scholarly journals Ion/ion reactions for top-down proteomics | Topology of inner membrane proteins | Proteomes of Plasmodium gametocytes | Changes in saliva biomarkers over time | On-chip protein treatment for SELDI MS | Protein preconcentrator | Quantitative proteomics with CDITs | Glycoprotein analysis | SNPs, alternative splicing, and PTMs | The missing selenoproteome

2005 ◽  
Vol 4 (4) ◽  
pp. 1045-1048
Keyword(s):  
Alternative Splicing ◽  
Membrane Proteins ◽  
Quantitative Proteomics ◽  
Top Down ◽  
Inner Membrane ◽  
On Chip ◽  
Protein Treatment ◽  
Over Time

scholarly journals ThermalAttackNet: Are CNNs Making It Easy to Perform Temperature Side-Channel Attack in Mobile Edge Devices?

2021 ◽  
Vol 13 (6) ◽  
pp. 146
Author(s):  
Somdip Dey ◽  
Amit Kumar Singh ◽  
Klaus McDonald-Maier
Keyword(s):  
Information Flow ◽  
Heat Dissipation ◽  
Side Channel ◽  
Side Channel Attack ◽  
Side Channel Attacks ◽  
Information Flow Control ◽  
On Chip ◽  
Temperature Side ◽  
Over Time ◽  
Memory Efficient

Side-channel attacks remain a challenge to information flow control and security in mobile edge devices till this date. One such important security flaw could be exploited through temperature side-channel attacks, where heat dissipation and propagation from the processing cores are observed over time in order to deduce security flaws. In this paper, we study how computer vision-based convolutional neural networks (CNNs) could be used to exploit temperature (thermal) side-channel attack on different Linux governors in mobile edge device utilizing multi-processor system-on-chip (MPSoC). We also designed a power- and memory-efficient CNN model that is capable of performing thermal side-channel attack on the MPSoC and can be used by industry practitioners and academics as a benchmark to design methodologies to secure against such an attack in MPSoC.

scholarly journals Ordering global governance complexes: The evolution of the governance complex for international civil aviation

2021 ◽  
Author(s):  
Mette Eilstrup-Sangiovanni
Keyword(s):  
Global Governance ◽  
International Institutions ◽  
Historical Data ◽  
Civil Aviation ◽  
Top Down ◽  
Bottom Up ◽  
Governance Systems ◽  
Governance Effectiveness ◽  
Political Agents ◽  
Over Time

AbstractMany observers worry that growing numbers of international institutions with overlapping functions undermine governance effectiveness via duplication, inconsistency and conflict. Such pessimistic assessments may undervalue the mechanisms available to states and other political agents to reduce conflictual overlap and enhance inter-institutional synergy. Drawing on historical data I examine how states can mitigate conflict within Global Governance Complexes (GGCs) by dissolving or merging existing institutions or by re-configuring their mandates. I further explore how “order in complexity” can emerge through bottom-up processes of adaptation in lieu of state-led reform. My analysis supports three theoretical claims: (1) states frequently refashion governance complexes “top-down” in order to reduce conflictual overlap; (2) “top-down” restructuring and “bottom-up” adaptation present alternative mechanisms for ordering relations among component institutions of GGCs; (3) these twin mechanisms ensure that GGCs tend to (re)produce elements of order over time–albeit often temporarily. Rather than evolving towards ever-greater fragmentation and disorder, complex governance systems thus tend to fluctuate between greater or lesser integration and (dis)order.

Precarity Unbound

2007 ◽  
Vol 32 (3) ◽  
pp. 319-340 ◽  
Author(s):  
Nancy Ettlinger
Keyword(s):  
Everyday Life ◽  
Final Section ◽  
Multiple Scales ◽  
Bush Administration ◽  
Radical Democracy ◽  
Top Down ◽  
Hardt And Negri ◽  
Global Events ◽  
Time Periods ◽  
Over Time

