scholarly journals Machine learning enables design automation of microfluidic flow-focusing droplet generation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Ali Lashkaripour ◽  
Christopher Rodriguez ◽  
Noushin Mehdipour ◽  
Rizki Mardian ◽  
David McIntyre ◽  
...  
Keyword(s):  
Machine Learning ◽  
Design Automation ◽  
Large Scale ◽  
Droplet Diameter ◽  
Absolute Error ◽  
Machine Learning Algorithms ◽  
Droplet Generation ◽  
Data Sets ◽  
Flow Focusing ◽  
Predictive Understanding

AbstractDroplet-based microfluidic devices hold immense potential in becoming inexpensive alternatives to existing screening platforms across life science applications, such as enzyme discovery and early cancer detection. However, the lack of a predictive understanding of droplet generation makes engineering a droplet-based platform an iterative and resource-intensive process. We present a web-based tool, DAFD, that predicts the performance and enables design automation of flow-focusing droplet generators. We capitalize on machine learning algorithms to predict the droplet diameter and rate with a mean absolute error of less than 10 μm and 20 Hz. This tool delivers a user-specified performance within 4.2% and 11.5% of the desired diameter and rate. We demonstrate that DAFD can be extended by the community to support additional fluid combinations, without requiring extensive machine learning knowledge or large-scale data-sets. This tool will reduce the need for microfluidic expertise and design iterations and facilitate adoption of microfluidics in life sciences.

scholarly journals Using Machine Learning Methods to Identify Particle Types from Doppler Lidar Measurements in Iceland

2021 ◽  
Vol 13 (13) ◽  
pp. 2433
Author(s):  
Shu Yang ◽  
Fengchao Peng ◽  
Sibylle von Löwis ◽  
Guðrún Nína Petersen ◽  
David Christian Finger
Keyword(s):  
Machine Learning ◽  
Weather Conditions ◽  
Dust Storms ◽  
Machine Learning Algorithms ◽  
Lidar Data ◽  
Data Sets ◽  
Doppler Lidar ◽  
Lidar Measurements ◽  
Using Data ◽  
Filter Noise

Doppler lidars are used worldwide for wind monitoring and recently also for the detection of aerosols. Automatic algorithms that classify the lidar signals retrieved from lidar measurements are very useful for the users. In this study, we explore the value of machine learning to classify backscattered signals from Doppler lidars using data from Iceland. We combined supervised and unsupervised machine learning algorithms with conventional lidar data processing methods and trained two models to filter noise signals and classify Doppler lidar observations into different classes, including clouds, aerosols and rain. The results reveal a high accuracy for noise identification and aerosols and clouds classification. However, precipitation detection is underestimated. The method was tested on data sets from two instruments during different weather conditions, including three dust storms during the summer of 2019. Our results reveal that this method can provide an efficient, accurate and real-time classification of lidar measurements. Accordingly, we conclude that machine learning can open new opportunities for lidar data end-users, such as aviation safety operators, to monitor dust in the vicinity of airports.

Prediction of aircraft estimated time of arrival using machine learning methods

2021 ◽  
pp. 1-15
Author(s):  
O. Basturk ◽  
C. Cetek
Keyword(s):  
Machine Learning ◽  
Web Application ◽  
Absolute Error ◽  
Machine Learning Algorithms ◽  
Weather Data ◽  
Time Of Arrival ◽  
Learning Models ◽  
Trajectory Data ◽  
Different Sources ◽  
Machine Learning Models

ABSTRACT In this study, prediction of aircraft Estimated Time of Arrival (ETA) is proposed using machine learning algorithms. Accurate prediction of ETA is important for management of delay and air traffic flow, runway assignment, gate assignment, collaborative decision making (CDM), coordination of ground personnel and equipment, and optimisation of arrival sequence etc. Machine learning is able to learn from experience and make predictions with weak assumptions or no assumptions at all. In the proposed approach, general flight information, trajectory data and weather data were obtained from different sources in various formats. Raw data were converted to tidy data and inserted into a relational database. To obtain the features for training the machine learning models, the data were explored, cleaned and transformed into convenient features. New features were also derived from the available data. Random forests and deep neural networks were used to train the machine learning models. Both models can predict the ETA with a mean absolute error (MAE) less than 6min after departure, and less than 3min after terminal manoeuvring area (TMA) entrance. Additionally, a web application was developed to dynamically predict the ETA using proposed models.

scholarly journals A novel framework for designing a multi-DoF prosthetic wrist control using machine learning

