scholarly journals The role of selenium metabolism and selenoproteins in cartilage homeostasis and arthropathies

2020 ◽  
Vol 52 (8) ◽  
pp. 1198-1208 ◽  
Author(s):  
Donghyun Kang ◽  
Jeeyeon Lee ◽  
Cuiyan Wu ◽  
Xiong Guo ◽  
Byeong Jae Lee ◽  
...  
Keyword(s):  
Redox Homeostasis ◽  
Selenium Deficiency ◽  
Cartilage Destruction ◽  
Metabolic System ◽  
Selenium Metabolism ◽  
Wide Range ◽  
Matrix Metabolism ◽  
Living Organisms ◽  
Low Selenium

Abstract As an essential nutrient and trace element, selenium is required for living organisms and its beneficial roles in human health have been well recognized. The role of selenium is mainly played through selenoproteins synthesized by the selenium metabolic system. Selenoproteins have a wide range of cellular functions including regulation of selenium transport, thyroid hormones, immunity, and redox homeostasis. Selenium deficiency contributes to various diseases, such as cardiovascular disease, cancer, liver disease, and arthropathy—Kashin–Beck disease (KBD) and osteoarthritis (OA). A skeletal developmental disorder, KBD has been reported in low-selenium areas of China, North Korea, and the Siberian region of Russia, and can be alleviated by selenium supplementation. OA, the most common form of arthritis, is a degenerative disease caused by an imbalance in matrix metabolism and is characterized by cartilage destruction. Oxidative stress serves as a major cause of the initiation of OA pathogenesis. Selenium deficiency and dysregulation of selenoproteins are associated with impairments to redox homeostasis in cartilage. We review the recently explored roles of selenium metabolism and selenoproteins in cartilage with an emphasis on two arthropathies, KBD and OA. Moreover, we discuss the potential of therapeutic strategies targeting the biological functions of selenium and selenoproteins for OA treatment.

scholarly journals Selenium deficiency and HIV infection

2010 ◽  
Vol 2 (2) ◽  
pp. 18 ◽  
Author(s):  
Stefano Di Bella ◽  
Elisabetta Grilli ◽  
Maria Adriana Cataldo ◽  
Nicola Petrosillo
Keyword(s):  
Hiv Infection ◽  
Disease Progression ◽  
Selenium Deficiency ◽  
Selenium Supplementation ◽  
Economic Resources ◽  
Common Finding ◽  
Hiv Viral Load ◽  
Conflicting Evidence ◽  
Low Selenium

Selenium is a non-metallic chemical element of great important to human health. Low selenium levels in humans are associated with several pathological conditions and are a common finding in HIV infected individuals. We conducted a review of the literature to assess if selenium deficiency or selenium supplementation could play a role in modifying the clinical course of HIV disease. Several studies investigated the role of selenium in disease progression, morbidity and mortality in HIV infected individuals. Larger studies were conducted in countries with poor economic resources and limited access to HAART. According to the majority of published studies low selenium levels appear to have an association with mortality, and selenium supplementation appears to play a beneficial role on survival or on slowing disease progression among HIV infected individuals. The role of selenium supplementation on preventing hospital admission among HIV outpatients was also noticed. The literature suggests an association between selenium deficiency and development of HIV associated cardiomyopathy and furthermore, selenium supplementation appears to improve the cardiac function in HIV infected individuals with cardiomyopathy. However, there is conflicting evidence regarding the role selenium in modifying HIV viral load and immune status in HIV infection.

scholarly journals The signalling role of ROS in the regulation of seed germination and dormancy

2019 ◽  
Vol 476 (20) ◽  
pp. 3019-3032 ◽  
Author(s):  
Christophe Bailly
Keyword(s):  
Seed Germination ◽  
Oxygen Species ◽  
Direct Oxidation ◽  
Cellular Events ◽  
Seed Physiology ◽  
Spatiotemporal Regulation ◽  
Wide Range ◽  
Living Organisms ◽  
Hormone Signalling

