A comprehensive study of isomerization and protonation reactions in the photocycle of the photoactive yellow protein

2014 ◽  
Vol 16 (46) ◽  
pp. 25263-25272 ◽  
Author(s):  
Lili Wei ◽  
Hongjuan Wang ◽  
Xuebo Chen ◽  
Weihai Fang ◽  
Haobin Wang
Keyword(s):  
Photoactive Yellow Protein ◽  
Wide Range ◽  
Comprehensive Picture ◽  
Comprehensive Study

A comprehensive picture of the overall photocycle was obtained to reveal a wide range of structural signals in the photoactive yellow protein.

Career Development Theory: An Integrated Analysis

2020 ◽  
Author(s):  
Julia Yates
Keyword(s):  
Career Choice ◽  
Subject Matter ◽  
Academic Disciplines ◽  
Development Theory ◽  
Integrated Analysis ◽  
Theoretical Frameworks ◽  
Wide Range ◽  
Comprehensive Picture ◽  
The Subject ◽  
Career Practice

Career theories are developed to help make sense of the complexity of career choice and development. The intricacy of the subject matter is such that career theories most often focus on one or two aspects of the phenomenon. As such, the challenges of integrating the theories with each other, and integrating them within career practice, are not insignificant. In this chapter, an overview of the theoretical landscape is offered that illustrates how the theories align with each other to build up a comprehensive picture of career choice and development. The chapter introduces a wide range of theoretical frameworks, spanning seven decades and numerous academic disciplines, and discusses the most well-known theorists alongside less familiar names. The chapter is structured around four concepts: identity, environment, career learning, and psychological career resources. Suggestions are offered for the incorporation of theories in career practice.

scholarly journals Controlling Teleportation-Based Locomotion in Virtual Reality with Hand Gestures: A Comparative Evaluation of Two-Handed and One-Handed Techniques

Electronics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 715
Author(s):  
Alexander Schäfer ◽  
Gerd Reis ◽  
Didier Stricker
Keyword(s):  
Virtual Reality ◽  
Virtual Worlds ◽  
User Preferences ◽  
Interaction Techniques ◽  
Hand Gestures ◽  
Wide Range ◽  
Effectiveness And Efficiency ◽  
High Degree ◽  
Additional Hardware ◽  
Comprehensive Study

Virtual Reality (VR) technology offers users the possibility to immerse and freely navigate through virtual worlds. An important component for achieving a high degree of immersion in VR is locomotion. Often discussed in the literature, a natural and effective way of controlling locomotion is still a general problem which needs to be solved. Recently, VR headset manufacturers have been integrating more sensors, allowing hand or eye tracking without any additional required equipment. This enables a wide range of application scenarios with natural freehand interaction techniques where no additional hardware is required. This paper focuses on techniques to control teleportation-based locomotion with hand gestures, where users are able to move around in VR using their hands only. With the help of a comprehensive study involving 21 participants, four different techniques are evaluated. The effectiveness and efficiency as well as user preferences of the presented techniques are determined. Two two-handed and two one-handed techniques are evaluated, revealing that it is possible to move comfortable and effectively through virtual worlds with a single hand only.

scholarly journals Role of Physical Exercise and Nutraceuticals in Modulating Molecular Pathways of Osteoarthritis

2021 ◽  
Vol 22 (11) ◽  
pp. 5722
Author(s):  
Alessandro de Sire ◽  
Nicola Marotta ◽  
Cinzia Marinaro ◽  
Claudio Curci ◽  
Marco Invernizzi ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Synergistic Effects ◽  
Molecular Pathways ◽  
Epigenetic Changes ◽  
Pathological Features ◽  
Oxidative Signaling ◽  
Cartilage Extracellular Matrix ◽  
Wide Range ◽  
Comprehensive Picture

Osteoarthritis (OA) is a painful and disabling disease that affects millions of patients. Its etiology is largely unknown, but it is most likely multifactorial. OA pathogenesis involves the catabolism of the cartilage extracellular matrix and is supported by inflammatory and oxidative signaling pathways and marked epigenetic changes. To delay OA progression, a wide range of exercise programs and naturally derived compounds have been suggested. This literature review aims to analyze the main signaling pathways and the evidence about the synergistic effects of these two interventions to counter OA. The converging nutrigenomic and physiogenomic intervention could slow down and reduce the complex pathological features of OA. This review provides a comprehensive picture of a possible signaling approach for targeting OA molecular pathways, initiation, and progression.

