanjun Wu ◽

Suyun Li ◽

Weijing Wang ◽

Dongfeng Zhang

Keyword(s):

Vitamin B12 ◽

Vitamin B6 ◽

Vitamin B1 ◽

B Vitamins ◽

Dietary Vitamin ◽

Dietary Intakes ◽

Vitamin B2 ◽

Logistic Regression Models ◽

The People ◽

The Impact

Abstract. Background: The impact of the dietary B vitamins intakes on the development of depression has been scarcely investigated. Thus, this study aimed to examine the associations of dietary B vitamins intakes with the risk of depression in American adults. Methods: The data we used in this study were from the National Health and Nutrition Examination Survey (NHANES) 2007-2014. We used the Logistic regression models to analyze the associations of the dietary intakes of B vitamins with the risk of depression. Results: 17,732 individuals (8,623 males and 9,109 females) were enrolled in the study and they were all 18 or older. Compared to the lowest quartile of dietary intake, the ORs (95%CIs) of the highest quartile were 0.64 (0.50–0.82), 0.78 (0.62–0.97), 0.60 (0.47–0.78), 0.65 (0.50–0.84), and 0.71 (0.54–0.95) for vitamin B1, vitamin B2, niacin, vitamin B6, and vitamin B12, respectively. Compared to the people whose dietary intakes below the RDA in the model 2, those with intake meeting the RDA of vitamin B1 (OR: 0.68; 95%CI: 0.56–0.84), niacin (OR: 0.65; 95%CI: 0.51–0.81), B6 (OR: 0.65; 95%CI: 0.52–0.81), or B12 (OR: 0.65; 95%CI: 0.48–0.88) had a lower risk of depression, severally. We also found a nonlinear negative association between dietary vitamin B1, vitamin B2, niacin, vitamin B6, and vitamin B12 intakes and the risk of depression in the dose-response analyses, severally. Conclusions: Our results suggested that dietary vitamin B1, vitamin B2, niacin, vitamin B6, and vitamin B12 intakes may be inversely associated with the risk of depression.

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B-Vitamins and Exercise: Does Exercise Alter Requirements?

International Journal of Sport Nutrition and Exercise Metabolism ◽

10.1123/ijsnem.16.5.453 ◽

2006 ◽

Vol 16 (5) ◽

pp. 453-484 ◽

Cited By ~ 62

Author(s):

Kathleen Woolf ◽

Melinda M. Manore

Keyword(s):

Nutritional Status ◽

The Body ◽

B Vitamins ◽

Vitamin B ◽

Dietary Intakes ◽

Food Groups ◽

Mineral Supplement ◽

Vitamin B 12 ◽

B Vitamin ◽

Activity Requirement

The B-vitamins (thiamin, ribofavin, vitamin B-6) are necessary in the energy-producing pathways of the body, while folate and vitamin B-12 are required for the synthesis of new cells, such as the red blood cells, and for the repair of damaged cells. Active individuals with poor or marginal nutritional status for a B-vitamin may have decreased ability to perform exercise at high intensities. This review focuses on the B-vitamins and their role in energy metabolism and cell regeneration. For each vitamin, function related to physical activity, requirement, and status measures are given. Research examining dietary intakes and nutritional status in active individuals is also presented. Current research suggests that exercise may increase the requirements for ribofavin and vitamin B-6, while data for folate and vitamin B-12 are limited. Athletes who have poor diets, especially those restricting energy intakes or eliminating food groups from the diet, should consider supplementing with a multivitamin/mineral supplement.

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Effects of the forage to concentrate ratio on B-vitamin concentrations in different ruminal fractions of dairy cows

Canadian Journal of Animal Science ◽

10.4141/a05-012 ◽

2005 ◽

Vol 85 (3) ◽

pp. 389-399 ◽

Cited By ~ 24

Author(s):

D. E. Santschi ◽

J. Chiquette ◽

R. Berthiaume ◽

R. Martineau ◽

J. J. Matte ◽

...