Departing from tendencies to bound precarity in particular time periods and world regions, this article develops an expansive view of precarity over time and across space. Beyond effects of specific global events and macroscale structures, precarity inhabits the microspaces of everyday life. However, people attempt to disengage the stress of precarious life by constructing the illusion of certainty. Reflexive denial of precarious life entails essentialist strategies that implicitly or explicitly classify and homogenize people and phenomena, legitimize the constructed boundaries, and in the process aim at eliminating difference and possibilities for negotiation; the tension between these goals and material realities helps explain misrepresentations that can be catastrophic at multiple scales, re-creating precarity. Reactions to 9/11 by the Bush administration represent a case in point of reflexive denial of precarity through strategies that created illusions of certainty with deleterious results. Normatively, the paradox of precarious life and reflexive denials prompts questions as to how urges for certainty in the context of precarity might be constructively channeled. the author approaches this challenge in the final section by drawing from a nexus of concerns about post-Habermasian radical democracy, individual thought and feeling, and network dynamics. Whereas Hardt and Negri reverse the direction of the Foucauldian concept of biopower from top-down to bottom-up, the author draws from Foucault's concept of governmentality in relation to resistance to imagine a cooperative politics operating within as well as across scales.

scholarly journals Prohibitins Regulate Membrane Protein Degradation by the m-AAA Protease in Mitochondria

1999 ◽  
Vol 19 (5) ◽  
pp. 3435-3442 ◽  
Author(s):  
Gregor Steglich ◽  
Walter Neupert ◽  
Thomas Langer
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Cell Growth ◽  
Membrane Proteins ◽  
Eukaryotic Cells ◽  
Mitochondrial Morphology ◽  
Regulatory Effect ◽  
Inner Membrane ◽  
Functional Activities ◽  
Native Molecular Mass ◽  
Affect Cell Growth

ABSTRACT Prohibitins comprise a protein family in eukaryotic cells with potential roles in senescence and tumor suppression. Phb1p and Phb2p, members of the prohibitin family in Saccharomyces cerevisiae, have been implicated in the regulation of the replicative life span of the cells and in the maintenance of mitochondrial morphology. The functional activities of these proteins, however, have not been elucidated. We demonstrate here that prohibitins regulate the turnover of membrane proteins by the m-AAA protease, a conserved ATP-dependent protease in the inner membrane of mitochondria. The m-AAA protease is composed of the homologous subunits Yta10p (Afg3p) and Yta12p (Rca1p). Deletion ofPHB1 or PHB2 impairs growth of Δyta10 or Δyta12 cells but does not affect cell growth in the presence of the m-AAA protease. A prohibitin complex with a native molecular mass of approximately 2 MDa containing Phb1p and Phb2p forms a supercomplex with them-AAA protease. Proteolysis of nonassembled inner membrane proteins by the m-AAA protease is accelerated in mitochondria lacking Phb1p or Phb2p, indicating a negative regulatory effect of prohibitins on m-AAA protease activity. These results functionally link members of two conserved protein families in eukaryotes to the degradation of membrane proteins in mitochondria.

scholarly journals Not So Dead Genes—Retrocopies as Regulators of Their Disease-Related Progenitors and Hosts

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 912
Author(s):  
Joanna Ciomborowska-Basheer ◽  
Klaudia Staszak ◽  
Magdalena Regina Kubiak ◽  
Izabela Makałowska
Keyword(s):  
Alternative Splicing ◽  
Gene Duplication ◽  
Epigenetic Regulation ◽  
Noncoding Rnas ◽  
Cardiovascular Disorders ◽  
Bioinformatics Analyses ◽  
Molecular Machinery ◽  
Stabilizing Factors ◽  
Host Genes ◽  
Over Time

Retroposition is RNA-based gene duplication leading to the creation of single exon nonfunctional copies. Nevertheless, over time, many of these duplicates acquire transcriptional capabilities. In human in most cases, these so-called retrogenes do not code for proteins but function as regulatory long noncoding RNAs (lncRNAs). The mechanisms by which they can regulate other genes include microRNA sponging, modulation of alternative splicing, epigenetic regulation and competition for stabilizing factors, among others. Here, we summarize recent findings related to lncRNAs originating from retrocopies that are involved in human diseases such as cancer and neurodegenerative, mental or cardiovascular disorders. Special attention is given to retrocopies that regulate their progenitors or host genes. Presented evidence from the literature and our bioinformatics analyses demonstrates that these retrocopies, often described as unimportant pseudogenes, are significant players in the cell’s molecular machinery.

scholarly journals Tailoring of Membrane Proteins by Alternative Splicing of Pre-mRNA

Biochemistry ◽  
2012 ◽  
Vol 51 (28) ◽  
pp. 5541-5556 ◽  
Author(s):  
Kathleen F. Mittendorf ◽  
Catherine L. Deatherage ◽  
Melanie D. Ohi ◽  
Charles R. Sanders
Keyword(s):  
Alternative Splicing ◽  
Membrane Proteins

