Physical activity: good for your health, very good for your gene expression

2001 ◽  
Vol 57 (4) ◽  
pp. 249-251 ◽  
Author(s):  
David Gurwitz
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Good For

scholarly journals Histochemical Characterisation and Gene Expression Analysis of Skeletal Muscles from Maremmana and Aubrac Steers Reared on Grazing and Feedlot Systems

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 656
Author(s):  
Giulia Foggi ◽  
Francesca Ciucci ◽  
Maria Conte ◽  
Laura Casarosa ◽  
Andrea Serra ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Muscle Fibre ◽  
Skeletal Muscles ◽  
Gene Expression Analysis ◽  
Type I ◽  
Triceps Brachii ◽  
Gene Expressions ◽  
Muscle Properties ◽  
Voluntary Physical Activity

This study aimed to characterise the fibre composition of Triceps brachii (TB) and Semimembranosus (SM) muscles from 20 Maremmana (MA) and 20 Aubrac (AU) steers, and the effect of grazing activity in comparison with feedlot system. The histochemical method was performed with the m-ATPase method with an acid pre-incubation, thus allowing to distinguish type I, IIA, and IIB fibres. Additionally, on total RNA extracted from SM muscle, the expressions of atp1a1, mt-atp6, and capn1 genes were evaluated, in order to find potential associations with muscle fibre histochemical characteristics. In SM muscle, the MA steers had the greater frequency of oxidative fibres (type I and IIA) and the higher atp1a1 expression, in comparison to AU steers. Conversely, AU steers had a greater frequency of type IIB fibres, and the higher capn1 expression. A similar histochemical pattern was observed in TB muscle. The grazing activity was probably insufficient to determine differences both for fibre proportion and size, and gene expressions, except for mt-atp6 expression that was surprisingly highest in feedlot MA in comparison to other steers. These findings further the knowledge of muscle properties belonging to these breeds, and the effect of voluntary physical activity since few studies were available in this regard.

scholarly journals Differences in Muscle and Adipose Tissue Gene Expression and Cardio-Metabolic Risk Factors in the Members of Physical Activity Discordant Twin Pairs

PLoS ONE ◽  
2010 ◽  
Vol 5 (9) ◽  
pp. e12609 ◽  
Author(s):  
Tuija Leskinen ◽  
Rita Rinnankoski-Tuikka ◽  
Mirva Rintala ◽  
Tuulikki Seppänen-Laakso ◽  
Eija Pöllänen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Risk Factors ◽  
Adipose Tissue ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Adipose Tissue Gene Expression ◽  
Tissue Gene Expression ◽  
Discordant Twin

scholarly journals The Impact of Long‐Term Physical Activity on Age‐Related Changes in Protein and Gene Expression

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Ian R Lanza ◽  
Daniel K Short ◽  
Kevin R Short ◽  
Yan W Asmann ◽  
Sreekumar Raghavakaimal ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Age Related ◽  
The Impact ◽  
Age Related Changes

scholarly journals Analysis of Activity-Dependent Energy Metabolism in Mice Reveals Regulation of Mitochondrial Fission and Fusion mRNA by Voluntary Physical Exercise in Subcutaneous Fat from Male Marathon Mice (DUhTP)

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2697
Author(s):  
Julia Brenmoehl ◽  
Daniela Ohde ◽  
Christina Walz ◽  
Martina Langhammer ◽  
Julia Schultz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Energy Metabolism ◽  
Fat Mass ◽  
Mitochondrial Fission ◽  
Subcutaneous Fat ◽  
Voluntary Exercise ◽  
Heart Weight ◽  
Mitochondrial Energy Metabolism ◽  
Voluntary Physical Activity

Physical inactivity is considered as one of the main causes of obesity in modern civilizations, and it has been demonstrated that resistance training programs can be used to reduce fat mass. The effects of voluntary exercise on energy metabolism are less clear in adipose tissue. Therefore, the effects of three different voluntary exercise programs on the control of energy metabolism in subcutaneous fat were tested in two different mouse lines. In a cross-over study design, male mice were kept for three or six weeks in the presence or absence of running wheels. For the experiment, mice with increased running capacity (DUhTP) were used and compared to controls (DUC). Body and organ weight, feed intake, and voluntary running wheel activity were recorded. In subcutaneous fat, gene expression of browning markers and mitochondrial energy metabolism were analyzed. Exercise increased heart weight in control mice (p < 0.05) but significantly decreased subcutaneous, epididymal, perinephric, and brown fat mass in both genetic groups (p < 0.05). Gene expression analysis revealed higher expression of browning markers and individual complex subunits present in the electron transport chain in subcutaneous fat of DUhTP mice compared to controls (DUC; p < 0.01), independent of physical activity. While in control mice, voluntary exercise had no effect on markers of mitochondrial fission or fusion, in DUhTP mice, reduced mitochondrial DNA, transcription factor Nrf1, fission- (Dnm1), and fusion-relevant transcripts (Mfn1 and 2) were observed in response to voluntary physical activity (p < 0.05). Our findings indicate that the superior running abilities in DUhTP mice, on one hand, are connected to elevated expression of genetic markers for browning and oxidative phosphorylation in subcutaneous fat. In subcutaneous fat from DUhTP but not in unselected control mice, we further demonstrate reduced expression of genes for mitochondrial fission and fusion in response to voluntary physical activity.

scholarly journals Increased Gene Expression of RUNX2 and SOX9 in Mesenchymal Circulating Progenitors Is Associated with Autophagy during Physical Activity

