scholarly journals The Y chromosome ancestry marker R1b1b2: a surrogate of the SARS-CoV-2 population affinity

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Muntaser Ibrahim ◽  
Abdalhameed Salih

AbstractIndividual and population susceptibilities to disease remain a murky area of investigation, clouded by past bias based on ideological differences and wars. The current SARS-CoV-2 pandemic, the largest in living memory, brought this matter to forefront as the disparity in disease burden became apparent. A timeline analysis of the pandemic revealed the presence of country clusters that display a marked preponderance of disease among populations carrying the ancestry marker R1b1b2, notably associated with both infection and mortality. This marker is a relic of past human expansions from western Asia and subsequently Europe and the rest of the world, which may have been accompanied by peculiar biological events rendering these populations vulnerable to SARS-CoV-2.

2021 ◽  
pp. 1-39
Author(s):  
Kevin Morris ◽  
Mohammad Nami ◽  
Joe F. Bolanos ◽  
Maria A. Lobo ◽  
Melody Sadri-Naini ◽  
...  

Neurological disorders significantly impact the world’s economy due to their often chronic and life-threatening nature afflicting individuals which, in turn, creates a global disease burden. The Group of Twenty (G20) member nations, which represent the largest economies globally, should come together to formulate a plan on how to overcome this burden. The Neuroscience-20 (N20) initiative of the Society for Brain Mapping and Therapeutics (SBMT) is at the vanguard of this global collaboration to comprehensively raise awareness about brain, spine, and mental disorders worldwide. This paper aims to provide a comprehensive review of the various brain initiatives worldwide and highlight the need for cooperation and recommend ways to bring down costs associated with the discovery and treatment of neurological disorders. Our systematic search revealed that the cost of neurological and psychiatric disorders to the world economy by 2030 is roughly $16T. The cost to the economy of the United States is $1.5T annually and growing given the impact of COVID-19. We also discovered there is a shortfall of effective collaboration between nations and a lack of resources in developing countries. Current statistical analyses on the cost of neurological disorders to the world economy strongly suggest that there is a great need for investment in neurotechnology and innovation or fast-tracking therapeutics and diagnostics to curb these costs. During the current COVID-19 pandemic, SBMT, through this paper, intends to showcase the importance of worldwide collaborations to reduce the population’s economic and health burden, specifically regarding neurological/brain, spine, and mental disorders.


1897 ◽  
Vol 29 (2) ◽  
pp. 205-226
Author(s):  
Robert Brown

Amongst the most remarkable instances of the result of careful observation and systematized thought which Western Asia has given to the world at large, are the Signs of the Zodiac, and the ancient extra-zodiacal constellation-figures, northern and southern; and by ‘ancient’ I mean those which have been enshrined for all future time in the Phainomena of Aratos. Of the Twelve Signs I shall only speak incidentally. It is now many years since Ideler and Guigniaut, contrary to the views of Letronne, arrived at the correct conclusion that the Signs of the Zodiac came, with so much else of archaic thought and civilization, from, the Euphrates Valley; and, having firmly established themselves in Hellenic usage, were afterwards carried by Greek conquerors as far as India in the east and Egypt in the south. But, although modern research has supplied an immense amount of material for the purpose, it is remarkable that the classic work of Ideler still gives the best account of the constellation-figures and their various stars. Surely, then, it is time that an effort was made to utilize in a connected form some at least of the results of subsequent investigation; and, although the inquiry, like all such, is progressive, and, like all researches into the ancient and archaic past, is beset with numerous difficulties, yet the principles to be applied and the general outlines of the subject are clear and distinct.


2012 ◽  
Vol 1 (3) ◽  
pp. 35 ◽  
Author(s):  
Adnan A. Hyder ◽  
Prasanthi Puvanachandra ◽  
Richard H. Morrow

Indicators that summarise the health status of a population and that provide comparable measures of a population disease burden are increasingly vital tools for health policy decision making. Decisions concerning health systems across the world are greatly affected by changes in disease profiles and population dynamics, and must develop the capacity to respond to such changes effectively within the resources of each nation. Decisions must be based on evidence of the patterns of diseases, their risk factors and the effectiveness of alternative interventions. This paper focuses on the main approaches used for developing summary measures that include mortality and morbidity occurring in a population. It discusses the rationale for composite measures and reviews the origins of each main approach. The paper also examines methodological differences among these approaches making explicit the value choices that each entails, outlines the advantages and limitations of each measure, and shows how they relate to one another.


