Alcohol Abuse, Sleep Disorders and Circadian Rhythms (R01): Grant# PA-12-177

2012 ◽  
Keyword(s):  
Circadian Rhythms ◽  
Alcohol Abuse ◽  
Sleep Disorders

scholarly journals Sleep Disorders in Pregnancy

2021 ◽  
Author(s):  
Patrizia Moretti ◽  
Giulia Menculini ◽  
Lucia Gonfia
Keyword(s):  
Risk Factors ◽  
Circadian Rhythms ◽  
Pregnant Women ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Pharmacological Treatments ◽  
Mother And Child ◽  
Physiological Sleep ◽  
In Pregnancy

Sleep disturbances and changes in circadian rhythms are commonly observed in pregnant women. These disorders can result from anatomical, physiological, psychological, and hormonal alterations that can influence sleeping during this phase. Sleep disorders during pregnancy can be responsible for detrimental effects on both mother and foetus. In this chapter we will focus on the epidemiology of sleep disorders, physiological sleep mechanisms and their alterations during pregnancy, as well as on risk factors for sleep disorders in pregnancy. We will then focus of the most frequent sleep disorders during pregnancy, also considering eventual adverse implications for both mother and child, prognosis, and possible pharmacological and non-pharmacological treatments.

Sleep health and diabetes: The role of sleep duration, subjective sleep, sleep disorders, and circadian rhythms on diabetes

2019 ◽  
pp. 213-225
Author(s):  
Azizi A. Seixas ◽  
Rebecca Robbins ◽  
Alicia Chung ◽  
Collin Popp ◽  
Tiffany Donley ◽  
...  
Keyword(s):  
Circadian Rhythms ◽  
Sleep Disorders ◽  
Sleep Duration ◽  
Sleep Health ◽  
Subjective Sleep

Assessment of the Relationship between Sleep Disorders and Circadian Type in Nurses with Shift and Daytime Work

2020 ◽  
Author(s):  
Lahya Afshari Saleh ◽  
Amir Rezaei Ardani ◽  
Ehsan Rafeemanesh ◽  
Pegah Kheradmand
Keyword(s):  
Circadian Rhythms ◽  
Sleep Disorders ◽  
Shift Work ◽  
Sleep Problems ◽  
Work Group ◽  
Severity Index ◽  
Teaching Hospitals ◽  
Cross Sectional ◽  
Significant Difference ◽  
Circadian Type

Background and Objective: Chronotypes vary in different people, and the daily function outside of the framework of this rhythm can affect the quality of work. This study aimed to investigate the association between sleep disorders and chronotypes among the shift and day work nurses. Materials and Methods: This cross-sectional study was performed among nurses in two teaching hospitals in Mash-had, Iran, during 2016-2017. A total of 180 randomly-selected nurses were divided into shift work and day work groups. Participants completed demographic information form, Circadian Type Inventory (CTI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Beck Anxiety Inventory (BAI), and Beck Depression Inventory (BDI). Results: A total of 180 female nurses (90 participants in each group) with a mean age of 35.62 ± 4.07 years were stud-ied. The prevalence of rigid circadian rhythm in the day work group (93.3%) was significantly (P = 0.004) higher than shift work group (78.9%). However, the groups did not show any significant difference regarding the languid/vigorous (LV) index of the CTI (P = 0.080). There was a significant difference in the mean score of CTI between individuals with rigid and flexible circadian rhythms in the shift work group (P = 0.021). Conclusion: In the present study, although there was no association between circadian type and sleep problems includ-ing insomnia and daytime sleepiness in shift work nurses, we observed the capability of coping with working in the rotating shifts in nurses with flexible circadian rhythms.  

scholarly journals SLEEP IN CHILDREN: FROM PHYSIOLOGY TO PATHOLOGY

2017 ◽  
pp. 97-102
Author(s):  
M. G. POLUEKTOV ◽  
P. V. PCHELINA
Keyword(s):  
Circadian Rhythms ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Behavioral Therapy ◽  
Adult Population ◽  
Brain Structures ◽  
Sleep Hygiene ◽  
Embryonic Period ◽  
Night Terrors ◽  
Light Sedation

Circadian rhythms and the mechanisms of sleep and wakefulness begin to form in the embryonic period and undergo many stages of development before acquire characteristics typical for an adult. Structure of sleep disturbances in children also differs from that in the adult population. Most sleep disorders in children are the result of immaturity of certain brain structures and mechanisms: primary sleep disorders, pediatric behavioral insomnia, sleepwalking, night terrors, enuresis. These disorders are benign, and usually disappear by adulthood. Treatment of benign sleep disorders in children should primarily be based on the methods of behavioral therapy, the rules of sleep hygiene and the purpose of light sedation.

scholarly journals MicroRNA: A Key Player for the Interplay of Circadian Rhythm Abnormalities, Sleep Disorders and Neurodegenerative Diseases

2020 ◽  
Vol 2 (3) ◽  
pp. 282-307
Author(s):  
Chisato Kinoshita ◽  
Yayoi Okamoto ◽  
Koji Aoyama ◽  
Toshio Nakaki
Keyword(s):  
Circadian Rhythm ◽  
Circadian Rhythms ◽  
Neurodegenerative Diseases ◽  
Neurodegenerative Disease ◽  
Sleep Disorders ◽  
Physiological Activity ◽  
Post Translational Modification ◽  
Cellular Processes ◽  
Non Coding Rna ◽  
And Behavior

