Waiting longer between pregnancies decreases the risk of premature birth

The objective: to study the psychological characteristics of women’s status in one of the most common complications of pregnancy - the threat of termination of pregnancy, depending on the level of stress load. Patients and methods. We have studied the psychological status (the Holmes-Rahe level of psychosocial stress, the Spielberg-Hanin level of anxiety, V.I.Dobryakov’s related to a pregnancy test, diagnosis of psychological defense mechanisms, assessment of quality of life) 60 pregnant women with threat of premature birth in the third trimester of pregnancy. Surveyed women were divided into 2 groups: group 1 included 30 pregnant women – forced migrant of Donetsk and Lugansk area and 2 group – 30 pregnant women who resided in Kiev. Results. At the same clinical picture of the threat of premature birth we detected discrepancy between the subjective assessment of their condition in women – forced migrants: a high level of situational and personal anxiety, decrease in physical (physical functioning, role-physical functioning) and psychological (social functioning, role emotional functioning) health, doubtful and pathological subtypes of gestational dominant. This creates prerequisites for complications of pregnancy, childbirth and postpartum future period and requires the participation of psychologists in the work with this category of patients. Conclusion. So, revealed a discrepancy between the objective clinical signs similar obstetric pathology (on the example of threatened abortion) in pregnant women with different levels of stress load and their subjective evaluation of their condition that affects their psychological status. This should be reflected in individually tailored therapy and be mainstreamed into the work of obstetricians and gynecologists with these patients, and requires mandatory participation of psychologists in the work with this category of patients. Key words: pregnancy, the threat of premature birth, stress, psychological status.

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Chorioamnionitis – premature birth and newborn development

Perinatologia ◽

10.26416/peri.2.2.2018.1811 ◽

2018 ◽

Vol 2 (2) ◽

pp. 72

Author(s):

Theodora Ştefania Mardale ◽

A. Burnei-Russu ◽

Octavian Rotaru ◽

Simona Vlădăreanu

Keyword(s):

Premature Birth

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Opportunities for treating opportunistic vaginal infections during pregnancy

GYNECOLOGY ◽

10.26442/2079-5696_19.6.11-15 ◽

2017 ◽

Vol 19 (6) ◽

pp. 11-15 ◽

Cited By ~ 1

Author(s):

T E Karapetyan ◽

V V Muravieva ◽

A S Ankirskaya ◽

L A Lyubasovskaya ◽

T V Priputnevich

Keyword(s):

Positive Result ◽

Pregnant Women ◽

Early Pregnancy ◽

Premature Birth ◽

Local Treatment ◽

Vaginal Infections ◽

Aerobic Vaginitis ◽

Early Gestation ◽

Early Stages ◽

Intrauterine Infections

The aim of the study was to evaluate the effectiveness of treatment of women with opportunistic vaginal infections during pregnancy. Materials and methods. A prospective cohort study included 330 pregnant women, of whom 151 were diagnosed with bacterial vaginosis (BV), 37 had aerobic vaginitis (AB), 109 had vulvovaginal candidiasis (VC), 20 had a combination of VC + BV. When carrying out antibiotic therapy in the early stages of pregnancy, the principle of local treatment was observed. Results. Most often (46.0%), vaginal infections were detected when women were treated early in pregnancy. In the treatment of BV in the early stages of pregnancy with antiseptic chlorhexidine, a positive result of therapy was noted in 97.6% of women. Therapy with metronidazole or clindamycin BV in women who applied in the II and III trimesters, gave a positive result, respectively, in 90.0% and 89.5% of cases. The course of therapy with chlorhexidine pregnant women with AB was effective in 91.7% of cases with treatment in the first trimester and 92.0% in treatment in the II and III trimesters. In the treatment of VC in early pregnancy, natamycin was effective in 95.0% of women. In the II and III trimesters, econazole treatment was successful in 88.2% and 88.6%, respectively. In the treatment of combination of BV + VC in early gestation, the complex course of chlorhexidine + natamycin was effective in 76.5% of women, in II and III trimesters Neo-Penotran Forte was effective in 93.8% of pregnant women. Relapses of vaginal infections were observed in 34 pregnant women (10.3%). Superinfection with fungi was noted in 9.3% of cases of BV treatment and in 8.1% of pregnant women with AB. Among women observed from early pregnancy, there were no cases of premature birth, manifestations of intrauterine infections were noted in 5.3% of newborns. At treatment in the II and III trimesters, premature birth was in 6.5% and 13.5% of women, and manifestations of intrauterine infections - in 15.3% of newborns. Thus, microbiological monitoring of timely detection and treatment of opportunistic vaginal infections in pregnant at-risk groups showed the advisability of treating these infections in early gestation.

