scholarly journals Elastic resistance training is more effective than vitamin D3 supplementation in reducing oxidative stress and strengthen antioxidant enzymes in healthy men

2021 ◽  
Author(s):  
Fardin Kalvandi ◽  
Mohammad Ali Azarbayjani ◽  
Ronak Azizbeigi ◽  
Kamal Azizbeigi
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Enzymes ◽  
Resistance Training ◽  
Vitamin D3 ◽  
Healthy Men ◽  
Elastic Resistance ◽  
Vitamin D3 Supplementation

scholarly journals Interaction Effects of Vitamin D Receptor Polymorphisms and Vitamin D3 Supplementation on Plasma Oxidative Stress and Apoptotic Biomarkers Among Breast Cancer Survivors (P05-027-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Elham Kazemin ◽  
Yasaman Jamshidi-naeini ◽  
Mohammad Esmaeil Akbari ◽  
Nariman Moradi ◽  
Safoora Gharibzadeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Vitamin D ◽  
Linear Regression ◽  
Cancer Survivors ◽  
Vitamin D Receptor ◽  
Vitamin D3 ◽  
Multiple Testing ◽  
Breast Cancer Survivors ◽  
Vitamin D3 Supplementation

Abstract Objectives Interactions of human genes and environmental exposures play a crucial role in cancer etiology and prognosis. We investigated whether response to vitamin D3 supplementation in terms of plasma oxidative stress (OS) and apoptotic biomarkers were mediated by the vitamin D receptor (VDR) single-nucleotide polymorphisms (SNPs) among breast cancer survivors. Methods Two hundred and fourteen women who were diagnosed with breast cancer (invasive or in situ) and had completed all treatment regimens received 4000 IU of vitamin D3 daily for 12 weeks. Anthropometric, dietary, sun exposure, physical activity, as well as laboratory assessments including plasma superoxide dismutase (SOD), total antioxidant capacity (TAC), malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG), and Bcl2 were performed at enrolment and post-intervention. VDR genotyping was performed at ApaI, TaqI, FokI, BsmI, and Cdx-2. Linear regression was used to analyze whether the effect of vitamin D3 supplementation on response variables was modulated by the selected VDR SNPs. Results Linear regression analysis adjusted for age, BMI, on-study plasma 25(OH)D changes, and baseline circulating 25(OH)D indicated that the AA genotype of the ApaI on VDR was associated with greater increase and decrease in plasma Bcl2 [0.21, 95% Confidence Interval (CI) (0.03, 0.39)] and MDA [−0.68, 95% CI (−1.35, −0.02)] compared to aa respectively. This association did not remain statistically significant after correction for multiple testing. Overall, we found no statistically significant interaction of the VDR SNPs and inferred haplotypes with the circulating OS and apoptotic biomarkers except for the FokI BsmI ApaIhaplotype and circulating MDA (p-value for global score = 0.02) after multiple testing correction. Conclusions Our findings indicate a weak interaction between the VDR haplotypes and responses of plasma OS and apoptotic biomarkers to vitamin D3 supplementation. However, further assessments of additional genes and biomarkers with longer intervention periods may further explain the complex interplay between genes and nutrients. Funding Sources Cancer Research Center, National Nutrition and Food Technology Research Institute, and the Endocrine Research Center of Shahid Beheshti University of Medical Sciences.

scholarly journals Effects of Vitamin D3 Supplementation and Resistance Training on 25-Hydroxyvitamin D Status and Functional Performance of Older Adults: A Randomized Placebo-Controlled Trial

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 86
Author(s):  
Rudolf Aschauer ◽  
Sandra Unterberger ◽  
Patrick A. Zöhrer ◽  
Agnes Draxler ◽  
Bernhard Franzke ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Resistance Training ◽  
Muscle Strength ◽  
Vitamin D3 ◽  
Functional Mobility ◽  
Timed Up And Go ◽  
Chair Stand ◽  
Hydroxyvitamin D ◽  
Vitamin D3 Supplementation

