scholarly journals Cost-effective fabrication of photopolymer molds with multi-level microstructures for PDMS microfluidic device manufacture

RSC Advances ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 4071-4079 ◽  
Author(s):  
Carol M. Olmos ◽  
Ana Peñaherrera ◽  
Gustavo Rosero ◽  
Karla Vizuete ◽  
Darío Ruarte ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Cost Effective ◽  
Mold Fabrication ◽  
Multi Level

This paper describes a methodology of photopolymer mold fabrication with multi-level microstructures for polydimethylsiloxane (PDMS) microfluidic device manufacture.

AlCu Pattern Generation on 3D StructuredWafer Using Multi Level Exposure Method on Electrodeposited Polymer Material

2003 ◽  
Vol 766 ◽  
Author(s):  
Vineet Sharma ◽  
Arief B. Suriadi ◽  
Frank Berauer ◽  
Laurie S. Mittelstadt
Keyword(s):  
Line Width ◽  
Metal Film ◽  
Focal Depth ◽  
Cost Effective ◽  
Pattern Generation ◽  
Promising Technique ◽  
Critical Dimensions ◽  
Exposure Method ◽  
Multi Level ◽  
3D Surfaces

AbstractNormal photolithography tools have focal depth limitations and are unable to meet the expectations of high resolution photolithography on highly topographic structures. This paper shows a cost effective and promising technique of combining two different approaches to achieve critical dimensions of traces on slope pattern continuity on highly topographic structures. Electrophoretically deposited photoresist is used on 3-D structured wafers. This photoresist coating technique is fairly known in the MEMS industries to achieve uniform and conformal photoresist films on 3D surfaces. Multi step exposures are used to expose electrophoretically deposited photoresist. AlCu (Cu-0.5%), 0.47-0.53 μm thick metal film is deposited on 3D structured silicon substrate to plate photoresist. By combining these two novel methods, metal (AlCu) traces of 75 μm line width and 150 μm pitch (from top flat to down the slope) have been demonstrated on isotropically etched 350 μm deep trenches with 5-10% line width loss.

scholarly journals Microsphere-Based Microfluidic Device for Plasma Separation and Potential Biochemistry Analysis Applications

Micromachines ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 487
Author(s):  
Hongyan Xu ◽  
Zhangying Wu ◽  
Jinan Deng ◽  
Jun Qiu ◽  
Ning Hu ◽  
...  
Keyword(s):  
Blood Sample ◽  
Microfluidic Device ◽  
Biochemical Analysis ◽  
Cost Effective ◽  
Clinical Diagnostics ◽  
Correction Factors ◽  
Separation Device ◽  
Blood Samples ◽  
Plasma Separation ◽  
Blood Biochemical

The development of a simple, portable, and cost-effective plasma separation platform for blood biochemical analysis is of great interest in clinical diagnostics. We represent a plasma separation microfluidic device using microspheres with different sizes as the separation barrier. This plasma separation device, with 18 capillary microchannels, can extract about 3 μL of plasma from a 50 μL blood sample in about 55 min. The effects of evaporation and the microsphere barrier on the plasma biochemical analysis results were studied. Correction factors were applied to compensate for these two effects. The feasibility of the device in plasma biochemical analysis was validated with clinical blood samples.

Manufacturing Metamaterials Using Synchrotron Lithography

2010 ◽  
Vol 75 ◽  
pp. 230-239
Author(s):  
Herbert O. Moser ◽  
Linke Jian ◽  
Shenbaga M.P. Kalaiselvi ◽  
Selven Virasawmy ◽  
Sivakumar M. Maniam ◽  
...  
Keyword(s):  
Electromagnetic Waves ◽  
Cost Effective ◽  
Pattern Generation ◽  
Geometrical Parameters ◽  
X Ray ◽  
Spectral Bands ◽  
Left Handed ◽  
Aspect Ratios ◽  
Multi Level ◽  
Primary Pattern

The function of metamaterials relies on their resonant response to electromagnetic waves in characteristic spectral bands. To make metamaterials homogeneous, the size of the basic resonant element should be less than 10% of the wavelength. For the THz range up to the visible, structure details of 50 nm to 30 μm are required as are high aspect ratios, tall heights, and large areas. For such specifications, lithography, in particular, synchrotron radiation deep X-ray lithography, is the method of choice. X-ray masks are made via primary pattern generation by means of electron or laser writing. Several different X-ray masks and accurate mask-substrate alignment are necessary for architectures requiring multi-level lithography. Lithography is commonly followed by electroplating of metallic replica. The process can also yield mould inserts for cost-effective manufacture by plastic moulding. We made metamaterials based on rod-split-rings, split-cylinders, S-string bi-layer chips, and S-string meta-foils. Left-handed resonance bands range from 2.4 to 216 THz. Latest is the all-metal self-supported flexible meta-foil with pass-bands of 45% up to 70% transmission at 3.4 to 4.5 THz depending on geometrical parameters.

scholarly journals Magnetic Control of an Electrochemical Microfluidic Device with an Arrayed Immunosensor for Simultaneous Multiple Immunoassays

2007 ◽  
Vol 53 (7) ◽  
pp. 1323-1329 ◽  
Author(s):  
Dianping Tang ◽  
Ruo Yuan ◽  
Yaqin Chai
Keyword(s):  
Tumor Markers ◽  
Microfluidic Device ◽  
Simultaneous Detection ◽  
Reference Electrode ◽  
Cost Effective ◽  
Sio2 Nanoparticles ◽  
Magnetic Bead ◽  
Label Free ◽  
Specific Tumor ◽  
Protein Diagnostics

