New Insight about Biocompatibility and Biodegradability of Iron Oxide Magnetic Nanoparticles: Stereological and In Vivo MRI Monitor

The noteworthy intensification in the development of nanotechnology has led to the development of various types of nanoparticles. The diverse applications of these nanoparticles make them desirable candidate for areas such as drug delivery, coasmetics, medicine, electronics, and contrast agents for magnetic resonance imaging (MRI) and so on. Iron oxide magnetic nanoparticles are a branch of nanoparticles which is specifically being considered as a contrast agent for MRI as well as targeted drug delivery vehicles, angiogenic therapy and chemotherapy as small size gives them advantage to travel intravascular or intracavity actively for drug delivery. Besides the mentioned advantages, the toxicity of the iron oxide magnetic nanoparticles is still less explored. For in vivo applications magnetic nanoparticles should be nontoxic and compatible with the body fluids. These particles tend to degrade in the body hence there is a need to understand the toxicity of the particles as whole and degraded products interacting within the body. Some nanoparticles have demonstrated toxic effects such inflammation, ulceration, and decreases in growth rate, decline in viability and triggering of neurobehavioral alterations in plants and cell lines as well as in animal models. The cause of nanoparticles’ toxicity is attributed to their specific characteristics of great surface to volume ratio, chemical composition, size, and dosage, retention in body, immunogenicity, organ specific toxicity, breakdown and elimination from the body. In the current review paper, we aim to sum up the current knowledge on the toxic effects of different magnetic nanoparticles on cell lines, marine organisms and rodents. We believe that the comprehensive data can provide significant study parameters and recent developments in the field. Thereafter, collecting profound knowledge on the background of the subject matter, will contribute to drive research in this field in a new sustainable direction.

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Facile Synthesis and Characterization of L-Aspartic Acid Coated Iron Oxide Magnetic Nanoparticles (IONPs) For Biomedical Applications

Drug Research ◽

10.1055/s-0043-120197 ◽

2017 ◽

Vol 68 (05) ◽

pp. 280-285 ◽

Cited By ~ 25

Author(s):

Marziyeh Salehiabar ◽

Hamed Nosrati ◽

Soodabeh Davaran ◽

Hossein Danafar ◽

Hamidreza Manjili

Keyword(s):

Electron Microscopy ◽

Iron Oxide ◽

Magnetic Nanoparticles ◽

Aspartic Acid ◽

Precipitation Method ◽

Scanning Calorimetry ◽

One Pot ◽

Iron Oxide Magnetic Nanoparticles

AbstractNatural L-aspartic acid coated iron oxide magnetic nanoparticles (Asp@IONPs) were prepared by a one pot, in-situ and green co–precipitation method in an aqueous medium. Functionalized iron oxide magnetic nanoparticles (IONPs) were characterized by Vibrating Sample Magnetometer (VSM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM) techniques. Cellular toxicity of IONPs was also investigated on HEK-293 cell lines. The results showed that the zeta potential of Asp@IONPs was about −21.1 mV and the average size was 17.80±3.09 nm. Cell toxicity results show that as prepared IONPs are biocompatible. Asp@IONPs show the possibility of using these nanoparticles in the development of in vitro and in vivo biomedical fields due to do not possess a toxic effect, good ζ-potential and related small and narrow size distribution.

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Size dependent biodistribution and toxicokinetics of iron oxide magnetic nanoparticles in mice

Nanoscale ◽

10.1039/c4nr05061d ◽

2015 ◽

Vol 7 (2) ◽

pp. 625-636 ◽

Cited By ~ 89

Author(s):

Lin Yang ◽

Huijuan Kuang ◽

Wanyi Zhang ◽

Zoraida P. Aguilar ◽

Yonghua Xiong ◽

...

Keyword(s):

Iron Oxide ◽

Magnetic Nanoparticles ◽

Size Dependent ◽

Iron Oxide Magnetic Nanoparticles ◽

Metabolic Activities ◽

Scanty Information

In spite of the immense benefits from iron oxide magnetic nanoparticles (IOMNs), there is scanty information regarding their metabolic activities and toxicity in vivo.

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Preparation and physical characterization of cobalt iron oxide magnetic nanoparticles loaded polyvinyl alcohol

Journal of Thermoplastic Composite Materials ◽

10.1177/0892705720985577 ◽

2021 ◽

pp. 089270572098557

Author(s):

M Abu-Abdeen ◽

O Saber ◽

E Mousa

Keyword(s):

Iron Oxide ◽

Magnetic Nanoparticles ◽

Polyvinyl Alcohol ◽

Saturation Magnetization ◽

Polymer Films ◽

Magnetic Hysteresis ◽

Thermal Method ◽

Cobalt Iron Oxide ◽

Cobalt Iron ◽

Iron Oxide Magnetic Nanoparticles

A solvent thermal method which depends on a thermal process under critical temperature and pressure was used to prepare cobalt iron oxide magnetic nanoparticles with a molar ratio 2. The prepared particles were in the form of nanoparticles with diameter ranging from 5 to 10 nm and with amorphous structure. Magnetic hysteresis behavior with saturation magnetization 36.31 emu/g and coercivity 4 Oe were observed for the nanoparticles. Polyvinyl alcohol was loaded with different concentrations of cobalt iron oxide nanoparticles using casting technique. Hysteresis loops for the polymer films were observed and both the saturation magnetization and coercivity were increased from 0.36 to 16.03 emu/g and 115 to 293 Oe for samples containing 5 and 20 wt% of nanoparticles, respectively. The elastic modulus of films was increased from 2.7 to 4.9 GPa for unloaded and loaded samples with 20 wt%, respectively. The storage modulus of the polymer films was found to obey the percolation behavior.