Vitamin D status is associated with muscle strength and performance in older adults. To examine the additive effects of vitamin D3 supplementation during resistance training, 100 seniors (65–85 years) participated in a 16-week intervention. Besides a daily dose of 400 mg of calcium, participants received either 800 IU vitamin D3 per day (VDD), 50,000 IU vitamin D3 per month (VDM) or nothing (CON). After the initial loading phase of four weeks, all groups started a 10-week resistance training program. Assessments of 25-hydroxyvitamin D (25(OH)D) status, muscle strength endurance (30-s chair stand and arm curl tests), aerobic capacity (6-min walk test) and functional mobility (gait speed and timed up and go test) were undertaken at baseline, after four weeks and at the end of the study. 25(OH)D status significantly improved in VDD and VDM, but not in CON (time x group: p = 0.021), as 15.2% of CON, 40.0% of VDD and 61.1% of VDM reached vitamin D sufficiency (>30 ng/mL; p = 0.004). Chair stand test, arm curl test, 6-min walk test, gait speed and timed up and go test improved over the whole intervention period (p < 0.05), however only chair stand and arm curl test were selectively affected by resistance training (p < 0.001). Neither muscle strength endurance, nor functional mobility or aerobic capacity were modulated by vitamin D supplementation. Therefore, the mere amelioration of 25(OH)D status of older adults does not lead to an additive effect on muscular performance during RT.

Lipid profile and C-reactive protein changes to elastic-band resistance training in young healthy men

2021 ◽  
pp. 1-8
Author(s):  
F. Kalvandi ◽  
R. Azizbeigi ◽  
K. Azizbeigi
Keyword(s):  
Resistance Training ◽  
Positive Impact ◽  
Density Lipoprotein ◽  
Lipid Profiles ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
C Reactive Protein ◽  
Healthy Men ◽  
Reactive Protein ◽  
Elastic Resistance

Resistance bands are a device for resistance training routine or rehabilitation program and come in various sizes, lengths, and strengths. The purpose of this study was to investigate the effect of elastic resistance training (ERT) on lipid profiles and C-reactive protein (CRP) changes in young and healthy men. Twenty untrained young and healthy men voluntarily participated in the study and were randomly assigned to the ERT (n=10) and control group (n=10). The ERT group performed three non-consecutive sessions per week for eight weeks. Blood was sampled before training and this was repeated after 72 h of the interval of the last session of ERT. The concentration of CRP and lipid profiles, including changes of high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and total cholesterol (TC), were measured. Also, changes in body fat percentage (BF%) were measured. It was observed that CRP was not significantly affected by ERT (P>0.05). Also, TC and TG did not change significantly due to ERT (P>0.05). However, ERT increased the HDL-C concentration (P=0.001) and significantly decreased LDL-C (P=0.033). It is concluded that although the elastic resistance training failed to improve CRP; however, with a positive impact on some of the lipid profiles and health indices, it can be a useful, simple and low-cost exercise training in health promotion.

Effect of vitamin D3 supplementation and influence of BsmI polymorphism of the VDR gene of the inflammatory profile and oxidative stress in elderly women with vitamin D insufficiency

2015 ◽  
Vol 66 ◽  
pp. 10-16 ◽  
Author(s):  
Isa Gabriela de Medeiros Cavalcante ◽  
Alexandre Sérgio Silva ◽  
Maria José Carvalho Costa ◽  
Darlene Camati Persuhn ◽  
ChariraTahaMad Ibraim Issa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Vitamin D3 ◽  
Elderly Women ◽  
Vitamin D Insufficiency ◽  
Vdr Gene ◽  
Bsmi Polymorphism ◽  
Vitamin D3 Supplementation ◽  
Inflammatory Profile ◽  
And Oxidative Stress

scholarly journals Vitamin D3 supplementation on plasma antioxidant enzymes in D3 deficient patients with COPD - a randomized controlled trial

2020 ◽  
Vol 15 (1) ◽  
pp. 23-32
Author(s):  
Salma Anjum ◽  
Taskina Ali ◽  
Kazi Saifuddin Bennoor ◽  
Md Ali Hossain ◽  
Md Saiful Islam ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Vitamin D3 ◽  
Controlled Trial ◽  
Male Smoker ◽  
Copd Patients ◽  
Vitamin D3 Supplementation ◽  
Plasma Antioxidant ◽  
Double Blinded ◽  
And Control

