scholarly journals Drug addiction: from bench to bedside

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Julian Cheron ◽  
Alban de Kerchove d’Exaerde
Keyword(s):  
Drug Addiction ◽  
General Public ◽  
Temporal Dynamics ◽  
Psychiatric Disease ◽  
Drug Induced ◽  
Sustained Effects ◽  
Fundamental Research ◽  
New Treatments ◽  
The Brain ◽  
The Way

AbstractDrug addiction is responsible for millions of deaths per year around the world. Still, its management as a chronic disease is shadowed by misconceptions from the general public. Indeed, drug consumers are often labelled as “weak”, “immoral” or “depraved”. Consequently, drug addiction is often perceived as an individual problem and not societal. In technical terms, drug addiction is defined as a chronic, relapsing disease resulting from sustained effects of drugs on the brain. Through a better characterisation of the cerebral circuits involved, and the long-term modifications of the brain induced by addictive drugs administrations, first, we might be able to change the way the general public see the patient who is suffering from drug addiction, and second, we might be able to find new treatments to normalise the altered brain homeostasis. In this review, we synthetise the contribution of fundamental research to the understanding drug addiction and its contribution to potential novel therapeutics. Mostly based on drug-induced modifications of synaptic plasticity and epigenetic mechanisms (and their behavioural correlates) and after demonstration of their reversibility, we tried to highlight promising therapeutics. We also underline the specific temporal dynamics and psychosocial aspects of this complex psychiatric disease adding parameters to be considered in clinical trials and paving the way to test new therapeutic venues.

scholarly journals Enlightening the frontiers of neurogastroenterology through optogenetics

2020 ◽  
Vol 319 (3) ◽  
pp. G391-G399
Author(s):  
Anthony C. Johnson ◽  
Tijs Louwies ◽  
Casey O. Ligon ◽  
Beverley Greenwood-Van Meerveld
Keyword(s):  
Delayed Gastric Emptying ◽  
Future Research ◽  
Great Promise ◽  
Gi Tract ◽  
The Past ◽  
Health And Disease ◽  
Fundamental Research ◽  
Irritable Bowel ◽  
New Treatments ◽  
The Brain

Neurogastroenterology refers to the study of the extrinsic and intrinsic nervous system circuits controlling the gastrointestinal (GI) tract. Over the past 5–10 yr there has been an explosion in novel methodologies, technologies and approaches that offer great promise to advance our understanding of the basic mechanisms underlying GI function in health and disease. This review focuses on the use of optogenetics combined with electrophysiology in the field of neurogastroenterology. We discuss how these technologies and tools are currently being used to explore the brain-gut axis and debate the future research potential and limitations of these techniques. Taken together, we consider that the use of these technologies will enable researchers to answer important questions in neurogastroenterology through fundamental research. The answers to those questions will shorten the path from basic discovery to new treatments for patient populations with disorders of the brain-gut axis affecting the GI tract such as irritable bowel syndrome (IBS), functional dyspepsia, achalasia, and delayed gastric emptying.

RELASI ULAMA DAN PENGUASA MASA KOLONIALISME

2020 ◽  
Vol 8 (2) ◽  
pp. 126-134
Author(s):  
Agung Perdana Kusuma
Keyword(s):  
The Netherlands ◽  
Private Sector ◽  
General Public ◽  
18Th Century ◽  
The Government ◽  
Colonial Government ◽  
The Way

In the 18th century, although the Dutch Company controlled most of the archipelago, the Netherlands also experienced a decline in trade. This was due to the large number of corrupt employees and the fall in the price of spices which eventually created the VOC. Under the rule of H.W. Daendels, the colonial government began to change the way of exploitation from the old conservative way which focused on trade through the VOC to exploitation managed by the government and the private sector. Ulama also strengthen their ties with the general public through judicial management, and compensation, and waqaf assets, and by leading congregational prayers and various ceremonies for celebrating birth, marriage and death. Their links with a large number of artisans, workers (workers), and the merchant elite were very influential.

