scholarly journals Extracellular vesicles from dHL-60 cells as delivery vehicles for diverse therapeutics

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jun-Kyu Kim ◽  
Young-Jin Youn ◽  
Yu-Bin Lee ◽  
Sun-Hwa Kim ◽  
Dong-Keun Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Extracellular Vesicles ◽  
Macrophage Polarization ◽  
Promyelocytic Leukemia ◽  
Leukemia Cells ◽  
Effector Functions ◽  
Potential Source ◽  
Monocyte Chemotaxis ◽  
Delivery Vehicles ◽  
Intercellular Communications

AbstractExtracellular vesicles (EVs) are membrane-derived heterogeneous vesicles that mediate intercellular communications. They have recently been considered as ideal vehicles for drug-delivery systems, and immune cells are suggested as a potential source for drug-loaded EVs. In this study, we investigated the possibility of neutrophils as a source for drug-loaded EVs. Neutrophil-like differentiated human promyelocytic leukemia cells (dHL-60) produced massive amounts of EVs within 1 h. The dHL-60 cells are also easily loaded with various cargoes such as antibiotics (penicillin), anticancer drug (paclitaxel), chemoattractant (MCP-1), miRNA, and Cas9. The EVs derived from the dHL-60 cells showed efficient incorporation of these cargoes and significant effector functions, such as bactericidal activity, monocyte chemotaxis, and macrophage polarization. Our results suggest that neutrophils or neutrophil-like promyelocytic cells could be an attractive source for drug-delivery EVs.

Cancer therapy based on extracellular vesicles as drug delivery vehicles

2020 ◽  
Vol 327 ◽  
pp. 296-315 ◽  
Author(s):  
Laura Cabeza ◽  
Gloria Perazzoli ◽  
Mercedes Peña ◽  
Ana Cepero ◽  
Cristina Luque ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Extracellular Vesicles ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Extracellular vesicles: Natural liver‐accumulating drug delivery vehicles for the treatment of liver diseases

2020 ◽  
Vol 10 (2) ◽  
Author(s):  
Gensheng Zhang ◽  
Xiaofang Huang ◽  
Huiqing Xiu ◽  
Yan Sun ◽  
Jiming Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Extracellular Vesicles ◽  
Liver Diseases ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Exosome-Based Delivery of Natural Products in Cancer Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Hang Song ◽  
Bin Liu ◽  
Bin Dong ◽  
Jing Xu ◽  
Hui Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Natural Products ◽  
Cancer Therapy ◽  
Natural Product ◽  
Current Knowledge ◽  
Donor Cell ◽  
Natural Compounds ◽  
Cellular Behaviors ◽  
Delivery Vehicles ◽  
Intercellular Communications

A rapidly growing research evidence has begun to shed light on the potential application of exosome, which modulates intercellular communications. As donor cell released vesicles, exosomes could play roles as a regulator of cellular behaviors in up-taken cells, as well as a delivery carrier of drugs for targeted cells. Natural product is an invaluable drug resources and it is used widely as therapeutic agents in cancers. This review summarizes the most recent advances in exosomes as natural product delivery carriers in cancer therapy from the following aspects: composition of exosomes, biogenesis of exosomes, and its functions in cancers. The main focus is the advantages and applications of exosomes for drug delivery in cancer therapy. This review also summarizes the isolation and application of exosomes as delivery carriers of natural products in cancer therapy. The recent progress and challenges of using exosomes as drug delivery vehicles for five representative anti-cancer natural products including paclitaxel, curcumin, doxorubicin, celastrol, and β-Elemene. Based on the discussion on the current knowledge about exosomes as delivery vehicles for drugs and natural compounds to the targeted site, this review delineates the landscape of the recent research, challenges, trends and prospects in exosomes as delivery vehicles for drugs and natural compounds for cancer treatment.

Extracellular Vesicles as Drug Delivery Vehicles for Rheumatoid Arthritis

2016 ◽  
Vol 11 (4) ◽  
pp. 329-342 ◽  
Author(s):  
Il-Kwon Kim ◽  
Sun-Hyun Kim ◽  
Seong-Mi Choi ◽  
Byung-Soo Youn ◽  
Han-Soo Kim
Keyword(s):  
Rheumatoid Arthritis ◽  
Drug Delivery ◽  
Extracellular Vesicles ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

Extracellular Vesicles as Drug Delivery Vehicles for Potent Redox Enzyme Catalase to Treat Parkinson's Disease

2018 ◽  
Vol 128 ◽  
pp. S18 ◽  
Author(s):  
Matthew J. Haney ◽  
Natalia L. Klyachko ◽  
Yuling Zhao ◽  
Alexander V. Kabanov ◽  
Elena V. Batrakova
Keyword(s):  
Parkinson’S Disease ◽  
Drug Delivery ◽  
Parkinson's Disease ◽  
Extracellular Vesicles ◽  
Redox Enzyme ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

scholarly journals Targeted Drug Delivery in Lipid-like Nanocages and Extracellular Vesicles

Acta Naturae ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 28-41 ◽  
Author(s):  
A. V. Sokolov ◽  
N. N. Kostin ◽  
L. A. Ovchinnikova ◽  
Y. A. Lomakin ◽  
A. A. Kudriaeva
Keyword(s):  
Drug Delivery ◽  
Extracellular Vesicles ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Structural Similarity ◽  
Biological Properties ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles ◽  
Targeted Drug ◽  
High Level

The possibility of targeted drug delivery to a specific tissue, organ, or cell has opened new promising avenues in treatment development. The technology of targeted delivery aims to create multifunctional carriers that are capable of long circulation in the patients organism and possess low toxicity at the same time. The surface of modern synthetic carriers has high structural similarity to the cell membrane, which, when combined with additional modifications, also promotes the transfer of biological properties in order to penetrate physiological barriers effectively. Along with artificial nanocages, further efforts have recently been devoted to research into extracellular vesicles that could serve as natural drug delivery vehicles. This review provides a detailed description of targeted delivery systems that employ lipid and lipid-like nanocages, as well as extracellular vesicles with a high level of biocompatibility, highlighting genetically encoded drug delivery vehicles.

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