Abstract Reactive oxygen species (ROS) are versatile compounds which can have toxic or signalling effects in a wide range living organisms, including seeds. They have been reported to play a pivotal role in the regulation of seed germination and dormancy but their mechanisms of action are still far from being fully understood. In this review, we sum-up the major findings that have been carried out this last decade in this field of research and which altogether shed a new light on the signalling roles of ROS in seed physiology. ROS participate in dormancy release during seed dry storage through the direct oxidation of a subset of biomolecules. During seed imbibition, the controlled generation of ROS is involved in the perception and transduction of environmental conditions that control germination. When these conditions are permissive for germination, ROS levels are maintained at a level which triggers cellular events associated with germination, such as hormone signalling. Here we propose that the spatiotemporal regulation of ROS production acts in concert with hormone signalling to regulate the cellular events involved in cell expansion associated with germination.

scholarly journals Investigating the Role of Shape and Size of Gold Nanoparticles on Their Toxicities to Fungi

2018 ◽  
Author(s):  
Kangze Liu ◽  
Zhonglei He ◽  
Hugh J. Byrne ◽  
James Curtin ◽  
Furong Tian
Keyword(s):  
Gold Nanoparticles ◽  
Penicillium Chrysogenum ◽  
Survival Rates ◽  
Relative Survival ◽  
Toxicity Assessment ◽  
Mucor Hiemalis ◽  
Wide Range ◽  
Living Organisms ◽  
Shape And Size

The possibility of releasing gold nanoparticles (GNP) into the environment has been rapidly increasing with the wide spread and flourishing application of gold nanoparticles (GNPs) in a wide range of areas. Consequently, environmental effects of GNP, especially toxicities to living organisms have drawn great attention. However, their toxicological characteristics still remain unclear. Fungi, as the decomposers of the ecosystem, interact directly with the environment and critically control the overall health of the biosphere. Thus, their sensitivity to GNP toxicity is particularly important. The aim of this study was to evaluate the role of shape and size of GNPs on their toxicities to fungi, which could help reveal the ecotoxicity of GNPs. Aspergillus niger, Mucor hiemalis and Penicillium chrysogenum were chosen for toxicity assessment, and circular and star/flower-shaped GNPs sized from 0.7 nm to large aggregates of 400 nm have been synthesised. After mixed with GNPs and reacting agents of GNPs accordingly and incubated for 48 hours, the relative survival rates of each kind of fungus was calculated and compared. The results indicated that with similar sizes, star/flower-shaped GNPs are more toxic to fungi than circular-shaped GNPs; the toxicity of star/flower-shaped GNPs increases with smaller sizes. The results also showed that different species of fungus reacts differently to same GNPs, and Penicillium chrysogenum was relatively more sensitive under the exposure to GNPs.

The Role of Selenium in Oxidative Stress and in Nonthyroidal Illness Syndrome (NTIS): An Overview

2020 ◽  
Vol 27 (3) ◽  
pp. 423-449 ◽  
Author(s):  
Andrea Silvestrini ◽  
Alvaro Mordente ◽  
Giuseppe Martino ◽  
Carmine Bruno ◽  
Edoardo Vergani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Redox Homeostasis ◽  
Nonthyroidal Illness ◽  
Cellular Redox ◽  
Selenium Metabolism ◽  
Glutathione Peroxidases ◽  
Iodothyronine Deiodinases ◽  
Correct Function ◽  
Thioredoxin Reductases

Selenium is a trace element, nutritionally classified as an essential micronutrient, involved in maintaining the correct function of several enzymes incorporating the selenocysteine residue, namely the selenoproteins. The human selenoproteome including 25 proteins is extensively described here. The most relevant selenoproteins, including glutathione peroxidases, thioredoxin reductases and iodothyronine deiodinases are required for the proper cellular redox homeostasis as well as for the correct thyroid function, thus preventing oxidative stress and related diseases. This review summarizes the main advances on oxidative stress with a focus on selenium metabolism and transport. Moreover, thyroid-related disorders are discussed, considering that the thyroid gland contains the highest selenium amount per gram of tissue, also for future possible therapeutic implication.

