Application of Fused Deposition Modelling (FDM) Method of 3D Printing in Drug Delivery

2017 ◽  
Vol 23 (3) ◽  
pp. 433-439 ◽  
Author(s):  
Jingjunjiao Long ◽  
Hamideh Gholizadeh ◽  
Jun Lu ◽  
Craig Bunt ◽  
Ali Seyfoddin
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Low Cost ◽  
Three Dimensional ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Fused Deposition ◽  
Accurate Dose ◽  
Drug Delivery Devices ◽  
3D Printing Technique

Three-dimensional (3D) printing is an emerging manufacturing technology for biomedical and pharmaceutical applications. Fused deposition modelling (FDM) is a low cost extrusion-based 3D printing technique that can deposit materials layer-by-layer to create solid geometries. This review article aims to provide an overview of FDM based 3D printing application in developing new drug delivery systems. The principle methodology, suitable polymers and important parameters in FDM technology and its applications in fabrication of personalised tablets and drug delivery devices are discussed in this review. FDM based 3D printing is a novel and versatile manufacturing technique for creating customised drug delivery devices that contain accurate dose of medicine( s) and provide controlled drug released profiles.

scholarly journals Parameters Affecting the Mechanical Properties of Three-Dimensional (3D) Printed Carbon Fiber-Reinforced Polylactide Composites

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2456
Author(s):  
Demei Lee ◽  
Guan-Yu Wu
Keyword(s):  
Mechanical Properties ◽  
Carbon Fiber ◽  
3D Printing ◽  
Three Dimensional ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Fused Deposition ◽  
Bed Temperature ◽  
3D Printed ◽  
The Impact

Three-dimensional (3D) printing is a manufacturing technology which creates three-dimensional objects layer-by-layer or drop-by-drop with minimal material waste. Despite the fact that 3D printing is a versatile and adaptable process and has advantages in establishing complex and net-shaped structures over conventional manufacturing methods, the challenge remains in identifying the optimal parameters for the 3D printing process. This study investigated the influence of processing parameters on the mechanical properties of Fused Deposition Modelling (FDM)-printed carbon fiber-filled polylactide (CFR-PLA) composites by employing an orthogonal array model. After printing, the tensile and impact strengths of the printed composites were measured, and the effects of different parameters on these strengths were examined. The experimental results indicate that 3D-printed CFR-PLA showed a rougher surface morphology than virgin PLA. For the variables selected in this analysis, bed temperature was identified as the most influential parameter on the tensile strength of CFR-PLA-printed parts, while bed temperature and print orientation were the key parameters affecting the impact strengths of printed composites. The 45° orientation printed parts also showed superior mechanical strengths than the 90° printed parts.

3D Printing: Basic Concepts Mathematics and Technologies

2013 ◽  
Vol 2 (2) ◽  
pp. 58-71
Author(s):  
Alexander Rompas ◽  
Charalampos Tsirmpas ◽  
Ianos Papatheodorou ◽  
Georgia Koutsouri ◽  
Dimitris Koutsouris
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Real Life ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Three Dimensional Objects ◽  
Stl File ◽  
Fused Deposition ◽  
3D Printers ◽  
Object Layer

3D printing is about being able to print any object layer by layer. But if one questions this proposition, can one find any three-dimensional objects that can't be printed layer by layer? To banish any disbeliefs the authors walked together through the mathematics that prove 3d printing is feasible for any real life object. 3d printers create three-dimensional objects by building them up layer by layer. The current generation of 3d printers typically requires input from a CAD program in the form of an STL file, which defines a shape by a list of triangle vertices. The vast majority of 3d printers use two techniques, FDM (Fused Deposition Modelling) and PBP (Powder Binder Printing). One advanced form of 3d printing that has been an area of increasing scientific interest the recent years is bioprinting. Cell printers utilizing techniques similar to FDM were developed for bioprinting. These printers give us the ability to place cells in positions that mimic their respective positions in organs. Finally, through a series of case studies the authors show that 3d printers have made a massive breakthrough in medicine lately.

scholarly journals A Low-Cost Multi-Sensor Data Acquisition System for Fault Detection in Fused Deposition Modelling

Sensors ◽  
2022 ◽  
Vol 22 (2) ◽  
pp. 517
Author(s):  
Satish Kumar ◽  
Tushar Kolekar ◽  
Shruti Patil ◽  
Arunkumar Bongale ◽  
Ketan Kotecha ◽  
...  
Keyword(s):  
3D Printing ◽  
Data Acquisition ◽  
Low Cost ◽  
Data Acquisition System ◽  
Acquisition System ◽  
Sensor Data ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Fused Deposition ◽  
Sensor Data Acquisition