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chinmay P. Swami ◽  
Nicholas Lenhard ◽  
Jiyeon Kang
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Upper Limb ◽  
Daily Living ◽  
Machine Learning Algorithms ◽  
Data Sets ◽  
Random Forest Regression ◽  
Prosthetic Devices ◽  
Upper Limb Function ◽  
The Neural Network

AbstractProsthetic arms can significantly increase the upper limb function of individuals with upper limb loss, however despite the development of various multi-DoF prosthetic arms the rate of prosthesis abandonment is still high. One of the major challenges is to design a multi-DoF controller that has high precision, robustness, and intuitiveness for daily use. The present study demonstrates a novel framework for developing a controller leveraging machine learning algorithms and movement synergies to implement natural control of a 2-DoF prosthetic wrist for activities of daily living (ADL). The data was collected during ADL tasks of ten individuals with a wrist brace emulating the absence of wrist function. Using this data, the neural network classifies the movement and then random forest regression computes the desired velocity of the prosthetic wrist. The models were trained/tested with ADLs where their robustness was tested using cross-validation and holdout data sets. The proposed framework demonstrated high accuracy (F-1 score of 99% for the classifier and Pearson’s correlation of 0.98 for the regression). Additionally, the interpretable nature of random forest regression was used to verify the targeted movement synergies. The present work provides a novel and effective framework to develop an intuitive control for multi-DoF prosthetic devices.

scholarly journals Clinician checklist for assessing suitability of machine learning applications in healthcare

2021 ◽  
Vol 28 (1) ◽  
pp. e100251
Author(s):  
Ian Scott ◽  
Stacey Carter ◽  
Enrico Coiera
Keyword(s):  
Machine Learning ◽  
Large Scale ◽  
Clinical Decision Making ◽  
Improve Patient Care ◽  
Clinical Decision ◽  
Routine Care ◽  
Machine Learning Algorithms ◽  
Clinical Settings ◽  
Machine Learning Applications ◽  
Key Issues

Machine learning algorithms are being used to screen and diagnose disease, prognosticate and predict therapeutic responses. Hundreds of new algorithms are being developed, but whether they improve clinical decision making and patient outcomes remains uncertain. If clinicians are to use algorithms, they need to be reassured that key issues relating to their validity, utility, feasibility, safety and ethical use have been addressed. We propose a checklist of 10 questions that clinicians can ask of those advocating for the use of a particular algorithm, but which do not expect clinicians, as non-experts, to demonstrate mastery over what can be highly complex statistical and computational concepts. The questions are: (1) What is the purpose and context of the algorithm? (2) How good were the data used to train the algorithm? (3) Were there sufficient data to train the algorithm? (4) How well does the algorithm perform? (5) Is the algorithm transferable to new clinical settings? (6) Are the outputs of the algorithm clinically intelligible? (7) How will this algorithm fit into and complement current workflows? (8) Has use of the algorithm been shown to improve patient care and outcomes? (9) Could the algorithm cause patient harm? and (10) Does use of the algorithm raise ethical, legal or social concerns? We provide examples where an algorithm may raise concerns and apply the checklist to a recent review of diagnostic imaging applications. This checklist aims to assist clinicians in assessing algorithm readiness for routine care and identify situations where further refinement and evaluation is required prior to large-scale use.

57 Precision neoantigen discovery using novel algorithms and expanded HLA-ligandome datasets

2020 ◽  
Vol 8 (Suppl 3) ◽  
pp. A62-A62
Author(s):  
Dattatreya Mellacheruvu ◽  
Rachel Pyke ◽  
Charles Abbott ◽  
Nick Phillips ◽  
Sejal Desai ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cell Lines ◽  
Antigen Processing ◽  
Large Scale ◽  
Prediction Models ◽  
K562 Cells ◽  
Machine Learning Algorithms ◽  
Training Data ◽  
High Quality ◽  
Tissue Samples

