scholarly journals Antipathogenic properties and applications of low-dimensional materials

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Z. L. Shaw ◽  
Sruthi Kuriakose ◽  
Samuel Cheeseman ◽  
Michael D. Dickey ◽  
Jan Genzer ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Critical Assessment ◽  
Health Concern ◽  
Design Parameters ◽  
Drug Resistant ◽  
Major Health ◽  
Future Design ◽  
Design Considerations ◽  
Low Dimensional ◽  
Low Dimensional Materials

AbstractA major health concern of the 21st century is the rise of multi-drug resistant pathogenic microbial species. Recent technological advancements have led to considerable opportunities for low-dimensional materials (LDMs) as potential next-generation antimicrobials. LDMs have demonstrated antimicrobial behaviour towards a variety of pathogenic bacterial and fungal cells, due to their unique physicochemical properties. This review provides a critical assessment of current LDMs that have exhibited antimicrobial behaviour and their mechanism of action. Future design considerations and constraints in deploying LDMs for antimicrobial applications are discussed. It is envisioned that this review will guide future design parameters for LDM-based antimicrobial applications.

scholarly journals A Case Report of Extensively Drug Resistant Typhoid in Karachi, Pakistan: A Major Health Concern to Curb the Outbreak

2021 ◽  
pp. 125-129
Author(s):  
Sarah Kamran Akbani ◽  
Fazeela Bibi
Keyword(s):  
Disease Burden ◽  
Health Policies ◽  
Health Concern ◽  
Limited Resources ◽  
Adolescent Male ◽  
Drug Resistant ◽  
Major Health ◽  
Younger Patients ◽  
Extensively Drug Resistant ◽  
National Health Policies

The disease burden of extensively drug resistant typhoid in developing countries is a major emerging issue that cannot be ignored. Since its emergence from multidrug strains, the majority of typhoid cases in Karachi, Pakistan, have been extensively drug resistant, mostly infecting younger patients. In the study, the authors analysed one such case in an adolescent male and discussed how, by the implementation of national health policies, the spread of these infectious diseases could be prevented and the overall burden on the healthcare system decreased in areas with already limited resources.

scholarly journals A Scoping Review on Minimum Foot Clearance: An Exploration of Level-Ground Clearance in Individuals with Abnormal Gait

2021 ◽  
Vol 18 (19) ◽  
pp. 10289
Author(s):  
Abdulrahman Al Bochi ◽  
Ghazaleh Delfi ◽  
Tilak Dutta
Keyword(s):  
Built Environment ◽  
Scoping Review ◽  
Health Concern ◽  
Journal Articles ◽  
Major Health ◽  
Future Studies ◽  
Future Design ◽  
Abnormal Gait ◽  
Foot Clearance ◽  
Conference Papers

Background: Falls are a major health concern, with one in three adults over the age of 65 falling each year. A key gait parameter that is indicative of tripping is minimum foot clearance (MFC), which occurs during the mid-swing phase of gait. This is the second of a two-part scoping review on MFC literature. The aim of this paper is to identify vulnerable populations and conditions that impact MFC mean or median relative to controls. This information will inform future design/maintenance standards and outdoor built environment guidelines. Methods: Four electronic databases were searched to identify journal articles and conference papers that report level-ground MFC characteristics. Two independent reviewers screened papers for inclusion. Results: Out of 1571 papers, 43 relevant papers were included in this review. Twenty-eight conditions have been studied for effects on MFC. Eleven of the 28 conditions led to a decrease in mean or median MFC including dual-task walking in older adults, fallers with multiple sclerosis, and treadmill walking. All studies were conducted indoors. Conclusions: The lack of standardized research methods and covariates such as gait speed made it difficult to compare MFC values between studies for the purpose of defining design and maintenance standards for the outdoor built environment. Standardized methods for defining MFC and an emphasis on outdoor trials are needed in future studies.