Circadian rhythms are endogenous 24-h oscillators that regulate the sleep/wake cycles and the timing of biological systems to optimize physiology and behavior for the environmental day/night cycles. The systems are basically generated by transcription–translation feedback loops combined with post-transcriptional and post-translational modification. Recently, evidence is emerging that additional non-coding RNA-based mechanisms are also required to maintain proper clock function. MicroRNA is an especially important factor that plays critical roles in regulating circadian rhythm as well as many other physiological functions. Circadian misalignment not only disturbs the sleep/wake cycle and rhythmic physiological activity but also contributes to the development of various diseases, such as sleep disorders and neurodegenerative diseases. The patient with neurodegenerative diseases often experiences profound disruptions in their circadian rhythms and/or sleep/wake cycles. In addition, a growing body of recent evidence implicates sleep disorders as an early symptom of neurodegenerative diseases, and also suggests that abnormalities in the circadian system lead to the onset and expression of neurodegenerative diseases. The genetic mutations which cause the pathogenesis of familial neurodegenerative diseases have been well studied; however, with the exception of Huntington’s disease, the majority of neurodegenerative diseases are sporadic. Interestingly, the dysfunction of microRNA is increasingly recognized as a cause of sporadic neurodegenerative diseases through the deregulated genes related to the pathogenesis of neurodegenerative disease, some of which are the causative genes of familial neurodegenerative diseases. Here we review the interplay of circadian rhythm disruption, sleep disorders and neurodegenerative disease, and its relation to microRNA, a key regulator of cellular processes.

Study of sleep disturbances in patients with alcohol abuse or dependence

2016 ◽  
Vol 33 (S1) ◽  
pp. S378-S378
Author(s):  
M.D.C. García Mahía ◽  
Á. Fernández Quintana
Keyword(s):  
Alcohol Abuse ◽  
Sleep Quality ◽  
Sleep Disorders ◽  
Sleep Disturbances ◽  
Psychiatric Patients ◽  
Poor Quality ◽  
Health Clinic ◽  
Global Functioning ◽  
Subjective Sleep Quality ◽  
Sociodemographic Variables

IntroductionPrevious studies inform that psychiatric patients often report problems with their sleep and alcohol increase sleep disturbances.AimsTo analyze the prevalence of sleep disturbances in patients diagnosed of Alcohol Abuse or Dependence and to study clinical and sociodemographic variables associated with sleep disorders.MethodsThe sample is composed of a randomized sample of patients diagnosed of Alcohol Abuse or Dependence following DSM-IV-TR criteria and treated in a Mental Health Clinic in a period of 3 years. Medical records were reviewed. Quality and patterns of sleep were evaluated using the Pittsburg Sleep Quality Index (PSQI) with a cut-off point 5-6.ResultsA total of 102 patients were included in the study, 69% were male and 31% were female. Mean age 39.4 years (SD 9.26).Sleep disorders were found in 91.6% of patients. The most altered subscales in the overall sample were the Use of Sleeping Medication and Sleep Disturbances. Women presented worse sleep quality compared to men (P < 0.01) with higher number of altered subscales. The most altered subscales in women were Subjective Sleep Quality (P < 0.005) and Sleep Disturbances (P < 0.02).Comorbidity with other psychiatric disorders and other clinical and sociodemographic variables are analyzed.ConclusionsSleep disorders have high prevalence in patients with alcohol abuse of dependence, especially in women and patients with other psychiatric comorbidity. Poor quality sleep may have a powerful impact on the global functioning and prognosis of these groups of psychiatric patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Proceedings of the Sleep and Epilepsy Workgroup: Section 2 Comorbidities: Sleep Related Comorbidities of Epilepsy

2021 ◽  
pp. 153575972110045
Author(s):  
Milena K. Pavlova ◽  
Marcus Ng ◽  
Rebecca M. Allen ◽  
Melanie Boly ◽  
Sanjeev Kothare ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Chronic Disease ◽  
Circadian Rhythms ◽  
Sleep Disorders ◽  
Treatment Options ◽  
Interdisciplinary Approach ◽  
Sleep Medicine ◽  
The Central Nervous System ◽  
Treatment Priorities

Epilepsy is a chronic disease with multiple, complex comorbidities. Bidirectional relationships exist among seizures, sleep, circadian rhythms, and diseases within and outside of the central nervous system. Seizures fragment sleep and can contribute to development of sleep disorders, which in turn leads to worse overall health and more seizures. Moreover, treatment options are often limited by interactions with anti-seizure medications. Advances in the fields of epilepsy and in sleep medicine have been made separately, and therefore treating patients with these comorbidities necessitates interdisciplinary approach. The focus of this section of the Sleep and Epilepsy Workgroup was to identify methods of collaboration and outline investigational, educational, and treatment priorities to mutually advance what we consider a combined field.

Circadian Rhythms, Sleep, and Aging

2020 ◽  
pp. 1-10 ◽  
Author(s):  
Sergio Garbarino ◽  
Paola Lanteri ◽  
Valeria Prada ◽  
Michael Falkenstein ◽  
Walter G. Sannita
Keyword(s):  
Circadian Rhythms ◽  
Sleep Disorders ◽  
Well Being ◽  
Organization Change ◽  
Behavioral Changes ◽  
Functional Changes ◽  
The Road ◽  
Sleep Rhythms ◽  
Circadian Organization ◽  
On The Road

Abstract. Circadian mechanisms and the sleep-wakefulness rhythms guarantee survival, adaptation, efficient action in everyday life or in emergencies and well-being. Disordered circadian processes at central and/or cellular levels, sleep disorders, and unhealthy wakefulness/sleep rhythms can impair the physiological circadian organization and result in subjective, professional, or behavioral changes ranging from functional inadequacy to higher risks at work or on the road to medical relevance. Circadian rhythms and the sleep organization change ontogenetically; major changes result from normal aging and from the multiple diseases that are often associated. There are circular functional interactions involving sleep/sleep disorders, the autonomic and immune systems, and the functional changes in the circadian system due to aging that deserve attention but have been overlooked thus far.

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