Keyword(s):

Dairy Cows ◽

B Vitamins ◽

Free Fluid ◽

Vitamin B ◽

Associated Bacteria ◽

Lactating Cows ◽

Liquid Portion ◽

B Vitamin ◽

High Forage ◽

Surrounding Fluid

Two studies were undertaken to verify the effect of the forage to concentrate ratio of the diet on B-vitamin concentrations in ruminal contents. In Study 1, eight primiparous and eight multiparous cows were used in a cross-over design, and concentrations of biotin, folates and vitamin B12 were determined in ruminal fluid and plasma of cows fed a high-forage (HF; 58:42 forage to concentrate ratio; DM basis) or a low-forage (LF; 37:63 forage to concentrate ratio; DM basis) diet. In Study 2, six ruminally cannulated lactating cows were used in a cross-over design to evaluate the effects of forage to concentrate ratio (HF = 60:40; LF = 40:60; DM basis) on concentrations of seven B-vitamins in the particle-free fluid and in both liquid- and solid-associated bacteria. Results showed that B-vitamins were present mainly in the bacterial fractions of the ruminal content, while only limited amounts were found in the surrounding fluid. A change in the forage to concentrate ratio had a greater effect on vitamin concentration in the bacteria associated with the solid fraction than in those present in the liquid portion of the rumen. The most noticeable effects of a low forage diet were an increase in riboflavin, but a decrease in true vitamin B12 concentrations in solid-associated bacteria as well as a decrease in biotin concentration in particle-free fluid. In conclusion, it appears that ruminal B-vitamin concentration is altered by changes in the forage to concentrate ratio, which suggests that the supply of vitamins to dairy cows is influenced by diet composition. Key words: B-vitamins, dairy cow, ruminal fractions, forage to concentrate ratio

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Folate and vitamin B12concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study

British Journal Of Nutrition ◽

10.1017/s0007114516004414 ◽

2017 ◽

Vol 117 (1) ◽

pp. 124-133 ◽

Cited By ~ 7

Author(s):

I. Iglesia ◽

I. Huybrechts ◽

M. González-Gross ◽

T. Mouratidou ◽

J. Santabárbara ◽

...

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Healthy Lifestyle ◽

Blood Parameters ◽

B Vitamins ◽

Vitamin B ◽

Total Homocysteine ◽

Underlying Mechanisms ◽

B Vitamin ◽

Helena Study

AbstractThis study aimed to examine the association between vitamin B6, folate and vitamin B12biomarkers and plasma fatty acids in European adolescents. A subsample from the Healthy Lifestyle in Europe by Nutrition in Adolescence study with valid data on B-vitamins and fatty acid blood parameters, and all the other covariates used in the analyses such as BMI, Diet Quality Index, education of the mother and physical activity assessed by a questionnaire, was selected resulting in 674 cases (43 % males). B-vitamin biomarkers were measured by chromatography and immunoassay and fatty acids by enzymatic analyses. Linear mixed models elucidated the association between B-vitamins and fatty acid blood parameters (changes in fatty acid profiles according to change in 10 units of vitamin B biomarkers). DHA, EPA) andn-3 fatty acids showed positive associations with B-vitamin biomarkers, mainly with those corresponding to folate and vitamin B12. Contrarily, negative associations were found withn-6:n-3 ratio,trans-fatty acids and oleic:stearic ratio. With total homocysteine (tHcy), all the associations found with these parameters were opposite (for instance, an increase of 10 nmol/l in red blood cell folate or holotranscobalamin in females produces an increase of 15·85 µmol/l of EPA (Pvalue <0·01), whereas an increase of 10 nmol/l of tHcy in males produces a decrease of 2·06 µmol/l of DHA (Pvalue <0·05). Positive associations between B-vitamins and specific fatty acids might suggest underlying mechanisms between B-vitamins and CVD and it is worth the attention of public health policies.

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B Vitamins and Cognitive Performance in Older Adults: Review

ISRN Nutrition ◽

10.5402/2013/650983 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 10

Author(s):

J. L. Reay ◽

M. A. Smith ◽

L. M. Riby

Keyword(s):