scholarly journals Professional characteristics of an educator: A survey of literature

2013 ◽  
Vol 25 (1) ◽  
pp. 1-22
Author(s):  
J. Anitha ◽  
R. Krishnaveni
Keyword(s):  
Student Outcome ◽  
Wide Scope ◽  
Review Of Literature ◽  
New Model ◽  
Professional Characteristics ◽  
Wide Range ◽  
Made In ◽  
Comprehensive Study

Literature has shown that various studies have dealt with different professional features of teaching and they have focused on one or few professional characteristics of educators. In spite of the immense amount of literature on educator characteristics, a comprehensive study that would encompass the vital professional characteristics of an educator in total is lacking. This has instigated the researcher to take up the study to identify the professional characteristics of an educator. An attempt was made in identifying the educators' characteristics using student outcome as a boundary criterion to select the characteristics from among several that are available in the literature. Therefore, a new model of professional characteristics of educators was proposed. This paper discusses in detail, the characteristics of a profession in general and the wide range of educator’s characteristics as studied in previous researches. The paper presents a wide scope for the models developed to be studied in depth to appreciate and investigate more about the professional characteristics identified through this review of literature. The models may also be tested empirically for further accumulation of knowledge in the field.

Effects of Head-Supported Devices on the Human and Manikin Necks

1997 ◽  
Author(s):  
Hashem Ashrafiuon ◽  
Nabih M. Alem ◽  
B. Joseph McEntire
Keyword(s):  
Center Of Gravity ◽  
Crash Simulation ◽  
Wide Range ◽  
Total Body ◽  
Comprehensive Study

Abstract A comprehensive study of the effect of Head-Supported Devices (HSDs) on the neck loading during helicopter accidents is presented. The new Articulated Total Body (ATB) model which treats the neck as a deformable segment was used for crash simulation. Different categories of human and manikin subjects were considered under several crash scenarios. Simulations were theoretically designed to include a wide range of HSDs by changing their weights and C. G. (center of gravity) locations relative to the head and studying the effects of these changes. HSDs were only included as added weight and inertia to the head and their possible detachment has not been modeled in the study. Hence, two typical detachable devices were modeled and selected simulations were repeated and compared not only to provide a theoretical measure of accuracy for the original results but also to see the effect of separation of these devices from the helmet.

scholarly journals Comprehensive study of sodium, copper, and silver clusters over a wide range of sizes 2≤N≤75

2009 ◽  
Vol 131 (17) ◽  
pp. 174510 ◽  
Author(s):  
Masahiro Itoh ◽  
Vijay Kumar ◽  
Tadafumi Adschiri ◽  
Yoshiyuki Kawazoe
Keyword(s):  
Silver Clusters ◽  
Wide Range ◽  
Comprehensive Study

A Discussion on recent research in air pollution - Plume rise estimates for electric generating stations

1969 ◽  
Vol 265 (1161) ◽  
pp. 221-243 ◽  
Keyword(s):  
Air Pollution ◽  
Pollution Control ◽  
Full Scale ◽  
Plume Rise ◽  
Air Pollution Control ◽  
Operational Conditions ◽  
The Public ◽  
Wide Range ◽  
Tennessee Valley ◽  
Comprehensive Study

The Tennessee Valley Authority, under sponsorship of the Public Health Service, National Air Pollution Control Administration, initiated a comprehensive study titled ‘ Full scale study of plume rise at large electric generating stations’ in 1963. The variability of plant sizes, stack heights, and stack configurations accommodated full scale assessment of plume rise over a wide range of meteorological and operational conditions.

scholarly journals Tensile and Interfacial Loading Characteristics of Boron Nitride-Carbon Nanosheet Reinforced Polymer Nanocomposites

Polymers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1075 ◽  
Author(s):  
Venkatesh Vijayaraghavan ◽  
Liangchi Zhang
Keyword(s):  
Boron Nitride ◽  
Polymer Nanocomposites ◽  
Elevated Temperatures ◽  
Tensile Loading ◽  
Interfacial Mechanics ◽  
Reinforced Polymer ◽  
Lattice Arrangement ◽  
Wide Range ◽  
New Generation ◽  
Comprehensive Study