2021 ◽  
Author(s):  
Jafar Yahyavi Dizaj ◽  
Manijeh Soleimanifar ◽  
Reza Hashempour ◽  
Ali Kazemi Karyani ◽  
Fateh Mohsen ◽  
...  

Abstract Background: MSK health is imperative for the active participation of an individual in society and MSK related disorders more direly affects a person's quality of life compared other non-communicable disease while it also negatively effects the health system and economy of a country. The current manuscript analyzed and describes the disease burden of MSK disorders in the EMRO region.Methods: This was a cross-sectional descriptive-analytical study conducted based on data published by the Global Burden of Disease Database for MSK disorders up to 2017. The study target comprised population from all countries of the EMRO region of World Health Organization. The present study considered, MSK disorders such as (rheumatoid arthritis), (osteoarthritis), (Low back pain), (neck pain), (gout) and (other Musculoskeletal disorders. The DALY index was used to measure total disease burden.Results: MSK disorders in the world and in the EMRO region was ranked 5th (4% of total disease burden) and 7th (5% of total disease burden) among all diseases in 2017, respectively. Women over 30 years of age in the EMRO region had the highest risk of MSK disorders compared to other regions and in addition, the DALY lost in EMRO region due to MSK disorders was higher in women of all age categories than men. According to the results of this study, Low back pain, Other musculoskeletal disorders and Neck pain had the highest prevalence and burden of disease in the EMRO region and the world. Bahrain, Iran, and Morocco had the highest incidence of MSK DALY score in the EMRO region, and Somalia, Djibouti, and Afghanistan had the lowest incidence of MSK disorders and DALY score, respectively.Conclusion: With the increase in geriatric population and obesity especially in developing countries, consequently, more people tend to suffer from MSK disorders and it is predicted that this spike will continue in the coming decades. Taking in to account the high prevalence and burden of MSK disorders, forces government and health-policy makers to focus more on preventive cares and rehabilitation.


Author(s):  
Piotr Michalowski

This chapter is dedicated to the external relationships of the Sargonic (Old Akkadian) polity, often described as the world’s first empire, and focuses primarily on military and diplomatic matters. The kings of this dynasty reigned over all of southern and northern Babylonia as well as patchworks of outposts, trade routes, and territory in neighboring Iran and Syria for approximately two and a half centuries, although their reach varied over time. The martial exploits of its rulers were remembered by later generations of Mesopotamian scribes and poets, who fictionalized them for their own purposes. This chapter eschews such information, focusing exclusively on the critical evaluation of contemporary sources. The Akkad polity was the first successful state of such a large size in Western Asia, with armies and organizational structures that were developed for maintaining strong, centralized control over its peripheries and the unruly central provinces, which were prone to revolt. Its armies were engaged in constant warfare, putting down native rebellions and venturing far and wide in search of booty and access to metals and stone, but often also engaged in defensive actions in Iran, contending with the expansive activities of the powerful state of Marhaši to the east.


Author(s):  
Peter M. M. G. Akkermans

This chapter deals with prehistoric Western Asia, ca. 9500–4000 BC, when this region was the focus of a series of far-reaching socioeconomic developments that were to change the world. Early in this period a gradual shift occurred from a mobile hunter-gatherer way of life to sustained settlement in villages that were increasingly dependent upon farming. Later on, social ranking, economic intensification, and craft specialization emerged at sites throughout the Middle East (Anatolia, Iran, Mesopotamia, and the Levant), laying the foundations for the earliest urban societies in the region. The chapter argues that these changes, far from being unilateral or monolithic, reflect significant multicultural developments and long-lasting trajectories of regional differentiation, requiring the agency of innumerable individuals and generations over millennia.


Author(s):  
Peter R. Joyce

The Global Burden of Disease, which is a comprehensive assessment of mortality and disability from diseases and injuries in 1990 and projected to 2020, highlights the importance of mood disorders for the world. Using the measure of disability-adjusted life years, it was determined that unipolar major depression was the fourth leading cause of disease burden in the world. It was also projected that, in the year 2020, unipolar major depression would be the second leading cause of disease burden in the world. Disabilityadjusted life years is based on both mortality and disability. If one looks at disability alone, then unipolar major depression was the leading cause of disability in the world in 1990, and bipolar disorder was the sixth leading cause. Across the world, 10.7 per cent of disability can be attributed to unipolar major depression and, in developed countries, unipolar major depression contributes to nearly 20 per cent of disease burden in women aged from 15 to 44 years. This chapter addresses bipolar disorders and depressive disorders, covering diagnostic issues, prevalence, comorbidity, use of health services, and risk factors for both types of disorder.