Background: Free radical is a crucial factor for progression of COPD. Antioxidant enzymes, including superoxide dismutase (SOD) and catalase (CAT) have been well known to reduce morbidity of chronic disease. Vitamin D3 has antioxidant effect in human body. Objectives: To assess the effects of D3 supplementation on plasma SOD and CAT levels in D3 deficient COPD patients. Method: A double blinded placebo controlled randomized clinical trial was carried out on 30 vitamin D3 deficient male, smoker and stable COPD patients of age >40 years. All the patients were randomly allocated to ‘Study’ (n=15) or ‘Control’ (n=15) and their baseline plasma SOD and CAT were measured. Study patients received 80,000 IU (2 oral capsules) of D3 per week for first 13 weeks. Subsequently, after checking their serum 25(OH)D or Ca2+, they received 40,000 IU (1 oral capsule) of D3 either per 1 week or per 2 weeks or per 6 weeks or no further supplementation for next 13 weeks. All the ‘Control’ patients received two oral capsules of placebo weekly for consecutive 26 weeks. Additionally, all patients of both groups were also advised to have sunlight exposure (within 11 to 14 hrs) at least for 5 to 15 minutes daily. After 26 weeks of follow up, both enzymes, serum 25(OH)D or Ca2+of all patients were measured by spectrophotometry. Data were analyzed by paired sample and independent sample ‘t’ test. Results: The baseline plasma SOD (14.80±3.86U/ml vs 11.95±4.03U/ml) and CAT (11.0±7.59U/ml vs14.41±4.83U/ml) in study and control was almost similar (p>0.05). However, the mean SOD (18.98±2.98U/ml) and CAT (32.75±9.70U/ml) significantly increased (p<0.01; p<0.001) after 26 weeks of follow up only in ‘Study’ patients. In addition, both enzymes were significantly (p<0.001) higher in the D3 supplemented patients than those of placebo treated patients after 26 weeks of follow up. Conclusion: The present study reveals that vitamin D3 supplementation increases the plasma antioxidant enzymes in D3 deficient patients with COPD. Trial registration: www.clinicaltrials.gov identifier NCT04011930 J Bangladesh Soc Physiol. 2020, June; 15(1): 23-32

scholarly journals Does Vitamin D3 supplementation affect antioxidant enzymes of D3 deficient patients with asthma COPD overlap (ACO)? - A randomized controlled trial

2020 ◽  
Vol 14 (2) ◽  
pp. 89-98
Author(s):  
Maksuda Bintey Mahmud ◽  
Taskina Ali ◽  
Kazi Saifuddin Bennoor ◽  
Md Ali Hossain ◽  
Mustafizur Rahman ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
Antioxidant Enzyme ◽  
Vitamin D3 ◽  
Controlled Trial ◽  
Enzyme Level ◽  
Control Group ◽  
Male Smoker ◽  
Vitamin D3 Supplementation ◽  
Double Blinded

Background: Asthma COPD overlap (ACO) is a new disease entity where respiratory tract is continuously exposed to oxidants. Supplementation of vitamin D3 have shown evidence of increasing antioxidant enzymes level which neutralize these oxidants. Objectives: To evaluate the effects of vitamin D3 supplementation on two antioxidant enzyme levels in D3 deficient ACO patients. Methods: A double blinded placebo controlled randomized clinical trial (RCT) was carried out on 60 (sixty) D3 deficient [serum 25-hydroxycholecalciferol, 25(OH) D<30 ng/ml], male, smoker, stable ACO patients of age 40 to 80 years. This RCT was registered at www.clinicaltrials.gov identifier NCT03931889. After the final selection, all the patients were randomly allocated to vitamin D3 supplemented ‘Study’ group (n=30) or placebo treated ‘Control’ group (n=30). Two antioxidant enzyme levels [plasma superoxide dismutase (SOD) and catalase (CAT)] were measured at their baseline. Subsequently, along with standard pharmacological treatment of ACO, ‘Study’ patients received 80,000 IU (2 oral capsules) of vitamin D3 per week for first 13 weeks. Thereafter, according to their serum 25(OH)D or calcium concentration, they received 40,000 IU (1 oral capsule) of D3 per 1 week or per 2 weeks or per 6 weeks or no further supplementation, for another 13 weeks. Whereas, all the ‘Control’ patients received two oral capsules of placebo weekly, for consecutive 26 weeks. All patients of both groups were also advised to have sunlight exposure (within 11 am to 4 pm) only for 20 minutes daily. After 26 weeks of follow up, both enzyme levels of all patients were again measured. Both enzymes were measured by ELISA method using spectrophotometry. Data were analyzed by Student’s paired and unpaired ‘t’ test, where p≤0.05 was accepted as significant. Results: Initially a total 60 patients were enrolled and randomized, but ultimately 40 of them completed the trial. The baseline antioxidant enzymes levels of two groups were not significantly different. However, the mean level of both enzymes increased in both groups after 26 weeks of follow up but it was statistically significant (p<0.001) only in ‘Study’ patients. In addition, SOD (p<0.05) and CAT (p<0.01) were significantly higher in the vitamin D3 supplemented patients than those of placebo treated patients after 26 weeks of follow up. Conclusion: The present study reveals that vitamin D3 supplementation increases the antioxidant enzyme level in vitamin D3 deficient stable ACO patients. J Bangladesh Soc Physiol. 2019, December; 14(2): 89-98

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