Illuminating the Biochemical Interaction of Antimicrobial Few-Layer Black Phosphorus with Microbial Cells Using Synchrotron macro-ATR-FTIR

2022 ◽  
Author(s):  
Zoe L Shaw ◽  
Samuel Cheeseman ◽  
Louisa Z.Y. Huang ◽  
Rowan Penman ◽  
Taimur Ahmed ◽  
...  
Keyword(s):  
Alternative Treatment ◽  
Treatment Method ◽  
Black Phosphorus ◽  
Drug Resistant ◽  
Promising Alternative ◽  
Microbial Cells ◽  
Biochemical Interaction ◽  
Low Dimensional ◽  
Low Dimensional Materials

In the fight against drug-resistant pathogenic bacterial and fungal cells, low-dimensional materials are emerging as a promising alternative treatment method. Specifically, few-layer black phosphorus (BP) has demonstrated its effectiveness against...

scholarly journals Mechanistic Insight into the Peptide Binding Modes to Two M. tb MazF Toxins

Toxins ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 319
Author(s):  
Ran Chen ◽  
Jie Zhou ◽  
Wei Xie
Keyword(s):  
Antimicrobial Agents ◽  
Drug Resistant ◽  
Binding Modes ◽  
Persister Cells ◽  
Major Health ◽  
Future Design ◽  
Mechanistic Insight ◽  
Insight Into ◽  
Specific Mrna

Tuberculosis (TB) is a contagious disease caused by Mycobacterium tuberculosis (M. tb). It is regarded as a major health threat all over the world, mainly because of its high mortality and drug-resistant nature. Toxin-antitoxin (TA) systems are modules ubiquitously found in prokaryotic organisms, and the well-studied MazEF systems (MazE means “what is it?” in Hebrew) are implicated in the formation of “persister cells” in the M. tb pathogen. Here, we report cocrystal structures of M. tb MazF-mt1 and -mt9, two important MazF members responsible for specific mRNA and tRNA cleavages, respectively, in complexes with truncated forms of their cognate antitoxin peptides. These peptides bind to the toxins with comparable affinities to their full-length antitoxins, which would reduce the RNA-cleavage capacities of the toxins in vitro. After structural analysis of the binding modes, we systemically tested the influence of the substitutions of individual residues in the truncated MazE-mt9 peptide on its affinity. This study provides structural insight into the binding modes and the inhibition mechanisms between the MazE/F-mt TA pairs. More importantly, it contributes to the future design of peptide-based antimicrobial agents against TB and potentially relieves the drug-resistance problems by targeting novel M. tb proteins.

scholarly journals The Highly Uniform Photoresponsivity from Visible to Near IR Light in Sb2Te3 Flakes

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1535
Author(s):  
Shiu-Ming Huang ◽  
Jai-Lung Hung ◽  
Mitch Chou ◽  
Chi-Yang Chen ◽  
Fang-Chen Liu ◽  
...  
Keyword(s):  
Band Structure ◽  
Energy Difference ◽  
Experimental Result ◽  
Light Illumination ◽  
Near Ir ◽  
State Band ◽  
Valence Bands ◽  
Low Dimensional ◽  
Low Dimensional Materials ◽  
Ir Light

Broadband photosensors have been widely studied in various kinds of materials. Experimental results have revealed strong wavelength-dependent photoresponses in all previous reports. This limits the potential application of broadband photosensors. Therefore, finding a wavelength-insensitive photosensor is imperative in this application. Photocurrent measurements were performed in Sb2Te3 flakes at various wavelengths ranging from visible to near IR light. The measured photocurrent change was insensitive to wavelengths from 300 to 1000 nm. The observed wavelength response deviation was lower than that in all previous reports. Our results show that the corresponding energies of these photocurrent peaks are consistent with the energy difference of the density of state peaks between conduction and valence bands. This suggests that the observed photocurrent originates from these band structure peak transitions under light illumination. Contrary to the most common explanation that observed broadband photocurrent carrier is mainly from the surface state in low-dimensional materials, our experimental result suggests that bulk state band structure is the main source of the observed photocurrent and dominates the broadband photocurrent.

scholarly journals Definition of a scoring parameter to identify low-dimensional materials components

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Peter Mahler Larsen ◽  
Mohnish Pandey ◽  
Mikkel Strange ◽  
Karsten Wedel Jacobsen
Keyword(s):  
Definition Of ◽  
Low Dimensional ◽  
Low Dimensional Materials

scholarly journals Environmental Detection and Potential Transmission of Equine Herpesviruses