8. Retrospect of Mental Philosophy (Periodical Literature.)

1880 ◽  
Vol 26 (113) ◽  
pp. 119
Author(s):  
B. F. C. Costelloe
Keyword(s):  
Periodical Literature ◽  
Main Interest ◽  
Intended Meaning ◽  
Border Line ◽  
Emotional Language ◽  
Ordinary Power ◽  
The Moment ◽  
The Brain ◽  
The Way

The first number for the year is not remarkable for any paper of striking value. Readers of the Journal will be chiefly attracted by the long and clearly written resumé of Dr. Hughlings Jackson's recent studies “On Affections of Speech from Disease of the Brain,” which is contributed by Mr. James Sully. He remarks on the great value of Dr. Jackson's attempts to classify the different forms of aphasia under the three main heads or stages of—(1) Defect of Speech, in which the patient has a full vocabulary, but confuses words; (2) Loss of Speech, in which the patient is practically speechless, and his pantomimic power is impaired as well; and (3) Loss of Language, in which, besides being speechless, he has altogether lost the power of pantomime, and even his faculty of emotional language is deeply involved in the wreck. All these states or stages again are, properly speaking, to be distinguished altogether from affections of speech in the way of loss of articulation (owing to paralysis of the tongue, &c.), or loss of vocalisation (owing to disease of the larynx); whereas the three degrees or stages of aphasia proper are due to a deep-seated and severe disorganisation of the brain. The main interest of the theory lies in the ingenious and carefully-argued analysis of the symptoms, by which Dr. Jackson arrives at the theory that as the process of destruction goes on, the superior “layers” or strata of speech fail first—those namely which involve the ordinary power of adapting sounds to the circumstances of the moment as they arise; after them fail the “more highly organized utterances” those, namely, which have in any way become automatic, such as “come on,” “wo! wo!” and even “yes” and “no,” which stand on the border-line between emotional and intellectual language; next fails the power of adapting other than vocal signs to convey an intended meaning, which is called, rather clumsily, “pantomimic propositionising;” and last of all dies out the power of uttering sounds or making signs expressive merely of emotion—a power which, of course, is not true speech at all.

scholarly journals Stability and flexibility in multisensory sampling: insights from perceptual illusions

2019 ◽  
Vol 121 (5) ◽  
pp. 1588-1590 ◽  
Author(s):  
Luca Casartelli
Keyword(s):  
Temporal Dynamics ◽  
Multisensory Processing ◽  
General Idea ◽  
Perceptual Illusions ◽  
The Brain ◽  
Multisensory Processes

Neural, oscillatory, and computational counterparts of multisensory processing remain a crucial challenge for neuroscientists. Converging evidence underlines a certain efficiency in balancing stability and flexibility of sensory sampling, supporting the general idea that multiple parallel and hierarchically organized processing stages in the brain contribute to our understanding of the (sensory/perceptual) world. Intriguingly, how temporal dynamics impact and modulate multisensory processes in our brain can be investigated benefiting from studies on perceptual illusions.

Temporal Brokering: A Measure of Brokerage as a Behavioral Process

2021 ◽  
pp. 109442812110029
Author(s):  
Eric Quintane ◽  
Martin Wood ◽  
John Dunn ◽  
Lucia Falzon
Keyword(s):  
Temporal Dynamics ◽  
Predictive Ability ◽  
Temporal Information ◽  
Behavioral Measure ◽  
Organizational Networks ◽  
Message Boards ◽  
Behavioral Process ◽  
Systematic Examination ◽  
The Way

Extant research in organizational networks has provided critical insights into understanding the benefits of occupying a brokerage position. More recently, researchers have moved beyond the brokerage position to consider the brokering processes (arbitration and collaboration) brokers engage in and their implications for performance. However, brokering processes are typically measured using scales that reflect individuals’ orientation toward engaging in a behavior, rather than the behavior itself. In this article, we propose a measure that captures the behavioral process of brokering. The measure indicates the extent to which actors engage in arbitration versus collaboration based on sequences of time stamped relational events, such as emails, message boards, and recordings of meetings. We demonstrate the validity of our measure as well as its predictive ability. By leveraging the temporal information inherent in sequences of relational events, our behavioral measure of brokering creates opportunities for researchers to explore the dynamics of brokerage and their impact on individuals, and also paves the way for a systematic examination of the temporal dynamics of networks.

scholarly journals The brain timewise: how timing shapes and supports brain function

2015 ◽  
Vol 370 (1668) ◽  
pp. 20140170 ◽  
Author(s):  
Riitta Hari ◽  
Lauri Parkkonen
Keyword(s):  
Human Brain ◽  
Brain Imaging ◽  
Brain Function ◽  
Temporal Dynamics ◽  
Generative Models ◽  
Network Activity ◽  
Brain Diseases ◽  
Specific Information ◽  
Non Invasive ◽  
The Brain