Cognitive Function ◽

Carbon Metabolism ◽

Optimal Dose ◽

Epidemiological Studies ◽

B Vitamins ◽

Therapeutic Window ◽

Vitamin Therapy ◽

One Carbon Metabolism ◽

B Vitamin ◽

The Impact

A copious amount of scientific scrutiny has been dedicated to documenting typical and atypical human ageing, with a substantial body of work focusing upon the impact of lifestyle choices. One such lifestyle choice is that of diet and, in particular, micronutrient ingestion. Epidemiological studies have reported positive associations between B vitamin status and cognitive function, including negative associations between biological markers (i.e., homocysteine) of dysregulated one-carbon metabolism and cognitive function. This has led to a surge of randomised control trials (RCTs) investigations into B vitamin therapy. However, results have continuingly failed to show beneficial behavioural effects. Despite this, results reliably show treatment-related increases in B vitamin level and decreases in homocysteine level—both of which have been identified as risk factors for atypical ageing. In this paper we argue that it would be premature to conclude that B vitamin therapy has no potential and that more research is needed to systematically investigate the optimal dose, the therapeutic “window,” and individual differences in therapy responders and nonresponders. We start with a brief look at one-carbon metabolism and then consider the evidence from epidemiological studies and RCTs in relation to three specific B vitamins: folic acid (B9), pyridoxine (B6), and cobamides (B12).

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Vitamin B-6 Intake Is Modestly Associated with Arsenic Methylation in Uruguayan Children with Low-Level Arsenic Exposure

Journal of Nutrition ◽

10.1093/jn/nxz331 ◽

2020 ◽

Vol 150 (5) ◽

pp. 1223-1229 ◽

Cited By ~ 1

Author(s):

Gauri Desai ◽

Marie Vahter ◽

Elena I Queirolo ◽

Fabiana Peregalli ◽

Nelly Mañay ◽

...

Keyword(s):

Arsenic Exposure ◽

B Vitamins ◽

Vitamin B ◽

Dimethylarsinic Acid ◽

Study Objective ◽

Low Level ◽

Urinary Arsenic ◽

Vitamin Intake ◽

Vitamin B 12 ◽

B Vitamin

ABSTRACT Background Detoxification of inorganic arsenic (iAs) occurs when it methylates to form monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). Lower proportions of urinary iAs and MMA, and higher proportions of DMA indicate efficient methylation. The role of B-vitamins in iAs methylation in children with low-level arsenic exposure is understudied. Objectives Our study objective was to assess the association between B-vitamin intake and iAs methylation in children with low-level arsenic exposure (<50 µg/L in water; urinary arsenic 5–50 µg/L). Methods We conducted a cross-sectional study in 290 ∼7-y-old children in Montevideo. Intake of thiamin, riboflavin, niacin, vitamin B-6, and vitamin B-12 was calculated by averaging 2 nonconsecutive 24-h recalls. Total urinary arsenic concentration was measured as the sum of urinary iAs, MMA, and DMA, and adjusted for urinary specific gravity; iAs methylation was measured as urinary percentage As, percentage MMA, and percentage DMA. Arsenic concentrations from household water sources were assessed. Linear regressions tested the relationships between individual energy-adjusted B-vitamins and iAs methylation. Results Median (range) arsenic concentrations in urine and water were 9.9 (2.2–48.7) and 0.45 (0.1–18.9) µg/L, respectively. The median (range) of urinary percentage iAs, percentage MMA, and percentage DMA was 10.6% (0.0–33.8), 9.7% (2.6–24.8), and 79.1% (58.5–95.4), respectively. The median (range) intake levels of thiamin, riboflavin, niacin, and vitamin B-6 were 0.81 (0.19–2.56), 1.0 (0.30–2.24), 8.6 (3.5–23.3), and 0.67 (0.25–1.73) mg/1000 kcal, respectively, whereas those of folate and vitamin B-12 were 216 (75–466) and 1.7 (0.34–8.3) µg/1000 kcal, respectively. Vitamin B-6 intake was inversely associated with urinary percentage MMA (β = −1.60; 95% CI: −3.07, −0.15). No other statistically significant associations were observed. Conclusions Although vitamin B-6 intake was inversely associated with urinary percentage MMA, our findings suggest limited support for a relation between B-vitamin intake and iAs methylation in children exposed to low-level arsenic.

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Dietary methyl donor micronutrients intake in relation to psychological disorders in adults

British Journal Of Nutrition ◽

10.1017/s0007114521003081 ◽

2021 ◽

pp. 1-33

Author(s):

Keyhan Lotfi ◽

Ammar Hassanzadeh Keshteli ◽

Parvane Saneei ◽

Hamid Afshar ◽

Ahmad Esmaillzadeh ◽

...