Conclusion

2021 ◽  
pp. 136-150
Author(s):  
Crawford Gribben
Keyword(s):  
Pacific Northwest ◽  
Mass Culture ◽  
First Generation ◽  
Political Strategies ◽  
Top Down ◽  
Marketplace Of Ideas ◽  
Moral Majority ◽  
Religious Conservatism ◽  
The Pacific ◽  
Over Time

Paradoxically, the failure of the first generation of Christian Reconstructionists to cohere, either personally or ideologically, has worked in the movement’s favor, creating an internal marketplace of ideas by means of which competing groupings within political and religious conservatism have been able to appropriate and adopt their central arguments. Recognizing that a “moral majority” does not exist, and therefore abandoning the top-down political strategies of earlier evangelicals, the believers who participate in the migration to the Pacific Northwest work to build communities that will expand organically and over time to renew America and to replace the supposed neutrality of its legislative base. The project is working. But it is not clear whether the integrity of these ideas will continue as their audience base grows. Mass culture routinizes what was once regarded as radical, with effects that may not easily be predicted at the “end of white, Christian America.”

scholarly journals Physiological Synchrony in EEG, Electrodermal Activity and Heart Rate Detects Attentionally Relevant Events in Time

2020 ◽  
Vol 14 ◽  
Author(s):  
Ivo V. Stuldreher ◽  
Nattapong Thammasan ◽  
Jan B. F. van Erp ◽  
Anne-Marie Brouwer
Keyword(s):  
Heart Rate ◽  
Stimulus Type ◽  
Electrodermal Activity ◽  
Physiological Signals ◽  
Independent Group ◽  
Top Down ◽  
Event Type ◽  
Physiological Synchrony ◽  
Electroencephalogram Eeg ◽  
Over Time

Interpersonal physiological synchrony (PS), or the similarity of physiological signals between individuals over time, may be used to detect attentionally engaging moments in time. We here investigated whether PS in the electroencephalogram (EEG), electrodermal activity (EDA), heart rate and a multimodal metric signals the occurrence of attentionally relevant events in time in two groups of participants. Both groups were presented with the same auditory stimulus, but were instructed to attend either to the narrative of an audiobook (audiobook-attending: AA group) or to interspersed emotional sounds and beeps (stimulus-attending: SA group). We hypothesized that emotional sounds could be detected in both groups as they are expected to draw attention involuntarily, in a bottom-up fashion. Indeed, we found this to be the case for PS in EDA or the multimodal metric. Beeps, that are expected to be only relevant due to specific “top-down” attentional instructions, could indeed only be detected using PS among SA participants, for EDA, EEG and the multimodal metric. We further hypothesized that moments in the audiobook accompanied by high PS in either EEG, EDA, heart rate or the multimodal metric for AA participants would be rated as more engaging by an independent group of participants compared to moments corresponding to low PS. This hypothesis was not supported. Our results show that PS can support the detection of attentionally engaging events over time. Currently, the relation between PS and engagement is only established for well-defined, interspersed stimuli, whereas the relation between PS and a more abstract self-reported metric of engagement over time has not been established. As the relation between PS and engagement is dependent on event type and physiological measure, we suggest to choose a measure matching with the stimulus of interest. When the stimulus type is unknown, a multimodal metric is most robust.

Imprinting Beyond the Founding Phase: How Sedimented Imprints Develop over Time

2020 ◽  
Vol 31 (6) ◽  
pp. 1579-1600
Author(s):  
Lien De Cuyper ◽  
Bart Clarysse ◽  
Nelson Phillips
Keyword(s):  
Process Model ◽  
External Environment ◽  
Top Down ◽  
Bottom Up ◽  
Social Venture ◽  
Changes Over Time ◽  
Over Time ◽  
Do So

In this study, we build on the foundational observations of Selznick and Stinchcombe that organizations bear the lasting imprint of their founding context and explore how characteristics shaped during founding are coherently carried forward through time. To do so, we draw on an ethnography of a social venture where the entrepreneurs left soon after founding. In examining how an initial organizational imprint evolves beyond a venture’s founding phase, we focus on the actions and interactions of organizational members, the founders’ imprint, the venture’s new leadership, and the external environment. The process model we develop shows how the organizational imprint evolves as a consequence of the interplay between top-down and bottom-up forces. We first find that the initial imprint is transmitted through a bottom-up mechanism of imprint reinforcement, and second, that the venture is reimprinted after the founding period through two processes which we call imprint reforming and imprint coupling. The result of this is the formation of a sedimented imprint. Our findings further illuminate that, although the initial imprint sticks, its function and manifestation changes over time.

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