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Chemical Effects and Predictive Factors in Premature Birth

Revista de Chimie ◽

10.37358/rc.18.7.6419 ◽

2018 ◽

Vol 69 (7) ◽

pp. 1796-1801

Author(s):

Adrian Neacsu ◽

Alina Calin ◽

Anca Daniela Braila ◽

Dan Navolan ◽

Mihai Dimitriu ◽

...

Keyword(s):

Extracellular Matrix ◽

Premature Birth ◽

Tissue Concentration ◽

Premature Labor ◽

New Born ◽

Uterine Contractions ◽

Chemical Effects ◽

Equal Importance ◽

Necrosis Factor

Premature birth is considered to be the consequence of independent alterations in the cervix and in the uterus. During labor, for full-term birth, as well as for premature birth, the cervix changes, from firm, long and closed, to soft and pliable, through a biochemical process characterized by the reshaping of the extracellular matrix and a growth of the tissue concentration of inflammatory mediators; the uterus proves an increase in contractility and sensitivity to endogenic hormones, such as oxytocin. Premature labor is associated with the premature activation of the release of cytokines in the decidua (mucosa lining uterus walls) and cervix. Interleukins IL-1 beta, IL-6, IL-8 and the alpha tumoral necrosis factor increase the production and activation of matrix metalloproteinases (MMP-1, MMP-3 and MMP-9) and of cathepsin S, which digests the collagen from the extracellular matrix of the cervix, causing the wiping and softening of the cervix. These cytokines are released by leukocytes in the myometer, leading to the production of prostaglandins and oxytocin, which stimulate uterine contractions. Therefore, the cervical shortening represented by ultrasound is believed to represent premature cervical softening. The obstetrical approach of aspects related to premature birth are based, considerably, on the prognosis expected by the obstetrician regarding the survival of the premature new-born baby, as well as the therapeutic variants to be followed. And not only survival is important, of equal importance is also the quality of life of underweight, immature new-born babies, who are considerably affected both physically, and intellectually.

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Meconium peritonitis: review of literature and own clinical observations

10.21516/2413-1458-2020-19-2-117-124 ◽

2020 ◽

Author(s):

E.N. Glavatskaya , O.V. Pribushenya , N.A. Venchikova

Keyword(s):

Prenatal Diagnosis ◽

Premature Birth ◽

Surgical Care ◽

Intestinal Wall ◽

Meconium Peritonitis ◽

Review Of Literature ◽

Review Of The Literature ◽

Clinical Observations ◽

Loop Expansion ◽

The Impact

Two clinical cases of meconium peritonitis in the fetuses are presented. The diagnosis was made prenatally at 30+5 and 20+1 weeks of gestation. The main ultrasound signs were ascites, loop expansion and thickening of the intestinal wall, peritoneal calcifications, meconium pseudocysts. In one case, pregnancy was complicated by polyhydramnios. In both cases, the pregnancy ended in premature birth, followed by surgical treatment during the first days of life. A review of the literature on the topic are discussed the etiology, the spectrum and frequency of ultrasound signs suggesting this condition in the fetus, the effectiveness of prenatal diagnosis, the prognosis for the life and health of the newborn, as well as the impact of the quality and timeliness of the prenatal diagnosis on the management of pregnancy and timeliness of surgical care for the newborn.

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The presence of lupus nephritis additionally increases the risk of preeclampsia among pregnant women with systemic lupus erythematosus

Lupus ◽

10.1177/09612033211004716 ◽

2021 ◽

pp. 096120332110047

Author(s):

Katarina Bremme ◽

Sonja Honkanen ◽

Iva Gunnarsson ◽

Roza Chaireti

Keyword(s):

