Thermoresponsive dendronized chitosan-based hydrogels as injectable stem cell carriers

2019 ◽  
Vol 10 (18) ◽  
pp. 2305-2315 ◽  
Author(s):  
Xiacong Zhang ◽  
Lin Cheng ◽  
Letian Feng ◽  
Yu Peng ◽  
Zhimin Zhou ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Schiff Base ◽  
Stem Cell ◽  
Self Healing ◽  
Physiological Conditions ◽  
Chitosan Hydrogels ◽  
Cell Carriers

A combination of dendronization and Schiff-base chemistry endows injectable chitosan hydrogels with thermoresponsiveness, self-healing abilities and enhanced mechanical properties under physiological conditions.

Injectable chitin hydrogels with self-healing property and biodegradability as stem cell carriers

2021 ◽  
Vol 256 ◽  
pp. 117574
Author(s):  
Xuefeng Yang ◽  
Hongye Yang ◽  
Xueyu Jiang ◽  
Boguang Yang ◽  
Kunkun Zhu ◽  
...  
Keyword(s):  
Stem Cell ◽  
Self Healing ◽  
Healing Property ◽  
Cell Carriers

scholarly journals Biocompatible Diselenide-Containing Protein Hydrogels with Effective Visible-Light-Initiated Self-Healing Properties

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4360
Author(s):  
Shengda Liu ◽  
Shengchao Deng ◽  
Tengfei Yan ◽  
Xin Zhang ◽  
Ruizhen Tian ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Schiff Base ◽  
Visible Light ◽  
Enzymatic Catalysis ◽  
Mechanical Damage ◽  
Covalent Bond ◽  
Light Response ◽  
Soft Materials ◽  
Self Healing ◽  
Protein Hydrogels

Smart hydrogels are typical functional soft materials, but their functional and mechanical properties are compromised upon micro- or macro-mechanical damage. In contrast, hydrogels with self-healing properties overcome this limitation. Herein, a dual dynamic bind, cross-linked, self-healing protein hydrogel is prepared, based on Schiff base bonds and diselenide bonds. The Schiff base bond is a typical dynamic covalent bond and the diselenide bond is an emerging dynamic covalent bond with a visible light response, which gives the resulting hydrogel a dual response in visible light and a desirable self-healing ability. The diselenide-containing protein hydrogels were biocompatible due to the fact that their main component was protein. In addition, the hydrogels loaded with glucose oxidase (GOx) could be transformed into sols in glucose solution due to the sensitive response of the diselenide bonds to the generated hydrogen peroxide (H2O2) by enzymatic catalysis. This work demonstrated a diselenide-containing protein hydrogel that could efficiently self-heal up to nearly 100% without compromising their mechanical properties under visible light at room temperature.

scholarly journals Nano-structured dynamic Schiff base cues as robust self-healing polymers for biomedical and tissue engineering applications: a review

2021 ◽  
Author(s):  
Umer Shahzad Malik ◽  
Muhammad Bilal Khan Niazi ◽  
Zaib Jahan ◽  
Mazhar Iqbal Zafar ◽  
Dai-Viet N. Vo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Schiff Base ◽  
Polymer Materials ◽  
Self Healing ◽  
Covalent Bonds ◽  
Physiological Conditions ◽  
Polymeric Networks ◽  
Robust Techniques ◽  
Reversible Covalent ◽  
Network Disruption

AbstractPolymer materials are vulnerable to damages, failures, and degradations, making them economically unreliable. Self-healing polymers, on the other hand, are multifunctional materials with superior properties of autonomic recovery from physical damages. These materials are suitable for biomedical and tissue engineering in terms of cost and durability. Schiff base linkages-based polymer materials are one of the robust techniques owing to their simple self-healing mechanism. These are dynamic reversible covalent bonds, easy to fabricate at mild conditions, and can self-reintegrate after network disruption at physiological conditions making them distinguished. Here we review self-healing polymer materials based on Schiff base bonds. We discuss the Schiff base bond formation between polymeric networks, which explains the self-healing phenomenon. These bonds have induced 100% recovery in optimal cases.

Natural-based Hydrogels: A Journey from Simple to Smart Networks for Medical Examination

2020 ◽  
Vol 27 (16) ◽  
pp. 2704-2733
Author(s):  
Javad Tavakoli ◽  
Jing Wang ◽  
Clarence Chuah ◽  
Youhong Tang
Keyword(s):  
Mechanical Properties ◽  
Targeted Delivery ◽  
Biological Properties ◽  
Medical Examination ◽  
Fine Tuning ◽  
Historical Evolution ◽  
Self Healing ◽  
Physiological Conditions ◽  
Wide Range ◽  
Fluorescent Bioprobes

Natural hydrogels, due to their unique biological properties, have been used extensively for various medical and clinical examinations that are performed to investigate the signs of disease. Recently, complex-crosslinking strategies improved the mechanical properties and advanced approaches have resulted in the introduction of naturally derived hydrogels that exhibit high biocompatibility, with shape memory and self-healing characteristics. Moreover, the creation of self-assembled natural hydrogels under physiological conditions has provided the opportunity to engineer fine-tuning properties. To highlight recent studies of natural-based hydrogels and their applications for medical investigation, a critical review was undertaken using published papers from the Science Direct database. This review presents different natural-based hydrogels (natural, natural-synthetic hybrid and complex-crosslinked hydrogels), their historical evolution, and recent studies of medical examination applications. The application of natural-based hydrogels in the design and fabrication of biosensors, catheters and medical electrodes, detection of cancer, targeted delivery of imaging compounds (bioimaging) and fabrication of fluorescent bioprobes is summarised here. Without doubt, in future, more useful and practical concepts will be derived to identify natural-based hydrogels for a wide range of clinical examination applications.