Fused deposition modelling (FDM)-based 3D printing is a trending technology in the era of Industry 4.0 that manufactures products in layer-by-layer form. It shows remarkable benefits such as rapid prototyping, cost-effectiveness, flexibility, and a sustainable manufacturing approach. Along with such advantages, a few defects occur in FDM products during the printing stage. Diagnosing defects occurring during 3D printing is a challenging task. Proper data acquisition and monitoring systems need to be developed for effective fault diagnosis. In this paper, the authors proposed a low-cost multi-sensor data acquisition system (DAQ) for detecting various faults in 3D printed products. The data acquisition system was developed using an Arduino micro-controller that collects real-time multi-sensor signals using vibration, current, and sound sensors. The different types of fault conditions are referred to introduce various defects in 3D products to analyze the effect of the fault conditions on the captured sensor data. Time and frequency domain analyses were performed on captured data to create feature vectors by selecting the chi-square method, and the most significant features were selected to train the CNN model. The K-means cluster algorithm was used for data clustering purposes, and the bell curve or normal distribution curve was used to define individual sensor threshold values under normal conditions. The CNN model was used to classify the normal and fault condition data, which gave an accuracy of around 94%, by evaluating the model performance based on recall, precision, and F1 score.

scholarly journals Additive Manufacturing in the Geopolymer Construction Technology: A Review

2020 ◽  
Vol 14 (1) ◽  
pp. 150-161
Author(s):  
Salmabanu Luhar ◽  
Ismail Luhar
Keyword(s):  
3D Printing ◽  
Computer Aided Design ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Construction Technology ◽  
Fused Deposition ◽  
Labor Requirements ◽  
Net Shaping

This research paper presents a scientific attempt of a comprehensive systematic review of three-dimensional printing in geopolymer construction technology. The concept of 3D printing is an automated manufacturing process, layer- by- layer command, with computer-aided design model to create physical objects, acquiring swift development for the last few decades. An expansion of novel Geopolymer technology has been adopted in the construction and infrastructure industries for decades. The critical challenges of construction and infrastructure industries, such as the need for architectural, holistic, and rational designs, can be dealt with 3D printing techniques. Plentiful advantages of this emerging novel technology include a reduced amount of cost, ease of construction, a lesser amount of time, freedom of design, less wastage, aptitude to create complex structures, decrease in labor requirements, etc. Accordingly, The paper discusses common 3D techniques, such as Fused Deposition Modelling, Selective Laser Sintering, Stereolithography, 3D plotting, Laminated Object Manufacturing technique, Direct Energy deposition technique or laser engineered net shaping, Powder Bed Fusion and Inject Head 3D printing and direct deposition method. Overall, this study provides an introduction of 3D printing automation and robotics processes in a geopolymer construction industry. Ultimately, the paper emphasizes to motivate researchers towards future studies about 3D printing.

scholarly journals An Overview of Natural Polymers as Reinforcing Agents for 3D Printing

2021 ◽  
Vol 5 (4) ◽  
pp. 78
Author(s):  
Beatrice Sabbatini ◽  
Alessandra Cambriani ◽  
Marco Cespi ◽  
Giovanni Filippo Palmieri ◽  
Diego Romano Perinelli ◽  
...  
Keyword(s):  
3D Printing ◽  
Low Cost ◽  
Selective Laser Sintering ◽  
Three Dimensional ◽  
Polymeric Materials ◽  
Industrial Wastes ◽  
Fused Deposition Modelling ◽  
Natural Polymers ◽  
Fused Deposition ◽  
Glass Carbon

Three-dimensional (3D) printing, or additive manufacturing, is a group of innovative technologies that are increasingly employed for the production of 3D objects in different fields, including pharmaceutics, engineering, agri-food and medicines. The most processed materials by 3D printing techniques (e.g., fused deposition modelling, FDM; selective laser sintering, SLS; stereolithography, SLA) are polymeric materials since they offer chemical resistance, are low cost and have easy processability. However, one main drawback of using these materials alone (e.g., polylactic acid, PLA) in the manufacturing process is related to the poor mechanical and tensile properties of the final product. To overcome these limitations, fillers can be added to the polymeric matrix during the manufacturing to act as reinforcing agents. These include inorganic or organic materials such as glass, carbon fibers, silicon, ceramic or metals. One emerging approach is the employment of natural polymers (polysaccharides and proteins) as reinforcing agents, which are extracted from plants or obtained from biomasses or agricultural/industrial wastes. The advantages of using these natural materials as fillers for 3D printing are related to their availability together with the possibility of producing printed specimens with a smaller environmental impact and higher biodegradability. Therefore, they represent a “green option” for 3D printing processing, and many studies have been published in the last year to evaluate their ability to improve the mechanical properties of 3D printed objects. The present review provides an overview of the recent literature regarding natural polymers as reinforcing agents for 3D printing.