Caesarean Section ◽

Lupus Nephritis ◽

Pregnant Women ◽

Lupus Erythematosus ◽

Premature Birth ◽

Renal Involvement ◽

Significant Risk ◽

Obstetric Outcomes ◽

Increased Risk ◽

Renal Lupus

Introduction Pregnant women with systematic lupus erythematosus (SLE) have an increased risk of obstetric complications, such as preeclampsia and premature births. Previous studies have suggested that renal involvement could further increase the risk for adverse obstetric outcomes. Aims: The aim of this study was to compare the obstetric outcomes in a Swedish cohort of patients with SLE with and without lupus nephritis (LN). Patients and methods The study was conducted as a retrospective observational study on 103 women with SLE, who gave birth at the Karolinska University Hospital between the years 2000-2017. Thirty-five women had previous or active LN and 68 women had non-renal lupus. Data was collected from digital medical records. The outcomes that were analysed included infants born small for gestational age (SGA), premature birth, preeclampsia, SLE- or nephritis flare and caesarean section. Results Women with LN, both with previous and with renal flare during pregnancy suffered from pre-eclampsia more often compared to women with non-renal lupus (25.7% vs 2.9%, p = 0.001) and this complication was associated with premature birth (p = 0.021) and caesarean section (p = 0.035). Conclusions Lupus nephritis is a significant risk factor for adverse obstetric outcomes in women with SLE, including preeclampsia. Those patients could benefit from more frequent antenatal controls and more vigorous follow-up.

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Premature birth, low birth weight, small for gestational age and chronic non-communicable diseases in adult life: A systematic review with meta-analysis

Early Human Development ◽

10.1016/j.earlhumdev.2020.105154 ◽

2020 ◽

Vol 149 ◽

pp. 105154 ◽

Cited By ~ 4

Author(s):

Elaine Luiza Santos Soares de Mendonça ◽

Mateus de Lima Macêna ◽

Nassib Bezerra Bueno ◽

Alane Cabral Menezes de Oliveira ◽

Carolina Santos Mello

Keyword(s):

Systematic Review ◽

Birth Weight ◽

Low Birth Weight ◽

Gestational Age ◽

Small For Gestational Age ◽

Premature Birth ◽

Meta Analysis ◽

Adult Life ◽

Communicable Diseases ◽

Non Communicable Diseases

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Progestogens for treatment and prevention of pregnancy disorders

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci.2010.069 ◽

2010 ◽

Vol 3 (3) ◽

Author(s):

Adolf E. Schindler

Keyword(s):

Premature Birth ◽

Previous History ◽

First Trimester ◽

Study Groups ◽

Treatment And Prevention ◽

Maternal Immune System ◽

Hydroxyprogesterone Caproate ◽

History Of ◽

Threatened Abortion ◽

In Pregnancy

AbstractProgesterone appears to be the dominant hormone not only establishing a proper secretory endometrial development but also adequate decidualization to establish pregnancy and sustain pregnancy development. Progesterone is the natural immunoregulator to control the maternal immune system and not to reject the allogeneic fetus. There are two sources of progesterone: corpus luteum first and placenta later. Three progestogens can be used in pregnancy: (i) progesterone (per os, intravaginal and intramuscular), (ii) dydrogesterone (per os), and (iii) 17α-hydroxyprogesterone caproate (intramuscular). There are three indications, for which these progestogens can be clinically used either for treatment or prevention: (i) first trimester threatened and recurrent (habitual) abortion, (ii) premature labor/premature birth, and (iii) pre-eclampsia (hypertension in pregnancy). The available data are limited and only partially randomized. In threatened abortion the use of progesterone, dydrogesterone and 17α-hydroxyprogesterone caproate leads to a significant improved outcome, when at the time of threatened abortion a viable fetus has been ascertained by ultrasound. For prevention of recurrent abortion there are also some data indicating a significant effect compared with women without progestogen treatment. Prevention of preterm birth by progestogens (progesterone vaginally, orally and 17α-hydroxyprogesterone caproate intramuscularly) was significantly effective. The main study groups include pregnant women with a previous history of premature birth. However, also in women with shortened cervix use of progesterone seems to be helpful. The studies done so far in women with risk factors for pre-eclampsia or established pre-eclampsia were based on parenteral progesterone application. However, new studies are urgently needed.

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Santa Orosia: a Thaumaturgic Saint

Antiquity ◽

10.1017/s0003598x00009388 ◽

1934 ◽

Vol 8 (31) ◽

pp. 281-289

Author(s):

Violet Alford

Keyword(s):

Premature Birth ◽

Premature Death ◽

Blood Sacrifice ◽

The Moment ◽

The Town

Windy Jaca, up on its terrace, its back to the snowy Colorado, is especially connected with that disastrous forerunner of the Spanish revolution, which coming to premature birth ended in premature death. We may see there the Street of the Martyrs, renamed by a Republic, born after all without bloodshed, in memory of its first blood sacrifice. Yet in spite of its rather red modernity, little Jaca still cherishes rags and tatters of tradition, and up there on its chilly height a local thaumaturgical goddess holds as much sway as she would in Andalusia. On the 25th of June the town celebrates its feast in honour of Santa Orosia. That is the moment to see the old Jaca behaving as it did before its seventeen towers came down, and its encircling walls were laid flat.

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