Relationship between the frequency of electrocautery of Hunner lesions and changes in bladder capacity in patients with Hunner type interstitial cystitis

AbstractElectrocautery is a promising treatment option for patients with Hunner type interstitial cystitis (HIC), but frequently requires multiple sessions due to recurrence of the lesions. In the present study, we assessed the relationship between the frequency of electrocautery of Hunner lesions and changes in maximum bladder capacity (MBC) at hydrodistension in a large cohort of 118 HIC patients. Three mixed-effect linear regression analyses were conducted for MBC against (1) the number of sessions; (2) the number of sessions and the time between each session and the first session; and (3) other relevant clinical parameters in addition to the Model (2). The mean number of sessions was 2.8 times. MBC decreased approximately 50 mL for each additional electrocautery session, but this loss was offset by 10 mL for each year the subsequent session was postponed. MBC of < 400 mL at the first session was a significant risk factor for MBC loss with further sessions. No other clinical parameters were associated with MBC over time. This study demonstrates a significant relationship between the frequency of electrocautery of Hunner lesions and MBC changes in HIC patients. Low MBC at the first session is a poor prognostic marker for MBC loss over multiple sessions.

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External Ventricular Drain Infection

Journal of Neurosurgery ◽

10.3171/jns-07/07/0248 ◽

2007 ◽

Vol 107 (1) ◽

pp. 248 ◽

Cited By ~ 3

Author(s):

George K. C. Wong ◽

Wayne W. S. Poon

Keyword(s):

Major Trauma ◽

Independent Predictor ◽

External Ventricular Drain ◽

Significant Risk ◽

Significant Risk Factor ◽

External Ventricular Drainage ◽

Infection Rates ◽

The Mean ◽

The Relationship ◽

Shed Light

Object The authors explored the relationship among the duration of external ventricular drainage, revision of external ventricular drains (EVDs), and cerebrospinal fluid (CSF) infection to shed light on the practice of electively revising these drains. Methods In a retrospective study of 199 patients with 269 EVDs in the intensive care unit at a major trauma center in Australasia, the authors found 21 CSF infections. Acinetobacter accounted for 10 (48%) of these infections. Whereas the duration of drainage was not an independent predictor of infection, multiple insertions of EVDs was a significant risk factor. Second and third EVDs in previously uninfected patients were more likely to become infected than first EVDs. An EVD infection was initially identified a mean of 5.5 ±0.7 days postinsertion (standard error of the mean); these data—that is, the number of days—were normally distributed. Conclusions This pattern of infection is best explained by EVD-associated CSF infections being acquired by the introduction of bacteria on insertion of the drain rather than by subsequent retrograde colonization. Elective EVD revision would be expected to increase infection rates in light of these results, and thus the practice has been abandoned by the authors' institution.

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External ventricular drain infections are independent of drain duration: an argument against elective revision

Journal of Neurosurgery ◽

10.3171/jns.2007.106.3.378 ◽

2007 ◽

Vol 106 (3) ◽

pp. 378-383 ◽

Cited By ~ 78

Author(s):

Cheng H. Lo ◽

Denis Spelman ◽

Michael Bailey ◽

D. James Cooper ◽

Jeffrey V. Rosenfeld ◽

...

Keyword(s):

Major Trauma ◽

Independent Predictor ◽

External Ventricular Drain ◽

Significant Risk ◽

Significant Risk Factor ◽

External Ventricular Drainage ◽

Infection Rates ◽

The Mean ◽

The Relationship ◽

Shed Light

Object The authors explored the relationship among the duration of external ventricular drainage, revision of external ventricular drains (EVDs), and cerebrospinal fluid (CSF) infection to shed light on the practice of electively revising these drains. Methods In a retrospective study of 199 patients with 269 EVDs in the intensive care unit at a major trauma center in Australasia, the authors found 21 CSF infections. Acinetobacter accounted for 10 (48%) of these infections. Whereas the duration of drainage was not an independent predictor of infection, multiple insertions of EVDs was a significant risk factor. Second and third EVDs in previously uninfected patients were more likely to become infected than first EVDs. An EVD infection was initially identified a mean of 5.5 ± 0.7 days postinsertion (standard error of the mean); these data—that is, the number of days—were normally distributed. Conclusions This pattern of infection is best explained by EVD-associated CSF infections being acquired by the introduction of bacteria on insertion of the drain rather than by subsequent retrograde colonization. Elective EVD revision would be expected to increase infection rates in light of these results, and thus the practice has been abandoned by the authors' institution.