Performance of Low-Cost 3D Printer in Medical Application

2021 ◽  
Author(s):  
Nor Aiman Sukindar ◽  
Azib Azhari Awang Dahan ◽  
Sharifah Imihezri Syed Shaharuddin ◽  
Nor Farah Huda Abd Halim
Keyword(s):  
Low Cost ◽  
Medical Application ◽  
Fused Deposition Modelling ◽  
3D Printer ◽  
Layer By Layer ◽  
Total Deformation ◽  
Element Analysis ◽  
Porosity Level ◽  
Fused Deposition ◽  
Printing Parameters

Abstract Fused Deposition Modelling (FDM) is an additive manufacturing (AM) process that produces a physical object directly from a CAD design using layer-by-layer deposition of the filament material that is extruded via a nozzle. In industry, FDM has become one of the most used AM processes for the production of low batch quantity and functional prototypes, due to its safety, efficiency, reliability, low cost, and ability to process manufacturing-grade engineering thermoplastic. Recently, the market is flooded with the availability of low-cost printers produced by numerous companies. This research aims to investigate the effect of different porosity levels on a scaffold structure produced using a low-cost 3D printer. Comparisons of these porous structures were made in terms of Von-Mises strain, total deformation, as well as compressive stress. Various porosity levels were created by varying printing parameters, including layer height, infill density, and shell thickness by slicing the initial solid CAD file using Repetier Host 3D printing software. Finite Element Analysis (FEA) simulation was then performed on the created scaffold structures by using Ansys Workbench 19.2. The simulation result indicates that the greater porosity level will result in higher total deformation of the structure. Meanwhile, the compression test shows that the minimum strength value obtained was favourable at 22 MPa and had exceeded that of the trabecular femur (15 MPa). However, its porosity level (maximum at 52%) was still below that of the minimum threshold of porosity level of 70 percent. However, the printing parameters currently used can be adjusted in the future. Therefore, it was deduced that the low-cost 3D printer offers promising potential to fabricate different porosity structures with multiple outcomes.

scholarly journals 3D Printing of Thermo-Sensitive Drugs

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1524
Author(s):  
Sadikalmahdi Abdella ◽  
Souha H. Youssef ◽  
Franklin Afinjuomo ◽  
Yunmei Song ◽  
Paris Fouladian ◽  
...  
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Fused Deposition Modelling ◽  
Future Directions ◽  
Digital Light Processing ◽  
Fused Deposition ◽  
Printing Technique ◽  
3D Printed ◽  
Semi Solid ◽  
Selection Of

Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam®) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations.

scholarly journals Three-Dimensional Printed Polylactic Acid (PLA) Surgical Retractors with Sonochemically Immobilized Silver Nanoparticles: The Next Generation of Low-Cost Antimicrobial Surgery Equipment

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 985 ◽  
Author(s):  
Lazaros Tzounis ◽  
Petros I. Bangeas ◽  
Aristomenis Exadaktylos ◽  
Markos Petousis ◽  
Nectarios Vidakis
Keyword(s):  
Electron Microscopy ◽  
3D Printing ◽  
Polylactic Acid ◽  
Low Cost ◽  
Three Dimensional ◽  
Film Deposition ◽  
Average Particle ◽  
Ag Nps ◽  
Fused Deposition ◽  
Vis Spectroscopy

A versatile method is reported for the manufacturing of antimicrobial (AM) surgery equipment utilising fused deposition modelling (FDM), three-dimensional (3D) printing and sonochemistry thin-film deposition technology. A surgical retractor was replicated from a commercial polylactic acid (PLA) thermoplastic filament, while a thin layer of silver (Ag) nanoparticles (NPs) was developed via a simple and scalable sonochemical deposition method. The PLA retractor covered with Ag NPs (PLA@Ag) exhibited vigorous AM properties examined by a reduction in Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli) bacteria viability (%) experiments at 30, 60 and 120 min duration of contact (p < 0.05). Scanning electron microscopy (SEM) showed the surface morphology of bare PLA and PLA@Ag retractor, revealing a homogeneous and full surface coverage of Ag NPs. X-Ray diffraction (XRD) analysis indicated the crystallinity of Ag nanocoating. Ultraviolent-visible (UV-vis) spectroscopy and transmission electron microscopy (TEM) highlighted the AgNP plasmonic optical responses and average particle size of 31.08 ± 6.68 nm. TEM images of the PLA@Ag crossection demonstrated the thickness of the deposited Ag nanolayer, as well as an observed tendency of AgNPs to penetrate though the outer surface of PLA. The combination of 3D printing and sonochemistry technology could open new avenues in the manufacturing of low-cost and on-demand antimicrobial surgery equipment.