2019 ◽  
pp. tobaccocontrol-2019-055181
Author(s):  
Wayne Gao ◽  
Mattia Sanna ◽  
Marita Hefler ◽  
Chi Pang Wen

Air pollution has been labelled the ‘new smoking’, with news articles bearing titles such as ‘If You Live in a Big City You Already Smoke Every Day’ and ‘The Air Is So Bad in These Cities, You May As Well Be Smoking’. Dr Tedros Adhanom Ghebreyesus, WHO Director-General, highlighted this attention-catching comparison, saying, ‘The world has turned the corner on tobacco. Now it must do the same for the ‘new tobacco’ – the toxic air that billions breathe every day’ and ‘Globally, with smoking on the decline, air pollution now causes more deaths annually than tobacco’ at the First Global Conference on Air Pollution and Health in 2018. The suggestion that the world has turned the corner on tobacco control and the reference to air pollution as the ‘new smoking’ raise a number of concerns. We generate outputs from GBD Compare (the online data visualisation tool of the Global Burden of Diseases and Injuries (GBD) Study) to demonstrate historical disease burden trends in terms of disability-adjusted life years and age-standardised mortality attributable to air pollution and tobacco use from 1990 to 2017 across the globe. We find that the disease burden caused by ambient air pollution declined significantly faster than the burden caused by tobacco use. We conclude that the world is still far from turning the corner on the tobacco endemic. Further, the suggestion that air pollution is as bad as actual smoking is not only inaccurate but also potentially dangerous to public health.


Antiquity ◽  
1947 ◽  
Vol 21 (83) ◽  
pp. 116-121
Author(s):  
M. E. L. Mallowan

IT is a pity that Hume, who carried the Cartesian system of philosophy to its logical conclusion, lived too early to contemplate the discoveries of the past century in Egypt and Babylonia, for he would readily have understood and assimilated the ancient processes of thought which arose at the dawn of history in Western Asia--‘ And no truth appears to me more evident ’, he said, ‘ than that beasts are endowed with thought and reason as well as man ’. The arguments are developed in section XVI of ‘ The Understanding ’, where there are many delightful passages of special relevance to the ancient concepts about life. Again, he said that a bird, that ‘chooses with such care and nicety the place and materials of the nest, and sits upon her eggs for a due time, and in a suitable season, with all the precaution that a chymist is capable of in the most delicate projection, furnishes us with a lively instance of animal sagacity’. Locke, on the other hand, in his discussion of animal rationale, had refused to be drawn so far. ‘ And if Balaam’s ass had, all his life, discussed as rationally as he did once with his master, I doubt yet whether any one would have thought him worthy the name ‘man’, or allowed him to be of the same species with himself ’. Of these two statements Hume’s approximates more closely to the earliest Asiatic view of life, and it is on these lines that Messrs. Frankfort, Wilson, and Jacobsen have approached their problem, which, briefly put is-how did the early thinkers of the Near East come to say what they did about creation, the state, and man ? Professor and Mrs Frankfort define the earliest mode of thought as an ‘ I-thou ’ relation-ship, by which they mean that the primitive Asiatic conceived of all creation in a reciprocal nexus wherein the material world was percipient as well as perceived, and Professor Wilson elaborates the same theme by saying that for the Egyptians the world was consubstantial, and that their view of life might be defined as monophysite. Pro-fessor Jacobsen’s contribution illustrates to what extent the Mesopotamian view of life conformed with this outlook, for example how salt and grain were conceived of as animate beings in a close relationship with man, responsible and responsive to him. Other ideas peculiar to the Mesopotamian mind are no less clearly stressed, and herein lies the fascination of the book, that we have a comparative examination of the Egyptian, Mesopotamian and Israelite approach to life, for Hebrew theology was cast out of a similar matrix. In a concluding chapter by the Frankforts, we see the dawn of a new intellectual era. The Greek physical philosophers, regardless of the data of experience, carried the old basic concepts of the Egyptians and Mesopotamians from a concrete to an abstract frame and worked them to a reductio ad absurdurn, much as Hume did for the concepts of Cartesian philosophy. Their prescience gave birth to science. Nor should we forget that Thales of Miletus prophesied an eclipse, thereby following in the wake of the Babylonian astronomers, who had made similar observations and recorded them centuries earlier.


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