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Hydroureteronephrosis in women with pelvic organ prolapse: a prospective cohort study

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20183773 ◽

2018 ◽

Vol 7 (9) ◽

pp. 3664

Author(s):

Pushplata Kumari ◽

Emily Divya Ebenezer ◽

Caroline Salomi ◽

Vaibhav Londhe ◽

Aruna Nitin Kekre

Keyword(s):

Chronic Kidney Disease ◽

Risk Factor ◽

Pelvic Organ Prolapse ◽

Kidney Disease ◽

Prospective Observational Study ◽

Surgical Repair ◽

Significant Risk ◽

Significant Risk Factor ◽

Pelvic Organ ◽

The Mean

Background: Pelvic organ prolapses (POP) is a common problem in women. The prevalence of POP increase with age. The true prevalence and risk factor for developing hydroureteronephrosis (HUN) in women with pelvic organ prolapse is still unclear due to lack of prospective studies on sufficiently large cohorts. This prospective study was done to study the prevalence of HUN in women with POP and to identify the risk factors for developing HUN.Methods: In this prospective observational study 219 patients were recruited for surgical repair for pelvic organ prolapse for 2 years. Preoperatively, all patients had transabdominal scan to assess the uterus, adnexa and to look for Hydroureteronephrosis (HUN). Women with presence of HUN were followed postoperatively look for the resolution of HUN.Results: The prevalence of bilateral HUN was 6.85%. The mean age of women with HUN ranged from 51-69 years. Diabetes and hypertension were significant risk factor for development of HUN (OR 4.70, 95% CI -1.59-13.88 and OR 3.72, 95% CI- 1.23-11.1 respectively). There was a statistically significant correlation between chronic kidney disease and HUN. (OR 1 with 95%: CI 9.49-30.42). The correlation between stage of pelvic organ prolapse and HUN was not statistically significant (p = 0.062). There was a statistically significant correlation between the duration (2years -15 years) of POP to HUN. (OR 0.233, 95%0.13-0.419). Patients were followed up post operatively for resolution of HUN. HUN resolved in 9 women (60%) and persisted in 6 (40%).Conclusions: The prevalence of bilateral HUN in women with pelvic organ prolapse was 6.8%. Presence of hypertension, diabetes and chronic kidney disease was a risk factor for HUN. HUN resolved in 60% of women after pelvic reconstructive surgery.

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Pelvic Floor Myofascial Pain Might Influence Treatment Outcome of Interstitial Cystitis/bladder Pain Syndrome

10.21203/rs.3.rs-1176386/v1 ◽

2021 ◽

Author(s):

Wan-Ru Yu ◽

Fei-Chi Chuang ◽

Wei-Chuan Chang ◽

Hann-Chorng Kuo

Keyword(s):

