scholarly journals Multifunctional graphene quantum dots for combined photothermal and photodynamic therapy coupled with cancer cell tracking applications

RSC Advances ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. 5251-5261 ◽  
Author(s):  
Mukeshchand Thakur ◽  
Mukesh Kumar Kumawat ◽  
Rohit Srivastava
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Carbon Source ◽  
Cancer Cell ◽  
Biomedical Applications ◽  
Cell Tracking ◽  
Graphene Quantum Dots ◽  
Green Factory ◽  
Fig Tree

An Indian fig tree serves as a green factory by providing withered leaves as a carbon source for graphene quantum dots synthesis. The quantum dots are multi-functional and have tremendous theranostic biomedical applications.

scholarly journals Organic dots (O-dots) for theranostic applications: preparation and surface engineering

RSC Advances ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 2253-2291
Author(s):  
Amin Shiralizadeh Dezfuli ◽  
Elmira Kohan ◽  
Sepand Tehrani Fateh ◽  
Neda Alimirzaei ◽  
Hamidreza Arzaghi ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Surface Engineering ◽  
Graphene Quantum Dots ◽  
Carbon Quantum Dots ◽  
Cargo Delivery ◽  
Bio Imaging ◽  
Theranostic Applications

Organic dots is a term used to represent materials including graphene quantum dots and carbon quantum dots because they rely on the presence of other atoms (O, H, and N) for their photoluminescence or fluorescence properties. Cargo delivery, bio-imaging, photodynamic therapy and photothermal therapy are major biomedical applications of organic dots.

scholarly journals Influence of Graphene Quantum Dots Surface Charge on their Uptake and Clearance in Melanoma Cells

2021 ◽  
Author(s):  
Lakshmi Narashimhan Ramana ◽  
Le N.M. Dinh ◽  
Vipul Agarwal
Keyword(s):  
Quantum Dots ◽  
Surface Charge ◽  
Biomedical Applications ◽  
Graphene Quantum Dots ◽  
Melanoma Cells ◽  
Rapid Clearance

Graphene quantum dots (GQDs) continue to draw interest in biomedical applications. However, their efficacy gets compromised due to their rapid clearance from body. On one side, rapid clearance is desired...

scholarly journals Effects of Doxorubicin Delivery by Nitrogen-Doped Graphene Quantum Dots on Cancer Cell Growth: Experimental Study and Mathematical Modeling

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 140
Author(s):  
Madison Frieler ◽  
Christine Pho ◽  
Bong Han Lee ◽  
Hana Dobrovolny ◽  
Giridhar R. Akkaraju ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Cell Growth ◽  
Cancer Cell ◽  
Graphene Quantum Dots ◽  
Maximum Effect ◽  
Cancer Cell Growth ◽  
Nitrogen Doped ◽  
Nitrogen Doped Graphene ◽  
Doped Graphene

With 18 million new cases diagnosed each year worldwide, cancer strongly impacts both science and society. Current models of cancer cell growth and therapeutic efficacy in vitro are time-dependent and often do not consider the Emax value (the maximum reduction in the growth rate), leading to inconsistencies in the obtained IC50 (concentration of the drug at half maximum effect). In this work, we introduce a new dual experimental/modeling approach to model HeLa and MCF-7 cancer cell growth and assess the efficacy of doxorubicin chemotherapeutics, whether alone or delivered by novel nitrogen-doped graphene quantum dots (N-GQDs). These biocompatible/biodegradable nanoparticles were used for the first time in this work for the delivery and fluorescence tracking of doxorubicin, ultimately decreasing its IC50 by over 1.5 and allowing for the use of up to 10 times lower doses of the drug to achieve the same therapeutic effect. Based on the experimental in vitro studies with nanomaterial-delivered chemotherapy, we also developed a method of cancer cell growth modeling that (1) includes an Emax value, which is often not characterized, and (2), most importantly, is measurement time-independent. This will allow for the more consistent assessment of the efficiency of anti-cancer drugs and nanomaterial-delivered formulations, as well as efficacy improvements of nanomaterial delivery.

Recent Advances in the Cancer Bioimaging with Graphene Quantum Dots

2018 ◽  
Vol 25 (25) ◽  
pp. 2876-2893 ◽  
Author(s):  
Keheng Li ◽  
Xinna Zhao ◽  
Gang Wei ◽  
Zhiqiang Su
Keyword(s):  
Quantum Dots ◽  
Biomedical Applications ◽  
Cell Imaging ◽  
Graphene Quantum Dots ◽  
Biological Properties ◽  
Live Cells ◽  
Physical Chemical ◽  
Specific Cancer ◽  
Good Biocompatibility ◽  
Low Cytotoxicity

Fluorescent graphene quantum dots (GQDs) have attracted increasing interest in cancer bioimaging due to their stable photoluminescence (PL), high stability, low cytotoxicity, and good biocompatibility. In this review, we present the synthesis and chemical modification of GQDs firstly, and then introduce their unique physical, chemical, and biological properties like the absorption, PL, and cytotoxicity of GQDs. Finally and most importantly, the recent applications of GQDs in cancer bioimaging are demonstrated in detail, in which we focus on the biofunctionalization of GQDs for specific cancer cell imaging and real-time molecular imaging in live cells. We expect this work would provide valuable guides on the synthesis and modification of GQDs with adjustable properties for various biomedical applications in the future.

Efficient synthesis of rice based graphene quantum dots and their fluorescent properties

RSC Advances ◽  
2016 ◽  
Vol 6 (28) ◽  
pp. 23518-23524 ◽  
Author(s):  
Hemen Kalita ◽  
Jeotikanta Mohapatra ◽  
Lina Pradhan ◽  
Arijit Mitra ◽  
Dhirendra Bahadur ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Carbon Source ◽  
Graphene Quantum Dots ◽  
Efficient Synthesis ◽  
Fluorescent Properties ◽  
Rice Grains ◽  
Green Approach

We present a facile green approach to synthesize monodisperse graphene quantum dots (GQDs) of sizes 2–6.5 nm using rice grains as a carbon source.

Quantum dots and their potential biomedical applications in photosensitization for photodynamic therapy

Nanomedicine ◽  
2009 ◽  
Vol 4 (3) ◽  
pp. 353-363 ◽  
Author(s):  
Elnaz Yaghini ◽  
Alexander M Seifalian ◽  
Alexander J MacRobert
Keyword(s):  
Quantum Dots ◽  
Photodynamic Therapy ◽  
Biomedical Applications

scholarly journals Core-shell Semiconductor Nanocrystals: Effect of Composition, Size, Surface Coatings on their Optical Properties, Toxicity and Pharmacokinetics

2017 ◽  
Vol 23 (3) ◽  
pp. 340-349 ◽  
Author(s):  
Wafa' T. Al-Jamal
Keyword(s):  
Quantum Dots ◽  
Optical Properties ◽  
Photodynamic Therapy ◽  
Biomedical Applications ◽  
Semiconductor Nanocrystals ◽  
Organic Dye ◽  
Surface Coatings ◽  
Core Shell ◽  
Biomedical Field

Quantum dots are semiconducting nanocrystals that exhibit extraordinary optical properties. QD have shown higher photostability compared to standard organic dye type probes. Therefore, they have been heavily explored in the biomedical field. This review will discuss the different approaches to synthesis, solubilise and functionalise QD. Their main biomedical applications in imaging and photodynamic therapy will be highlighted. Finally, QD biodistribution profile and in vivo toxicity will be discussed.

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