Neurological Deficit and Disturbances in Higher Nervous Activity during Modeling of Perinatal Hypoxic-Ischemic Damage to the Central Nervous System in Rat Pups

2003 ◽  
Vol 136 (3) ◽  
pp. 242-245 ◽  
Author(s):  
S. V. Lebedev ◽  
N. N. Volodin ◽  
D. V. Blinov ◽  
I. P. Lazarenko ◽  
S. O. Rogatkin ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neurological Deficit ◽  
Nervous Activity ◽  
Ischemic Damage ◽  
Rat Pups ◽  
Higher Nervous Activity ◽  
The Central Nervous System

scholarly journals In memory of Academician Ivan Petrovich Pavlov (on the 170th anniversary of his birth)

2019 ◽  
Vol 21 (2) ◽  
pp. 273-279
Author(s):  
V Ya Apchel ◽  
T Sh Morgoshiia
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Natural Science ◽  
Nervous Activity ◽  
Chronic Experiment ◽  
Secretory Process ◽  
Natural Scientist ◽  
Brain Functions ◽  
Higher Nervous Activity ◽  
The Central Nervous System

The main years of the life and scientific creativity of I.P. Pavlova. Illuminated little-known facts from the life of a scientist. It is noted that IP Pavlov is one of the most prominent representatives of modern natural science, the creator of the materialistic theory of higher nervous activity of humans and animals, the founder of the largest physiological school of modernity and new approaches and methods of research in physiology. Pavlov I.P, studied many topical problems of physiology and medicine, but his most systematic and thorough research relates to the physiology of the circulatory and digestive systems, as well as the higher parts of the central nervous system: they are rightfully considered classic, which opened new pages in the relevant sections of physiology and medicine. New and valuable were the results of his research also on individual issues of the physiology of the endocrine system, comparative physiology, physiology of labor and pharmacology. Being deeply convinced that “for a natural scientist, everything is in a method,” IP Pavlov elaborated and introduced the practice of physiological research into the method of a chronic experiment, based on the need for a multilateral and detailed study of the body’s functions in natural conditions, in inseparable communication and interaction with the environment. This method brought the physiology out of the impasse created by a one-sided, analytical method of acute vivisection experiment that prevailed for a long time. Used in the early works of Pavlov on the physiology of blood circulation, the method of chronic experiment was elevated to the rank of a new scientific experimental principle in basic research on the physiology of digestion and then perfected when studying the functions of the higher parts of the central nervous system. Pavlov I.P comprehensively researched and studied the dynamics of the secretory process of the gastric and salivary glands, pancreatic glands, the work of the liver in the use of food of different quality, proved their ability to adapt to the nature of the causative agents of secretion. Created by Pavlov’s theory of higher nervous activity is one of the greatest achievements of natural science in the 20th century. It is a system of the most reliable, complete, accurate and deep knowledge of brain functions and is of great practical importance for medicine, psychology, pedagogy, and scientific organization of complex labor processes.

An Investigation of the Effects of Curcumin on the Changes in the Central Nervous System of Rats Exposed to Aroclor 1254 in the Prenatal Period

2018 ◽  
Vol 17 (2) ◽  
pp. 132-143 ◽  
Author(s):  
Mehmet Eray Alcigir ◽  
Halef Okan Dogan ◽  
Begum Yurdakok Dikmen ◽  
Kubra Dogan ◽  
Sevil Atalay Vural ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuron Specific Enolase ◽  
Control Group ◽  
Albino Rats ◽  
Prenatal Period ◽  
Aroclor 1254 ◽  
Rat Pups ◽  
Tunel Reaction ◽  
The Central Nervous System

Background & Objective: Aroclor 1254 is a widespread toxic compound of Polychlorinated Biphenyls (PCBs), which can create significant nervous problems. No remedies have been found to date. The aim of this study was to reveal the damage that occurs in the central nervous system of rat pups exposed to Aroclor 1254 in the prenatal period and to show the inhibiting effect of curcumin, which is a strong anti-oxidant and neuroprotective substance. Method: The study established 3 groups of adult female and male Wistar albino rats. The rats were mated within these groups and the offspring rats were evaluated within the group given Aroclor 1254 only (n=10) and the group was given both Aroclor 1254 and curcumin (n=10) and the control group (n=10). The groups were compared in respect of pathomorphological damage. The immunohistochemical evaluation was made of 8-hydroxdeoxyguanosine (8-OHdG), 4-hydroxynoneal (4HNE), myelin basic protein (MBP) expressions and TUNEL reaction. The biochemical evaluation was made of the changes in the TAS-TOS and Neuron Specific Enolase (NSE) levels. Damage was seen to have been reduced with curcumin in the 8OHdG and TUNEL reactions, especially in the forebrain and the midbrain, although the dosage applied did not significantly change TAS and TOS levels. Consequently, it was understood that Aroclor 1254 caused damage in the central nervous system of the pup in the prenatal period, and curcumin reduced these negative effects, particularly in the forebrain and the midbrain. Conclusion: It was concluded that curcumin could be a potential neuroprotective agent and would be more effective at higher doses.