Pelvic Floor ◽

Interstitial Cystitis ◽

Myofascial Pain ◽

Pelvic Floor Muscle ◽

Pain Syndrome ◽

Response Assessment ◽

Bladder Capacity ◽

Bladder Pain Syndrome ◽

Bladder Pain ◽

The Relationship

Abstract IntroductionIn patients with interstitial cystitis or bladder pain syndrome (IC/BPS), 85% were found to have pelvic floor myofascial pain (PFMP) and hypertonicity (PFH). However, they are not typically trained to consider or assess PFMP as a contributing factor to patients’ IC/BPS symptoms. This study aimed to explore the relationship between PFMP and treatment outcomes in women with IC/BPS.MethodsPatients with IC/BPS who received any type of treatment were prospectively enrolled. They underwent vaginal digital examination at baseline. PFMP severity was quantified on the visual analog scale (VAS). Subject assessment items included O’Leary-Sant symptom score (OSS), Global Response Assessment (GRA), and Beck’s anxiety inventory. Object assessment items included bladder computed tomography (CT), urodynamic parameters, maximum bladder capacity, and grade of glomerulation.ResultsA total of 65 women with IC/BPS (mean age, 57.1 ± 11.3 years) were enrolled in the study. Patients with more severe PFMP had significantly higher rate of dyspareunia (p = .031); more comorbidities (p = .010); higher number of PFMP sites (p < .001); and higher OSS (p = .012). PFMP severity was not significantly correlated with bladder conditions, whether subjective or objective. Moreover, PFMP severity (VAS) was significantly negatively associated with GRA score.ConclusionPFMP might affect the subjective results of IC/BPS treatment but not the bladder condition. Therefore, in the future treatment of patients with IC/BPS, digital vaginal examinations of pelvic floor muscles should be performed and focused more on the PFM-related conditions, and necessary PFM treatments, such as the vaginal pelvic floor muscle message, should be scheduled.

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Oral Mucosal Lesions and DMFT Index Assessment in Rheumatoid Arthritis Patients in Birjand, Iran, in 2018

The Open Rheumatology Journal ◽

10.2174/1874312902014010034 ◽

2020 ◽

Vol 14 (1) ◽

pp. 34-39

Author(s):

Parvin Parvaei ◽

Afsaneh Dorri-giv ◽

Gholamreza Sharifzadeh ◽

Hakimeh Malakimoghadam ◽

Elham Atabati

Keyword(s):

Rheumatoid Arthritis ◽

Significant Risk ◽

Significant Risk Factor ◽

Index Score ◽

Common Finding ◽

Cross Sectional ◽

Oral Mucosal Lesions ◽

Dmft Index ◽

The Mean ◽

Mucosal Lesions

Introduction: Rheumatoid Arthritis (RA) may cause malfunction in the immune system and the inability to observe oral hygiene in patients due to physical deficits. A bacterial infection caused as such can constitute a significant risk factor for the development of systemic infection. The present study aimed to investigate the oral mucosal lesions, the DMFT index, and the Modified Gingival Index (MGI) in RA patients treated in Birjand city. Materials and Methods: This descriptive cross-sectional study was performed with 80 RA patients referred to rheumatology clinics of Birjand in 2018. Data were collected through observation, clinical examination, information forms, and medical records. After the patients were informed about the research purposes and signed consent forms for participation, they were examined at the rheumatology clinics. The collected data were analyzed in SPSS software (version 19). Results: Of the 80 patients, n = 64 (80%) had oral mucosal lesions. Dry mouth (66.3%) was the most common finding. The mean DMFT index score was 18.7. Conclusion: Oral mucosal lesions and the mean DMFT index score seem to be at high levels in RA patients, possibly due to the complications of the disease or the consumed medications.

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Prevalence of Gastroesophageal Reflux in Infants with Recurrent Brief Apneic Episodes

Canadian Respiratory Journal ◽

10.1155/1999/546420 ◽

1999 ◽

Vol 6 (5) ◽

pp. 401-404 ◽

Cited By ~ 16

Author(s):

Shahid Sheikh ◽

Thomas C Stephen ◽

Barbara Sisson

Keyword(s):