N-acetyl-cysteine in Schizophrenia: Potential Role on the Sensitive Cysteine Proteome

2020 ◽  
Vol 27 (37) ◽  
pp. 6424-6439 ◽  
Author(s):  
Marcos Martínez-Banaclocha
Keyword(s):  
Potential Role ◽  
Redox Homeostasis ◽  
Cellular Growth ◽  
Bioenergetic Metabolism ◽  
Wide Range ◽  
Structural Network ◽  
Schizophrenic Patients ◽  
Acetyl Cysteine ◽  
Cysteine Thiols

Background: N-acetyl-cysteine (NAC) has shown widespread utility in different psychiatric disorders, including a beneficial role in schizophrenic patients. Although the replenishment of glutathione and the antioxidant activity of NAC have been suggested as the mechanisms that improve such a wide range of disorders, no one seems to be sufficiently specific to explain these intriguing effects. A sensitive cysteine proteome is emerging as a functional and structural network of interconnected sensitive cysteine-containing proteins (SCCPs) that together with reactive species and the cysteine/glutathione cycles can regulate the bioenergetic metabolism, the redox homeostasis and the cellular growth, differentiation and survival, acting through different pathways that are regulated by the same thiol radical in cysteine residues. Objective: Since this sensitive cysteine network has been implicated in the pathogenesis of Parkinson and Alzheimer´s diseases, I have reviewed if the proteins that play a role in schizophrenia can be classified too as SCCPs. Results: I have revised the major proteins implicated in the physiopathology of schizophrenia searching for those proteins that are redox-regulated through sensitive cysteine thiols. Results show that the principal proteins playing a role in schizophrenia can be classified as SCCPs, suggesting that the sensitive cysteine proteome (cysteinet) is defective in this type of psychosis. Conclusion: The present review proposes that there is a deregulation of the sensitive cysteine proteome in schizophrenia as the consequence of a functional imbalance among different SCCPs, which play different functions in neurons and glial cells. In this context, the role of NAC to restore and prevent schizophrenic disorders is discussed.

scholarly journals Glutathione metabolism in cancer progression and treatment resistance

2018 ◽  
Vol 217 (7) ◽  
pp. 2291-2298 ◽  
Author(s):  
Ankita Bansal ◽  
M. Celeste Simon
Keyword(s):  
Cancer Progression ◽  
Treatment Options ◽  
Redox Homeostasis ◽  
Treatment Resistance ◽  
Glutathione Metabolism ◽  
Therapeutic Resistance ◽  
Cellular Redox ◽  
Gsh Metabolism ◽  
Living Organisms

Glutathione (GSH) is the most abundant antioxidant found in living organisms and has multiple functions, most of which maintain cellular redox homeostasis. GSH preserves sufficient levels of cysteine and detoxifies xenobiotics while also conferring therapeutic resistance to cancer cells. However, GSH metabolism plays both beneficial and pathogenic roles in a variety of malignancies. It is crucial to the removal and detoxification of carcinogens, and alterations in this pathway can have a profound effect on cell survival. Excess GSH promotes tumor progression, where elevated levels correlate with increased metastasis. In this review, we discuss recent studies that focus on deciphering the role of GSH in tumor initiation and progression as well as mechanisms underlying how GSH imparts treatment resistance to growing cancers. Targeting GSH synthesis/utilization therefore represents a potential means of rendering tumor cells more susceptible to different treatment options such as chemotherapy and radiotherapy.

Selenium deficiency as a possible factor in the pathogenesis of myxoedematous endemic cretinism

1987 ◽  
Vol 114 (4) ◽  
pp. 497-502 ◽  
Author(s):  
P. Goyens ◽  
J. Golstein ◽  
B. Nsombola ◽  
H. Vis ◽  
J. E. Dumont
Keyword(s):  
Glutathione Peroxidase ◽  
Oxygen Toxicity ◽  
Selenium Deficiency ◽  
Serum Levels ◽  
Serum Selenium ◽  
Endemic Cretinism ◽  
Plasma Glutathione Peroxidase ◽  
Plasma Glutathione ◽  
Low Selenium

Abstract. Myxoedematous endemic cretinism is prevalent in African goitre endemies. It has been related to a thyroid 'exhaustion' atrophy occurring near birth. It is proposed that this might result from the low resistance of a fragile tissue to enhanced H2O2 generation under intense thyroid stimulation by thyrotropin. In support of this hypothesis, low selenium and glutathione peroxidase serum levels have been found in the African endemic area of the Idjwi Island (Kivu, Zaire). Serum selenium and plasma glutathione peroxidase were lower in the area of high endemicity of goitre and cretinism (Northern part of the Island). However, only the former difference is statistically significant. These data thus suggest a role of oligoelements and oxygen toxicity in the pathogenesis of endemic cretinism.