Keyword(s):

Psychological Distress ◽

General Health Questionnaire ◽

Depression Scale ◽

Psychological Disorders ◽

Cross Sectional Study ◽

Dietary Intakes ◽

Cross Sectional ◽

Lower Odds ◽

Methyl Donor ◽

Stratified Analysis

Abstract Previous investigations have mostly studied an individual methyl donor nutrient in relation to psychological disorders and the findings were inconsistent. We investigated the association of methyl donor micronutrients (folate, B6, B12, choline, betaine, and methionine) with psychological disorders (depression, anxiety, psychological distress) in Iranian adults. In this cross-sectional study, dietary intakes of 3299 adults were collected using a validated food frequency questionnaire. Methyl donor micronutrient score (MDMS) was calculated based on energy-adjusted deciles of each nutrient. Hospital Anxiety and Depression Scale (HADS) and General Health Questionnaire (GHQ), validated for Iranians, have been applied to assess depression, anxiety, and psychological distress. Participants had a mean age of 36.3±7.9 years, of whom 58.5% were women. After considering potential confounders, adults in the top quartile of MDMS, compared to the bottom one, had decreased odds of anxiety (OR: 0.53, 95%CI: 0.37–0.75), depression (OR: 0.75, 95%CI: 0.58–0.97) and psychological distress (OR: 0.61, 95%CI: 0.46–0.80). Stratified analysis revealed that the highest category of MDMS among men was related to a 68% lower odds of anxiety (95%CI: 0.15–0.68). Among women, the top quartile of MDMS was protectively associated with anxiety (OR: 0.60, 95%CI: 0.40–0.90), depression (OR: 0.68, 95%CI: 0.50–0.93) and psychological distress (OR: 0.53, 95%CI: 0.38–0.74). Overweight and obese subjects in the highest quartile of MDMS had a 67%, 35%, and 53% lower odds of anxiety (95%CI: 0.20–0.56), depression (95%CI: 0.44–0.94), and psychological distress (95%CI: 0.31–0.70), respectively. We found that high consumption of methyl donor micronutrients was related to a reduced odds of psychological disorders, especially in women and overweight or obese individuals. Further prospective studies are needed to affirm these findings.

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Comparison of an interactive 24-h recall and weighed food record for measuring energy and nutrient intakes from complementary foods among 9–10-month-old Malawian infants consuming lipid-based nutrient supplements

British Journal Of Nutrition ◽

10.1017/s0007114518002374 ◽

2018 ◽

Vol 120 (11) ◽

pp. 1262-1271

Author(s):

Jaimie Hemsworth ◽

Mary Arimond ◽

Chiza Kumwenda ◽

Andrea M. Rehman ◽

Kenneth Maleta ◽

...

Keyword(s):

Measurement Error ◽

Intervention Group ◽

Dietary Intakes ◽

Percentage Agreement ◽

Food Record ◽

Fish Eggs ◽

Nutrient Intakes ◽

Complementary Foods ◽

Nutrient Supplements ◽

The Impact

AbstractFortifying complementary foods with lipid-based nutrient supplements (LNS) may improve energy and nutrient intakes of infants at risk for undernutrition. We aimed to determine the relative validity of an interactive 24-h recall (i-24-HR) for assessing the impact of an LNS intervention on dietary intakes of energy and nutrients among rural Malawian 9–10-month-old infants (n 132) participating in the International Lipid‐Based Nutrient Supplements Dose (iLiNS-DOSE) trial. Dietary data were collected for the same day via i-24-HR and weighed food records. Inter-method agreements were estimated overall and by intervention group, using Bland–Altman plots and paired t tests; measurement error models (differential error); and percentage of food omissions and intrusions were estimated. Overall, inter-method differences in mean intakes of energy and most nutrients were not significant. When stratified by group, recalled energy intakes were under-estimated (−368 kJ; P=0·01) in the control but not in the intervention group (−42 kJ; P=0·6). This differential reporting error was related to an over-estimation of recalled LNS (8·1 v. 4·5 g; P<0·001) in the intervention group, compensating for an under-estimation of energy and nutrient intakes from complementary foods. Sources of measurement error in the i-24-HR were under-estimations of starchy staples, meat/fish/eggs and legumes/nuts/seeds (overall percentage agreement between 38 and 89 %; P<0·028); and over-estimations of added sugar, soups/broths and LNS (overall percentage agreement between 138 and 149 %; P<0·001). Common (>30 % eating occasions) omissions were milk/fish/eggs, starchy roots/vegetables and sweetened snacks. Common intrusions were milk/yogurt. Starchy staples and LNS were recalled when consumed (>85 %) (i.e. matched). These results emphasise the importance of considering differential error when interpreting dietary results in LNS trials.

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