BackgroundAccurately identified neoantigens can be effective therapeutic agents in both adjuvant and neoadjuvant settings. A key challenge for neoantigen discovery has been the availability of accurate prediction models for MHC peptide presentation. We have shown previously that our proprietary model based on (i) large-scale, in-house mono-allelic data, (ii) custom features that model antigen processing, and (iii) advanced machine learning algorithms has strong performance. We have extended upon our work by systematically integrating large quantities of high-quality, publicly available data, implementing new modelling algorithms, and rigorously testing our models. These extensions lead to substantial improvements in performance and generalizability. Our algorithm, named Systematic HLA Epitope Ranking Pan Algorithm (SHERPA™), is integrated into the ImmunoID NeXT Platform®, our immuno-genomics and transcriptomics platform specifically designed to enable the development of immunotherapies.MethodsIn-house immunopeptidomic data was generated using stably transfected HLA-null K562 cells lines that express a single HLA allele of interest, followed by immunoprecipitation using W6/32 antibody and LC-MS/MS. Public immunopeptidomics data was downloaded from repositories such as MassIVE and processed uniformly using in-house pipelines to generate peptide lists filtered at 1% false discovery rate. Other metrics (features) were either extracted from source data or generated internally by re-processing samples utilizing the ImmunoID NeXT Platform.ResultsWe have generated large-scale and high-quality immunopeptidomics data by using approximately 60 mono-allelic cell lines that unambiguously assign peptides to their presenting alleles to create our primary models. Briefly, our primary ‘binding’ algorithm models MHC-peptide binding using peptide and binding pockets while our primary ‘presentation’ model uses additional features to model antigen processing and presentation. Both primary models have significantly higher precision across all recall values in multiple test data sets, including mono-allelic cell lines and multi-allelic tissue samples. To further improve the performance of our model, we expanded the diversity of our training set using high-quality, publicly available mono-allelic immunopeptidomics data. Furthermore, multi-allelic data was integrated by resolving peptide-to-allele mappings using our primary models. We then trained a new model using the expanded training data and a new composite machine learning architecture. The resulting secondary model further improves performance and generalizability across several tissue samples.ConclusionsImproving technologies for neoantigen discovery is critical for many therapeutic applications, including personalized neoantigen vaccines, and neoantigen-based biomarkers for immunotherapies. Our new and improved algorithm (SHERPA) has significantly higher performance compared to a state-of-the-art public algorithm and furthers this objective.

scholarly journals Birds Sound Classification Based on Machine Learning Algorithms

2021 ◽  
pp. 1-11
Author(s):  
Aska E. Mehyadin ◽  
Adnan Mohsin Abdulazeez ◽  
Dathar Abas Hasan ◽  
Jwan N. Saeed
Keyword(s):  
Machine Learning ◽  
Noise Suppression ◽  
Bird Species ◽  
Machine Learning Algorithms ◽  
Data Sets ◽  
Learning Technology ◽  
Species Classification ◽  
Data Set ◽  
Sound Classification ◽  
Mel Frequency Cepstral Coefficient

The bird classifier is a system that is equipped with an area machine learning technology and uses a machine learning method to store and classify bird calls. Bird species can be known by recording only the sound of the bird, which will make it easier for the system to manage. The system also provides species classification resources to allow automated species detection from observations that can teach a machine how to recognize whether or classify the species. Non-undesirable noises are filtered out of and sorted into data sets, where each sound is run via a noise suppression filter and a separate classification procedure so that the most useful data set can be easily processed. Mel-frequency cepstral coefficient (MFCC) is used and tested through different algorithms, namely Naïve Bayes, J4.8 and Multilayer perceptron (MLP), to classify bird species. J4.8 has the highest accuracy (78.40%) and is the best. Accuracy and elapsed time are (39.4 seconds).

scholarly journals MACHINE LEARNING METHODS IN MONITORING OPERATING BEHAVIOUR OF MARINE TWO-STROKE DIESEL ENGINE

Transport ◽  
2020 ◽  
Vol 35 (5) ◽  
pp. 462-473
Author(s):  
Aleksandar Vorkapić ◽  
Radoslav Radonja ◽  
Karlo Babić ◽  
Sanda Martinčić-Ipšić
Keyword(s):  
Machine Learning ◽  
Anomaly Detection ◽  
Fuel Consumption ◽  
Performance Monitoring ◽  
Absolute Error ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Operating Parameters ◽  
Detection Model ◽  
Modelling Framework

The aim of this article is to enhance performance monitoring of a two-stroke electronically controlled ship propulsion engine on the operating envelope. This is achieved by setting up a machine learning model capable of monitoring influential operating parameters and predicting the fuel consumption. Model is tested with different machine learning algorithms, namely linear regression, multilayer perceptron, Support Vector Machines (SVM) and Random Forests (RF). Upon verification of modelling framework and analysing the results in order to improve the prediction accuracy, the best algorithm is selected based on standard evaluation metrics, i.e. Root Mean Square Error (RMSE) and Relative Absolute Error (RAE). Experimental results show that, by taking an adequate combination and processing of relevant sensory data, SVM exhibit the lowest RMSE 7.1032 and RAE 0.5313%. RF achieve the lowest RMSE 22.6137 and RAE 3.8545% in a setting when minimal number of input variables is considered, i.e. cylinder indicated pressures and propulsion engine revolutions. Further, article deals with the detection of anomalies of operating parameters, which enables the evaluation of the propulsion engine condition and the early identification of failures and deterioration. Such a time-dependent, self-adopting anomaly detection model can be used for comparison with the initial condition recorded during the test and sea run or after survey and docking. Finally, we propose a unified model structure, incorporating fuel consumption prediction and anomaly detection model with on-board decision-making process regarding navigation and maintenance.