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Click Synthesis of Hydrophilic Maltose-Functionalized Iron Oxide Magnetic Nanoparticles Based on Dopamine Anchors for Highly Selective Enrichment of Glycopeptides

ACS Applied Materials & Interfaces ◽

10.1021/acsami.5b06991 ◽

2015 ◽

Vol 7 (44) ◽

pp. 24670-24678 ◽

Cited By ~ 70

Author(s):

Changfen Bi ◽

Yingran Zhao ◽

Lijin Shen ◽

Kai Zhang ◽

Xiwen He ◽

...

Keyword(s):

Iron Oxide ◽

Magnetic Nanoparticles ◽

Selective Enrichment ◽

Iron Oxide Magnetic Nanoparticles ◽

Click Synthesis

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Fe3O4 Magnetic Nanoparticles: Characterization and Performance Exemplified by the Degradation of Methylene Blue in the Presence of Persulfate

Journal of Advanced Oxidation Technologies ◽

10.1515/jaots-2016-0105 ◽

2016 ◽

Vol 19 (1) ◽

Cited By ~ 2

Author(s):

Chang-Mao Hung ◽

Chiu-Wen Chen ◽

Yu-Zhe Jhuang ◽

Cheng-Di Dong

Keyword(s):

Methylene Blue ◽

Iron Oxide ◽

Magnetic Nanoparticles ◽

Fe3o4 Magnetic Nanoparticles ◽

Iron Oxide Magnetic Nanoparticles ◽

Nanoparticles Characterization ◽

And Performance

AbstractIn this study, the oxidation of methylene blue (MB) over iron oxide magnetic nanoparticles (Fe

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Application of Immobilized Fungi Phanerochaete chrysosporium in Removal of Heavy-Metals from Wastewater

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.779-780.1674 ◽

2013 ◽

Vol 779-780 ◽

pp. 1674-1677 ◽

Cited By ~ 2

Author(s):

Dan Lian Huang ◽

Guang Ming Zeng ◽

Piao Xu ◽

Cui Lai ◽

Mei Hua Zhao ◽

...

Keyword(s):

Heavy Metals ◽

Iron Oxide ◽

Magnetic Nanoparticles ◽

Phanerochaete Chrysosporium ◽

High Efficiency ◽

Metal Removal ◽

Heavy Metal Removal ◽

Removal Of Heavy Metals ◽

Iron Oxide Magnetic Nanoparticles ◽

Ca Alginate

Immobilized microbe technologies are expected to be effectively used in wastewater treatment. Removal of heavy-metals from wastewater by immobilized Phanerochaete chrysosporium (Pc) with Ca-alginate and iron oxide magnetic nanoparticles (MNPs) was studied. The results showed that a biosorbent as Pc immobilized by Ca-alginate and iron oxide magnetic nanoparticles was successfully developed. And the iron oxide magnetic nanoparticles played an important role in the increase of biosorption capacity of Pc. Energy dispersive spectrometer (EDS) analysis confirmed that metal ions adsorbed to the surface of the biosorbents were partly transmitted to the interior of biosorbents, mainly embedded with iron oxide nanoparticles and Ca-alginate. Moreover, it was found that MNPs-Ca-alginate immobilized Pc showed a good affinity to various heavy metals, such as Pb(II), Zn(II), Cd(II) or Mg(II) and so on. The results proved the high efficiency of the biosorbents for heavy-metal removal and its potential application in the treatment of metal-containing wastewater.

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In Vivo Study on Magnetomotive Ultrasound Imaging in the Framework of Nanoparticle based Magnetic Drug Targeting

Current Directions in Biomedical Engineering ◽

10.1515/cdbme-2020-3139 ◽

2020 ◽

Vol 6 (3) ◽

pp. 543-546

Author(s):

Michael Fink ◽

Stefan J. Rupitsch ◽

Helmut Ermert ◽

Stefan Lyer

Keyword(s):

Iron Oxide ◽

Magnetic Nanoparticles ◽

Drug Targeting ◽

Imaging Technique ◽

Small Animal ◽

Magnetic Drug Targeting ◽

Oxide Nanoparticles ◽

Medical Procedures ◽

First Time

AbstractVarious medical procedures make use of magnetic nanoparticles, such as Magnetic Drug Targeting (MDT), which boosts the demand for imaging modalities that are capable of in vivo visualizing this kind of particles. Magnetomotive Ultrasound is an imaging technique that can detect tissue, which is perfused by magnetic nanoparticles. In this contribution, we investigate the suitability of Magnetomotive Ultrasound to serve as a monitoring system during MDT. With the conducted measurements, it was possible for the first time to observe in vivo the accumulation of iron-oxide nanoparticles during a Magnetic Drug Targeting cancer treatment applied to a small animal (rabbit).

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