We discuss the importance of timing in brain function: how temporal dynamics of the world has left its traces in the brain during evolution and how we can monitor the dynamics of the human brain with non-invasive measurements. Accurate timing is important for the interplay of neurons, neuronal circuitries, brain areas and human individuals. In the human brain, multiple temporal integration windows are hierarchically organized, with temporal scales ranging from microseconds to tens and hundreds of milliseconds for perceptual, motor and cognitive functions, and up to minutes, hours and even months for hormonal and mood changes. Accurate timing is impaired in several brain diseases. From the current repertoire of non-invasive brain imaging methods, only magnetoencephalography (MEG) and scalp electroencephalography (EEG) provide millisecond time-resolution; our focus in this paper is on MEG. Since the introduction of high-density whole-scalp MEG/EEG coverage in the 1990s, the instrumentation has not changed drastically; yet, novel data analyses are advancing the field rapidly by shifting the focus from the mere pinpointing of activity hotspots to seeking stimulus- or task-specific information and to characterizing functional networks. During the next decades, we can expect increased spatial resolution and accuracy of the time-resolved brain imaging and better understanding of brain function, especially its temporal constraints, with the development of novel instrumentation and finer-grained, physiologically inspired generative models of local and network activity. Merging both spatial and temporal information with increasing accuracy and carrying out recordings in naturalistic conditions, including social interaction, will bring much new information about human brain function.

Value, drug addiction and the brain

2021 ◽  
pp. 106816
Author(s):  
Kavinash Loganathan ◽  
Eric Tatt Wei Ho
Keyword(s):  
Drug Addiction ◽  
The Brain

scholarly journals Inferring brain-computational mechanisms with models of activity measurements

2016 ◽  
Vol 371 (1705) ◽  
pp. 20160278 ◽  
Author(s):  
Nikolaus Kriegeskorte ◽  
Jörn Diedrichsen
Keyword(s):  
Computational Models ◽  
Brain Activity ◽  
Visual Object ◽  
Visual Object Recognition ◽  
Summary Statistics ◽  
Activity Data ◽  
Individual Measurement ◽  
Activity Measurements ◽  
The Brain ◽  
The Way

High-resolution functional imaging is providing increasingly rich measurements of brain activity in animals and humans. A major challenge is to leverage such data to gain insight into the brain's computational mechanisms. The first step is to define candidate brain-computational models (BCMs) that can perform the behavioural task in question. We would then like to infer which of the candidate BCMs best accounts for measured brain-activity data. Here we describe a method that complements each BCM by a measurement model (MM), which simulates the way the brain-activity measurements reflect neuronal activity (e.g. local averaging in functional magnetic resonance imaging (fMRI) voxels or sparse sampling in array recordings). The resulting generative model (BCM-MM) produces simulated measurements. To avoid having to fit the MM to predict each individual measurement channel of the brain-activity data, we compare the measured and predicted data at the level of summary statistics. We describe a novel particular implementation of this approach, called probabilistic representational similarity analysis (pRSA) with MMs, which uses representational dissimilarity matrices (RDMs) as the summary statistics. We validate this method by simulations of fMRI measurements (locally averaging voxels) based on a deep convolutional neural network for visual object recognition. Results indicate that the way the measurements sample the activity patterns strongly affects the apparent representational dissimilarities. However, modelling of the measurement process can account for these effects, and different BCMs remain distinguishable even under substantial noise. The pRSA method enables us to perform Bayesian inference on the set of BCMs and to recognize the data-generating model in each case. This article is part of the themed issue ‘Interpreting BOLD: a dialogue between cognitive and cellular neuroscience’.

Anatomy of a trial

PEDIATRICS ◽  
1977 ◽  
Vol 60 (6) ◽  
pp. 932-934
Author(s):  
Neil A. Holtzman
Keyword(s):  
Clinical Trials ◽  
Clinical Situation ◽  
Enzyme Deficiency ◽  
Efficacy And Safety ◽  
Controlled Clinical Trials ◽  
Biochemical Alterations ◽  
New Treatments ◽  
The Way

Efficacy and safety of new treatments can seldom be predicted with certainty. Even when it addresses biochemical alterations, a therapy may not improve the clinical situation. The low-phenylalanine diet for phenylketonuria (PKU), for instance, followed logically from the discovery of an enzyme deficiency, but the diet's effectiveness in preventing retardation in asymptomatic infants was still in doubt a decade after it was introduced. Studies in which some subjects are not treated can often establish the benefits and risks of therapy. Many obstacles, however, lie in the way of controlled clinical trials despite the advantage they offer. The PKU story exemplifies the issues.

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