On humoral factors in nervous activity

1935 ◽  
Vol 31 (6) ◽  
pp. 777-787
Author(s):  
D. S. Vorontsov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nervous Activity ◽  
Active Part ◽  
Humoral Factors ◽  
The Central Nervous System ◽  
Relationship Of ◽  
The Relationship

Not only in the peripheral working organs, irritating substances are formed, which, as we can see, take an active part in their regulation, but also in the central nervous system, in the relationship of its individual elements, such substances apparently play an important role.

scholarly journals Contribution of Professor B.M. Savin to the development ofaviation and space medicine

2020 ◽  
Vol 22 (2) ◽  
pp. 268-270
Author(s):  
A. A. Blaginin ◽  
I. V. Bukhtiarov ◽  
P. S. Pashenko ◽  
A. V. Savin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nervous Activity ◽  
The Body ◽  
Space Medicine ◽  
Scientific Publications ◽  
Daily Work ◽  
Military Medical Academy ◽  
The Central Nervous System ◽  
Life Path

The main milestones of scientific and pedagogical activity, as well as the life path of one of the leading representatives of aviation medicine, Doctor of Medical Sciences, professor, outstanding researcher and wonderful teacher, author of works on the problem of influence of overload and hypervesomity on the body and central nervous system of man- Boris MikhailvichSavin are considered. Separate moments of his participation in the Great Patriotic War before daily work as the head of research department of the Military Medical Academy named after S.M. Kirov are presented. The contribution of Boris Savin to the study of issues related to aviation and space medicine, in particular: the study of the action on the body of overload and the clarification of physiological mechanisms underlying changes in higher nervous activity at accelerations, was analyzed; Studying the state of the central nervous system when exposed to various factors; Development of neuroreflective theory of adverse effect of accelerations on human body. Boris Mikhailvich has made a huge contribution to the development of aviation and space medicine and has entered the history of aviation and space medicine through his research and scientific publications, which include monographs The influence of overload on the functional state of the central nervous system and the mechanism of disruption of its activities and Hypervesomeness and functions of the central nervous system.

scholarly journals Do the results of the sensomotor response reflect the typological properties of the central nervous system?

2021 ◽  
pp. 69-77
Author(s):  
V. S. Lyzohub ◽  
V. V. Shpanyuk ◽  
V. O. Pustovalov ◽  
T. V. Kozhemyako ◽  
V. O. Suprunovich
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Reaction Rate ◽  
Nervous Activity ◽  
Functional Mobility ◽  
Temporal Characteristics ◽  
The Central Nervous System ◽  
Visual Motor ◽  
The Individual ◽  
The Relationship

Introduction.During the study, we tried to find out whether the temporal characteristics of sensory-motor response can reflect the typological properties of the central nervous system. Such research is essential to reveal the mechanisms of development of higher mental functions and mental capacity.Purpose.To establish the relationship between the speed characteristics of visual-motor reaction different complexity and individual-typological properties of the central nervous system.Methods.Individual differences of sensorimotor reaction and the properties of the main nervous processes were determined by the method of M. V. Makarenko [8] using the computer system "Diagnost-1". 32 teenagers aged 10-11 were examined. During the study, the indicators of latent periods of simple (SVMR) and complex visual-motor reactions of choice (RC1-2, RC2-3), functional mobility of nervous processes (FMNS) were investigated. Results.Speed characteristics of simple (SVMR) and complex visual-motor reactions of choice of one (RC1-3) and choice of two (RC2-3) excitatory and inhibitory signals were studied in order to 202177use them to assess individual typological properties of the central nervous system (CNS) in adolescents 10-11 years old. There is no evidence of a relationship between the rate of SVMR with different levels of functional mobility (FMNS) of nervous processes in adolescents 10-11 years old.The reaction rate did not differ statistically and was the same in representatives with high, medium and low levels oftypological properties of nervous system. The results of the correlation analysis between SVMR and FMNP were r = 0.13 (p = 0.59), which indicated no relationship between them. The relationship of sensorimotor response time with individual-typological features of the CNS was established in complex information differentiation RC2-3. The temporal characteristics of RC2-3 were dependent on the individual-typological properties of the CNS.The reaction rate of RC2-3 was higher in adolescents 10-11 years old with high levels of -3 were r = 0.35 (p = 0.034).The results show that the velocity characteristics of complex neurodynamic acts, in contrast to simple ones, can be used as quantitative characteristics of the typological properties of the CNS.Originality.The results of our research may be evidence that the indicator RC2-3 can be used as an additional informative criterion for assessing the individual-typological properties of the higher parts of the central nervous system.Conclusion. The temporal characteristics of SVMR and RC1-3 cannot be considered as informative criteria for assessing the individual-typological properties of CNS in adolescents 10-11 years. Time characteristics of RC2-3 differentiation reactions can be used as additional indicators for assessing the individual-typological properties of higher nervous activity in adolescents 10-11 years, namely, the level of functional mobility of nervous processes.Key words:processing of information of various complexity, speed characteristics of simple reactions, motor acts of choice and differentiation, individual-typological properties, functional mobility of nervous processes