Abstract Background: Methods based on magnetic bead probes have been developed for immunoassay, but most involve complicated labeling or stripping procedures and are unsuitable for routine use. Methods: We synthesized magnet core/shell NiFe2O4/SiO2 nanoparticles and fabricated an electrochemical magnetic controlled microfluidic device for the detection of 4 tumor markers. The immunoassay system consisted of 5 working electrodes and an Ag/AgCl reference electrode integrated on a glass substrate. Each working electrode contained a different antibody immobilized on the NiFe2O4/SiO2 nanoparticle surface and was capable of measuring a specific tumor marker using noncompetitive electrochemical immunoassay. Results: Under optimal conditions, the multiplex immunoassay enabled the simultaneous detection of 4 tumor markers. The sensor detection limit was <0.5 μg/L (or <0.5 kunits/L) for most analytes. Intra- and interassay imprecisions (CVs) were <4.5% and 8.7% for analyte concentrations >5 μg/L (or >5 kunits/L), respectively. No nonspecific adsorption was observed during a series of procedures to detect target proteins, and electrochemical cross-talk (CV) between neighboring sites was <10%. Conclusion: This immunoassay system offers promise for label-free, rapid, simple, cost-effective analysis of biological samples. Importantly, the chip-based immunosensor could be suitable for use in the mass production of miniaturized lab-on-a-chip devices and open new opportunities for protein diagnostics and biosecurity.

scholarly journals Citizen-Led Sampling to Monitor Phosphate Levels in Freshwater Environments Using a Simple Paper Microfluidic Device

2021 ◽  
Author(s):  
Samantha Richardson ◽  
Alexander Iles ◽  
Jeanette M. Rotchell ◽  
Tim Charlson ◽  
Annabel Hanson ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Mobile Technology ◽  
High Frequency ◽  
Microfluidic Devices ◽  
Cost Effective ◽  
Smartphone App ◽  
Test Device ◽  
Monitoring Campaign ◽  
Paper Microfluidic ◽  
Freshwater Environments

We demonstrate how a combination of paper microfluidic devices and handheld mobile technology can be used by citizen scientists to carry out a sustained water monitoring campaign. We have developed a paper-based analysis device and a 3 minute sampling workflow that requires no more than a container, a test device and a smartphone app. The contaminant measured in these pilots are phosphates, detectable down to 3 mg L<sup>-1</sup>. Together these allow volunteers to successfully carry out cost-effective, high frequency, phosphate monitoring over an extended geographies and periods.

scholarly journals A Textile-Based Microfluidic Platform for the Detection of Cytostatic Drug Concentration in Sweat Samples

2020 ◽  
Vol 10 (12) ◽  
pp. 4392 ◽  
Author(s):  
Goran M. Stojanović ◽  
Maja M. Radetić ◽  
Zoran V. Šaponjić ◽  
Marija B. Radoičić ◽  
Milan R. Radovanović ◽  
...  
Keyword(s):  
Microfluidic Device ◽  
Cost Effective ◽  
Electrical Contacts ◽  
Cytostatic Drug ◽  
Variable Resistor ◽  
Microfluidic Platform ◽  
Textile Fabrics ◽  
Drug Concentrations ◽  
Artificial Sweat ◽  
Conductive Textile

This work presents a new multilayered microfluidic platform, manufactured using a rapid and cost-effective xurography technique, for the detection of drug concentrations in sweat. Textile fabrics made of cotton and polyester were used as a component of the platform, and they were positioned in the middle of the microfluidic device. In order to obtain a highly conductive textile, the fabrics were in situ coated with different amounts of polyaniline and titanium dioxide nanocomposite. This portable microfluidic platform comprises at least three layers of optically transparent and flexible PVC foils which were stacked one on top of the other. Electrical contacts were provided from the edge of the textile material when a microfluidic variable resistor was actually created. The platform was tested in plain artificial sweat and in artificial sweat with a dissolved cytostatic test drug, cyclophosphamide, of different concentrations. The proposed microfluidic device decreased in resistance when the sweat was applied. In addition, it could successfully detect different concentrations of cytostatic medication in the sweat, which could make it a very useful tool for simple, reliable, and fast diagnostics.

scholarly journals Rapid and cost-effective fabrication of selectively permeable calcium-alginate microfluidic device using “modified” embedded template method

2012 ◽  
Vol 6 (1) ◽  
pp. 012821 ◽  
Author(s):  
Amit Asthana ◽  
Kwang Ho Lee ◽  
Kyeong-Ohn Kim ◽  
Dong-Myung Kim ◽  
Dong-Pyo Kim
Keyword(s):  
Microfluidic Device ◽  
Calcium Alginate ◽  
Cost Effective ◽  
Template Method

Multi-level modelling approach for cost effective t-cell manufacture

Cytotherapy ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. S198
Author(s):  
M. Shariatzadeh ◽  
K.E. Glen ◽  
R.J. Thomas
Keyword(s):  
T Cell ◽  
Cost Effective ◽  
Multi Level ◽  
Modelling Approach

scholarly journals Cost-effective 97%-efficiency charge-pump voltage balancer for multi-level PWM photovoltaic micro-inverter

2017 ◽  
Vol 14 (8) ◽  
pp. 20170038-20170038 ◽  
Author(s):  
Mohana Sundar ◽  
Jeong-Hyun Park ◽  
Changkun Park ◽  
Joung-Hu Park
Keyword(s):  
Charge Pump ◽  
Cost Effective ◽  
Multi Level ◽  
Micro Inverter
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