SeisBench: A toolbox for benchmarking and applying machine learning in seismology.

2021 ◽  
Author(s):  
Jack Woollam ◽  
Jannes Münchmeyer ◽  
Carlo Giunchi ◽  
Dario Jozinovic ◽  
Tobias Diehl ◽  
...  
Keyword(s):  
Machine Learning ◽  
Model Comparison ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Quality Data ◽  
Data Sets ◽  
Waveform Data ◽  
Detection Techniques ◽  
Benchmark Data

<p>Machine learning methods have seen widespread adoption within the seismological community in recent years due to their ability to effectively process large amounts of data, while equalling or surpassing the performance of human analysts or classic algorithms. In the wider machine learning world, for example in imaging applications, the open availability of extensive high-quality datasets for training, validation, and the benchmarking of competing algorithms is seen as a vital ingredient to the rapid progress observed throughout the last decade. Within seismology, vast catalogues of labelled data are readily available, but collecting the waveform data for millions of records and assessing the quality of training examples is a time-consuming, tedious process. The natural variability in source processes and seismic wave propagation also presents a critical problem during training. The performance of models trained on different regions, distance and magnitude ranges are not easily comparable. The inability to easily compare and contrast state-of-the-art machine learning-based detection techniques on varying seismic data sets is currently a barrier to further progress within this emerging field. We present SeisBench, an extensible open-source framework for training, benchmarking, and applying machine learning algorithms. SeisBench provides access to various benchmark data sets and models from literature, along with pre-trained model weights, through a unified API. Built to be extensible, and modular, SeisBench allows for the simple addition of new models and data sets, which can be easily interchanged with existing pre-trained models and benchmark data. Standardising the access of varying quality data, and metadata simplifies comparison workflows, enabling the development of more robust machine learning algorithms. We initially focus on phase detection, identification and picking, but the framework is designed to be extended for other purposes, for example direct estimation of event parameters. Users will be able to contribute their own benchmarks and (trained) models. In the future, it will thus be much easier to compare both the performance of new algorithms against published machine learning models/architectures and to check the performance of established algorithms against new data sets. We hope that the ease of validation and inter-model comparison enabled by SeisBench will serve as a catalyst for the development of the next generation of machine learning techniques within the seismological community. The SeisBench source code will be published with an open license and explicitly encourages community involvement.</p>

Identification of DNA-binding proteins via Hypergraph based Laplacian Support Vector Machine

2021 ◽  
Vol 16 ◽  
Author(s):  
Yuqing Qian ◽  
Hao Meng ◽  
Weizhong Lu ◽  
Zhijun Liao ◽  
Yijie Ding ◽  
...  
Keyword(s):  
Machine Learning ◽  
Dna Binding ◽  
Large Scale ◽  
Binding Proteins ◽  
Predictive Accuracy ◽  
Dna Binding Proteins ◽  
Research Field ◽  
Support Vector ◽  
Data Sets ◽  
Independent Test

Background: The identification of DNA binding proteins (DBP) is an important research field. Experiment-based methods are time-consuming and labor-intensive for detecting DBP. Objective: To solve the problem of large-scale DBP identification, some machine learning methods are proposed. However, these methods have insufficient predictive accuracy. Our aim is to develop a sequence-based machine learning model to predict DBP. Methods: In our study, we extract six types of features (including NMBAC, GE, MCD, PSSM-AB, PSSM-DWT, and PsePSSM) from protein sequences. We use Multiple Kernel Learning based on Hilbert-Schmidt Independence Criterion (MKL-HSIC) to estimate the optimal kernel. Then, we construct a hypergraph model to describe the relationship between labeled and unlabeled samples. Finally, Laplacian Support Vector Machines (LapSVM) is employed to train the predictive model. Our method is tested on PDB186, PDB1075, PDB2272 and PDB14189 data sets. Result: Compared with other methods, our model achieves best results on benchmark data sets. Conclusion: The accuracy of 87.1% and 74.2% are achieved on PDB186 (Independent test of PDB1075) and PDB2272 (Independent test of PDB14189), respectively.

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