On humoral factors in nervous activity

1935 ◽  
Vol 31 (5) ◽  
pp. 650-663
Author(s):  
D. S. Vorontsov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nervous Activity ◽  
Chemical System ◽  
Humoral Factors ◽  
The Central Nervous System

Until recently, science has held the view that the body's activities are managed in two fundamentally different ways - the nervous system, where the central nervous system plays the main coordinating role, and the chemical system.

scholarly journals Lithium Toxicity in the Setting of Nonsteroidal Anti-Inflammatory Medications

2013 ◽  
Vol 2013 ◽  
pp. 1-2
Author(s):  
Syed Hassan ◽  
Fatima Khalid ◽  
Zaid Alirhayim ◽  
Syed Amer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Improvement ◽  
Neurological Deficit ◽  
Multiple Organ ◽  
Lithium Toxicity ◽  
Lithium Clearance ◽  
Organ Systems ◽  
The Central Nervous System ◽  
Anti Inflammatory

Lithium toxicity is known to affect multiple organ systems, including the central nervous system. Lithium levels have been used in the diagnosis of toxicity and in assessing response to management. There is evidence that nonsteroidal anti-inflammatory medications (NSAIDs) can increase lithium levels and decrease renal lithium clearance. We present a case of lithium toxicity, which demonstrates this effect and also highlights the fact that lithium levels do not correlate with clinical improvement, especially the neurological deficit.

scholarly journals An Intracerebral Penetration of Air Shotgun Pellet in Toddler: A Case without Neurological Sequelae

2018 ◽  
Vol 6 (8) ◽  
pp. 1446-1449 ◽  
Author(s):  
Wayan Niryana ◽  
Hendry Irawan ◽  
I Putu Eka Widyadharma
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neurological Deficit ◽  
Pediatric Population ◽  
Surgical Removal ◽  
Severe Damage ◽  
Neurological Sequelae ◽  
Before And After ◽  
The Central Nervous System ◽  
The Brain

BACKGROUND: A non-powder firearm including air shotgun remains a significant source of injury to children. It causes severe damage and can involve the brain, eyes, heart, abdomen, and other body parts.CASE REPORT: A toddler boy was accidentally shot by an air shotgun at the forehead, and there was no sign of neurological deficit, both before and after surgical removal of the pellet. Herein, we report a case of air shotgun pellet which penetrated a toddler’s head from the forehead, all the way up to the occiput. Removal of the pellet was successfully performed without eliciting any neurological sequelae.CONCLUSION: Air shotgun pellet may potentially cause severe injury to the central nervous system when the head is affected, which can be safely prevented by a prompt but deliberate surgical removal. The study would also like to emphasise the importance of education to reduce gunshot incidence in the pediatric population.

scholarly journals Predictive significance of pro-inflammatory interleukins at newborns with hypoxic-ischemic encephalopathy

2021 ◽  
pp. 12-19
Author(s):  
Liudmila Yur'evna Barycheva ◽  
Aminat Sultanovna Idrisova ◽  
Ekaterina Sergeevna Kuzmina ◽  
Oleg Vilenovich Agranovich ◽  
Kazbek Sultanovich Mezhidov
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Inflammatory Responses ◽  
Hypoxic Ischemic Encephalopathy ◽  
Enzyme Linked Immunosorbent Assay ◽  
Ischemic Damage ◽  
The Central Nervous System ◽  
Term Newborns ◽  
Ischemic Encephalopathy ◽  
Pro Inflammatory Cytokines

Relevance. Hypoxic-ischemic damage to the central nervous system is accompanied by overproduction of pro-inflammatory interleukins in newborns. Perinatal inflammatory responses contribute to unfavorable outcomes. Methods of investigation. The analysis of the cytokine profile in the blood serum was performed in 45 full-term newborns by the method of enzyme-linked immunosorbent assay within 4–96 hours after birth. 32 children had the signs of HIE stage 2, 13 children — HIE stage 3. Unfavorable neurological consequences were formed in 47,4% of children. Research results. Revealed an increase in the levels of IL1β — 17,7 [13,6; 25,4] and IL6 35,2 [24,9; 45,0] in newborns with HIE. A significant increase in pro-inflammatory cytokines was found in patients with unfavorable outcomes compared with favorable ones. When predicting the disabling consequences of DIE, a high predictive value was established for IL1β and IL6. Conclusion. In newborns with hypoxic-ischemic encephalopathy, an increase in serum IL1β and IL6 is observed. It is advisable to use an increase in IL1β >19,4 pg/ml (OR=12,80; 95% CI: 2,90–56,58) and IL6 >40,1 pg/ml (OR=11,33; 95% CI: 2,46–52,15).

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