Autonomous self-healing polyisoprene elastomers with high modulus and good toughness based on the synergy of dynamic ionic crosslinks and highly disordered crystals

2020 ◽  
Vol 11 (41) ◽  
pp. 6549-6558
Author(s):  
Yohei Miwa ◽  
Mayu Yamada ◽  
Yu Shinke ◽  
Shoichi Kutsumizu
Keyword(s):  
Mechanical Properties ◽  
Room Temperature ◽  
Self Healing ◽  
High Modulus ◽  
Disordered Crystals ◽  
Ionic Crosslinks

We designed a novel polyisoprene elastomer with high mechanical properties and autonomous self-healing capability at room temperature facilitated by the coexistence of dynamic ionic crosslinks and crystalline components that slowly reassembled.

Polypyrrole/PU hybrid hydrogels: electrically conductive and fast self-healing for the potential application in body-monitor sensor

2021 ◽  
Author(s):  
Zhanyu Jia ◽  
Guangyao Li ◽  
Juan Wang ◽  
shouhua Su ◽  
Jie Wen ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Electrical Conductivity ◽  
Potential Application ◽  
Self Healing ◽  
Electrically Conductive ◽  
Sensor Application ◽  
Hybrid Hydrogels ◽  
Health Monitor

Conductivity, self-healing and moderate mechanical properties are necessary for multifunctional hydrogels which have great potential in health-monitor sensor application. However, the combination of electrical conductivity, self-healing and good mechanical properties...

Self-healing, Highly Elastic and Amphiphilic Silicone-based Polyurethane for Antifouling Coatings

2021 ◽  
Author(s):  
Xiaobin Lin ◽  
Qingyi Xie ◽  
Chunfeng Ma ◽  
Guangzhao Zhang
Keyword(s):  
Mechanical Properties ◽  
Silicone Elastomer ◽  
Self Healing ◽  
Fouling Resistance ◽  
The Poor ◽  
Antifouling Coatings ◽  
Fouling Release

Silicone elastomer coatings have attracted increasing attention owing to its eco-friendly nature, excellent fouling release ability and drag-reducing property. However, the poor mechanical properties and lack of fouling resistance limits...

The preparation of hydrogels with highly efficient self-healing and excellent mechanical properties

2021 ◽  
Vol 329 ◽  
pp. 115581
Author(s):  
Chaoxian Chen ◽  
Zhongcun Li ◽  
Siwen Chen ◽  
Lingzhi Kong ◽  
Zhihao Guo ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Self Healing ◽  
Highly Efficient

Mesenchymal stem cell carriers enhance antitumor efficacy induced by oncolytic reovirus in acute myeloid leukemia

2021 ◽  
Vol 94 ◽  
pp. 107437
Author(s):  
Xianyao Wang ◽  
Yichen Yang ◽  
Nianxue Wang ◽  
Xijun Wu ◽  
Jianwei Xu ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Myeloid Leukemia ◽  
Antitumor Efficacy ◽  
Cell Carriers ◽  
Acute Myeloid

scholarly journals The Effect of Superabsorbent Polymers on the Microstructure and Self-Healing Properties of Cementitious-Based Composite Materials

2021 ◽  
Vol 11 (2) ◽  
pp. 700
Author(s):  
Irene A. Kanellopoulou ◽  
Ioannis A. Kartsonakis ◽  
Costas A. Charitidis
Keyword(s):  
Mechanical Properties ◽  
Composite Materials ◽  
Hybrid Structure ◽  
The Self ◽  
Self Healing ◽  
Cementitious Composite ◽  
Superabsorbent Polymers ◽  
Porosity Reduction ◽  
Environment Control ◽  
The Impact

Cementitious structures have prevailed worldwide and are expected to exhibit further growth in the future. Nevertheless, cement cracking is an issue that needs to be addressed in order to enhance structure durability and sustainability especially when exposed to aggressive environments. The purpose of this work was to examine the impact of the Superabsorbent Polymers (SAPs) incorporation into cementitious composite materials (mortars) with respect to their structure (hybrid structure consisting of organic core—inorganic shell) and evaluate the microstructure and self-healing properties of the obtained mortars. The applied SAPs were tailored to maintain their functionality in the cementitious environment. Control and mortar/SAPs specimens with two different SAPs concentrations (1 and 2% bwoc) were molded and their mechanical properties were determined according to EN 196-1, while their microstructure and self-healing behavior were evaluated via microCT. Compressive strength, a key property for mortars, which often degrades with SAPs incorporation, in this work, practically remained intact for all specimens. This is coherent with the porosity reduction and the narrower range of pore size distribution for the mortar/SAPs specimens as determined via microCT. Moreover, the self-healing behavior of mortar-SAPs specimens was enhanced up to 60% compared to control specimens. Conclusively, the overall SAPs functionality in cementitious-based materials was optimized.

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