scholarly journals Investigation of a Short Carbon Fibre-Reinforced Polyamide and Comparison of Two Manufacturing Processes: Fused Deposition Modelling (FDM) and Polymer Injection Moulding (PIM)

Materials ◽  
2020 ◽  
Vol 13 (3) ◽  
pp. 672 ◽  
Author(s):  
Elena Verdejo de Toro ◽  
Juana Coello Sobrino ◽  
Alberto Martínez Martínez ◽  
Valentín Miguel Eguía ◽  
Jorge Ayllón Pérez
Keyword(s):  
Mechanical Properties ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Injection Moulding ◽  
New Technologies ◽  
Mechanical Response ◽  
Fused Deposition Modelling ◽  
Layer By Layer ◽  
Polymer Injection ◽  
Fused Deposition

New technologies are offering progressively more effective alternatives to traditional ones. Additive Manufacturing (AM) is gaining importance in fields related to design, manufacturing, engineering and medicine, especially in applications which require complex geometries. Fused Deposition Modelling (FDM) is framed within AM as a technology in which, due to their layer-by-layer deposition, thermoplastic polymers are used for manufacturing parts with a high degree of accuracy and minimum material waste during the process. The traditional technology corresponding to FDM is Polymer Injection Moulding, in which polymeric pellets are injected by pressure into a mould using the required geometry. The increasing use of PA6 in Additive Manufacturing makes it necessary to study the possibility of replacing certain parts manufactured by injection moulding with those created using FDM. In this work, PA6 was selected due to its higher mechanical properties in comparison with PA12. Moreover, its higher melting point has been a limitation for 3D printing technology, and a further study of composites made of PA6 using 3D printing processes is needed. Nevertheless, analysis of the mechanical response of standardised samples and the influence of the manufacturing process on the polyamide’s mechanical properties needs to be carried out. In this work, a comparative study between the two processes was conducted, and conclusions were drawn from an engineering perspective.

scholarly journals Three-dimensional Printing Versus Conventional Machining in the Creation of a Meatal Urethral Dilator: a Cost and Mechanical Strength Analysis

2020 ◽  
Author(s):  
Michael Yue-Cheng Chen ◽  
Jacob Skewes ◽  
Ryan Daley ◽  
Maria Ann Woodruff ◽  
Nicholas John Rukin
Keyword(s):  
3D Printing ◽  
Three Dimensional ◽  
Patient Specific ◽  
Strength Analysis ◽  
Fused Deposition Modelling ◽  
3D Printer ◽  
Current Time ◽  
Fused Deposition ◽  
3D Printed ◽  
Conventional Machining

Abstract BackgroundThree-dimensional (3D) printing is a promising technology but the limitations are often poorly understood. We compare different 3D printingmethods with conventional machining techniques in manufacturing meatal urethral dilators which were recently removed from the Australian market. MethodsA prototype dilator was 3D printed vertically orientated on a low cost fused deposition modelling (FDM) 3D printer in polylactic acid (PLA) and acrylonitrile butadiene styrene (ABS). It was also 3D printed horizontally orientated in ABS on a high-end FDM 3D printer with soluble support material, as well as on a SLS 3D printer in medical nylon. The dilator was also machined in stainless steel using a lathe. All dilators were tested mechanically in a custom rig by hanging calibrated weights from the handle until the dilator snapped. ResultsThe horizontally printed ABS dilator experienced failure at a greater load than the vertically printed PLA and ABS dilators respectively (503g vs 283g vs 163g, p < 0.001). The SLS nylon dilator and machined steel dilator did not fail. The steel dilator is most expensive with a quantity of five at 98 USD each, but this decreases to 30 USD each for a quantity of 1000. In contrast, the cost for the SLS dilator is 33 USD each for five and 27 USD each for 1000. ConclusionsAt the current time 3D printing is not a replacement for conventional manufacturing. 3D printing is best used for patient-specific parts, prototyping or manufacturing complex parts that have additional functionality that cannot otherwise beachieved.

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