Risk Factor ◽

Gastroesophageal Reflux ◽

Medical Records ◽

Significant Risk ◽

Significant Risk Factor ◽

Acid Reflux ◽

Diagnostic Dilemma ◽

Esophageal Ph ◽

Life Threatening ◽

The Relationship

BACKGROUND: Apnea in an infant can be a diagnostic dilemma for the treating pediatrician. It is suggested that in some infants, gastroesophageal reflux (GER) might be a factor in the pathogenesis of apnea, although its role as a cause of apnea is still controversial.OBJECTIVE: To evaluate the prevalence of GER in infants presenting with recurrent brief apneic periods.PATIENTS AND METHODS: A retrospective review of the medical records of all the infants who underwent prolonged esophageal pH studies for brief apneic episodes (n=105) at the Kosair Children’s Hospital in the six years from January 1992 to December 1997 was performed. Infants presenting with apparent life-threatening episodes were excluded.RESULTS: Of 105 infants, 72 (68.6%) were younger than two months of age and 22 (21%) were born preterm. Fifty of 105 infants (47.6%) had positive esophageal pH studies for acid reflux. Among infants with positive pH studies, only 21 (42%) had associated gastrointestinal or feeding complaints.CONCLUSION: GER is present in a large number of infants presenting with brief apneic episodes. Though the relationship between the two is still not fully established, GER may be a significant risk factor for such apneic episodes in infants.

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Relationship of Gallbladder Perforation and Bacteriobilia with Occurrence of Surgical Site Infections following Laparoscopic Cholecystectomy

Minimally Invasive Surgery ◽

10.1155/2015/204508 ◽

2015 ◽

Vol 2015 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Nikhar Jain ◽

Sushanto Neogi ◽

Rajandeep Singh Bali ◽

Niket Harsh

Keyword(s):

Laparoscopic Cholecystectomy ◽

Significant Risk ◽

Surgical Site Infections ◽

Significant Risk Factor ◽

Gallbladder Perforation ◽

E Coli ◽

The Mean ◽

Monomicrobial Infection ◽

Relationship Of ◽

Gallbladder Rupture

Aim. To assess the occurrence of SSIs in patients with spillage of gallbladder contents and bacteriobilia during laparoscopic cholecystectomy.Methods. We evaluated 113 patients who underwent laparoscopic cholecystectomy between September 2013 and April 2015. The SSIs and their relationship with gallbladder rupture and bacteriobilia were assessed.Results. The mean age of patients developing SSIs was 45.57 ± 8.89 years. 18 patients (16%) had spillage of bile from the gallbladder. Percentage of SSIs overall was 6%, while percentage of SSIs in gallbladder content spillage was 5.5%. Organism profile of the culture from surgical site showed monomicrobial infection: 58%Staphylococcus aureus, 14%Pseudomonas, and 14%E. coli. The occurrence of SSIs in patients with bacteriobilia was 16% as compared to 2% in patients without bacteriobilia.Conclusions. Gallbladder content spillage is not a significant risk factor leading to increase in SSIs. The occurrence of SSIs is significantly higher in patients with bacteriobilia.

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The Relationship Between Padi4 -94G/A Polymorphism and Rheumatoid Arthritis: A Meta-analysis in Multi Ethnic Groups

10.21203/rs.3.rs-32405/v1 ◽

2020 ◽

Author(s):

Changchun Jian ◽

Jingsong Pu

Keyword(s):

Rheumatoid Arthritis ◽

Ethnic Groups ◽

Meta Analysis ◽

Significant Risk ◽

Significant Risk Factor ◽

Peptidylarginine Deiminase ◽

Increased Risk ◽

Different Populations ◽

The Relationship ◽

Strength Of Association

Abstract Background: A number of studies have reported the association between peptidylarginine deiminase 4 (PADI4) -94G/A polymorphisms and rheumatoid arthritis (RA) risk in different populations, however, the results remained inconclusive. Objecitve: We therefore aim to address this association by performed an updated meta-analysis in multi ethnic groups. Methods: The PubMed and Chinese related databases were searched up to January 2019. The strength of association between PADI -94G/A polymorphism and RA susceptibility was assessed with odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 22 studies with 14514 RA cases and 21138 controls were finally included in the analysis. Six ethnic groups such as China, Japan, USA, UK, Sweden and Spain were contained. In the overall population, it revealed that PADI -94G/A polymorphism was significantly associated with an increased risk of RA. In the subgroup analyses by ethnicity, significant association was found in China as well as in Japan and USA. Conclusions: This meta-analysis demonstrates that the PADI4 -94G/A polymorphisms may represent a significant risk factor for RA in China, in Japan and USA. Further studies are needed to clarify this finding, since most available studies were conducted among Chinese and Japanese in this study.