The discovery of hybrid boron nitride–carbon (BN–C) nanostructures has triggered enormous research interest in the design and fabrication of new generation nanocomposites. The robust design of these nanocomposites for target applications requires their mechanical strength to be characterized with a wide range of factors. This article presents a comprehensive study, with the aid of molecular dynamics analysis, of the tensile loading mechanics of BN–C nanosheet reinforced polyethylene (PE) nanocomposites. It is observed that the geometry and lattice arrangement of the BN–C nanosheet influences the tensile loading characteristics of the nanocomposites. Furthermore, defects in the nanosheet can severely impact the tensile loading resistance, the extent of which is determined by the defect’s location. This study also found that the tensile loading resistance of nanocomposites tends to weaken at elevated temperatures. The interfacial mechanics of the BN–C nanocomposites are also investigated. This analysis revealed a strong dependency with the carbon concentration in the BN–C nanosheet.

scholarly journals Correlation Study of Honey Regarding their Physicochemical Properties and Sugars and Cyclitols Content

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 34 ◽  
Author(s):  
Ileana Andreea Ratiu ◽  
Hossam Al-Suod ◽  
Małgorzata Bukowska ◽  
Magdalena Ligor ◽  
Bogusław Buszewski
Keyword(s):  
Electrical Conductivity ◽  
Antioxidant Activity ◽  
Statistical Analysis ◽  
Physicochemical Properties ◽  
Sugar Content ◽  
Correlation Study ◽  
Osmotic Effect ◽  
Defensive Role ◽  
Wide Range ◽  
Comprehensive Study

Honey is a natural sweetener, with an osmotic effect on microorganisms due to the increased sugar content and low amount of water. Cyclitols are minor constituents of honey. They play a defensive role in plants against unfavorable environmental conditions. Honey’s physicochemical properties can vary, resulting in a wide range of colors, flavors, scents, antioxidant activity, dissimilar values of pH, acidity, electrical conductivity, etc. Some literature regarding correlation between honey types is already available, but a comprehensive study displaying an ample evaluation of multifarious aspects is still needed. This study focuses on the correlation between 18 honey types, originating from 10 countries, collected during four years, summarizing a total of 38 samples. A total of 6 physicochemical properties and 18 target components (sugars and cyclitols) were considered as variables. A correlation analysis is presented between the investigated parameters and between honey types, together with the statistical analysis which allowed for observation of the clusters’ distribution according with the investigated variables.

scholarly journals RUNX1-ETO: Attacking the Epigenome for Genomic Instable Leukemia

2019 ◽  
Vol 20 (2) ◽  
pp. 350 ◽  
Author(s):  
Emiel van der Kouwe ◽  
Philipp Staber
Keyword(s):  
Fusion Protein ◽  
Target Genes ◽  
Underlying Mechanism ◽  
Current Data ◽  
Distal Enhancer ◽  
Dna Repair Mechanisms ◽  
Genome Wide ◽  
Wide Range ◽  
Repair Mechanisms ◽  
Comprehensive Picture

Oncogenic fusion protein RUNX1-ETO is the product of the t(8;21) translocation, responsible for the most common cytogenetic subtype of acute myeloid leukemia. RUNX1, a critical transcription factor in hematopoietic development, is fused with almost the entire ETO sequence with the ability to recruit a wide range of repressors. Past efforts in providing a comprehensive picture of the genome-wide localization and the target genes of RUNX1-ETO have been inconclusive in understanding the underlying mechanism by which it deregulates native RUNX1. In this review; we dissect the current data on the epigenetic impact of RUNX1 and RUNX1-ETO. Both share similarities however, in recent years, research focused on epigenetic factors to explain their differences. RUNX1-ETO impairs DNA repair mechanisms which compromises genomic stability and favors a mutator phenotype. Among an increasing pool of mutated factors, regulators of DNA methylation are frequently found in t(8;21) AML. Together with the alteration of both, histone markers and distal enhancer regulation, RUNX1-ETO might specifically disrupt normal chromatin structure. Epigenetic studies on the fusion protein uncovered new mechanisms contributing to leukemogenesis and hopefully will translate into clinical applications.

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