scholarly journals Hydrogen Sulfide and Cellular Redox Homeostasis

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Zhi-Zhong Xie ◽  
Yang Liu ◽  
Jin-Song Bian
Keyword(s):  
Hydrogen Sulfide ◽  
Antioxidant Defense ◽  
Redox Homeostasis ◽  
Antioxidant Defense System ◽  
Ros Generation ◽  
Cellular Redox ◽  
Wide Range ◽  
Underlying Mechanisms ◽  
Antioxidant Effects

Intracellular redox imbalance is mainly caused by overproduction of reactive oxygen species (ROS) or weakness of the natural antioxidant defense system. It is involved in the pathophysiology of a wide array of human diseases. Hydrogen sulfide (H2S) is now recognized as the third “gasotransmitters” and proved to exert a wide range of physiological and cytoprotective functions in the biological systems. Among these functions, the role of H2S in oxidative stress has been one of the main focuses over years. However, the underlying mechanisms for the antioxidant effect of H2S are still poorly comprehended. This review presents an overview of the current understanding of H2S specially focusing on the new understanding and mechanisms of the antioxidant effects of H2S based on recent reports. Both inhibition of ROS generation and stimulation of antioxidants are discussed. H2S-induced S-sulfhydration of key proteins (e.g., p66Shc and Keap1) is also one of the focuses of this review.

scholarly journals miRNA Regulation of Glutathione Homeostasis in Cancer Initiation, Progression and Therapy Resistance

MicroRNA ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 187-197
Author(s):  
Barbara Marengo ◽  
Alessandra Pulliero ◽  
Alberto Izzotti ◽  
Cinzia Domenicotti
Keyword(s):  
Second Messengers ◽  
Redox Homeostasis ◽  
Neuroblastoma Cells ◽  
Therapy Resistance ◽  
Mirna Regulation ◽  
Cancer Initiation ◽  
Current Therapies ◽  
Living Organisms ◽  
Cell Growth And Proliferation

Glutathione (GSH) is the most abundant antioxidant that contributes to regulating the cellular production of Reactive Oxygen Species (ROS) which, maintained at physiological levels, can exert a function of second messengers in living organisms. In fact, it has been demonstrated that moderate amounts of ROS can activate the signaling pathways involved in cell growth and proliferation, while high levels of ROS induce DNA damage leading to cancer development. Therefore, GSH is a crucial player in the maintenance of redox homeostasis and its metabolism has a role in tumor initiation, progression, and therapy resistance. Our recent studies demonstrated that neuroblastoma cells resistant to etoposide, a common chemotherapeutic drug, show a partial monoallelic deletion of the locus coding for miRNA 15a and 16-1 leading to a loss of these miRNAs and the activation of GSH-dependent responses. Therefore, the aim of this review is to highlight the role of specific miRNAs in the modulation of intracellular GSH levels in order to take into consideration the use of modulators of miRNA expression as a useful strategy to better sensitize tumors to current therapies.

scholarly journals Impact of Biocorrosion on the Durability of Etics and Empirical Findings About the Periodocity of Maintenance

2013 ◽  
Vol 21 (2) ◽  
pp. 21-28
Author(s):  
Naďa Antošová
Keyword(s):  
Building Materials ◽  
Composite System ◽  
Chemical Processes ◽  
Biological Factors ◽  
Wide Range ◽  
Living Organisms ◽  
Physical And Chemical ◽  
The Impact ◽  
Complete Collapse

Abstract Generally, the role of living organisms (especially bacteria, cyanophytes, algae and fungi) in the physical and chemical processes of the biocorrosion of an external thermal insulation composite system (ETICS) is underestimated. These organisms are the ones that are responsible for a wide range of changes in or "diseases" of building materials and constructions, including damage to a building´s appearance or the destruction and complete collapse of the characteristics and requirements of materials and the ETICS construction. The following article concerns the impact of biological factors on the durability of ETICS. It shows the importance of and necessity to maintain it, and the method and periodicity of the maintenance.

Sign in / Sign up

Export Citation Format

Share Document