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PREVALENCE OF ANEMIA IN CHRONIC KIDNEY DISEASE PATIENTS

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v5i2.1742 ◽

2021 ◽

Vol 5 (2) ◽

Author(s):

Asma Ismail Alismail

Keyword(s):

Chronic Kidney Disease ◽

Standard Deviation ◽

Kidney Disease ◽

Significant Risk ◽

Public Health Problem ◽

Premature Death ◽

Significant Risk Factor ◽

The Mean ◽

End Stage ◽

Prevalence Of Anemia

Background: Chronic kidney disease (CKD), defined as renal damage with persistent and usually progressive deterioration of ultrafiltration, is a worldwide public health problem. Is considered as a significant risk factor for end-stage renal disease, anemia, cardiovascular disease, and premature death. The aging of the population and the generally increasing rates of obesity, hypertension, and diabetes worldwide suggest that the incidence and prevalence of CKD will rise over the next decades. Materials and Method: The data will consider all patients visiting outpatient’s department at the primary health center attached to King Faisal University in Al-Ahsa between 1st January 2010 and 31st December 2011. From the patients` files, we was record the age, gender, GFR, stages of CKD and state of anemia. Results: In this study, 49.3% of participants were male, and 50.7% was female—only 2.6% of participants on hemodialysis. The prevalence of anemia among the participants in our study was 55.5%. According to the results of the participants in this research, the mean age was 57.82, with a standard deviation of 17.067. The mean Hemoglobin of the participants was 11.775, with a standard deviation of 2.5334. The mean results of the participants by using CKD-EPI formula, to calculate GFR was 74.496 with a standard a deviation of 36.6787, which was the lowest mean of GFR. In Quadratic EGFR formula that was used to calculate GFR, the mean was 84.47 with a standard deviation of 35.677, which was the highest mean of GFR. DMRD formula was also used in this research to calculate the GFR, with a mean of 78.84 with a standard deviation of 50.371. Conclusions: In our data analysis, 100% of patients in the end stage of CKD had anemia although we used three different formulas to calculate GFR; however, the result was the same regarding patients in the end-stage. A surprising fact was found looking to other stages of CKD, and it is a correlation with anemia, the analysis of the data in this study did not show an increasing number of anemic patients to the stage of CKD in a stepwise manner. Keyword: Anemia, CKD, Al-Ahsa

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Obesity and hypertension

Orvosi Hetilap ◽

10.1556/oh.2013.29738 ◽

2013 ◽

Vol 154 (44) ◽

pp. 1736-1742 ◽

Cited By ~ 2

Author(s):

Gábor Simonyi ◽

Réka Kollár

Keyword(s):

Sympathetic Activity ◽

Cardiac Death ◽

Cardiovascular Events ◽

Significant Risk ◽

Vagal Tone ◽

Significant Risk Factor ◽

Autonomous Nervous System ◽

Body Fat Mass ◽

The Relationship ◽

Increased Activity

The frequency of hypertension and obesity is gradually growing in Hungary. At present 68.5% of men and 78% of women are obese. Hypertension and obesity are the most important risk factors of morbidity and mortality from cardiovascular disease. The relationship between increased sympathetic activity and hypertension is well known. Waist circumference and body fat mass correlate significantly with sympathetic activity, in which hyperlipidemia plays also a role. The increased activity of renin-angiotensin-aldosterone system via its vascular and renal effects also contributes to an increase of blood pressure. Increased sympathetic activity with decreasing vagal tone accompanying the imbalance of the autonomous nervous system is independent and significant risk factor of cardiovascular events including sudden cardiac death. Orv. Hetil., 154 (44), 1736–1742.

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