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
L. Dalle Carbonare ◽  
M. Mottes ◽  
S. Cheri ◽  
M. Deiana ◽  
F. Zamboni ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Physical Exercise ◽  
Cellular Functions ◽  
Enhanced Expression ◽  
Chondrocytic Differentiation ◽  
Marathon Performance ◽  
Array Analyses

Lack of physical exercise is considered an important risk factor for chronic diseases. On the contrary, physical exercise reduces the morbidity rates of obesity, diabetes, bone disease, and hypertension. In order to gain novel molecular and cellular clues, we analyzed the effects of physical exercise on differentiation of mesenchymal circulating progenitor cells (M-CPCs) obtained from runners. We also investigated autophagy and telomerase-related gene expression to evaluate the involvement of specific cellular functions in the differentiation process. We performed cellular and molecular analyses in M-CPCs, obtained by a depletion method, of 22 subjects before (PRE RUN) and after (POST RUN) a half marathon performance. In order to prove our findings, we performed also in vitro analyses by testing the effects of runners’ sera on a human bone marrow-derived mesenchymal stem (hBM-MSC) cell line. PCR array analyses of PRE RUN versus POST RUN M-CPC total RNAs put in evidence several genes which appeared to be modulated by physical activity. Our results showed that physical exercise promotes differentiation. Osteogenesis-related genes as RUNX2, MSX1, and SPP1 appeared to be upregulated after the run; data showed also increased levels of BMP2 and BMP6 expressions. SOX9, COL2A1, and COMP gene enhanced expression suggested the induction of chondrocytic differentiation as well. The expression of telomerase-associated genes and of two autophagy-related genes, ATG3 and ULK1, was also affected and correlated positively with MSC differentiation. These data highlight an attractive cellular scenario, outlining the role of autophagic response to physical exercise and suggesting new insights into the benefits of physical exercise in counteracting chronic degenerative conditions.

scholarly journals Changes in nucleus accumbens gene expression accompany sex-specific suppression of spontaneous physical activity in aromatase knockout mice

2020 ◽  
Vol 121 ◽  
pp. 104719
Author(s):  
Dusti A. Shay ◽  
Rebecca J. Welly ◽  
Scott A. Givan ◽  
Nathan Bivens ◽  
Jill Kanaley ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Nucleus Accumbens ◽  
Knockout Mice ◽  
Specific Suppression ◽  
Spontaneous Physical Activity

scholarly journals Hippocampal gene expression patterns linked to late-life physical activity oppose age and AD-related transcriptional decline

2019 ◽  
Vol 78 ◽  
pp. 142-154 ◽  
Author(s):  
Nicole C. Berchtold ◽  
G. Aleph Prieto ◽  
Michael Phelan ◽  
Daniel L. Gillen ◽  
Pierre Baldi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Expression Patterns ◽  
Late Life ◽  
Gene Expression Patterns

Effects of Physical Activity on Neurophysiological and Gene Expression Profiles in Chronic Back Pain

2020 ◽  
Vol 69 (1) ◽  
pp. 74-81
Author(s):  
Kyounghae Kim ◽  
Divya Ramesh ◽  
Mallory Perry ◽  
Katherine M. Bernier ◽  
Erin E. Young ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Back Pain ◽  
Chronic Back Pain ◽  
Expression Profiles ◽  
Gene Expression Profiles

scholarly journals Physical Activity and Brain Health

Genes ◽  
2019 ◽  
Vol 10 (9) ◽  
pp. 720 ◽  
Author(s):  
Di Liegro ◽  
Schiera ◽  
Proia ◽  
Di Liegro
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Cognitive Processes ◽  
Sedentary Lifestyle ◽  
Brain Aging ◽  
Brain Health ◽  
Metabolic Outcomes ◽  
Antidepressant Effects ◽  
Cellular Pathways ◽  
Sound Mind

Physical activity (PA) has been central in the life of our species for most of its history, and thus shaped our physiology during evolution. However, only recently the health consequences of a sedentary lifestyle, and of highly energetic diets, are becoming clear. It has been also acknowledged that lifestyle and diet can induce epigenetic modifications which modify chromatin structure and gene expression, thus causing even heritable metabolic outcomes. Many studies have shown that PA can reverse at least some of the unwanted effects of sedentary lifestyle, and can also contribute in delaying brain aging and degenerative pathologies such as Alzheimer’s Disease, diabetes, and multiple sclerosis. Most importantly, PA improves cognitive processes and memory, has analgesic and antidepressant effects, and even induces a sense of wellbeing, giving strength to the ancient principle of “mens sana in corpore sano” (i.e., a sound mind in a sound body). In this review we will discuss the potential mechanisms underlying the effects of PA on brain health, focusing on hormones, neurotrophins, and neurotransmitters, the release of which is modulated by PA, as well as on the intra- and extra-cellular pathways that regulate the expression of some of the genes involved.

scholarly journals Physical activity and prostate gene expression in men with low-risk prostate cancer

2014 ◽  
Vol 25 (4) ◽  
pp. 515-523 ◽  
Author(s):  
Mark Jesus M. Magbanua ◽  
Erin L. Richman ◽  
Eduardo V. Sosa ◽  
Lee W. Jones ◽  
Jeff Simko ◽  
...  
Keyword(s):  
Gene Expression ◽  
Physical Activity ◽  
Prostate Cancer ◽  
Low Risk ◽  
Risk Prostate Cancer ◽  
Low Risk Prostate Cancer
Sign in / Sign up

Export Citation Format

Share Document