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 423
Author(s):  
Anisha Dayaram ◽  
Peter A. Seeber ◽  
Alex D. Greenwood
Keyword(s):  
Environmental Samples ◽  
Environmental Stability ◽  
Health Concern ◽  
Viral Dynamics ◽  
Major Health ◽  
Environmental Detection ◽  
Environmental Transmission ◽  
Direct Exposure ◽  
Equine Herpesviruses ◽  
Important Disease

Equine herpesviruses (EHV) are a major health concern for domestic and wild equids and represent one of the most economically important disease agents of horses. Most known EHVs are transmitted directly between individuals as a result of direct exposure to exudates and aerosols. However, accumulating evidence suggests that environmental transmission may play a role including air, water, and fomites. Here, we reviewed studies on environmental stability and transmission of EHVs, which may influence viral dynamics and the use of environmental samples for monitoring EHV shedding.

scholarly journals Multiple Exciton Generation in Isolated and Interacting Silicon Nanocrystals

Nanoscale ◽  
2021 ◽  
Author(s):  
Ivan Marri ◽  
Stefano Ossicini
Keyword(s):  
Renewable Energy ◽  
Solar Cell ◽  
Silicon Nanocrystals ◽  
Photovoltaic Systems ◽  
Multiple Exciton Generation ◽  
Important Challenge ◽  
Low Dimensional ◽  
Low Dimensional Materials

An important challenge in the field of renewable energy is the development of novel nanostructured solar cell devices which implement low-dimensional materials to overcome the limits of traditional photovoltaic systems....

Reasonably designed 2D WS2 and CdS microwire heterojunction for high performance photoresponse

Nanoscale ◽  
2021 ◽  
Author(s):  
Z.Q. Zheng ◽  
Yuchen Zhou ◽  
Wei Gao ◽  
Li Zhang ◽  
Mengmeng Yang ◽  
...  
Keyword(s):  
High Performance ◽  
Low Dimensional ◽  
Low Dimensional Materials

Heterojunctions based on low-dimensional materials can combine the superiorities of each composition and realize novel properties. Herein, a mixed-dimensional heterojunction comprising multilayer WS2, CdS microwire and few-layer WS2 has been...

scholarly journals Molecular characterization and antimicrobial resistance of potentially human‐pathogenic Escherichia coli strains isolated from riding horses

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Pouya Reshadi ◽  
Fatemeh Heydari ◽  
Reza Ghanbarpour ◽  
Mahboube Bagheri ◽  
Maziar Jajarmi ◽  
...  
Keyword(s):  
Public Health ◽  
Escherichia Coli ◽  
Antimicrobial Resistance ◽  
Health Concern ◽  
Zoonotic Potential ◽  
Drug Resistant ◽  
Public Health Concern ◽  
E Coli ◽  
Pathogenic Escherichia Coli ◽  
Amoxicillin Clavulanic Acid

Abstract Background Transmission of antimicrobial resistant and virulent Escherichia coli (E. coli) from animal to human has been considered as a public health concern. This study aimed to determine the phylogenetic background and prevalence of diarrheagenic E. coli and antimicrobial resistance in healthy riding-horses in Iran. In this research, the genes related to six main pathotypes of E. coli were screened. Also, genotypic and phenotypic antimicrobial resistance against commonly used antibiotics were studied, then phylo-grouping was performed on all the isolates. Results Out of 65 analyzed isolates, 29.23 % (n = 19) were determined as STEC and 6.15 % (n = 4) as potential EPEC. The most prevalent antimicrobial resistance phenotypes were against amoxicillin/clavulanic acid (46.2 %) and ceftriaxone (38.5 %). blaTEM was the most detected resistance gene (98.4 %) among the isolates and 26.15 % of the E. coli isolates were determined as multi-drug resistant (MDR). Three phylo-types including B1 (76.92 %), A (13.85 %) and D (3.08 %) were detected among the isolates. Conclusions Due to the close interaction of horses and humans, these findings would place emphasis on the pathogenic and zoonotic potential of the equine strains and may help to design antimicrobial resistance stewardship programs to control the dissemination of virulent and multi-drug resistant E. coli strains in the community.

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